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Ataluren for treating Duchenne muscular dystrophy with a nonsense mutation in the dystrophin gene (HST3)

Evidence-based recommendations on ataluren (Translarna) for treating Duchenne muscular dystrophy with a nonsense mutation in the dystrophin gene..

Highly specialised technologies guidance Published July 2016

Elosulfase alfa for treating mucopolysaccharidosis type IVa (HST2)

Evidence-based recommendations on elosulfase alfa (Vimizim) for treating mucopolysaccharidosis type IVa (MPS IVA)

Highly specialised technologies guidance Published December 2015

Eculizumab for treating atypical haemolytic uraemic syndrome (HST1)

Evidence-based recommendations on culizumab (Soliris) for treating atypical haemolytic uraemic syndrome (aHUS)

Highly specialised technologies guidance Published January 2015

Migalastat for treating Fabry disease (HST4)

Evidence-based recommendations on migalastat (Galafold) for treating Fabry disease in people over 16

Highly specialised technologies guidance Published February 2017

Eliglustat for treating type 1 Gaucher disease (HST5)

Evidence-based recommendations on eliglustat (Cerdelga) for treating type 1 Gaucher disease in adults

Highly specialised technologies guidance Published June 2017

Burosumab for treating X-linked hypophosphataemia in children and young people (HST8)

Evidence-based recommendations on burosumab (Crysvita) for treating X-linked hypophosphataemia (XLH) in children and young people

Highly specialised technologies guidance Published October 2018

Asfotase alfa for treating paediatric-onset hypophosphatasia (HST6)

Evidence-based recommendations on asfotase alfa (Strensiq) for treating paediatric-onset hypophosphatasia in adults and children

Highly specialised technologies guidance Published August 2017

Patisiran for treating hereditary transthyretin amyloidosis (HST10)

Evidence-based recommendations on patisiran (Onpattro) for treating hereditary transthyretin amyloidosis in adults with stage 1 and stage 2 polyneuropathy

Highly specialised technologies guidance Published August 2019

Strimvelis for treating adenosine deaminase deficiency–severe combined immunodeficiency (HST7)

Evidence-based recommendation on Strimvelis for adenosine deaminase deficiency–severe combined immunodeficiency (ADA–SCID)

Highly specialised technologies guidance Published February 2018

Inotersen for treating hereditary transthyretin amyloidosis (HST9)

Evidence-based recommendations on inotersen (Tegsedi) for stage 1 and stage 2 polyneuropathy in adults with hereditary transthyretin amyloidosis

Highly specialised technologies guidance Published May 2019

Voretigene neparvovec for treating inherited retinal dystrophies caused by RPE65 gene mutations (HST11)

Evidence-based recommendations on voretigene neparvovec (Luxturna) for RPE65-mediated inherited retinal dystrophies (confirmed biallelic RPE65 gene mutations)

Highly specialised technologies guidance Published October 2019

Transapical transcatheter mitral valve-in-valve implantation for a failed surgically implanted mitral valve bioprosthesis (IPG541)

Evidence-based recommendations on transapical transcatheter mitral valve-in-valve implantation for a failed surgically implanted mitral valve bioprosthesis

Interventional procedures guidance Published December 2015

Electrical stimulation of the lower oesophageal sphincter for treating gastro-oesophageal reflux disease (IPG540)

Evidence-based recommendations on electrical stimulation of the lower oesophageal sphincter for treating gastro-oesophageal reflux disease (GORD)

Interventional procedures guidance Published December 2015

Implantation of a corneal graft–keratoprosthesis for severe corneal opacity in wet blinking eyes (IPG534)

Evidence-based recommendations on implantation of a corneal graft–keratoprosthesis for severe corneal opacity in wet blinking eyes

Interventional procedures guidance Published November 2015

Radiofrequency ablation for symptomatic interdigital (Morton's) neuroma (IPG539)

Evidence-based recommendations on radiofrequency ablation for symptomatic interdigital (Morton’s) neuroma

Interventional procedures guidance Published December 2015

Insertion of a subretinal prosthesis system for retinitis pigmentosa (IPG537)

