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How does the timing and frequency of ultrasound examination affect diagnosis and outcomes of early pregnancy complications, including women's experience and cost effectiveness?

Recommendation ID NG126/1 Question How does the timing and frequency of ultrasound examination affect diagnosis and outcomes of early pregnancy

Research recommendation Published August 2019

What are the costs associated with best supportive care?

Recommendation ID TA575/1 Question What are the costs associated with best supportive care? Any explanatory notes(if applicable)

Research recommendation Published August 2019

What is the best technique for delivering surfactant in a minimally invasive manner?

Recommendation ID NG124/2 Question What is the best technique for delivering surfactant in a minimally invasive manner? Any explanatory

Research recommendation Published August 2019

Does caesarean section protect against cerebral haemorrhage in women with a history of subarachnoid haemorrhage or cerebrovascular malformation?

Recommendation ID NG121/1 Question Does caesarean section protect against cerebral haemorrhage in women with a history of subarachnoid haemorrhage

Research recommendation Published August 2019

What clinical features and laboratory investigations can be used to better stratify risk for women in labour with signs of sepsis (including fever and tachycardia)?

Recommendation ID NG121/4 Question What clinical features and laboratory investigations can be used to better stratify risk for women in

Research recommendation Published August 2019

Are progesterone or progestogens effective in treating threatened miscarriage?

Recommendation ID NG136/3 Question Are progesterone or progestogens effective in treating threatened miscarriage? Any explanatory notes(if

Research recommendation Published August 2019

What is the clinical and cost effectiveness of intermittent auscultation compared with continuous cardiotocography for women in labour who have had a previous caesarean section?

Recommendation ID NG121/5 Question What is the clinical and cost effectiveness of intermittent auscultation compared with continuous cardiotocography

Research recommendation Published August 2019

What is the most effective combination of an analgesic with a neuromuscular blocker, or an analgesic with an anaesthetic agent, for premedication in preterm babies requiring elective or semi-elective intubation?

Recommendation ID NG124/5 Question What is the most effective combination of an analgesic with a neuromuscular blocker, or an analgesic

Research recommendation Published August 2019

Does targeting higher oxygen saturations of 92% to 97% in preterm babies lead to improved survival without significant complications?

Recommendation ID NG124/4 Question Does targeting higher oxygen saturations of 92% to 97% in preterm babies lead to improved survival without...

Research recommendation Published August 2019

Is obesity an independent risk factor for perinatal morbidity and mortality?

Recommendation ID NG121/3 Question Is obesity an independent risk factor for perinatal morbidity and mortality? Any explanatory notes(if

Research recommendation Published August 2019

What is the effectiveness of high-pressure non-invasive positive pressure ventilation (NIPPV) compared with continuous positive airways pressure (CPAP) flow driver as the primary mode of ventilation?

Recommendation ID NG124/1 Question What is the effectiveness of high-pressure non-invasive positive pressure ventilation (NIPPV) compared

Research recommendation Published August 2019

NICE concluded that the cost consequences of using HumiGard in abdominal surgery are very uncertain, and that further research is needed on resource use.

Recommendation ID MTG31/2 Question NICE concluded that the cost consequences of using HumiGard in abdominal surgery are very uncertain,

Research recommendation Published April 2017

Vegetation and street trees:- What factors influence how vegetation and street trees affect urban air quality?

Recommendation ID NG70/1 Question Vegetation and street trees:- What factors influence how vegetation and street trees affect urban air

Research recommendation Published October 2018

Telematics:- How can information about driving style gathered from telematics devices and other technologies (such as apps or in-car global positioning systems) be used to reduce individual fuel consumption and vehicle emissions?

Recommendation ID NG70/4 Question Telematics:- How can information about driving style gathered from telematics devices and other technologies (such

Research recommendation Published October 2018

Promoting a shift to zero- and low-emission travel:- What methods are effective and cost effective at promoting a shift to zero- and low-emission modes of travel, including active travel?

Recommendation ID NG70/2 Question Promoting a shift to zero- and low-emission travel:- What methods are effective and cost effective at

Research recommendation Published October 2018

NICE encourages the company, NHS England and treatment centres to collect more evidence, particularly on the longer-term benefits and costs of eliglustat and enzyme replacement therapy for treating type 1 Gaucher disease.

Recommendation ID HST5/1 Question NICE encourages the company, NHS England and treatment centres to collect more evidence, particularly

Research recommendation Published October 2018

Exposure to air pollution using different modes of transport How does altering a person's mode of transport and route affect their personal exposure to air pollution?

Recommendation ID NG70/6 Question Exposure to air pollution using different modes of transport How does altering a person's mode of transport

Research recommendation Published October 2018

Clean air zones:- How do different elements of a clean air zone interact to improve air quality and what is the overall effect on people's health?

Recommendation ID NG70/3 Question Clean air zones:- How do different elements of a clean air zone interact to improve air quality and what

Research recommendation Published October 2018

Clinicians are encouraged to collect long-term data on clinical outcomes and patient-reported quality-of-life outcomes using validated scales. NICE may update the guidance on publication of further evidence into infracoccygeal sacropexy using mesh to repair uterine prolapse.

Recommendation ID IPG582/1 Question Clinicians are encouraged to collect long-term data on clinical outcomes and patient-reported quality-of-life

Research recommendation Published October 2018

Clinicians are encouraged to collect long-term data on clinical outcomes and patient-reported quality-of-life outcomes using validated scales. NICE may update the guidance on publication of further evidence.

