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Safe midwifery staffing for maternity settings (NG4)

This guideline covers safe midwifery staffing in all maternity settings, including at home, in the community, in day assessment units, in obstetric units, and in units led by midwives (both alongside hospitals and free-standing). It aims to improve maternity care by giving advice on monitoring staffing levels and actions to take if there are not enough midwives to meet the needs of women and babies in the service.

NICE guideline Published February 2015

Safe staffing for nursing in adult inpatient wards in acute hospitals (SG1)

This guideline covers organisational and managerial approaches to safe nurse staffing of inpatient wards for people aged 18 and over in acute hospitals. It aims to ensure that patients receive the nursing care they need, regardless of the ward to which they are allocated, the time of the day, or the day of the week.

Safe staffing guideline Published July 2014

Eculizumab for treating atypical haemolytic uraemic syndrome (HST1)

Evidence-based recommendations on culizumab (Soliris) for treating atypical haemolytic uraemic syndrome (aHUS)

Highly specialised technologies guidance Published January 2015

Ataluren for treating Duchenne muscular dystrophy with a nonsense mutation in the dystrophin gene (HST3)

Evidence-based recommendations on ataluren (Translarna) for treating Duchenne muscular dystrophy with a nonsense mutation in the dystrophin gene..

Highly specialised technologies guidance Published July 2016

Elosulfase alfa for treating mucopolysaccharidosis type IVa (HST2)

Evidence-based recommendations on elosulfase alfa (Vimizim) for treating mucopolysaccharidosis type IVa (MPS IVA)

Highly specialised technologies guidance Published December 2015

Eliglustat for treating type 1 Gaucher disease (HST5)

Evidence-based recommendations on eliglustat (Cerdelga) for treating type 1 Gaucher disease in adults

Highly specialised technologies guidance Published June 2017

Asfotase alfa for treating paediatric-onset hypophosphatasia (HST6)

Evidence-based recommendations on asfotase alfa (Strensiq) for treating paediatric-onset hypophosphatasia in adults and children

Highly specialised technologies guidance Published August 2017

Migalastat for treating Fabry disease (HST4)

Evidence-based recommendations on migalastat (Galafold) for treating Fabry disease in people over 16

Highly specialised technologies guidance Published February 2017

Voretigene neparvovec for treating inherited retinal dystrophies caused by RPE65 gene mutations (HST11)

Evidence-based recommendations on voretigene neparvovec (Luxturna) for RPE65-mediated inherited retinal dystrophies (confirmed biallelic RPE65 gene mutations)

Highly specialised technologies guidance Published October 2019

Strimvelis for treating adenosine deaminase deficiency–severe combined immunodeficiency (HST7)

Evidence-based recommendation on Strimvelis for adenosine deaminase deficiency–severe combined immunodeficiency (ADA–SCID)

Highly specialised technologies guidance Published February 2018

Patisiran for treating hereditary transthyretin amyloidosis (HST10)

Evidence-based recommendations on patisiran (Onpattro) for treating hereditary transthyretin amyloidosis in adults with stage 1 and stage 2 polyneuropathy

Highly specialised technologies guidance Published August 2019

Inotersen for treating hereditary transthyretin amyloidosis (HST9)

Evidence-based recommendations on inotersen (Tegsedi) for stage 1 and stage 2 polyneuropathy in adults with hereditary transthyretin amyloidosis

Highly specialised technologies guidance Published May 2019

Burosumab for treating X-linked hypophosphataemia in children and young people (HST8)

Evidence-based recommendations on burosumab (Crysvita) for treating X-linked hypophosphataemia (XLH) in children and young people

Highly specialised technologies guidance Published October 2018

Metreleptin for treating lipodystrophy (ID861)

In development [GID-HST10011] Expected publication date: TBC

Highly specialised technologies guidance In development

Afamelanotide for treating erythropoietic protoporphyria [ID927]

