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  1. Aspirin prophylaxis for people with fragility fractures of the pelvis, hip or proximal femur:- What is the clinical and cost effectiveness of aspirin alone versus other pharmacological and/or mechanical prophylaxis strategies (alone or in combination) for people with fragility fractures of the pelvis, hip or proximal femur?

    Recommendation ID NG89/4 Question Aspirin prophylaxis for people with fragility fractures of the pelvis, hip or proximal femur:- What is

  2. Research is recommended to address uncertainties about the claimed benefits of using Mepilex Border Heel and Sacrum dressings. This research should also explore issues such as:- the incidence of heel and sacrum pressure ulcers in NHS acute care settings- criteria for patient selection to reduce pressure ulcer incidence with Mepilex Border Heel and Sacrum dressings in addition to standard care.NICE will consider reviewing this guidance when substantive new evidence becomes available.

    Recommendation ID MTG40/1 Question Research is recommended to address uncertainties about the claimed benefits of using Mepilex Border

  3. Predictive accuracy of the ASQ-3 for children born preterm:- What is the concurrent and predictive accuracy of the parent-completed Ages and Stages Questionnaire, 3rd edition (ASQ-3) for detecting concurrent learning disability (intellectual disability) and motor impairment between the ages of 2 years (corrected) and 4 years (uncorrected) in children born preterm?

    Recommendation ID NG72/3 Question Predictive accuracy of the ASQ-3 for children born preterm:- What is the concurrent and predictive accuracy

  4. Pulmonary rehabilitation during hospital admission:- In people with COPD, does pulmonary rehabilitation during hospital admission for exacerbation and/or in the early recovery period (within 1 month of an exacerbation) improve quality of life and reduce hospitalisations and exacerbations compared with a later (defined as after 1 month)pulmonary rehabilitation programme, and in which groups is it most clinically and cost effective?

    Recommendation ID NG115/1 Question Pulmonary rehabilitation during hospital admission:- In people with COPD, does pulmonary rehabilitation

  5. The evidence on the safety of reinforcement of a permanent stoma with a synthetic or biological mesh to prevent a parastomal hernia shows there are serious but well-recognised complications. The evidence on efficacy is limited in quantity and quality. Therefore, this procedure should not be used unless  special arrangements   are in place for clinical governance, consent, and audit or research.

    Recommendation ID IPG654/1 Question The evidence on the safety of reinforcement of a permanent stoma with a synthetic or biological mesh

  6. Limiting emergency department opening hours:- What is the clinical and cost effectiveness of limiting emergency department opening hours, and what effect does this have on local healthcare provision and outcomes for people with medical emergencies? [See the evidence review on emergency department opening hours.]

    Recommendation ID NG94/11 Question Limiting emergency department opening hours:- What is the clinical and cost effectiveness of limiting

  7. Management of poor prognosis:- What is the clinical and cost effectiveness of managing RA with a poor prognosis (identified as presence of anti-cyclic citrullinated peptide [CCP] antibodies or evidence of erosions on X-ray at diagnosis) with a different strategy from that used for standard management of RA?

    Recommendation ID NG100/5 Question Management of poor prognosis:- What is the clinical and cost effectiveness of managing RA with a poor

  8. Advance planning about end of life care:- What is the effectiveness and cost effectiveness of advance care planning for end of life care for people growing older with learning disabilities, and their family members and carers?What processes are in place to document and follow the wishes of people growing older with learning disabilities about their decisions on end of life care?

    Recommendation ID NG96/5 Question Advance planning about end of life care:- What is the effectiveness and cost effectiveness of advance

  9. Targeted interventions to support and improve decision-making capacity for treatment:- What is the effectiveness and cost effectiveness of different targeted interventions (speech and language therapy and psychological and psychosocial interventions) to support and improve decision-making capacity for treatment in specific groups?

    Recommendation ID NG108/2 Question Targeted interventions to support and improve decision-making capacity for treatment:- What is the effectiveness