Updating results

What are the clinically and cost-effective surgical approaches to managing complicated acute diverticulitis, including timing of surgery (elective or emergency)?

Recommendation ID NG147/5 Question What are the clinically and cost-effective surgical approaches to managing complicated acute diverticulitis

Research recommendation Published February 2020

What training, support or interventions help to reduce caring-related accidents or incidents?

Recommendation ID NG150/3 Question What training, support or interventions help to reduce caring-related accidents or incidents?

Research recommendation Published February 2020

What is the cost effectiveness and safety of non-surgical ablation and stereotactic body radiotherapy compared to resection for people with metastatic colorectal cancer in the lung amenable to local treatment?

Recommendation ID NG151/1 Question What is the cost effectiveness and safety of non-surgical ablation and stereotactic body radiotherapy

Research recommendation Published February 2020

Further evidence to address the uncertainties in the current clinical evidence,including the impact of gammaCore on all treatments and care as well as itslong-term benefits, would be welcome.

Recommendation ID MTG46/1 Question Further evidence to address the uncertainties in the current clinical evidence,including the impact

Research recommendation Published February 2020

What is the health impact of exposure to individual air pollutants alone or combined with each other in the home?

Recommendation ID NG149/1 Question What is the health impact of exposure to individual air pollutants alone or combined with each other

Research recommendation Published February 2020

What is the effectiveness and safety of sacral nerve stimulation and transanal irrigation compared to symptomatic treatment for people with major low anterior resection syndrome?

Recommendation ID NG151/2 Question What is the effectiveness and safety of sacral nerve stimulation and transanal irrigation compared to

Research recommendation Published February 2020

What is the most clinically and cost-effective treatment for diverticular disease?

Recommendation ID NG147/3 Question What is the most clinically and cost-effective treatment for diverticular disease? Any explanatory

Research recommendation Published February 2020

Does early review of service provision and referral to additional specialist palliative care services improve outcomes for adults with progressive non-cancer disease thought to be approaching the end of their life?

Recommendation ID NG142/1 Question Does early review of service provision and referral to additional specialist palliative care services

Research recommendation Published November 2019

Which of the electronic information-sharing systems perform best for the care of people approaching the end of their life?

Recommendation ID NG142/2 Question Which of the electronic information-sharing systems perform best for the care of people approaching

Research recommendation Published November 2019

What are the benefits of planned, regular community-based reviews compared with as-required review of non-cancer patients approaching the end of their life?

Recommendation ID NG142/3 Question What are the benefits of planned, regular community-based reviews compared with as-required review of

Research recommendation Published November 2019

How often should people with diabetic foot problems (foot ulcers, soft tissue infections, osteomyelitis or gangrene) be reviewed?

Recommendation ID NG19/8 Question How often should people with diabetic foot problems (foot ulcers, soft tissue infections, osteomyelitis

Research recommendation Published November 2019

When is it safe to stop contact casting in the treatment of acute Charcot arthropathy?

Recommendation ID NG19/12 Question When is it safe to stop contact casting in the treatment of acute Charcot arthropathy? Any explanatory

Research recommendation Published November 2019

Which risk stratification tools can be used to predict the likelihood of Charcot arthropathy?

Recommendation ID NG19/11 Question Which risk stratification tools can be used to predict the likelihood of Charcot arthropathy?

Research recommendation Published November 2019

What is the clinical effectiveness of maggot debridement therapy in the debridement of diabetic foot ulcers?

Recommendation ID NG19/10 Question What is the clinical effectiveness of maggot debridement therapy in the debridement of diabetic foot

Research recommendation Published November 2019

What is the clinical effectiveness of negative pressure wound therapy in the treatment of diabetic foot ulcers?

Recommendation ID NG19/9 Question What is the clinical effectiveness of negative pressure wound therapy in the treatment of diabetic foot

Research recommendation Published November 2019

What is the optimal way of discharging people approaching the end of their life from hospitals back to their place of residence?

Recommendation ID NG142/4 Question What is the optimal way of discharging people approaching the end of their life from hospitals back

Research recommendation Published November 2019

Evidence on the safety and efficacy of midcarpal hemiarthroplasty for wrist arthritis is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of  research .

Recommendation ID IPG663/1 Question Evidence on the safety and efficacy of midcarpal hemiarthroplasty for wrist arthritis is inadequate

Research recommendation Published November 2019

What is the role of educational models and psycho-behavioural interventions in prevention of diabetic foot complications?

Recommendation ID NG19/3 Question What is the role of educational models and psycho-behavioural interventions in prevention of diabetic

Research recommendation Published November 2019

When and with what criteria should people with diabetes be referred to the foot protection service or the multidisciplinary foot care service?

Recommendation ID NG19/2 Question When and with what criteria should people with diabetes be referred to the foot protection service or

Research recommendation Published November 2019

What are the initial and add-on AEDs of choice in the treatment of the epilepsy syndromes with onset in childhood, for example, myoclonic-astatic epilepsy and Dravet syndrome?

Recommendation ID CG137/2 Question What are the initial and add-on AEDs of choice in the treatment of the epilepsy syndromes with onset

Research recommendation Published November 2019

What is the clinical effectiveness of double-dose PPIs in people with severe erosive reflux disease (Los Angeles classification grade C/D or Savary–Miller grade 3/4): to reduce severe oesophagitis to control symptoms as maintenance therapy?

Recommendation ID CG184/3 Question What is the clinical effectiveness of double-dose PPIs in people with severe erosive reflux disease

Research recommendation Published November 2019

In infants, children and young people with overt or occult reflux, is fundoplication effective in reducing acid reflux as determined by oesophageal pH monitoring?

