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Eculizumab for treating atypical haemolytic uraemic syndrome (HST1)

Evidence-based recommendations on eculizumab (Soliris) for treating atypical haemolytic uraemic syndrome in adults and children

Highly specialised technologies guidance Published January 2015

Voretigene neparvovec for treating inherited retinal dystrophies caused by RPE65 gene mutations (HST11)

Evidence-based recommendations on voretigene neparvovec (Luxturna) for RPE65-mediated inherited retinal dystrophies in people with vision loss caused by inherit

Highly specialised technologies guidance Published October 2019

Cerliponase alfa for treating neuronal ceroid lipofuscinosis type 2 (HST12)

Evidence-based recommendations on cerliponase alfa (Brineura) for treating neuronal ceroid lipofuscinosis type 2 in children

Highly specialised technologies guidance Published November 2019

Elosulfase alfa for treating mucopolysaccharidosis type IVa (HST2)

Evidence-based recommendations on elosulfase alfa (Vimizim) for treating mucopolysaccharidosis type IVa in adults and children

Highly specialised technologies guidance Published December 2015

Ataluren for treating Duchenne muscular dystrophy with a nonsense mutation in the dystrophin gene (HST3)

Evidence-based recommendations on ataluren (Translarna) for treating Duchenne muscular dystrophy with a nonsense mutation in the dystrophin gene in people aged

Highly specialised technologies guidance Published July 2016

Burosumab for treating X-linked hypophosphataemia in children and young people (HST8)

Evidence-based recommendations on burosumab (Crysvita) for treating X-linked hypophosphataemia (XLH) in children and young people

Highly specialised technologies guidance Published October 2018

Inotersen for treating hereditary transthyretin amyloidosis (HST9)

Evidence-based recommendations on inotersen (Tegsedi) for stage 1 and stage 2 polyneuropathy in adults with hereditary transthyretin amyloidosis

Highly specialised technologies guidance Published May 2019

Eliglustat for treating type 1 Gaucher disease (HST5)

Evidence-based recommendations on eliglustat (Cerdelga) for treating type 1 Gaucher disease in adults

Highly specialised technologies guidance Published June 2017

Asfotase alfa for treating paediatric-onset hypophosphatasia (HST6)

Evidence-based recommendations on asfotase alfa (Strensiq) for treating paediatric-onset hypophosphatasia in adults and children

Highly specialised technologies guidance Published August 2017

Migalastat for treating Fabry disease (HST4)

Evidence-based recommendations on migalastat (Galafold) for treating Fabry disease in people over 16

Highly specialised technologies guidance Published February 2017

Strimvelis for treating adenosine deaminase deficiency–severe combined immunodeficiency (HST7)

Evidence-based recommendation on Strimvelis for adenosine deaminase deficiency–severe combined immunodeficiency

Highly specialised technologies guidance Published February 2018

Patisiran for treating hereditary transthyretin amyloidosis (HST10)

Evidence-based recommendations on patisiran (Onpattro) for treating hereditary transthyretin amyloidosis in adults with stage 1 and stage 2 polyneuropathy

Highly specialised technologies guidance Published August 2019

Placement of pectus bar for pectus excavatum (also known as MIRPE or the Nuss procedure) (IPG310)

Evidence-based recommendations on placing a pectus bar (MIRPE/the Nuss procedure) to treat pectus excavatum (‘funnel chest’)

Interventional procedures guidance Published August 2009

Extracorporeal shockwave therapy for refractory plantar fasciitis (IPG311)

Evidence-based recommendations on extracorporeal shockwave therapy for refractory plantar fasciitis (ligament deterioration between the heel and foot)

Interventional procedures guidance Published August 2009

Extracorporeal shockwave therapy for refractory tennis elbow (IPG313)

Evidence-based recommendations on extracorporeal shockwave (inaudible sound waves) therapy for refractory tennis elbow

Interventional procedures guidance Published August 2009

Extracorporeal albumin dialysis for acute liver failure (IPG316)

Evidence-based recommendations on extracorporeal albumin dialysis for acute liver failure

