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Voretigene neparvovec for treating inherited retinal dystrophies caused by RPE65 gene mutations (HST11)

Evidence-based recommendations on voretigene neparvovec (Luxturna) for RPE65-mediated inherited retinal dystrophies in people with vision loss caused by inherit

Highly specialised technologies guidance Published October 2019

Cerliponase alfa for treating neuronal ceroid lipofuscinosis type 2 (HST12)

Evidence-based recommendations on cerliponase alfa (Brineura) for treating neuronal ceroid lipofuscinosis type 2 in children

Highly specialised technologies guidance Published November 2019

Eliglustat for treating type 1 Gaucher disease (HST5)

Evidence-based recommendations on eliglustat (Cerdelga) for treating type 1 Gaucher disease in adults

Highly specialised technologies guidance Published June 2017

Asfotase alfa for treating paediatric-onset hypophosphatasia (HST6)

Evidence-based recommendations on asfotase alfa (Strensiq) for treating paediatric-onset hypophosphatasia in adults and children

Highly specialised technologies guidance Published August 2017

Strimvelis for treating adenosine deaminase deficiency–severe combined immunodeficiency (HST7)

Evidence-based recommendation on Strimvelis for adenosine deaminase deficiency–severe combined immunodeficiency

Highly specialised technologies guidance Published February 2018

Burosumab for treating X-linked hypophosphataemia in children and young people (HST8)

Evidence-based recommendations on burosumab (Crysvita) for treating X-linked hypophosphataemia (XLH) in children and young people

Highly specialised technologies guidance Published October 2018

Inotersen for treating hereditary transthyretin amyloidosis (HST9)

Evidence-based recommendations on inotersen (Tegsedi) for stage 1 and stage 2 polyneuropathy in adults with hereditary transthyretin amyloidosis

Highly specialised technologies guidance Published May 2019

Patisiran for treating hereditary transthyretin amyloidosis (HST10)

Evidence-based recommendations on patisiran (Onpattro) for treating hereditary transthyretin amyloidosis in adults with stage 1 and stage 2 polyneuropathy

Highly specialised technologies guidance Published August 2019

Extraurethral (non-circumferential) retropubic adjustable compression devices for stress urinary incontinence in women (IPG576)

Evidence-based recommendations on extraurethral (non-circumferential) retropubic adjustable compression devices for stress urinary incontinence in women

Interventional procedures guidance Published March 2017

Sacrocolpopexy with hysterectomy using mesh to repair uterine prolapse (IPG577)

Evidence-based recommendations on sacrocolpopexy with hysterectomy (removal of womb) using mesh to repair uterine prolapse (prolapsed womb)

Interventional procedures guidance Published March 2017

Minimally invasive sacroiliac joint fusion surgery for chronic sacroiliac pain (IPG578)

Evidence-based recommendations on minimally invasive sacroiliac joint fusion surgery for chronic sacroiliac pain (lower back pain)

Interventional procedures guidance Published April 2017

Irreversible electroporation for treating pancreatic cancer (IPG579)

Evidence-based recommendations on irreversible electroporation (IRE) for treating pancreatic cancer

Interventional procedures guidance Published May 2017

Endoscopic full thickness removal of non-lifting colonic polyps (IPG580)

Evidence-based recommendations on endoscopic full thickness removal of non-lifting colonic polyps (colonic adenomas/growths)

Interventional procedures guidance Published May 2017

Infracoccygeal sacropexy using mesh to repair vaginal vault prolapse (IPG581)

Evidence-based recommendations on infracoccygeal sacropexy using mesh to repair vaginal vault prolapse in women

Interventional procedures guidance Published June 2017

Infracoccygeal sacropexy using mesh to repair uterine prolapse (IPG582)

Evidence-based recommendations on infracoccygeal sacropexy using mesh to repair uterine (womb) prolapse in women

Interventional procedures guidance Published June 2017

Sacrocolpopexy using mesh to repair vaginal vault prolapse (IPG583)

Evidence-based recommendations on sacropolpopexy using mesh to repair vaginal vault prolapse in women

Interventional procedures guidance Published June 2017

Uterine suspension using mesh (including sacrohysteropexy) to repair uterine prolapse (IPG584)