In development [GID-HST10009] Expected publication date: TBC

Highly specialised technologies guidance In development

Intrathecal idursulfase for treating Mucopolysaccharidosis type II ID1223

Proposed [GID-HST10019] Expected publication date: TBC

Highly specialised technologies guidance Proposed

VTS-270 for treating Niemann-Pick type C1 (ID1267)

Proposed [GID-HST10020] Expected publication date: TBC

Highly specialised technologies guidance Proposed

OTL-101 for treating adenosine deaminase deficiency–severe combined immunodeficiency [ID1152]

Proposed [GID-HST10022] Expected publication date: TBC

Highly specialised technologies guidance Proposed

Ravulizumab for treating paroxysmal nocturnal haemoglobinuria ID1457

Proposed [GID-HST10023] Expected publication date: TBC

Highly specialised technologies guidance Proposed

Onasemnogene abeparvovec for treating spinal muscular atrophy type 1 [ID1473]

In development [GID-HST10026] Expected publication date: 08 September 2020

Highly specialised technologies guidance In development

Lysosomal acid lipase deficiency - sebelipase alfa [ID737]

In development [GID-LYSOSOMALACIDLIPASEDEFICIENCYSEBELIPASEALFAID737] Expected publication date: TBC

Highly specialised technologies guidance In development

Elosulfase alfa for treating mucopolysaccharidosis type IVa (review of HST2) [ID1643]

In development [GID-HST10027] Expected publication date: TBC

Highly specialised technologies guidance In development

Velmanase alfa for treating alpha-mannosidosis [ID800]

In development [GID-HST10010] Expected publication date: TBC

Highly specialised technologies guidance In development

Volanesorsen for treating familial chylomicronaemia syndrome [ID1326]

In development [GID-HST10015] Expected publication date: 03 June 2020

Highly specialised technologies guidance In development

Human alpha1-proteinase inhibitor for treating emphysema ID856

In development [GID-HST10017] Expected publication date: TBC

Highly specialised technologies guidance In development

Cerliponase alfa for treating neuronal ceroid lipofuscinosis type 2 [ID943]

In development [GID-HST10008] Expected publication date: 27 November 2019

Highly specialised technologies guidance In development

Balloon dilation for eustachian tube dysfunction

In development [GID-IPG10125] Expected publication date: 11 December 2019

Interventional procedures guidance In development

Balloon cryoablation for Barrett's oesophagus

In development [GID-IPG10127] Expected publication date: 11 December 2019

Interventional procedures guidance In development

Balloon cryoablation for squamous dysplasia of the oesophagus

In development [GID-IPG10139] Expected publication date: 11 December 2019

Interventional procedures guidance In development

Atezolizumab with carboplatin and etoposide for untreated extensive-stage small-cell lung cancer ID1504

In development [GID-TA10400] Expected publication date: 11 December 2019

Technology appraisal guidance In development

Electrical stimulation of the lower oesophageal sphincter for treating gastro-oesophageal reflux disease (IPG540)

Evidence-based recommendations on electrical stimulation of the lower oesophageal sphincter for treating gastro-oesophageal reflux disease (GORD)

Interventional procedures guidance Published December 2015

Implantation of a corneal graft–keratoprosthesis for severe corneal opacity in wet blinking eyes (IPG534)

Evidence-based recommendations on implantation of a corneal graft–keratoprosthesis for severe corneal opacity in wet blinking eyes

Interventional procedures guidance Published November 2015

Radiofrequency ablation for symptomatic interdigital (Morton's) neuroma (IPG539)

Evidence-based recommendations on radiofrequency ablation for symptomatic interdigital (Morton’s) neuroma

Interventional procedures guidance Published December 2015

Insertion of a subretinal prosthesis system for retinitis pigmentosa (IPG537)

Evidence-based recommendations on insertion of a subretinal prosthesis system for retinitis pigmentosa (RP)

Interventional procedures guidance Published December 2015

Low energy contact X-ray brachytherapy (the Papillon technique) for early stage rectal cancer (IPG532)