Interventional procedures guidance Published September 2009

Individually magnetic resonance imaging-designed unicompartmental interpositional implant insertion for osteoarthritis of the knee (IPG317)

Evidence-based recommendations on inserting individually MRI-designed unicompartmental, interpositional (customised) implant for knee osteoarthritis

Interventional procedures guidance Published September 2009

Endoscopic transsphenoidal pituitary adenoma resection (IPG32)

Evidence-based recommendations on endoscopic transsphenoidal pituitary adenoma resection for treating pituitary adenomas (benign tumours)

Interventional procedures guidance Published December 2003

Balloon catheter insertion for Bartholin's cyst or abscess (IPG323)

Evidence-based recommendations on balloon catheter insertion for treating Bartholin's cyst or abscess

Interventional procedures guidance Published December 2009

Electrocautery cutting balloon treatment for pelviureteric junction obstruction (IPG324)

Evidence-based recommendations on electrocautery cutting balloon treatment for pelviureteric junction (PUJ) obstruction

Interventional procedures guidance Published December 2009

Endopyelotomy for pelviureteric junction obstruction (IPG325)

Evidence-based recommendations on endopyelotomy for treating pelviureteric junction (PUJ) obstruction

Interventional procedures guidance Published December 2009

Corneal endothelial transplantation (IPG304)

Evidence-based recommendations on corneal endothelial transplantation (endothelial keratoplasty/EK) to replace the inner layers of the cornea

Interventional procedures guidance Published June 2009

Sinus tarsi implant insertion for mobile flatfoot (IPG305)

Evidence-based recommendations on inserting a sinus tarsi implant to treat mobile flatfoot

Interventional procedures guidance Published July 2009

Prosthetic intervertebral disc replacement in the lumbar spine (IPG306)

Evidence-based recommendations on prosthetic intervertebral disc replacement in the lumbar spine (replacing worn discs in the lower spine with artificial discs)

Interventional procedures guidance Published July 2009

Extracorporeal shockwave therapy for Peyronie's disease (IPG29)

Evidence-based recommendations on extracorporeal shockwave therapy (ESWT) for treating Peyronie's disease

Interventional procedures guidance Published December 2003

Photodynamic therapy for brain tumours (IPG290)

Evidence-based recommendations on photodynamic therapy (PDT) for brain tumours (brain cancer)

Interventional procedures guidance Published March 2009

Implantation of an opaque intraocular lens for intractable double vision (IPG293)

Evidence-based recommendations on implantation of an opaque intraocular lens for intractable double vision (diplopia)

Interventional procedures guidance Published March 2009

Transmyocardial laser revascularisation for refractory angina pectoris (IPG301)

Evidence-based recommendations on transmyocardial laser revascularisation (TMLR) for refractory angina pectoris

Interventional procedures guidance Published May 2009

Percutaneous laser revascularisation for refractory angina pectoris (IPG302)

Evidence-based recommendations on percutaneous laser revascularisation (keyhole surgery) for refractory angina pectoris

Interventional procedures guidance Published May 2009

Percutaneous endoscopic laser cervical discectomy (IPG303)

Evidence-based recommendations on percutaneous endoscopic laser cervical discectomy (keyhole surgery to treat slipped disc in upper back)

Interventional procedures guidance Published June 2009

Image-guided radiofrequency excision biopsy of breast lesions (IPG308)

Evidence-based recommendations on image-guided radiofrequency excision biopsy of breast lesions to test for breast cancer

Interventional procedures guidance Published July 2009

Endoscopic laser foraminoplasty (IPG31)

Evidence-based recommendations on endoscopic laser foraminoplasty for treating back pain caused by a prolapsed intervertebral disc

Interventional procedures guidance Published December 2003

Percutaneous (non-thoracoscopic) epicardial catheter radiofrequency ablation for atrial fibrillation (IPG294)

Evidence-based recommendations on percutaneous (non-thoracoscopic) epicardial catheter radiofrequency ablation for atrial fibrillation (AF)