Evidence-based recommendations on insertion of a subretinal prosthesis system for retinitis pigmentosa (RP)

Interventional procedures guidance Published December 2015

Low energy contact X-ray brachytherapy (the Papillon technique) for early stage rectal cancer (IPG532)

Evidence-based recommendations on low energy contact X-ray brachytherapy (the Papillon technique) for treating early stage rectal cancer

Interventional procedures guidance Published September 2015

Transcranial direct current stimulation (tDCS) for depression (IPG530)

Evidence-based recommendations on transcranial direct current stimulation (tDCS) for depression

Interventional procedures guidance Published August 2015

Insertion of a double balloon catheter for induction of labour in pregnant women without previous caesarean section (IPG528)

Evidence-based recommendations on the insertion of a double balloon catheter for inducing labour in pregnant women without previous caesarean section

Interventional procedures guidance Published July 2015

Joint distraction for knee osteoarthritis without alignment correction (IPG529)

Evidence-based recommendations on joint distraction for knee osteoarthritis without alignment correction

Interventional procedures guidance Published July 2015

Implantation of a sphenopalatine ganglion stimulation device for chronic cluster headache (IPG527)

Evidence-based recommendations on the implantation of a sphenopalatine ganglion stimulation device for treating chronic cluster headaches

Interventional procedures guidance Published June 2015

Electrotherapy for the treatment of haemorrhoids (IPG525)

Evidence-based recommendations on electrotherapy for treating haemorrhoids

Interventional procedures guidance Published June 2015

Single-incision short sling mesh insertion for stress urinary incontinence in women (IPG566)

Evidence-based recommendations on single-incision short sling mesh insertion for stress urinary incontinence in women

Interventional procedures guidance Published October 2016

Percutaneous insertion of craniocaudal expandable implants for vertebral compression fracture (IPG568)

Evidence-based recommendations on percutaneous insertion of craniocaudal expandable implants for vertebral compression fracture in adults

Interventional procedures guidance Published November 2016

Miniature lens system implantation for advanced age-related macular degeneration (IPG565)

Evidence-based recommendations on miniature lens system implantation for advanced age-related macular degeneration (AMD)

Interventional procedures guidance Published September 2016

Percutaneous endoscopic laser balloon pulmonary vein isolation for atrial fibrillation (IPG563)

Evidence-based recommendations on percutaneous endoscopic laser balloon pulmonary vein isolation for atrial fibrillation (AF) in adults

Interventional procedures guidance Published July 2016

Ultrasound-guided percutaneous radiofrequency ablation for benign thyroid nodules (IPG562)

Evidence-based recommendations on ultrasound-guided percutaneous radiofrequency ablation for treating benign thyroid nodules in adults

Interventional procedures guidance Published June 2016

Microstructural scaffold (patch) insertion without autologous cell implantation for repairing symptomatic chondral knee defects (IPG560)

Evidence-based recommendations on microstructural scaffold (patch) insertion without autologous cell implantation for repairing chrondral knee defects

Interventional procedures guidance Published June 2016

Biodegradable subacromial spacer insertion for rotator cuff tears (IPG558)

Evidence-based recommendations on biodegradable subacromial spacer insertion for rotator cuff tears in the shoulder

Interventional procedures guidance Published May 2016

Transcutaneous electrical stimulation of the supraorbital nerve for treating and preventing migraine (IPG559)

Evidence-based recommendations on transcutaneous electrical stimulation of the supraorbital nerve for treating and preventing migraine

Interventional procedures guidance Published May 2016

Endovenous mechanochemical ablation for varicose veins (IPG557)

Evidence-based recommendations on endovenous mechanochemical ablation for treating varicose veins

Interventional procedures guidance Published May 2016

Microwave ablation for treating liver metastases (IPG553)

Evidence-based recommendations on microwave ablation for treating liver metastases (cancer)

Interventional procedures guidance Published April 2016

Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension (IPG554)

Evidence-based recommendations on balloon pulmonary angioplasty for treating chronic thromboembolic pulmonary hypertension

