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  1. The committee recommends more research on: the accuracy of PredictSURE IBD and IBDX tests in identifying people at high or low risk of following a severe course of Crohn's disease how PredictSURE IBD and IBDX tests, when used alongside clinical features, affect clinical decisions about whether step-up or top-down treatment is offered the clinical outcomes and costs resulting from a top-down treatment strategy compared with a step-up treatment strategy how PredictSURE IBD and IBDX tests affect clinical outcomes once someone has been assigned to top-down or step-up treatment, considering the different pathways that children and adults may follow.

    PredictSURE IBD and IBDX tests in identifying people at high or low risk of following a severe course of Crohn's disease how PredictSURE...

  2. Further research is recommended on clinical outcomes associated with using the ELISA kits (LISA-TRACKER, IDKmonitor and Promonitor) in people whose Crohn's disease is losing response to a TNF-alpha inhibitor. This could be through a prospective study, for local audit, or for submission to a registry. (The IBD Registry is being adapted to receive data on TNF-alpha inhibitor levels and antibodies against TNF-alpha inhibitors).

    prospective study, for local audit, or for submission to a registry. (The IBD Registry is being adapted to receive data on TNF-alpha...