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  1. NICE encourages further research into transapical transcatheter mitral valvein-ring implantation after failed annuloplasty for mitral valve repair. Studies should include details on patient selection, type and size of valve used, functional outcomes (New York Heart Association functional class, mitral valve regurgitation), quality of life, patient-reported outcome measures, survival and complications. Studies should report long-term follow up of clinical outcomes and valve durability. NICE may update this guidance on publication of further evidence.

    Recommendation ID IPG707/1 Question NICE encourages further research into transapical transcatheter mitral valvein-ring implantation after

  2. NICE encourages further research into transapical transcatheter mitral valvein-valve implantation for a failed surgically implanted mitral valve bioprosthesis. Studies should include details on patient selection, type and size of valve used, functional outcomes (New York Heart Association functional class, mitral valve regurgitation), quality of life, patient-reported outcome measures, survival and complications. Studies should report long-term follow up of clinical outcomes and valve durability. NICE may update this guidance on publication of further evidence.

    Recommendation ID IPG706/1 Question NICE encourages further research into transapical transcatheter mitral valvein-valve implantation for

  3. Evidence on the safety of laparoscopic removal of uterine fibroids with power morcellation shows potentially serious complications. In particular there is a risk of spreading undiagnosed malignant tissue, which has higher prevalence in people who are postmenopausal or over 50. Evidence on the procedure's efficacy is limited in quantity. Therefore, further research should report details of patient selection, surgical technique (including any containment system used) and long-term outcomes.

    Recommendation ID IPG703/1 Question Evidence on the safety of laparoscopic removal of uterine fibroids with power morcellation shows potentially

  4. Evidence on the safety of magnetic resonance therapy for knee osteoarthritis shows no major safety concerns. Evidence on efficacy is inadequate in quality and quantity and shows no benefit over placebo. Therefore, this procedure should not be used unless it is part of a research study. Further research should be in the form of appropriately powered randomised  controlled trials comparing the procedure with placebo. It should report patient  selection and treatment protocols, including the number of sessions and  magnetic field strength.

    Recommendation ID IPG702/1 Question Evidence on the safety of magnetic resonance therapy for knee osteoarthritis shows no major safety

  5. Interventions to improve CPAP adherence: Which interventions, including behavioural interventions, are most clinically and cost effective to improve adherence to CPAP in people with OSAHS, obesity hypoventilation syndrome (OHS) and COPD–OSAHS (chronic obstructive pulmonary disease–OSAHS) overlap syndrome who have difficulty using CPAP?

    Recommendation ID NG202/3 Question Interventions to improve CPAP adherence: Which interventions, including behavioural interventions, are

  6. Evidence on the safety and efficacy of lateral elbow resurfacing for arthritis is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page. Further research, which could include case series with long-term follow up, should report range of motion, patient-reported outcomes and complications.

    Recommendation ID IPG705/1 Question Evidence on the safety and efficacy of lateral elbow resurfacing for arthritis is limited in quantity