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  1. Proposals for further data collection in the Cancer Drugs Fund include:- recurrence-free survival- distant metastases-free survival- overall survival- long-term follow-up of people who received pembrolizumab as an adjuvant treatment- who develop advanced disease and receive pembrolizumab again to treat metastatic disease.

    Recommendation ID TA553/1 Question Proposals for further data collection in the Cancer Drugs Fund include:- recurrence-free survival- distant

  2. Psychological treatments for binge eating disorder: - Compare the clinical and cost effectiveness of individual eating-disorder-focused cognitive behavioural therapy (CBT-ED) with guided self-help and group CBT-ED for adults with binge eating disorder. Compare the clinical and cost effectiveness of individual eating-disorder-focused CBT-ED with guided self-help and group CBT-ED for children and young people with binge eating disorder

    Recommendation ID NG69/1 Question Psychological treatments for binge eating disorder: - Compare the clinical and cost effectiveness of

  3. Pulmonary rehabilitation during hospital admission:- In people with COPD, does pulmonary rehabilitation during hospital admission for exacerbation and/or in the early recovery period (within 1 month of an exacerbation) improve quality of life and reduce hospitalisations and exacerbations compared with a later (defined as after 1 month)pulmonary rehabilitation programme, and in which groups is it most clinically and cost effective?

    Recommendation ID NG115/1 Question Pulmonary rehabilitation during hospital admission:- In people with COPD, does pulmonary rehabilitation

  4. Research is recommended on HumiGard compared with standard insufflation gases in patients having laparoscopic or open surgery alongside general measures to reduce the risk of perioperative hypothermia (described in section 2.5). Research should report on the comparative rate of surgical site infections and other complications associated with hypothermia and normothermia, as well as related resource use.

    Recommendation ID MTG31/1 Question Research is recommended on HumiGard compared with standard insufflation gases in patients having laparoscopic

  5. Research is recommended to address uncertainties about the claimed benefits of using Mepilex Border Heel and Sacrum dressings. This research should also explore issues such as:- the incidence of heel and sacrum pressure ulcers in NHS acute care settings- criteria for patient selection to reduce pressure ulcer incidence with Mepilex Border Heel and Sacrum dressings in addition to standard care.NICE will consider reviewing this guidance when substantive new evidence becomes available.

    Recommendation ID MTG40/1 Question Research is recommended to address uncertainties about the claimed benefits of using Mepilex Border

  6. Advance planning about end of life care:- What is the effectiveness and cost effectiveness of advance care planning for end of life care for people growing older with learning disabilities, and their family members and carers?What processes are in place to document and follow the wishes of people growing older with learning disabilities about their decisions on end of life care?

    Recommendation ID NG96/5 Question Advance planning about end of life care:- What is the effectiveness and cost effectiveness of advance

  7. Targeted interventions to support and improve decision-making capacity for treatment:- What is the effectiveness and cost effectiveness of different targeted interventions (speech and language therapy and psychological and psychosocial interventions) to support and improve decision-making capacity for treatment in specific groups?

    Recommendation ID NG108/2 Question Targeted interventions to support and improve decision-making capacity for treatment:- What is the effectiveness

  8. Identifying health conditions:- What is the effectiveness and cost effectiveness of different ways of identifying age-related and other physical and mental health conditions, in people growing older with learning disabilities?What can mainstream and specialist health services do to facilitate:- early identification of health conditions in people with learning disabilities?- equal access to health services in people with learning disabilities?

    Recommendation ID NG96/2 Question Identifying health conditions:- What is the effectiveness and cost effectiveness of different ways of

  9. Limiting emergency department opening hours:- What is the clinical and cost effectiveness of limiting emergency department opening hours, and what effect does this have on local healthcare provision and outcomes for people with medical emergencies? [See the evidence review on emergency department opening hours.]

    Recommendation ID NG94/11 Question Limiting emergency department opening hours:- What is the clinical and cost effectiveness of limiting

  10. Management of poor prognosis:- What is the clinical and cost effectiveness of managing RA with a poor prognosis (identified as presence of anti-cyclic citrullinated peptide [CCP] antibodies or evidence of erosions on X-ray at diagnosis) with a different strategy from that used for standard management of RA?

    Recommendation ID NG100/5 Question Management of poor prognosis:- What is the clinical and cost effectiveness of managing RA with a poor