Updating results

What is the clinical and cost effectiveness of intermittent auscultation compared with continuous cardiotocography for women in labour who have had a previous caesarean section?

Recommendation ID NG121/5 Question What is the clinical and cost effectiveness of intermittent auscultation compared with continuous cardiotocography

Research recommendation Published August 2019

Are progesterone or progestogens effective in treating threatened miscarriage?

Recommendation ID NG136/3 Question Are progesterone or progestogens effective in treating threatened miscarriage? Any explanatory notes(if

Research recommendation Published August 2019

Does caesarean section protect against cerebral haemorrhage in women with a history of subarachnoid haemorrhage or cerebrovascular malformation?

Recommendation ID NG121/1 Question Does caesarean section protect against cerebral haemorrhage in women with a history of subarachnoid haemorrhage

Research recommendation Published August 2019

What is the best technique for delivering surfactant in a minimally invasive manner?

Recommendation ID NG124/2 Question What is the best technique for delivering surfactant in a minimally invasive manner? Any explanatory

Research recommendation Published August 2019

What clinical features and laboratory investigations can be used to better stratify risk for women in labour with signs of sepsis (including fever and tachycardia)?

Recommendation ID NG121/4 Question What clinical features and laboratory investigations can be used to better stratify risk for women in

Research recommendation Published August 2019

Does targeting higher oxygen saturations of 92% to 97% in preterm babies lead to improved survival without significant complications?

Recommendation ID NG124/4 Question Does targeting higher oxygen saturations of 92% to 97% in preterm babies lead to improved survival without...

Research recommendation Published August 2019

What is the effectiveness of high-pressure non-invasive positive pressure ventilation (NIPPV) compared with continuous positive airways pressure (CPAP) flow driver as the primary mode of ventilation?

Recommendation ID NG124/1 Question What is the effectiveness of high-pressure non-invasive positive pressure ventilation (NIPPV) compared

Research recommendation Published August 2019

Is obesity an independent risk factor for perinatal morbidity and mortality?

Recommendation ID NG121/3 Question Is obesity an independent risk factor for perinatal morbidity and mortality? Any explanatory notes(if

Research recommendation Published August 2019

In women with confirmed miscarriage, does the type of management strategy (expectant, medical and surgical) impact on women's experience, including psychological and emotional outcomes?

Recommendation ID NG126/4 Question In women with confirmed miscarriage, does the type of management strategy (expectant, medical and surgical)

Research recommendation Published August 2019

What are the costs associated with best supportive care?

Recommendation ID TA575/1 Question What are the costs associated with best supportive care? Any explanatory notes(if applicable)

Research recommendation Published August 2019

Is the application of antiseptics and antibiotics in the operative field before wound closure, clinically and cost effective in reducing surgical site infection rates?

Recommendation ID NG125/4 Question Is the application of antiseptics and antibiotics in the operative field before wound closure, clinically

Research recommendation Published August 2019

What is the clinical and cost effectiveness of chlorhexidine in alcohol at different concentrations in the prevention of surgical site infection when applied to the skin before incision?

Recommendation ID NG125/3 Question What is the clinical and cost effectiveness of chlorhexidine in alcohol at different concentrations in

Research recommendation Published August 2019

Which patient groups, contamination groups and which layers gain the most benefit from the use of triclosan-coated or triclosan-impregnated sutures?

Recommendation ID NG125/5 Question Which patient groups, contamination groups and which layers gain the most benefit from the use of triclosan-coated

Research recommendation Published August 2019

In women with ectopic pregnancy, does the type of intervention impact on women's experience, including psychological and emotional outcomes?

Recommendation ID NG126/5 Question In women with ectopic pregnancy, does the type of intervention impact on women's experience, including

Research recommendation Published August 2019

What is the effectiveness of diuretics compared with placebo in preventing bronchopulmonary dysplasia (BPD) in preterm babies on respiratory support?

Recommendation ID NG124/3 Question What is the effectiveness of diuretics compared with placebo in preventing bronchopulmonary dysplasia

Research recommendation Published August 2019

What are the cost associated with best supportive care?