Evidence-based recommendations on uterine suspension using mesh (including sacrohysteropexy) to repair uterine prolapse in women

Interventional procedures guidance Published June 2017

Laparoscopic insertion of a magnetic titanium ring for gastro-oesophageal reflux disease (IPG585)

Evidence-based recommendations on laparoscopic insertion of a magnetic titanium ring for gastro-oesophageal reflux disease (GORD) in adults

Interventional procedures guidance Published July 2017

Transcatheter aortic valve implantation for aortic stenosis (IPG586)

Evidence-based recommendations on transcatheter aortic valve implantation (TAVI) for aortic stenosis

Interventional procedures guidance Published July 2017

Liposuction for chronic lymphoedema (IPG588)

Evidence-based recommendations on liposuction for chronic lymphoedema in adults to remove build-up of fluid and excess fat tissue in limbs

Interventional procedures guidance Published August 2017

Radiofrequency treatment for haemorrhoids (IPG589)

Evidence-based recommendations on radiofrequency treatment for haemorrhoids in adults

Interventional procedures guidance Published August 2017

Bioprosthetic plug insertion for anal fistula (IPG662)

Evidence-based recommendations on bioprosthetic plug insertion for anal fistula in adults. This involves putting a plug into the fistula and stitching it in

Interventional procedures guidance Published September 2019

Midcarpal hemiarthroplasty for wrist arthritis (IPG663)

Evidence-based recommendations on midcarpal hemiarthroplasty (using a metal implant to create an artificial wrist joint) for wrist arthritis in adults

Interventional procedures guidance Published October 2019

Irreversible electroporation for primary liver cancer (IPG664)

Evidence-based recommendations on irreversible electroporation for primary liver cancer in adults

Interventional procedures guidance Published November 2019

Balloon dilation for chronic eustachian tube dysfunction (IPG665)

Evidence-based recommendations on balloon dilation for chronic eustachian tube dysfunction in adults and children

Interventional procedures guidance Published December 2019

Reducing the risk of transmission of Creutzfeldt–Jakob disease (CJD) from surgical instruments used for interventional procedures on high-risk tissues (IPG666)

Evidence-based recommendations on reducing the risk of Creutzfeldt–Jakob disease (CJD) transmission from surgical instruments used for interventional procedures

Interventional procedures guidance Published January 2020

Fetoscopic prenatal repair for open neural tube defects in the fetus (IPG667)

Evidence-based recommendations on fetoscopic prenatal repair of open neural tube defects in the fetus

Interventional procedures guidance Published January 2020

Open prenatal repair for open neural tube defects in the fetus (IPG668)

Evidence-based recommendations on open prenatal repair of open neural tube defects in the fetus

Interventional procedures guidance Published January 2020

Implant insertion for prominent ears (IPG660)

Evidence-based recommendations on implant insertion for prominent ears in children, young people and adults

Interventional procedures guidance Published September 2019

High-intensity focused ultrasound for glaucoma (IPG661)

Evidence-based recommendations on high-intensity focused ultrasound for glaucoma in adults. This involves using high-intensity ultrasound to destroy a small

Interventional procedures guidance Published September 2019

Biodegradable spacer insertion to reduce rectal toxicity during radiotherapy for prostate cancer (IPG590)

Evidence-based recommendations on biodegradable spacer insertion (gel or balloon) to reduce rectal toxicity during radiotherapy for prostate cancer in adults

Interventional procedures guidance Published August 2017

Ab externo canaloplasty for primary open-angle glaucoma (IPG591)

Evidence-based recommendations on ab externo canaloplasty (widening eye’s main draining canal) for primary open-angle glaucoma (damaged optic nerve)

Interventional procedures guidance Published September 2017

High-intensity focused ultrasound for symptomatic breast fibroadenoma (IPG592)

Evidence-based recommendations on high-intensity focused ultrasound for symptomatic breast fibroadenoma (benign/non-cancerous lumps in the breast)

Interventional procedures guidance Published September 2017

Intramuscular diaphragm stimulation for ventilator-dependent chronic respiratory failure caused by motor neurone disease (IPG593)