Evidence-based recommendations on low energy contact X-ray brachytherapy (the Papillon technique) for treating early stage rectal cancer

Interventional procedures guidance Published September 2015

Transcranial direct current stimulation (tDCS) for depression (IPG530)

Evidence-based recommendations on transcranial direct current stimulation (tDCS) for depression

Interventional procedures guidance Published August 2015

Insertion of a double balloon catheter for induction of labour in pregnant women without previous caesarean section (IPG528)

Evidence-based recommendations on the insertion of a double balloon catheter for inducing labour in pregnant women without previous caesarean section

Interventional procedures guidance Published July 2015

Joint distraction for knee osteoarthritis without alignment correction (IPG529)

Evidence-based recommendations on joint distraction for knee osteoarthritis without alignment correction

Interventional procedures guidance Published July 2015

Implantation of a sphenopalatine ganglion stimulation device for chronic cluster headache (IPG527)

Evidence-based recommendations on the implantation of a sphenopalatine ganglion stimulation device for treating chronic cluster headaches

Interventional procedures guidance Published June 2015

Electrotherapy for the treatment of haemorrhoids (IPG525)

Evidence-based recommendations on electrotherapy for treating haemorrhoids

Interventional procedures guidance Published June 2015

Transcutaneous stimulation of the cervical branch of the vagus nerve for cluster headache and migraine (IPG552)

Evidence-based recommendations on transcutaneous stimulation of the cervical branch of the vagus nerve for cluster headache and migraine

Interventional procedures guidance Published March 2016

Percutaneous transforaminal endoscopic lumbar discectomy for sciatica (IPG556)

Evidence-based recommendations on percutaneous transforaminal endoscopic lumbar discectomy for sciatica

Interventional procedures guidance Published April 2016

Endoscopic carbon dioxide laser cricopharyngeal myotomy for relief of oropharyngeal dysphagia (IPG550)

Evidence-based recommendations on endoscopic carbon dioxide laser cricopharyngeal myotomy for relieving oropharyngeal dysphagia (swallowing difficulties)

Interventional procedures guidance Published March 2016

Endoscopic injection of bulking agents for gastro-oesophageal reflux disease (IPG55)

Evidence-based recommendations on endoscopic injection of bulking agents for gastro-oesophageal reflux disease (GORD)

Interventional procedures guidance Published April 2004

Mechanical clot retrieval for treating acute ischaemic stroke (IPG548)

Evidence-based recommendations on mechanical blood clot retrieval for treating acute ischaemic stroke

Interventional procedures guidance Published February 2016

Angioplasty and stenting to treat peripheral arterial disease causing refractory erectile dysfunction (IPG546)

Evidence-based recommendations on angioplasty and stenting to treat peripheral arterial disease (PAD) causing refractory erectile dysfunction

Interventional procedures guidance Published February 2016

Percutaneous intradiscal radiofrequency treatment of the intervertebral disc nucleus for low back pain (IPG545)

Evidence-based recommendations on percutaneous intradiscal radiofrequency treatment of the intervertebral disc nucleus for low back pain

Interventional procedures guidance Published January 2016

Percutaneous electrothermal treatment of the intervertebral disc annulus for low back pain and sciatica (IPG544)

Evidence-based recommendations on percutaneous electrothermal treatment of the intervertebral disc annulus for low back pain and sciatica

Interventional procedures guidance Published January 2016

Repetitive transcranial magnetic stimulation for depression (IPG542)

Evidence-based recommendations on repetitive transcranial magnetic stimulation for depression

Interventional procedures guidance Published December 2015

Transapical transcatheter mitral valve-in-valve implantation for a failed surgically implanted mitral valve bioprosthesis (IPG541)

Evidence-based recommendations on transapical transcatheter mitral valve-in-valve implantation for a failed surgically implanted mitral valve bioprosthesis

Interventional procedures guidance Published December 2015