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ion (with or without type 2 diabetes), what are the appropriate risk and blood pressure thresholds for starting treatment?

Recommendation ID NG136/2 Question ion (with or without type 2 diabetes), what are the appropriate risk and blood pressure thresholds for

Research recommendation Published November 2019

What are the costs associated with best supportive care?

Recommendation ID TA575/1 Question What are the costs associated with best supportive care? Any explanatory notes(if applicable)

Research recommendation Published August 2019

What are the clinically and cost-effective surgical approaches to managing complicated acute diverticulitis, including timing of surgery (elective or emergency)?

Recommendation ID NG147/5 Question What are the clinically and cost-effective surgical approaches to managing complicated acute diverticulitis

Research recommendation Published February 2020

What training, support or interventions help to reduce caring-related accidents or incidents?

Recommendation ID NG150/3 Question What training, support or interventions help to reduce caring-related accidents or incidents?

Research recommendation Published February 2020

Treating an eating disorder in people with a comorbidity:- What is the impact of comorbidities on treatment outcomes for eating disorders, and whatapproaches are effective in managing these comorbidities?

Recommendation ID NG69/4 Question Treating an eating disorder in people with a comorbidity:- What is the impact of comorbidities on treatment

Research recommendation Published October 2018

For isoniazid-resistant TB, what is the most effective regimen for reducing mortality andmorbidity?

Recommendation ID NG33/3 Question For isoniazid-resistant TB, what is the most effective regimen for reducing mortality andmorbidity?

Research recommendation Published November 2019

Which signs and symptoms (or combinations of signs and symptoms) predict a diagnosis of Kawasaki disease in children under 5 presenting with fever lasting 5 days or more?

Recommendation ID NG143/8 Question Which signs and symptoms (or combinations of signs and symptoms) predict a diagnosis of Kawasaki disease

Research recommendation Published February 2020

What is the clinical and cost effectiveness of cannabis-based medicinal products other than THC: CBD spray for children, young people and adults with spasticity? In particular, what is the impact of spasticity on improvements in quality of life?

Recommendation ID NG144/5 Question What is the clinical and cost effectiveness of cannabis-based medicinal products other than THC: CBD

Research recommendation Published February 2020

Are there subgroups of people with hypertension who should start on dual therapy?

Recommendation ID NG136/4 Question Are there subgroups of people with hypertension who should start on dual therapy? Any explanatory

Research recommendation Published November 2019

What is the effectiveness and cost effectiveness of stereotactic ablative radiotherapy (SABR) compared with surgery (for example, sublobar, wedge resection, lobectomy) for people with non-small-cell lung cancer (stage I and IIA) in whom surgery is suitable?

Recommendation ID NG122/2 Question What is the effectiveness and cost effectiveness of stereotactic ablative radiotherapy (SABR) compared

Research recommendation Published June 2019

Stopping rules for antiangiogenic treatment for late AMD (wet):- When should anti-vascular endothelial growth factor (VEGF) treatment be suspended or stoppedin people with late AMD (wet)?

Recommendation ID NG82/3 Question Stopping rules for antiangiogenic treatment for late AMD (wet):- When should anti-vascular endothelial

Research recommendation Published November 2018

Strategies to slow the progression of age-related macular degeneration (AMD):- What is the effectiveness of antioxidant and zinc supplements on AMD disease progression for people with early AMD at high risk of progression in the context of a randomised controlled trial?

Recommendation ID NG82/1 Question Strategies to slow the progression of age-related macular degeneration (AMD):- What is the effectiveness

Research recommendation Published November 2018

Frequency of review:- What is the most clinical and cost-effective frequency of review for people on peritoneal dialysis, haemodiafiltration, haemodialysis or conservative management?

Recommendation ID NG107/4 Question Frequency of review:- What is the most clinical and cost-effective frequency of review for people on

Research recommendation Published December 2018

Timing of pre-emptive transplant:- What is the most clinical and cost-effective strategy for timing of pre-emptive transplantation?

Recommendation ID NG107/2 Question Timing of pre-emptive transplant:- What is the most clinical and cost-effective strategy for timing

Research recommendation Published December 2018

Non-steroidal anti-inflammatory drugs (NSAIDs) – route of administration:- What is the most clinically and cost effective route of administration for NSAIDs in the management of acute pain thought to be due to renal or ureteric stones?

Recommendation ID NG118/5 Question Non-steroidal anti-inflammatory drugs (NSAIDs) – route of administration:- What is the most clinically

Research recommendation Published March 2019

Specialised units for older people:- What is the most clinically and cost effective way to configure services to assess frail older people who present to hospital with a medical emergency?

Recommendation ID NG94/4 Question Specialised units for older people:- What is the most clinically and cost effective way to configure

Research recommendation Published November 2018

Management of type 3c diabetes:- What is the most clinically effective and cost-effective insulin regimen to minimise hypo- and hyperglycaemia for type 3c diabetes secondary to pancreatitis?

Recommendation ID NG104/5 Question Management of type 3c diabetes:- What is the most clinically effective and cost-effective insulin regimen

Research recommendation Published December 2018

Pain management: small duct disease:- What is the most clinically effective and cost-effective intervention for managing small duct disease (in the absence of pancreatic duct obstruction, inflammatory mass or pseudocyst) in people with chronic pancreatitis presenting with pain?

Recommendation ID NG104/4 Question Pain management: small duct disease:- What is the most clinically effective and cost-effective intervention

Research recommendation Published December 2018

Speed of intravenous fluid resuscitation for people with acute pancreatitis:- What is the most clinically effective and cost-effective speed of administration of intravenous fluid for resuscitation in people with acute pancreatitis?

