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Management of vomiting in children and young people with gastroenteritis: ondansetron (ESUOM34)

Summary of the evidence on ondansetron for the management of vomiting in children and young people with acute gastroenteritis...

Evidence summary Published October 2014

Immune (idiopathic) thrombocytopenic purpura: rituximab (ESUOM35)

Summary of the evidence on rituximab for immune (idiopathic) thrombocytopenic purpura in adults to inform local NHS planning and decision-making

Evidence summary Published October 2014

Systemic lupus erythematosus: oral mycophenolate (ESUOM36)

Summary of the evidence on oral mycophenolate for systemic lupus erythematosus (SLE) to inform local NHS planning and decision-making

Evidence summary Published November 2014

Cystic fibrosis: long-term azithromycin (ESUOM37)

Summary of the evidence on long-term azithromycinoral for treating cystic fibrosis (CF) to inform local NHS planning and decision-making

Evidence summary Published November 2014

Schizophrenia: omega-3 fatty acid medicines (ESUOM19)

Summary of the evidence on omega-3 fatty acid medicines for treating schizophrenia to inform local NHS planning and decision-making

Evidence summary Published September 2013

Sleep disorders in children and young people with attention deficit hyperactivity disorder: melatonin (ESUOM2)

Summary of the evidence on melatonin for sleep disorders in children and young people with attention deficit hyperactivity disorder (ADHD)..

Evidence summary Published January 2013

Postural hypotension in adults: fludrocortisone (ESUOM20)

Summary of the evidence on fludrocortisone for treating postural hypotension in adults to inform local NHS planning and decision-making

Evidence summary Published October 2013

Ovarian cancer (advanced): bevacizumab 7.5 mg/kg in combination with paclitaxel and carboplatin for first-line treatment (ESUOM21)

Summary of the evidence on bevacizumab 7.5 mg/kg with paclitaxel and carboplatin for the first-line treatment of advanced ovarian cancer..

Evidence summary Published October 2013

Chronic obstructive pulmonary disease: aclidinium bromide (ESNM8)

Summary of the evidence on aclidinium bromide for treating chronic obstructive pulmonary disease (COPD) to inform local NHS planning and decision-making

Evidence summary Published January 2013

Chronic obstructive pulmonary disease: glycopyrronium bromide (ESNM9)

Summary of the evidence on glycopyrronium bromide for treating chronic obstructive pulmonary disease (COPD) to inform local NHS planning and decision-making

Evidence summary Published January 2013

Significant haemorrhage following trauma: tranexamic acid (ESUOM1)

Summary of the evidence on tranexamic acid for significant haemorrhage (bleeding) after trauma (major injury) to inform local NHS planning and decision-making

Evidence summary Published October 2012

Bile acid malabsorption: colesevelam (ESUOM22)

Summary of the evidence on colesevelam for treating bile acid malabsorption (BAM) to inform local NHS planning and decision-making

Evidence summary Published October 2013

Transient ischaemic attack: clopidogrel (ESUOM23)

Summary of the evidence on clopidogrel for treating transient ischaemic attack (TIA) to inform local NHS planning and decision-making

Evidence summary Published December 2013

Non-cystic fibrosis bronchiectasis: colistimethate sodium (ESUOM25)

Summary of the evidence on colistimethate sodium (Colobreathe) for non-cystic fibrosis bronchiectasis to inform local NHS planning and decision-making

Evidence summary Published January 2014

Psychotropic medicines in people with learning disabilities whose behaviour challenges (KTT19)

This document summarises the evidence base on psychotropic medicines in people with learning disabilities whose behaviour challenges . It is a key therapeutic topic that has been identified to support medicines optimisation. It is not formal NICE guidance .

Key therapeutic topic Published January 2017 Last updated September 2019

Renin-angiotensin system drugs: dual therapy (KTT2)

The key therapeutic topic renin-angiotensin system drugs: dual therapy has been retired from the 2017 update of medicines optimisation: key therapeutic topics. The version published in 2016 is available here for information but it has not been updated since February 2016. Like all the other key therapeutic topics it is not formal NICE guidance .

Key therapeutic topic Published January 2015 Last updated February 2016

Safer insulin prescribing (KTT20)

This document summarises the evidence base on safer insulin prescribing . It is a key therapeutic topic that has been identified to support medicines optimisation. It is not formal NICE guidance .