Interventional procedures guidance Published April 2016

Transcutaneous stimulation of the cervical branch of the vagus nerve for cluster headache and migraine (IPG552)

Evidence-based recommendations on transcutaneous stimulation of the cervical branch of the vagus nerve for cluster headache and migraine

Interventional procedures guidance Published March 2016

Percutaneous transforaminal endoscopic lumbar discectomy for sciatica (IPG556)

Evidence-based recommendations on percutaneous transforaminal endoscopic lumbar discectomy for sciatica

Interventional procedures guidance Published April 2016

Endoscopic carbon dioxide laser cricopharyngeal myotomy for relief of oropharyngeal dysphagia (IPG550)

Evidence-based recommendations on endoscopic carbon dioxide laser cricopharyngeal myotomy for relieving oropharyngeal dysphagia (swallowing difficulties)

Interventional procedures guidance Published March 2016

Endoscopic injection of bulking agents for gastro-oesophageal reflux disease (IPG55)

Evidence-based recommendations on endoscopic injection of bulking agents for gastro-oesophageal reflux disease (GORD)

Interventional procedures guidance Published April 2004

Mechanical clot retrieval for treating acute ischaemic stroke (IPG548)

Evidence-based recommendations on mechanical blood clot retrieval for treating acute ischaemic stroke

Interventional procedures guidance Published February 2016

Angioplasty and stenting to treat peripheral arterial disease causing refractory erectile dysfunction (IPG546)

Evidence-based recommendations on angioplasty and stenting to treat peripheral arterial disease (PAD) causing refractory erectile dysfunction

Interventional procedures guidance Published February 2016

Percutaneous intradiscal radiofrequency treatment of the intervertebral disc nucleus for low back pain (IPG545)

Evidence-based recommendations on percutaneous intradiscal radiofrequency treatment of the intervertebral disc nucleus for low back pain

Interventional procedures guidance Published January 2016

Percutaneous electrothermal treatment of the intervertebral disc annulus for low back pain and sciatica (IPG544)

Evidence-based recommendations on percutaneous electrothermal treatment of the intervertebral disc annulus for low back pain and sciatica

Interventional procedures guidance Published January 2016

Repetitive transcranial magnetic stimulation for depression (IPG542)

Evidence-based recommendations on repetitive transcranial magnetic stimulation for depression

Interventional procedures guidance Published December 2015

Laser sheath removal of pacing leads (IPG63)

Evidence-based recommendations on laser sheath removal of pacing (pacemaker) leads

Interventional procedures guidance Published June 2004

Sacral nerve stimulation for urge incontinence and urgency-frequency (IPG64)

Evidence-based recommendations on sacral nerve stimulation for treating overactive bladder (urge incontinence and urgency-frequency)

Interventional procedures guidance Published June 2004

Transpupillary thermotherapy for age-related macular degeneration (IPG58)

Evidence-based recommendations on transpupillary thermotherapy for treating age-related macular degeneration (AMD)

Interventional procedures guidance Published May 2004

Subfascial endoscopic perforator vein surgery (IPG59)

Evidence-based recommendations on subfascial endoscopic perforator vein surgery for treating ulcers caused by chronic venous insufficiency

Interventional procedures guidance Published May 2004

Irreversible electroporation for treating pancreatic cancer (IPG579)

Evidence-based recommendations on irreversible electroporation (IRE) for treating pancreatic cancer

Interventional procedures guidance Published May 2017

Extraurethral (non-circumferential) retropubic adjustable compression devices for stress urinary incontinence in women (IPG576)

Evidence-based recommendations on extraurethral (non-circumferential) retropubic adjustable compression devices for stress urinary incontinence in women

Interventional procedures guidance Published March 2017

Trabecular stent bypass microsurgery for open-angle glaucoma (IPG575)

Evidence-based recommendations on trabecular stent bypass microsurgery for open-angle glaucoma (damaged optic nerve)

Interventional procedures guidance Published February 2017

Radiation therapy for early Dupuytren's disease (IPG573)

Evidence-based recommendations on radiation therapy (low energy X-rays) for treating early Dupuytren’s contractures in adults

Interventional procedures guidance Published December 2016