Recommendation ID TA574/1 Question What are the cost associated with best supportive care? Any explanatory notes(if applicable)

Research recommendation Published August 2019

Is the use of chlorhexidine body wash associated with increased antimicrobial resistance?

Recommendation ID NG125/2 Question Is the use of chlorhexidine body wash associated with increased antimicrobial resistance? Any explanatory

Research recommendation Published August 2019

What is the clinical effectiveness of preoperative nasal decolonisation using mupirocin in combination with a chlorhexidine body wash in the whole population?

Recommendation ID NG125/1 Question What is the clinical effectiveness of preoperative nasal decolonisation using mupirocin in combination

Research recommendation Published August 2019

Does the use of ultrasound of the lumbar spine improve siting of regional anaesthetic needles in pregnant women with a BMI over 30 kg/m2 at the booking appointment?

Recommendation ID NG121/2 Question Does the use of ultrasound of the lumbar spine improve siting of regional anaesthetic needles in pregnant

Research recommendation Published August 2019

How does the timing and frequency of ultrasound examination affect diagnosis and outcomes of early pregnancy complications, including women's experience and cost effectiveness?

Recommendation ID NG126/1 Question How does the timing and frequency of ultrasound examination affect diagnosis and outcomes of early pregnancy

Research recommendation Published August 2019

What is the most effective combination of an analgesic with a neuromuscular blocker, or an analgesic with an anaesthetic agent, for premedication in preterm babies requiring elective or semi-elective intubation?

Recommendation ID NG124/5 Question What is the most effective combination of an analgesic with a neuromuscular blocker, or an analgesic

Research recommendation Published August 2019

What is the long-term effectiveness of bladder wall injection with botulinum toxin type A for overactive bladder in women?

Recommendation ID NG123/6 Question What is the long-term effectiveness of bladder wall injection with botulinum toxin type A for overactive

Research recommendation Published June 2019

What are the long-term risks of mesh surgery compared with non-mesh surgery for stress urinary incontinence and pelvic organ prolapse in women?

Recommendation ID NG123/5 Question What are the long-term risks of mesh surgery compared with non-mesh surgery for stress urinary incontinence

Research recommendation Published June 2019

What is the effectiveness of ultrasound-guided visualisation compared with clinical assessment to identify complications after mesh surgery for stress urinary incontinence or pelvic organ prolapse in women?

Recommendation ID NG123/3 Question What is the effectiveness of ultrasound-guided visualisation compared with clinical assessment to identify

Research recommendation Published June 2019

What is the effectiveness and cost effectiveness of immunotherapy in people with stage IIIA-N2 non-small-cell lung cancer following multimodality treatment including surgery?

Recommendation ID NG122/1 Question What is the effectiveness and cost effectiveness of immunotherapy in people with stage IIIA-N2 non-small-cell

Research recommendation Published June 2019

What is the effectiveness of pain management for women who present with chronic pain 3 months after mesh surgery for stress urinary incontinence or pelvic organ prolapse?

Recommendation ID NG123/8 Question What is the effectiveness of pain management for women who present with chronic pain 3 months after mesh

Research recommendation Published June 2019

What is the effectiveness of colpocleisis compared with sacrospinous fixation for pelvic organ prolapse in elderly women?

Recommendation ID NG123/2 Question What is the effectiveness of colpocleisis compared with sacrospinous fixation for pelvic organ prolapse

Research recommendation Published June 2019

What is the effectiveness and safety of anticholinergic medicines for overactive bladder in older women?

Recommendation ID NG123/1 Question What is the effectiveness and safety of anticholinergic medicines for overactive bladder in older women

Research recommendation Published June 2019

What is the effectiveness and cost effectiveness of stereotactic ablative radiotherapy (SABR) compared with surgery (for example, sublobar, wedge resection, lobectomy) for people with non-small-cell lung cancer (stage I and IIA) in whom surgery is suitable?

Recommendation ID NG122/2 Question What is the effectiveness and cost effectiveness of stereotactic ablative radiotherapy (SABR) compared

Research recommendation Published June 2019

What is the effectiveness and cost effectiveness of prophylactic cranial irradiation compared with routine MRI follow-up in people with extensive-stage small-cell lung cancer without brain metastases?

