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  1. Diagnosis of chronic pancreatitis:- In people with suspected (or under investigation for) chronic pancreatitis, whose diagnosis has not been confirmed by the use of 'first-line' tests (for example, CT scan, ultrasound scan, upper gastrointestinal [GI] endoscopy or combinations of these), what is the accuracy of magnetic resonance cholangiopancreatography (MRCP) with or without secretin and endoscopic ultrasound to identify whether chronic pancreatitis is present?

    Recommendation ID NG104/1 Question Diagnosis of chronic pancreatitis:- In people with suspected (or under investigation for) chronic pancreatitis

  2. Advance planning about end of life care:- What is the effectiveness and cost effectiveness of advance care planning for end of life care for people growing older with learning disabilities, and their family members and carers?What processes are in place to document and follow the wishes of people growing older with learning disabilities about their decisions on end of life care?

    Recommendation ID NG96/5 Question Advance planning about end of life care:- What is the effectiveness and cost effectiveness of advance

  3. Targeted interventions to support and improve decision-making capacity for treatment:- What is the effectiveness and cost effectiveness of different targeted interventions (speech and language therapy and psychological and psychosocial interventions) to support and improve decision-making capacity for treatment in specific groups?

    Recommendation ID NG108/2 Question Targeted interventions to support and improve decision-making capacity for treatment:- What is the effectiveness

  4. Training and support for practitioners:- What is the effectiveness and cost effectiveness of different training programmes on the Mental Capacity Act 2005 at improving practice for practitioners involved in supporting decision-making, conducting capacity assessments and making best interests decisions?

    Recommendation ID NG108/1 Question Training and support for practitioners:- What is the effectiveness and cost effectiveness of different

  5. Identifying health conditions:- What is the effectiveness and cost effectiveness of different ways of identifying age-related and other physical and mental health conditions, in people growing older with learning disabilities?What can mainstream and specialist health services do to facilitate:- early identification of health conditions in people with learning disabilities?- equal access to health services in people with learning disabilities?

    Recommendation ID NG96/2 Question Identifying health conditions:- What is the effectiveness and cost effectiveness of different ways of

  6. Characteristics of a person delivering an intervention:- How do the professional characteristics of pharmacy staff affect the effectiveness and cost effectiveness of delivering information, advice, education or behavioural support to underserved groups and the general population? (Characteristics include, for example, job roles such as health champion, as well as competencies and level of training.)

    Recommendation ID NG102/4 Question Characteristics of a person delivering an intervention:- How do the professional characteristics of

  7. People with limited mobility:- How effective and cost effective are environmental changes to increase physical activity among people with limited mobility because of either enduring or life-stage specific factors (for example, small children, parents with prams or buggies, disabled people including those with sensoryimpairments and learning disabilities, older people, people with dementia and their carers)? Are effects maintained over time?

    Recommendation ID NG90/4 Question People with limited mobility:- How effective and cost effective are environmental changes to increase

  8. Use of public open spaces by particular groups:- How effective and cost effective are environmental changes to increase physical activity through use of public open spaces (including blue, green and grey spaces) by the following groups:- black and minority ethnic groups- groups with low socioeconomic status- groups experiencing other forms of disadvantage, for example carers, people with severe mental health conditions?Are effects maintained over time?

    Recommendation ID NG90/3 Question Use of public open spaces by particular groups:- How effective and cost effective are environmental changes

  9. Effective interventions for addressing child abuse and neglect in the UK:- What interventions, approaches and methodologies provided by social care and voluntary sectorservices are effective and cost effective in the UK to prevent the recurrence of child abuse and neglect, and to improve the wellbeing of children, young people and families?

    Recommendation ID NG76/9 Question Effective interventions for addressing child abuse and neglect in the UK:- What interventions, approaches

  10. Effective interventions for children and young people who have experienced online-facilitated abuse, including online grooming:- What interventions are effective and cost effective in improving the wellbeing of children and young people who have experienced online-facilitated abuse, including grooming online?

    Recommendation ID NG76/8 Question Effective interventions for children and young people who have experienced online-facilitated abuse,

  11. Effective interventions for parents or carers with substance misuse problems:- What interventions, including family behaviour therapy, are effective and cost effective inimproving parenting and preventing recurrence of neglect by parents or carers with substance misuse problems and whose children are on a child protection plan under the category of neglect in the UK?

    Recommendation ID NG76/13 Question Effective interventions for parents or carers with substance misuse problems:- What interventions, including

  12. Diagnosing asthma in children and young people aged 5 to 16:- What is the acceptability and diagnostic accuracy of objective tests that could be used to comprisea diagnostic pathway for asthma in children and young people aged 5 to 16 (for example, exercise challenge, direct bronchial challenge with histamine or methacholine, indirect bronchial challenge with mannitol and peripheral blood eosinophil count)?

    Recommendation ID NG80/1 Question Diagnosing asthma in children and young people aged 5 to 16:- What is the acceptability and diagnostic

  13. In patients with negative MRI (Likert score 1 or 2), what is the next best diagnostic investigation to rule out clinically significant prostate cancer? What is the diagnostic accuracy of transperineal mapping biopsy compared with transperineal non-mapping biopsy in the diagnosis of clinically significant prostate cancer?

    Recommendation ID NG131/7 Question In patients with negative MRI (Likert score 1 or 2), what is the next best diagnostic investigation

  14. Further research on selective internal radiation therapy (SIRT) for unresectable primary intrahepatic cholangiocarcinoma in the form of prospective studies, including randomised controlled trials, should address patient selection, quality-of-life outcomes and overall survival. Patient selection for the research studies should be done by amultidisciplinary team. The procedure should only be done in specialist centres by clinicians trained and experienced in managing cholangiocarcinoma.

    Recommendation ID IPG630/1 Question Further research on selective internal radiation therapy (SIRT) for unresectable primary intrahepatic

  15. Further research on the routine adoption of Actim Partus and PartoSure to help diagnose preterm labour in women with intact membranes when transvaginal ultrasound measurement of cervical length is needed on the accuracy of the tests and their effect on clinical outcomes. Centres using the tests to help diagnose preterm labour in women with intact membranes are encouraged to take part in studies to address the research considerations (see the guidance sections 5.12 to 5.16). Data are needed on:- the impact of gestational age on the accuracy of the tests- how the tests affect clinical decision-making- the effect of the tests on outcomes for mother and baby

    Recommendation ID DG33/1 Question Further research on the routine adoption of Actim Partus and PartoSure to help diagnose preterm labour