Evidence-based recommendations on intramuscular diaphragm stimulation for ventilator-dependent chronic respiratory failure in people with motor neurone disease

Interventional procedures guidance Published September 2017

Intramuscular diaphragm stimulation for ventilator-dependent chronic respiratory failure caused by high spinal cord injuries (IPG594)

Evidence-based recommendations on intramuscular diaphragm stimulation for ventilator-dependent chronic respiratory failure caused by high spinal cord injuries

Interventional procedures guidance Published September 2017

Total distal radioulnar joint replacement for symptomatic joint instability or arthritis (IPG595)

Evidence-based recommendations on total distal radioulnar joint replacement for symptomatic joint instability or arthritis in adults

Interventional procedures guidance Published November 2017

Extracranial to intracranial bypass for intracranial atherosclerosis (IPG596)

Evidence-based recommendations on extracranial to intracranial bypass for intracranial atherosclerosis

Interventional procedures guidance Published November 2017

Superior rectal artery embolisation for haemorrhoids (IPG627)

Evidence-based recommendations on superior rectal artery embolisation for haemorrhoids in adults

Interventional procedures guidance Published August 2018

Intravesical microwave hyperthermia and chemotherapy for non-muscle-invasive bladder cancer (IPG628)

Evidence-based recommendations on intravesical microwave hyperthermia and chemotherapy for non-muscle-invasive bladder cancer

Interventional procedures guidance Published September 2018

Transurethral water jet ablation for lower urinary tract symptoms caused by benign prostatic hyperplasia (IPG629)

Evidence-based recommendations on transurethral water jet ablation for lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH)

Interventional procedures guidance Published September 2018

Selective internal radiation therapy for unresectable primary intrahepatic cholangiocarcinoma (IPG630)

Evidence-based recommendations on selective internal radiation therapy (SIRT) for unresectable primary intrahepatic cholangiocarcinoma in adults

Interventional procedures guidance Published October 2018

Subcutaneous automated low-flow pump implantation for refractory ascites caused by cirrhosis (IPG631)

Evidence-based recommendations on subcutaneous automated low-flow pump implantation for refractory ascites caused by liver cirrhosis in adults

Interventional procedures guidance Published November 2018

Transcranial MRI-guided focused ultrasound thalamotomy for neuropathic pain (IPG632)

Evidence-based recommendations on transcranial MRI-guided focused ultrasound thalamotomy for neuropathic pain in adults

Interventional procedures guidance Published November 2018

Percutaneous insertion of a temporary heart pump for left ventricular haemodynamic support in high-risk percutaneous coronary interventions (IPG633)

Evidence-based recommendations on percutaneous insertion of a temporary heart pump for left ventricular haemodynamic support in high-risk PCIs

Interventional procedures guidance Published November 2018

Transcutaneous neuromuscular electrical stimulation for oropharyngeal dysphagia in adults (IPG634)

Evidence-based recommendations on transcutaneous neuromuscular electrical stimulation for oropharyngeal dysphagia (difficulty swallowing) in adults

Interventional procedures guidance Published December 2018

Bronchial thermoplasty for severe asthma (IPG635)

Evidence-based recommendations on bronchial thermoplasty for severe asthma in adults

Interventional procedures guidance Published December 2018

Ex-situ machine perfusion for extracorporeal preservation of livers for transplantation (IPG636)

Evidence-based recommendations on ex-situ machine perfusion for extracorporeal preservation of livers for transplantation in people of all ages

Interventional procedures guidance Published January 2019

Endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused by cancer (IPG614)

Evidence-based recommendations on endoscopic bipolar radiofrequency ablation (heat energy) to treat biliary obstruction (bile duct blockage) caused by cancer

Interventional procedures guidance Published May 2018

Low-level laser therapy for preventing or treating oral mucositis caused by radiotherapy or chemotherapy (IPG615)

Evidence-based recommendations on low-level laser therapy for preventing or treating oral mucositis caused by radiotherapy or chemotherapy

Interventional procedures guidance Published May 2018

Intranasal phototherapy for allergic rhinitis (IPG616)

Evidence-based recommendations on intranasal phototherapy to reduce inflammation inside the nose in allergic rhinitis in adults

Interventional procedures guidance Published June 2018