Recommendation ID NG122/4 Question What is the effectiveness and cost effectiveness of prophylactic cranial irradiation compared with routine

Research recommendation Published June 2019

What are the long-term outcomes, including patient satisfaction, from the use of pessaries compared with surgery for pelvic organ prolapse in women?

Recommendation ID NG123/4 Question What are the long-term outcomes, including patient satisfaction, from the use of pessaries compared with

Research recommendation Published June 2019

What is the most effective surgical management for women with both stress urinary incontinence and pelvic organ prolapse, including the sequence of interventions?

Recommendation ID NG123/7 Question What is the most effective surgical management for women with both stress urinary incontinence and pelvic

Research recommendation Published June 2019

What is the effectiveness and cost effectiveness of routinely performing contrast-enhanced brain CT at the time of initial diagnosis and/or staging CT?

Recommendation ID NG122/3 Question What is the effectiveness and cost effectiveness of routinely performing contrast-enhanced brain CT at

Research recommendation Published June 2019

What is the benefit of bilateral cochlear implantation compared with unilateral cochlear implantation in adults with severe to profound deafness?

Recommendation ID TA566/1 Question What is the benefit of bilateral cochlear implantation compared with unilateral cochlear implantation

Research recommendation Published May 2019

In people in hospital who have delirium, which is the most effective medication (atypical antipsychotics, typical antipsychotics or benzodiazepines) compared with placebo or each other for treating delirium?

Recommendation ID CG103/2 Question In people in hospital who have delirium, which is the most effective medication (atypical antipsychotics

Research recommendation Published May 2019

How common is delirium and what are its adverse outcomes in people in long-term care?

Recommendation ID CG103/4 Question How common is delirium and what are its adverse outcomes in people in long-term care? Any explanatory

Research recommendation Published May 2019

For people in long-term care, is a multicomponent non-pharmacological intervention more clinically and cost effective than usual care in preventing the development of delirium?

Recommendation ID CG103/3 Question For people in long-term care, is a multicomponent non-pharmacological intervention more clinically and

Research recommendation Published May 2019

Does a staff education programme (compared with an educational leaflet or usual care) reduce the incidence of delirium and improve the recognition and recording of delirium in people in hospital?

Recommendation ID CG103/5 Question Does a staff education programme (compared with an educational leaflet or usual care) reduce the incidence

Research recommendation Published May 2019

Evidence on the progression of X-linked hypophosphataemia (XLH) over time and the long-term benefits of burosumab would also be valuable.

Recommendation ID HST8/3 Question Evidence on the progression of X-linked hypophosphataemia (XLH) over time and the long-term benefits of

Research recommendation Published March 2019

Further research should report details of patient selection, nodule size and position, and whether the nodule is cystic.

Recommendation ID IPG643/1 Question Further research should report details of patient selection, nodule size and position, and whether the

Research recommendation Published March 2019

Further research should include details of patient selection, durability and the incidence of complications. Outcomes should be published.

Recommendation ID IPG642/1 Question Further research should include details of patient selection, durability and the incidence of complications

Research recommendation Published March 2019

The health-related quality-of-life evidence of patients with perianal fistulas is also lacking, therefore further research is recommended. Any research should measure the effect of treatment using preference-based measures (such as use of the EQ-5D questionnaire).

Recommendation ID TA556/2 Question The health-related quality-of-life evidence of patients with perianal fistulas is also lacking, therefore

Research recommendation Published March 2019

Splinting to improve or maintain posture or function:- What is the optimum regimen for splints applied to the upper limb in adults with cerebral palsy to improve or maintain posture or function?

Recommendation ID NG119/5 Question Splinting to improve or maintain posture or function:- What is the optimum regimen for splints applied

Research recommendation Published March 2019

Selective dorsal rhizotomy treatment to reduce spasticity:- What is the clinical and cost effectiveness of selective dorsal rhizotomy compared with intrathecal baclofen to reduce spasticity in adults with cerebral palsy?

Recommendation ID NG119/2 Question Selective dorsal rhizotomy treatment to reduce spasticity:- What is the clinical and cost effectiveness

Research recommendation Published March 2019