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  1. Method of botulinum toxin type A injection in treating focal spasticity:- Is guided botulinum toxin type A injection using electrical localisation (electrostimulation orelectromyography) of muscles more clinically and cost effective than ultrasound-guided injections or clinical positioning for localisation of injections in treating focal spasticity in adults with cerebral palsy?

    Recommendation ID NG119/1 Question Method of botulinum toxin type A injection in treating focal spasticity:- Is guided botulinum toxin

  2. Hysteroscopy compared with ultrasound or empiric pharmacological treatment in the diagnosis and management of heavy menstrual bleeding (HMB): -Is initial testing using hysteroscopy more effective than testing with pelvic ultrasound or empiric pharmacological treatment in the diagnosis and management of HMB?

    Recommendation ID NG88/1 Question Hysteroscopy compared with ultrasound or empiric pharmacological treatment in the diagnosis and management

  3. Maternal request for Casarean Section (CS): What support or psychological interventions would be appropriate for women who have a fear of vaginal childbirth and request a CS? Interventions for evaluation could include: • support from a named member of the maternity team • continuity of carer • formal counselling • cognitive behavioural therapy. Outcomes could include: • mode of birth planned at term • psychological outcomes (postnatal depression, post-traumatic stress disorder, self-esteem, mother–infant bonding) • breastfeeding.

    Recommendation ID CG132/4 Question Maternal request for Casarean Section (CS): What support or psychological interventions would be appropriate

  4. Monitoring asthma control using tele-healthcare:- What is the long-term (more than 12 months) clinical and cost effectiveness of using telehealthcare as a means to monitor asthma control in adults, young people and children? Methods of tele-healthcare can include telephone interview (with healthcare professional involvement) andinternet or smartphone-based monitoring support (no healthcare professional involvement).

    Recommendation ID NG80/5 Question Monitoring asthma control using tele-healthcare:- What is the long-term (more than 12 months) clinical

  5. More trials of apixaban compared with other low molecular weight heparin (LMWHs) in total hip and knee replacement would decrease the uncertainty of the clinical and cost effectiveness of these treatments. Trials directly comparing apixaban with rivaroxaban, dabigatran etexilate and fondaparinux would strengthen the evidence base for these comparisons.

    Recommendation ID TA245/1 Question More trials of apixaban compared with other low molecular weight heparin (LMWHs) in total hip and knee

  6. Methods and approaches for gathering the experiences of people who use adult social care services:- When conducting research for the purposes of service improvement, what research methods are acceptable, appropriate and effective in meaningfully gathering the views and experiences of people who use services?

    Recommendation ID NG86/1 Question Methods and approaches for gathering the experiences of people who use adult social care services:- When

  7. Methotrexate and risk of hepatotoxicity:- What is the impact of methotrexate compared with other approaches to care (for example other systemic non-biological or biological treatments) on risk of significant liver disease in people with psoriasis and do risk factors such as obesity, alcohol use or diabetes alter this risk?

    Recommendation ID CG153/2 Question Methotrexate and risk of hepatotoxicity:- What is the impact of methotrexate compared with other approaches

  8. Maintaining benefits after successful treatment of anorexia nervosa:- What factors (including comorbidities, personal, social and demographic factors, treatment type,and subsequent relapse prevention interventions) are associated with continued benefit after successful treatment for anorexia nervosa?

    Recommendation ID NG69/5 Question Maintaining benefits after successful treatment of anorexia nervosa:- What factors (including comorbidities