Recommendation ID IPG581/1 Question Clinicians are encouraged to collect long-term data on clinical outcomes and patient-reported quality-of-life

Research recommendation Published October 2018

Awareness raising:- What is the effectiveness and cost effectiveness of different methods of awareness raising about air pollution (including air pollution alerts) on people's behaviour and on acute and chronic health outcomes?

Recommendation ID NG70/5 Question Awareness raising:- What is the effectiveness and cost effectiveness of different methods of awareness

Research recommendation Published October 2018

Treating an eating disorder in people with a comorbidity:- What is the impact of comorbidities on treatment outcomes for eating disorders, and whatapproaches are effective in managing these comorbidities?

Recommendation ID NG69/4 Question Treating an eating disorder in people with a comorbidity:- What is the impact of comorbidities on treatment

Research recommendation Published October 2018

Predictors of acute physical risk:- What clinical and biochemical markers are the best predictors of acute physical risk for people with eating disorders?

Recommendation ID NG69/3 Question Predictors of acute physical risk:- What clinical and biochemical markers are the best predictors of acute

Research recommendation Published October 2018

Further research, preferably in the form of randomised controlled trials, should assess the effect of the procedure on local tumour control, patient survival, paincontrol and quality of life.

Recommendation ID IPG579/1 Question Further research, preferably in the form of randomised controlled trials, should assess the effect of

Research recommendation Published October 2018

Further research is recommended on patient acceptability of using virtual chromoendoscopy for real-time assessment of diminutive polyps compared with assessment using histopathology

Recommendation ID DG28/1 Question Further research is recommended on patient acceptability of using virtual chromoendoscopy for real-time

Research recommendation Published October 2018

Duration and intensity of psychological treatment:- What is the effectiveness of treating eating disorders with psychological treatments of reduced duration and reduced intensity, compared with standard treatment?

Recommendation ID NG69/2 Question Duration and intensity of psychological treatment:- What is the effectiveness of treating eating disorders

Research recommendation Published October 2018

What measures would make up an effective, standardised approach to evaluation of condom distribution schemes?: How can we develop a standardised framework to evaluate condom schemes and what would be included in that evaluation?

Recommendation ID NG68/1 Question What measures would make up an effective, standardised approach to evaluation of condom distribution schemes

Research recommendation Published October 2018

For women who are having medical abortion between 10+1 and 12+0 weeks, what is the efficacy and acceptability of expulsion at home compared with expulsion in a clinical setting?

Recommendation ID NG140/4 Question For women who are having medical abortion between 10+1 and 12+0 weeks, what is the efficacy and acceptability

Research recommendation Published November 2019

Are there subgroups of people with hypertension who should start on dual therapy?

Recommendation ID NG136/4 Question Are there subgroups of people with hypertension who should start on dual therapy? Any explanatory

Research recommendation Published November 2019

What is the utility of routine cardiovascular evaluation for asymptomatic people with FH?

Recommendation ID CG71/6 Question What is the utility of routine cardiovascular evaluation for asymptomatic people with FH? Any explanatory

Research recommendation Published November 2019

When is it safe to stop contact casting in the treatment of acute Charcot arthropathy?

Recommendation ID NG19/12 Question When is it safe to stop contact casting in the treatment of acute Charcot arthropathy? Any explanatory

Research recommendation Published November 2019

Which risk stratification tools can be used to predict the likelihood of Charcot arthropathy?

Recommendation ID NG19/11 Question Which risk stratification tools can be used to predict the likelihood of Charcot arthropathy? Any

Research recommendation Published November 2019

What is the effectiveness and cost effectiveness of a trial of hydrolysed formula in formula‑fed infants with frequent regurgitation associated with marked distress?

Recommendation ID NG1/2 Question What is the effectiveness and cost effectiveness of a trial of hydrolysed formula in formula‑fed infants

Research recommendation Published November 2019

What is the malformation rate and longer term neurodevelopmental outcome of children born to mothers who have taken AEDs during pregnancy?

Recommendation ID CG137/5 Question What is the malformation rate and longer term neurodevelopmental outcome of children born to mothers

Research recommendation Published November 2019

What is the clinical effectiveness of maggot debridement therapy in the debridement of diabetic foot ulcers?

Recommendation ID NG19/10 Question What is the clinical effectiveness of maggot debridement therapy in the debridement of diabetic foot

Research recommendation Published November 2019

What is the clinical effectiveness of negative pressure wound therapy in the treatment of diabetic foot ulcers?

Recommendation ID NG19/9 Question What is the clinical effectiveness of negative pressure wound therapy in the treatment of diabetic foot

Research recommendation Published November 2019

What is the clinical effectiveness of different dressing types in treating diabetic foot problems?

Recommendation ID NG19/5 Question What is the clinical effectiveness of different dressing types in treating diabetic foot problems?

Research recommendation Published November 2019

What is the clinical effectiveness of double-dose PPIs in people with severe erosive reflux disease (Los Angeles classification grade C/D or Savary–Miller grade 3/4): to reduce severe oesophagitis to control symptoms as maintenance therapy?

Recommendation ID CG184/3 Question What is the clinical effectiveness of double-dose PPIs in people with severe erosive reflux disease (Los

Research recommendation Published November 2019

Which of the electronic information-sharing systems perform best for the care of people approaching the end of their life?

Recommendation ID NG142/2 Question Which of the electronic information-sharing systems perform best for the care of people approaching the

Research recommendation Published November 2019