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Further research on endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused by cancer should address: patient selection, relief of biliary obstruction, quality of life and survival.

Recommendation ID IPG614/1 Question Further research on endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused

Research recommendation Published December 2018

Core outcome set for studies of management of Lyme disease:- Can a core outcome set be developed for clinical trials of management of Lyme disease?

Recommendation ID NG95/1 Question Core outcome set for studies of management of Lyme disease:- Can a core outcome set be developed for clinical

Research recommendation Published November 2018

NICE encourages further research into microinvasive subconjunctival insertion of a trans-scleral gelatin stent for primary open-angle glaucoma, including randomised studies. Further research should include details of patient selection and long-term outcomes.

Recommendation ID IPG612/1 Question NICE encourages further research into microinvasive subconjunctival insertion of a trans-scleral gelatin

Research recommendation Published November 2018

Further research is needed to understand the effect of having the additional information provided by the adjunctive colposcopy technologies on anxiety for people having a colposcopy, when this information is shown to a person during the examination.

Recommendation ID DG32/3 Question Further research is needed to understand the effect of having the additional information provided by the

Research recommendation Published November 2018

Frequency of monitoring:- How frequently should children be measured to identify faltering growth?

Recommendation ID NG75/4 Question Frequency of monitoring:- How frequently should children be measured to identify faltering growth?

Research recommendation Published October 2018

Behavioural interventions:- What is the effectiveness of behavioural interventions compared with usual care/advice for children with faltering growth?

Recommendation ID NG75/3 Question Behavioural interventions:- What is the effectiveness of behavioural interventions compared with usual

Research recommendation Published October 2018

Duration and intensity of home-based intermediate care:- How effective and cost effective are different approaches, in terms of duration and intensity, to providing home-based intermediate care for adults?

Recommendation ID NG74/7 Question Duration and intensity of home-based intermediate care:- How effective and cost effective are different

Research recommendation Published October 2018

Effectiveness of home visiting following child abuse or neglect:- Are home visiting interventions effective and cost effective in improving parenting and preventingrecurrence of child abuse and neglect in families in which abuse or neglect is occurring or has occurred?

Recommendation ID NG76/12 Question Effectiveness of home visiting following child abuse or neglect:- Are home visiting interventions effective

Research recommendation Published October 2018

Interventions to manage cystoid macular oedema:- What is the most effective postoperative medical management for cystoid macular oedema?

Recommendation ID NG77/4 Question Interventions to manage cystoid macular oedema:- What is the most effective postoperative medical management

Research recommendation Published October 2018

Interventions to prevent endophthalmitis:- What is the effectiveness of postoperative antibiotic drops to reduce rates of endophthalmitis after cataract surgery?

Recommendation ID NG77/5 Question Interventions to prevent endophthalmitis:- What is the effectiveness of postoperative antibiotic drops

Research recommendation Published October 2018

Interventions with fathers and male carers:- What interventions are effective and cost effective when working with fathers and male carers to improve their parenting in families where children are being, or have been, abused or neglected?

Recommendation ID NG76/10 Question Interventions with fathers and male carers:- What interventions are effective and cost effective when

Research recommendation Published October 2018

Interventions with male foster carers and adoptive parents:- What interventions are effective and cost effective when working with male foster carers and adoptive parents who are caring for children and young people who have been abused in the past?

Recommendation ID NG76/11 Question Interventions with male foster carers and adoptive parents:- What interventions are effective and cost

Research recommendation Published October 2018

Psychological assessment:- What is the most effective measure of psychological functioning to use as a test for thresholds of concern in people with cystic fibrosis?

Recommendation ID NG78/4 Question Psychological assessment:- What is the most effective measure of psychological functioning to use as a

Research recommendation Published October 2018

Quality of life in cataract surgery:- What vision-specific, quality-of-life measures best capture visual changes in a population with cataracts?

Recommendation ID NG77/2 Question Quality of life in cataract surgery:- What vision-specific, quality-of-life measures best capture visual

Research recommendation Published October 2018

Monitoring for cystic-fibrosis-related diabetes:- What is the most effective strategy to detect diabetes in people with cystic fibrosis?

Recommendation ID NG78/5 Question Monitoring for cystic-fibrosis-related diabetes:- What is the most effective strategy to detect diabetes

Research recommendation Published October 2018

Mucoactive agents:- What is the most clinically and cost-effective dose of rhDNase (dornase alfa; recombinant human deoxyribonuclease) for people with cystic fibrosis?

