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  1. Further research is recommended to assess the diagnostic yield of the BioMonitor 2‑AF and Confirm Rx (or later devices) for atrial fibrillation when used in people who have had a cryptogenic stroke. The committee noted that existing ongoing research may provide further data for these devices (see  section 3.51   and  section 4.19 ).

    Recommendation ID DG41/1 Question Further research is recommended to assess the diagnostic yield of the BioMonitor 2‑AF and Confirm Rx

  2. NICE encourages further research into implanted vagus nerve stimulation for treatment-resistant depression, in the form of randomised controlled trials with a placebo or sham stimulation arm. Studies should report details of patient selection. Outcomes should include validated depression rating scales, patient-reported quality of life, time to onset of effect and duration of effect, and any changes in concurrent treatments.

    Recommendation ID IPG679/1 Question NICE encourages further research into implanted vagus nerve stimulation for treatment-resistant depression

  3. Evidence on the safety of transcranial magnetic stimulation for auditory hallucinations is adequate and raises no major safety concerns. However, evidence on its efficacy is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research. Find out  what only in research means on the NICE interventional procedures guidance page . Further research should be in the form of randomised controlled trials and should use well described treatment protocols. Studies should report details of patient selection including specific psychopathology, underlying disease and other treatments, the area of brain treated and the imaging used to target it, and long-term outcomes for at least 1 year.

    Recommendation ID IPG680 Question Evidence on the safety of transcranial magnetic stimulation for auditory hallucinations is adequate