Interventional procedures guidance Published March 2009

Percutaneous (non-thoracoscopic) epicardial catheter radiofrequency ablation for ventricular tachycardia (IPG295)

Evidence-based recommendations on percutaneous (non-thoracoscopic) epicardial catheter radiofrequency ablation for ventricular tachycardia

Interventional procedures guidance Published March 2009

Palliative photodynamic therapy for advanced oesophageal cancer (IPG206)

Evidence-based recommendations on palliative photodynamic therapy (PDT/blue light therapy) for treating advanced oesophageal (gullet) cancer

Interventional procedures guidance Published January 2007

Stimulated graciloplasty for faecal incontinence (IPG159)

Evidence-based recommendations on stimulated graciloplasty for faecal incontinence (creating a new anal sphincter muscle)

Interventional procedures guidance Published March 2006

Functional electrical stimulation for drop foot of central neurological origin (IPG278)

Evidence-based recommendations on functional electrical stimulation for drop foot of central neurological origin

Interventional procedures guidance Published January 2009

Hysteroscopic morcellation of uterine leiomyomas (fibroids) (IPG522)

Evidence-based recommendations on hysteroscopic morcellation of uterine leiomyomas (uterine myomas or fibroids)

Interventional procedures guidance Published June 2015

Electrotherapy for the treatment of haemorrhoids (IPG525)

Evidence-based recommendations on electrotherapy for treating haemorrhoids

Interventional procedures guidance Published June 2015

Cyanoacrylate glue occlusion for varicose veins (IPG526)

Evidence-based recommendations on cyanoacrylate glue occlusion for varicose veins

Interventional procedures guidance Published June 2015

Implantation of a sphenopalatine ganglion stimulation device for chronic cluster headache (IPG527)

Evidence-based recommendations on the implantation of a sphenopalatine ganglion stimulation device for treating chronic cluster headaches

Interventional procedures guidance Published June 2015

Insertion of a double balloon catheter for induction of labour in pregnant women without previous caesarean section (IPG528)

Evidence-based recommendations on the insertion of a double balloon catheter for inducing labour in pregnant women without previous caesarean section

Interventional procedures guidance Published July 2015

Implantation of a left ventricular assist device for destination therapy in people ineligible for heart transplantation (IPG516)

Evidence-based recommendations on the implantation of a left ventricular assist device for destination therapy in people ineligible for heart transplant

Interventional procedures guidance Published March 2015

Insertion of endobronchial nitinol coils to improve lung function in emphysema (IPG517)

Evidence-based recommendations on endobronchial nitinol coils to improve lung function in emphysema (chronic obstructive pulmonary disease [COPD])

Interventional procedures guidance Published March 2015

Implantation of a duodenal–jejunal bypass liner for managing type 2 diabetes (IPG518)

Evidence-based recommendations on implanting a duodenal–jejunal bypass liner for managing type 2 diabetes

Interventional procedures guidance Published March 2015

Insertion of an epiretinal prosthesis for retinitis pigmentosa (IPG519)

Evidence-based recommendations on the insertion of an epiretinal prosthesis for treating retinitis pigmentosa (RP)

Interventional procedures guidance Published June 2015

Endovenous laser treatment of the long saphenous vein (IPG52)

Evidence-based recommendations on endovenous laser treatment (using laser and heat to seal up vein) of the long saphenous vein

Interventional procedures guidance Published March 2004

Radiofrequency ablation for gastric antral vascular ectasia (IPG520)

Evidence-based recommendations on radiofrequency ablation for treating gastric antral vascular ectasia (GAVE) syndrome

Interventional procedures guidance Published June 2015

Suture fixation of acute disruption of the distal tibiofibular syndesmosis (IPG521)

Evidence-based recommendations on suture fixation of acute disruption of the distal tibiofibular syndesmosis (ligament injuries)

Interventional procedures guidance Published June 2015

Normothermic extracorporeal preservation of hearts for transplantation following donation after brainstem death (IPG549)

Evidence-based recommendations on normothermic extracorporeal heart preservation for transplantation following donation after brainstem death

Interventional procedures guidance Published February 2016