Recommendation ID NG78/6 Question Mucoactive agents:- What is the most clinically and cost-effective dose of rhDNase (dornase alfa; recombinant

Research recommendation Published October 2018

Effectiveness of web-based parenting programmes:- Are web-based parenting programmes effective and cost effective for improving parenting and preventing recurrence of child abuse and neglect in families where child abuse or neglect has occurred?

Recommendation ID NG76/14 Question Effectiveness of web-based parenting programmes:- Are web-based parenting programmes effective and cost

Research recommendation Published October 2018

Effective prevention of child abuse and neglect in the UK:- What interventions are effective and cost effective in the UK to prevent abuse and neglect of children and young people in families at risk of, or showing early signs of, abuse and neglect?

Recommendation ID NG76/5 Question Effective prevention of child abuse and neglect in the UK:- What interventions are effective and cost

Research recommendation Published October 2018

Early help home visiting:- What are the components of effective home visiting programmes for preventing child abuse and neglect in families of children and young people at risk of child abuse and neglect in the UK?

Recommendation ID NG76/4 Question Early help home visiting:- What are the components of effective home visiting programmes for preventing

Research recommendation Published October 2018

Peer support for children and young people who have been abused or neglected:- What peer support programmes are effective and cost effective in improving the wellbeing of children and young people who have been abused or neglected?

Recommendation ID NG76/16 Question Peer support for children and young people who have been abused or neglected:- What peer support programmes

Research recommendation Published October 2018

Liver disease:- Should all children with meconium ileus receive ursodeoxycholic acid from diagnosis?

Recommendation ID NG78/1 Question Liver disease:- Should all children with meconium ileus receive ursodeoxycholic acid from diagnosis?

Research recommendation Published October 2018

Relative effectiveness of interventions to support foster carers:- What is the relative effectiveness and cost effectiveness of the KEEP intervention for foster carersof abused or neglected children compared to other interventions?

Recommendation ID NG76/15 Question Relative effectiveness of interventions to support foster carers:- What is the relative effectiveness

Research recommendation Published October 2018

Diagnosing asthma in adults (aged 17 and over):- What is the clinical and cost effectiveness of using an indirect bronchial challenge test with mannitol to diagnose asthma in adults (aged 17 and over)?

Recommendation ID NG80/2 Question Diagnosing asthma in adults (aged 17 and over):- What is the clinical and cost effectiveness of using

Research recommendation Published October 2018

Decreasing pharmacological treatment:- In adults, young people and children with well-controlled asthma, what are the objective measurements and prognostic factors that indicate that a decrease in regular maintenance treatment is appropriate?

Recommendation ID NG80/9 Question Decreasing pharmacological treatment:- In adults, young people and children with well-controlled asthma

Research recommendation Published October 2018

An instrument to measure quality of life in people with glaucoma:- What instrument should be used to measure health related quality of life in people with glaucoma?

Recommendation ID NG81/3 Question An instrument to measure quality of life in people with glaucoma:- What instrument should be used to measure

Research recommendation Published October 2018

Monitoring adherence to treatment:- What is the clinical and cost effectiveness of using electronic alert systems designed to monitor and improve adherence with regular inhaled maintenance therapy in people with asthma?

Recommendation ID NG80/3 Question Monitoring adherence to treatment:- What is the clinical and cost effectiveness of using electronic alert

Research recommendation Published October 2018

Further research is recommended to assess the diagnostic accuracy of the tests included in this assessment when used in combination; for example sequentially.

Recommendation ID DG31/3 Question Further research is recommended to assess the diagnostic accuracy of the tests included in this assessment

Research recommendation Published October 2018

Further research is recommended to assess:- inter-observer reproducibility of tests involving ultrasound scans (the ADNEX model and Simple Rules)- changes in clinical management based on test results from the ADNEX model, Overa (MIA2G), ROMA and Simple Rules.

Recommendation ID DG31/2 Question Further research is recommended to assess:- inter-observer reproducibility of tests involving ultrasound

Research recommendation Published October 2018

Optical coherence tomography for glaucoma:- What is the effectiveness and cost effectiveness of optical coherence tomography (OCT) for diagnosing and monitoring glaucoma?

Recommendation ID NG81/4 Question Optical coherence tomography for glaucoma:- What is the effectiveness and cost effectiveness of optical

Research recommendation Published October 2018

Treatment for people with an IOP of 22 or 23 mmHg:- What is the clinical and cost effectiveness of treating an intraocular pressure (IOP) of 22 or 23 mmHg in people with normal optic discs and visual fields?

Recommendation ID NG81/2 Question Treatment for people with an IOP of 22 or 23 mmHg:- What is the clinical and cost effectiveness of treating

Research recommendation Published October 2018