Key therapeutic topic Published January 2017 Last updated September 2019

Medicines optimisation in chronic pain (KTT21)

This document summarises the evidence base on medicines optimisation in chronic pain . It is a key therapeutic topic that has been identified to support medicines optimisation. It is not formal NICE guidance .

Key therapeutic topic Published January 2017 Last updated September 2019

Chemotherapy dose standardisation (KTT22)

This document summarises the evidence base on chemotherapy dose standardisation . It is a key therapeutic topic that has been identified to support medicines optimisation. It is not formal NICE guidance .

Key therapeutic topic Published February 2018 Last updated September 2019

Shared decision making (KTT23)

This document summarises the evidence base on shared decision making . It is a key therapeutic topic that has been identified to support Medicines Optimisation. It is not formal NICE guidance .

Key therapeutic topic Published March 2019 Last updated September 2019

Suicide prevention: optimising medicines and reducing access to medicines as a means of suicide (KTT24)

This document summarises the evidence base on suicide prevention: optimising medicines and reducing access to medicines as a means of suicide . It is a key therapeutic topic that has been identified to support medicines optimisation. It is not formal NICE guidance .

Key therapeutic topic Published March 2019 Last updated September 2019

Lipid-modifying drugs (KTT3)

This key therapeutic topic has been reincluded in the September 2019 update of medicines optimisation: key therapeutic topics. This document summarises the evidence base on lipid-modifying drugs. It is a key therapeutic topic that has been identified to support medicines optimisation. It is not formal NICE guidance .

Key therapeutic topic Published January 2015 Last updated September 2019

Asthma: medicines safety priorities (KTT5)

This document summarises the evidence base on asthma: medicines safety priorities . It is a key therapeutic topic that has been identified to support medicines optimisation. It is not formal NICE guidance .

Key therapeutic topic Published January 2015 Last updated September 2019

Hypnotics (KTT6)

This document summarises the evidence base on hypnotics . It is a key therapeutic topic that has been identified to support medicines optimisation. It is not formal NICE guidance .

Key therapeutic topic Published January 2015 Last updated September 2019

Antipsychotics in people living with dementia (KTT7)

This document summarises the evidence base on antipsychotics in people living with dementia . It is a key therapeutic topic that has been identified to support medicines optimisation. It is not formal NICE guidance .

Key therapeutic topic Published January 2015 Last updated September 2019

First-choice antidepressant use in adults with depression or generalised anxiety disorder (KTT8)

The key therapeutic topic first-choice antidepressant use in adults with depression or generalised anxiety disorder has been retired from the 2017 update of medicines optimisation: key therapeutic topics. The version published in 2016 is available here for information but it has not been updated since February 2016. Like all the other key therapeutic topics it is not formal NICE guidance .

Key therapeutic topic Published January 2015 Last updated February 2016

Antimicrobial stewardship: prescribing antibiotics (KTT9)

This document summarises the evidence base on antimicrobial stewardship: prescribing antibiotics . It is a key therapeutic topic that has been identified to support medicines optimisation. It is not formal NICE guidance .

Key therapeutic topic Published January 2015 Last updated September 2019

MiniMed 640G system with SmartGuard for managing blood glucose levels in people with type 1 diabetes (MIB51)

Advice on the MiniMed 640G system with SmartGuard for managing blood glucose levels in type 1 diabetes to aid local decision-making

Medtech innovation briefing Published February 2016

Xpert Carba-R to identify people carrying carbapenemase-producing organisms (MIB52)

Advice on the Xpert Carba-R test for identifying organisms that have carbapenemase genes to aid local decision-making

Medtech innovation briefing Published February 2016

Aquilion PRIME CT scanner for imaging coronary artery disease in adults in whom imaging is difficult (MIB53)

Advice on the use of the Aquilion PRIME CT scanner for imaging coronary artery disease to aid local decision-making

Medtech innovation briefing Published March 2016 Last updated July 2017

Somatom Definition Edge CT scanner for imaging coronary artery disease in adults in whom imaging is difficult (MIB54)

Advice on the use of the Somatom Definition Edge CT scanner for imaging coronary artery disease to aid local decision-making

Medtech innovation briefing Published March 2016 Last updated July 2017

Secca System for faecal incontinence (MIB66)

Advice on the use of the Secca system for treating faecal incontinence to aid local decision-making

Medtech innovation briefing Published May 2016

LATITUDE NXT Patient Management System for monitoring cardiac devices at home (MIB67)

