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  1. Further research on the routine adoption of Actim Partus and PartoSure to help diagnose preterm labour in women with intact membranes when transvaginal ultrasound measurement of cervical length is needed on the accuracy of the tests and their effect on clinical outcomes. Centres using the tests to help diagnose preterm labour in women with intact membranes are encouraged to take part in studies to address the research considerations (see the guidance sections 5.12 to 5.16). Data are needed on:- the impact of gestational age on the accuracy of the tests- how the tests affect clinical decision-making- the effect of the tests on outcomes for mother and baby

    Recommendation ID DG33/1 Question Further research on the routine adoption of Actim Partus and PartoSure to help diagnose preterm labour

  2. Further research on the safety of unilateral MRI-guided focused ultrasound thalamotomy for treatment-resistant essential tremor, which could include randomised controlled trials, should address patient selection, report on functional improvement and quality of life, and provide long-term follow-up data.

    Recommendation ID IPG617/1 Question Further research on the safety of unilateral MRI-guided focused ultrasound thalamotomy for treatment-resistant

  3. How effective are programmes that aim to prevent domestic violence and abuse from ever happening in the first place? This includes media-based public health awareness campaigns. It also includes social movements to establish people's rights, and community-building and primary prevention activities that tackle underlying assumptions in society. (Examples of the latter might include the role and status of women.)

    Recommendation ID PH50/1 Question How effective are programmes that aim to prevent domestic violence and abuse from ever happening in the

  4. How effective are the following interventions in the short, medium and long term, across various levels of risk and including diverse and marginalised groups: - advocacy - domestic abuse recovery programmes - perpetrator programmes - psychological or social interventions modified for domestic violence and abuse, including programmes for those who have suffered multiple forms of abuse and those who are still experiencing it - interventions for primary carers apart from mothers (for example, fathers, grandparents) - interventions for other family members?

    Recommendation ID PH50/3 Question How effective are the following interventions in the short, medium and long term, across various levels

  5. How strong are the associations between hearing and visual loss, and sleep patterns and positive and negative health outcomes, in particular the development of dementia, disability and frailty? What are the most effective and cost-effective interventions to protect hearing and vision and improve sleep and what is their effect on the development of dementia, disability and frailty?

    Recommendation ID NG16/4 Question How strong are the associations between hearing and visual loss, and sleep patterns and positive and

  6. How strong are the cultural motivations (stemming from religion, tradition, media, and advertising) to use smokeless tobacco among people of South Asian origin? How do they compare with the physical addiction to nicotine? How might this information help in designing smokeless tobacco cessation programmes that are culturally appropriate?

    Recommendation ID PH39/6 Question How strong are the cultural motivations (stemming from religion, tradition, media, and advertising) to

  7. How effective are different behavioural strategies in helping people to cut down, either in order to stop smoking or to reduce the amount they smoke? This should include an evaluation of behavioural support used on its own and evaluations of specific components of such support (such as scheduling). It should also include evaluations of different types of behavioural support and follow-up, delivered within a clearly defined harm-reduction intervention.

    Recommendation ID PH45/4 Question How effective are different behavioural strategies in helping people to cut down, either in order to

  8. How effective are interventions to help people reduce the amount they smoke (without the intention of stopping)? How great are the health benefits of smoking reduction (by substituting some cigarettes with licensed nicotine-containing products) compared to stopping smoking? What proportion of people who reduce the amount they smoke go on to stop smoking? How soon after starting to reduce the amount they smoke do they stop completely?

    Recommendation ID PH45/3 Question How effective are interventions to help people reduce the amount they smoke (without the intention of

  9. How effective are lifestyle weight management programmes available in the UK, when directly compared using high-quality trials? In particular, what effect do specific components of a multicomponent lifestyle weight management programme have on adherence, effectiveness and cost effectiveness? This includes: - components, or combinations of components, that support weight loss or the prevention of weight regain - the effect of programme length, intensity, setting and means of delivery (examples of the latter include group, individual and remote support) - specific behaviour change techniques (using a recognised taxonomy) - the effect of new technologies - the effect of additional support services, such as self-help groups and networks approaches to commissioning - processes for collecting long-term follow-up data.

    Recommendation ID PH53/1 Question How effective are lifestyle weight management programmes available in the UK, when directly compared

  10. Noisy respiratory secretions:- In people considered to be in the last few hours and days of life, are antisecretory anti-muscarinic drugs (used alongside nursing interventions, such as repositioning and oropharyngeal suction) better at reducing noisy respiratory secretions and patient, family and carer distress without causing unwanted side effects, than nursing interventions alone?

    Recommendation ID NG31/3 Question Noisy respiratory secretions:- In people considered to be in the last few hours and days of life, are