Recommendation ID NG104/2 Question Speed of intravenous fluid resuscitation for people with acute pancreatitis:- What is the most clinically

Research recommendation Published December 2018

Idiopathic sudden sensorineural hearing loss:- What is the most effective route of administration of steroids as a first-line treatment for idiopathic sudden sensorineural hearing loss?

Recommendation ID NG98/1 Question Idiopathic sudden sensorineural hearing loss:- What is the most effective route of administration of

Research recommendation Published December 2018

Cardiac MRI versus other imaging techniques for diagnosing heart failure:- What is the optimal imaging technique for the diagnosis of heart failure?

Recommendation ID NG106/2 Question Cardiac MRI versus other imaging techniques for diagnosing heart failure:- What is the optimal imaging

Research recommendation Published December 2018

The impact of atrial fibrillation on the natriuretic peptide threshold for diagnosing heart failure:- What is the optimal NT-proBNP threshold for the diagnosis of heart failure in people with atrial fibrillation?

Recommendation ID NG106/3 Question The impact of atrial fibrillation on the natriuretic peptide threshold for diagnosing heart failure:- What

Research recommendation Published December 2018

What is the optimal way of discharging people approaching the end of their life from hospitals back to their place of residence?

Recommendation ID NG142/4 Question What is the optimal way of discharging people approaching the end of their life from hospitals back

Research recommendation Published November 2019

Splinting to improve or maintain posture or function:- What is the optimum regimen for splints applied to the upper limb in adults with cerebral palsy to improve or maintain posture or function?

Recommendation ID NG119/5 Question Splinting to improve or maintain posture or function:- What is the optimum regimen for splints applied

Research recommendation Published March 2019

Surgery to the breast:- What is the optimum tumour-free margin width after breast-conserving surgery for women with ductal carcinoma in situ (DCIS) and invasive breast cancer?

Recommendation ID NG101/1 Question Surgery to the breast:- What is the optimum tumour-free margin width after breast-conserving surgery

Research recommendation Published December 2018

Hearing loss prevalence in people who under-present for hearing loss:- What is the prevalence of hearing loss among populations who under-present for possible hearingloss?

Recommendation ID NG98/4 Question Hearing loss prevalence in people who under-present for hearing loss:- What is the prevalence of hearing

Research recommendation Published December 2018

Case management:- What is the effectiveness and cost effectiveness of high-intensity case management compared with usual care on quality of life (for the person living with dementia and for their carers) and the timing of entry to long-term care?

Recommendation ID NG97/1 Question Case management:- What is the effectiveness and cost effectiveness of high-intensity case management

Research recommendation Published December 2018

Models of supported living:- What is the effectiveness and cost effectiveness of models of shared, supported living, such as Shared Lives?What are the views and experiences of people sharing their home and people who live with themunder programmes such as Shared Lives?

Recommendation ID NG93/3 Question Models of supported living:- What is the effectiveness and cost effectiveness of models of shared, supported

Research recommendation Published November 2018

Advocacy and support for decision-making:- What is the effectiveness, cost effectiveness and acceptability of advocacy as a means of supporting people to make decisions?

Recommendation ID NG108/3 Question Advocacy and support for decision-making:- What is the effectiveness, cost effectiveness and acceptability

Research recommendation Published December 2018

Structured clinical management interventions in probation service providers:- What is the effectiveness of structured clinical (case) management in improving mental health outcomes using interventions within probation service providers?

Recommendation ID NG66/2 Question Structured clinical management interventions in probation service providers:- What is the effectiveness

Research recommendation Published May 2017

Prophylactic antibiotics for preventing exacerbations: - What is the long-term clinical and cost effectiveness of prophylactic antibiotics for people with stable COPD who are at high risk of exacerbations?

Recommendation ID NG115/7 Question Prophylactic antibiotics for preventing exacerbations: - What is the long-term clinical and cost effectiveness

Research recommendation Published February 2019

What measures would make up an effective, standardised approach to evaluation of condom distribution schemes?: How can we develop a standardised framework to evaluate condom schemes and what would be included in that evaluation?

Recommendation ID NG68/1 Question What measures would make up an effective, standardised approach to evaluation of condom distribution

Research recommendation Published October 2018

Community-based models of flu vaccination:- What models of community-based flu vaccination provision (for example, community pharmacies, community nursing and midwifery teams and outreach services) are effective and cost-effective for increasing uptake in eligible groups?

Recommendation ID NG103/5 Question Community-based models of flu vaccination:- What models of community-based flu vaccination provision

Research recommendation Published December 2018

Personalisation and risk markers:- What prognostic and prescriptive factors are important in determining the choice of PTSD treatment?

Recommendation ID NG116/4 Question Personalisation and risk markers:- What prognostic and prescriptive factors are important in determining

Research recommendation Published February 2019

Supporting family members, carers and staff:- What types of services or approaches are effective in supporting family members, carers and staffto be resilient and able to provide care and support to people with a learning disability and behaviour that challenges?

Recommendation ID NG93/2 Question Supporting family members, carers and staff:- What types of services or approaches are effective in supporting

Research recommendation Published November 2018

Seroprevalence of Lyme disease-specific antibodies and other tick-borne infections in the UK population:- What is the current seroprevalence of Lyme disease-specific antibodies and other tick-borne infections in people in the UK?

Recommendation ID NG95/3 Question Seroprevalence of Lyme disease-specific antibodies and other tick-borne infections in the UK population:- What

Research recommendation Published November 2018