Recommendation ID NG1/3 Question In infants, children and young people with overt or occult reflux, is fundoplication effective in reducing

Research recommendation Published November 2019

What are the implications of FH for the safety of a mother during pregnancy and what are the risks of fetal malformations attributable to pharmacological therapies

Recommendation ID CG71/5 Question What are the implications of FH for the safety of a mother during pregnancy and what are the risks of

Research recommendation Published November 2019

What is the effectiveness of different footwear, insoles and orthoses in the prevention of foot problems?

Recommendation ID NG19/7 Question What is the effectiveness of different footwear, insoles and orthoses in the prevention of foot problems

Research recommendation Published November 2019

What strategies may be useful in the prevention of Charcot arthropathy?

Recommendation ID NG19/4 Question What strategies may be useful in the prevention of Charcot arthropathy? Any explanatory notes(if

Research recommendation Published November 2019

In people who experience symptoms of gastro-oesophageal reflux disease (GORD) or symptoms suggestive of GORD, what patient characteristics, risk factors and predictors indicate when endoscopy is needed to exclude Barrett's oesophagus?

Recommendation ID CG184/1 Question In people who experience symptoms of gastro-oesophageal reflux disease (GORD) or symptoms suggestive

Research recommendation Published November 2019

What are the appropriate indications, effectiveness and safety of LDL apheresis in people with heterozygous FH?

Recommendation ID CG71/4 Question What are the appropriate indications, effectiveness and safety of LDL apheresis in people with heterozygous

Research recommendation Published November 2019

What is the clinical effectiveness and safety of differing doses of lipid-modifying therapy in children with FH?

Recommendation ID CG71/3 Question What is the clinical effectiveness and safety of differing doses of lipid-modifying therapy in children

Research recommendation Published November 2019

What are the long-term effects of statin therapy on sub-clinical atherosclerosis in children with FH who are treated with statin therapy?

Recommendation ID CG71/2 Question What are the long-term effects of statin therapy on sub-clinical atherosclerosis in children with FH

Research recommendation Published November 2019

Current evidence on the safety and efficacy of implant insertion for prominent ears is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of  research .

Recommendation ID IPG660/1 Question Current evidence on the safety and efficacy of implant insertion for prominent ears is inadequate in

Research recommendation Published November 2019

Does intensive monitoring of people at risk of diabetic foot disease reduce the morbidity associated with developing the disease and is such monitoring cost effective?

Recommendation ID NG19/1 Question Does intensive monitoring of people at risk of diabetic foot disease reduce the morbidity associated

Research recommendation Published November 2019

Does treatment response relate to cause in infantile spasms? Does early treatment success in seizure control and resolution of the hypsarrhythmic EEG influence the long-term developmental and cognitive outcomes more than the underlying cause of the spasms?

Recommendation ID CG137/3 Question Does treatment response relate to cause in infantile spasms? Does early treatment success in seizure

Research recommendation Published November 2019

What is the effectiveness of laparoscopic fundoplication compared with medical management in people with GORD that does not respond to optimal proton pump inhibitor (PPI) treatment?

Recommendation ID CG184/2 Question What is the effectiveness of laparoscopic fundoplication compared with medical management in people

Research recommendation Published November 2019

Current evidence on the safety and efficacy of low-energy contact X‑ray brachytherapy (the Papillon technique) for locally advanced rectal cancer is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of  research .

Recommendation ID IPG659/1 Question Current evidence on the safety and efficacy of low-energy contact X‑ray brachytherapy (the Papillon

Research recommendation Published November 2019

What are the symptoms of GORD in infants, children and young people with a neurodisability?

Recommendation ID NG1/1 Question What are the symptoms of GORD in infants, children and young people with a neurodisability? Any

Research recommendation Published November 2019

When and with what criteria should people with diabetes be referred to the foot protection service or the multidisciplinary foot care service?

Recommendation ID NG19/2 Question When and with what criteria should people with diabetes be referred to the foot protection service or

Research recommendation Published November 2019

What is the malformation rate and longer term neurodevelopmental outcome of children born to mothers who have taken AEDs during pregnancy?

Recommendation ID CG137/5 Question What is the malformation rate and longer term neurodevelopmental outcome of children born to mothers

Research recommendation Published November 2019

Current evidence on the safety and efficacy of bronchoscopic thermal vapour ablation for upper-lobe emphysema is inadequate in quantity and quality. Therefore the procedure should only be used in the context of  research .

Recommendation ID IPG652/1 Question Current evidence on the safety and efficacy of bronchoscopic thermal vapour ablation for upper-lobe

Research recommendation Published November 2019

The evidence on cardiac contractility modulation device implantation for heart failure raises no major safety concerns. However, the evidence on efficacy is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of  research .

Recommendation ID IPG655 Question The evidence on cardiac contractility modulation device implantation for heart failure raises no major

Research recommendation Published November 2019

What is the utility of routine cardiovascular evaluation for asymptomatic people with FH?

Recommendation ID CG71/6 Question What is the utility of routine cardiovascular evaluation for asymptomatic people with FH? Any

Research recommendation Published November 2019

What is the effectiveness and cost effectiveness of a trial of hydrolysed formula in formula‑fed infants with frequent regurgitation associated with marked distress?

Recommendation ID NG1/2 Question What is the effectiveness and cost effectiveness of a trial of hydrolysed formula in formula‑fed infants

Research recommendation Published November 2019

What is the clinical effectiveness of different dressing types in treating diabetic foot problems?

Recommendation ID NG19/5 Question What is the clinical effectiveness of different dressing types in treating diabetic foot problems?

Research recommendation Published November 2019