Advice on the use of the LATITUDE NXT Patient Management System for monitoring cardiac devices to aid local decision-making

Medtech innovation briefing Published May 2016

Cellvizio confocal endomicroscopy system for characterising pancreatic cysts (MIB69)

Advice on the use of Cellvizio confocal endomicroscopy system (CLS) for characterising pancreatic cysts to aid local decision-making

Medtech innovation briefing Published June 2016

CORTRAK 2 Enteral Access System for placing nasoenteral feeding tubes (MIB48)

Advice on the use of the CORTRAK 2 Enteral Access System (EAS) for the placement of nasoenteral feeding tube to aid local decision-making

Medtech innovation briefing Published January 2016 Last updated December 2016

EarlySense for heart and respiratory monitoring and predicting patient deterioration (MIB49)

Advice on the use of EarlySense for heart and respiratory monitoring and predicting patient deterioration to aid local decision-making

Medtech innovation briefing Published January 2016

Acoustic CR Neuromodulation for adults with chronic subjective tonal tinnitus (MIB5)

Advice on the use of the Acoustic CR Neuromodulation system for adults with chronic subjective tonal tinnitus to aid local decision-making

Medtech innovation briefing Published June 2014

BladderScan BVI 9400 3D portable ultrasound scanner for measuring bladder volume (MIB50)

Advice on the BladderScan BVI 9400 3D portable ultrasound scanner for measuring bladder volume to aid local decision-making

Medtech innovation briefing Published January 2016

ClearWay RX for drug delivery to coronary artery thrombotic lesions (MIB55)

Advice ClearWay RX for drug delivery to coronary artery thrombotic lesions to aid local decision-making

Medtech innovation briefing Published March 2016

ODFS Pace and Pace XL functional electrical stimulation devices for treating drop foot (MIB56)

Advice on the use of ODFS Pace and Pace XL functional electrical stimulation devices for treating drop foot to aid local decision-making

Medtech innovation briefing Published March 2016

Icare rebound tonometer to measure intraocular pressure (MIB57)

Advice on the use of the Icare rebound tonometer to measure intraocular pressure and assess the risk of developing glaucoma to aid local decision-making

Medtech innovation briefing Published March 2016

Mersey Burns for calculating fluid resuscitation volume when managing burns (MIB58)

Advice on the use of the Mersey Burns app for calculating fluid resuscitation when managing burns to aid local decision-making

Medtech innovation briefing Published March 2016

The hTEE system for transoesophageal echocardiographic monitoring of haemodynamic instability (MIB7)

Advice on the use of the hTEE system for transoesophageal echocardiographic monitoring of haemodynamic instability to aid local decision-making

Medtech innovation briefing Published August 2014

Mobi-C for cervical disc replacement (MIB70)

Advice on the use of Mobi-C for cervical disc replacement to aid local decision-making

Medtech innovation briefing Published June 2016

Alair bronchial thermoplasty system for adults with severe difficult to control asthma (MIB71)

Advice on the use of the Alair bronchial thermoplasty system for treating adults with severe, difficult to control asthma to aid local decision-making

Medtech innovation briefing Published July 2016

PneuX for preventing ventilator-associated pneumonia in intensive care (MIB45)

Advice on the use of PneuX for preventing ventilator-associated pneumonia in intensive care to aid local decision-making

Medtech innovation briefing Published November 2015

AdenoPlus point-of-care test for diagnosing adenoviral conjunctivitis (MIB46)

Advice on the use of the AdenoPlus point-of-care test for diagnosing adenoviral conjunctivitis to aid local decision-making

Medtech innovation briefing Published December 2015

TearLab osmolarity system for diagnosing dry eye disease (MIB47)

Advice on the use of the TearLab osmolarity system for diagnosing dry eye disease to aid local decision-making

Medtech innovation briefing Published December 2015

TheraSphere for treating operable and inoperable hepatocellular carcinoma (MIB62)

Advice on the use of TheraSphere for treating operable and inoperable hepatocellular carcinoma (liver cancer) to aid local decision-making

Medtech innovation briefing Published March 2016

SIR-Spheres for treating inoperable hepatocellular carcinoma (MIB63)

Advice on the use of SIR-Spheres for treating inoperable hepatocellular carcinoma (HCC) (liver cancer) to aid local decision-making

Medtech innovation briefing Published March 2016