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Further research on ex-situ machine perfusion for extracorporeal preservation of livers for transplantation should report the exact method of perfusion used (such ashypothermic or normothermic), graft survival and the use of marginal grafts.

Recommendation ID IPG636/1 Question Further research on ex-situ machine perfusion for extracorporeal preservation of livers for transplantation

Research recommendation Published February 2019

Further research on electrically stimulated intravesical chemotherapy for nonmuscle-invasive bladder cancer should include randomised controlled trials compared withstandard care, which should report details of patient selection.

Recommendation ID IPG638/1 Question Further research on electrically stimulated intravesical chemotherapy for nonmuscle-invasive bladder

Research recommendation Published February 2019

Detection and management of respiratory disorders in primary and community care:- Can detection and management of respiratory disorders in adults with cerebral palsy be improved in primary and community care?

Recommendation ID NG119/3 Question Detection and management of respiratory disorders in primary and community care:- Can detection and management

Research recommendation Published March 2019

Prophylactic antibiotics for respiratory disorders:- Are prophylactic antibiotics clinically and cost effective in the management of respiratory symptoms in adults with cerebral palsy with significant respiratory comorbidity?

Recommendation ID NG119/4 Question Prophylactic antibiotics for respiratory disorders:- Are prophylactic antibiotics clinically and cost

Research recommendation Published March 2019

Augmentative and alternative communication systems:- Are augmentative and alternative communication systems clinically and cost effective in promoting  communication for adults with cerebral palsy who have communication difficulties?

Recommendation ID NG119/6 Question Augmentative and alternative communication systems:- Are augmentative and alternative communication systems

Research recommendation Published March 2019

Standardised criteria for hospital discharge:- Are standardised criteria for hospital discharge clinically and cost effective in specific medical emergencies? [See the evidence review on standardised discharge criteria.]

Recommendation ID NG94/14 Question Standardised criteria for hospital discharge:- Are standardised criteria for hospital discharge clinically

Research recommendation Published November 2018

Personalisation and risk markers:- What prognostic and prescriptive factors are important in determining the choice of PTSD treatment?

Recommendation ID NG116/4 Question Personalisation and risk markers:- What prognostic and prescriptive factors are important in determining

Research recommendation Published February 2019

Specialised units for older people:- What is the most clinically and cost effective way to configure services to assess frail older people who present to hospital with a medical emergency?

Recommendation ID NG94/4 Question Specialised units for older people:- What is the most clinically and cost effective way to configure services

Research recommendation Published November 2018

Extended access to social care services:- What is the clinical and cost effectiveness of providing extended access to social care services, for example during early mornings and evenings, and 7 days a week?

Recommendation ID NG94/2 Question Extended access to social care services:- What is the clinical and cost effectiveness of providing extended

Research recommendation Published November 2018

Primary care-led assessment models:- Which primary care-led models of assessment of people with a suspected medical emergency in the community, such as GP home visits, are most clinically and cost effective? [See the evidence review on GP-led home visits.]

Recommendation ID NG94/8 Question Primary care-led assessment models:- Which primary care-led models of assessment of people with a suspected

Research recommendation Published November 2018

Hospital escalation policies:- Which components of a hospital escalation policy to deal with surges in demand are the most clinically and cost effective? [See the evidence review on escalation measures.]

Recommendation ID NG94/17 Question Hospital escalation policies:- Which components of a hospital escalation policy to deal with surges in

Research recommendation Published November 2018

'Physician extenders':- What is the clinical and cost effectiveness of providing 'physician extenders' such as advanced nurse practitioners, 'physician associates' and advanced clinical practitioners in secondary care?[See the evidence review on physician extenders.]

Recommendation ID NG94/15 Question 'Physician extenders':- What is the clinical and cost effectiveness of providing 'physician extenders'

Research recommendation Published November 2018

Same-day plain X-ray radiology or ultrasound:- What is the clinical and cost effectiveness of providing GPs with access to plain X-ray radiology or ultrasound with same-day results? [See the evidence review on GP access to radiology.]

Recommendation ID NG94/9 Question Same-day plain X-ray radiology or ultrasound:- What is the clinical and cost effectiveness of providing

Research recommendation Published November 2018

Extended access to community nursing:- What is the clinical and cost effectiveness of providing extended access to community nursing, for example during evenings and weekends? [See the evidence review on community nursing.]

Recommendation ID NG94/10 Question Extended access to community nursing:- What is the clinical and cost effectiveness of providing extended

Research recommendation Published November 2018

GPs located in or near emergency departments:- What is the clinical and cost effectiveness of having GPs within or adjoining emergency departments?

Recommendation ID NG94/3 Question GPs located in or near emergency departments:- What is the clinical and cost effectiveness of having GPs

Research recommendation Published November 2018

Integrated patient information systems:- What is the clinical and cost effectiveness of different methods for integrating patient information throughout the emergency medical care pathway?

Recommendation ID NG94/5 Question Integrated patient information systems:- What is the clinical and cost effectiveness of different methods

Research recommendation Published November 2018

Remote decision-support technologies:- Are paramedic remote decision-support technologies clinically and cost effective? [See the evidence review on paramedic remote support.]

Recommendation ID NG94/7 Question Remote decision-support technologies:- Are paramedic remote decision-support technologies clinically and

Research recommendation Published November 2018

Extended access to GP services:- Is extended access to GP services, for example during early mornings, evenings and weekends, more clinically and cost effective than standard access?

Recommendation ID NG94/1 Question Extended access to GP services:- Is extended access to GP services, for example during early mornings

Research recommendation Published November 2018

Prophylactic antibiotics for preventing exacerbations: - What is the long-term clinical and cost effectiveness of prophylactic antibiotics for people with stable COPD who are at high risk of exacerbations?

Recommendation ID NG115/7 Question Prophylactic antibiotics for preventing exacerbations: - What is the long-term clinical and cost effectiveness

Research recommendation Published February 2019

Prophylactic antibiotics for preventing exacerbations:- What is the comparative effectiveness of seasonal versus continuous prophylactic antibiotics for people with stable COPD who are at high risk of exacerbations?

Recommendation ID NG115/9 Question Prophylactic antibiotics for preventing exacerbations:- What is the comparative effectiveness of seasonal

Research recommendation Published February 2019

Prophylactic antibiotics for preventing exacerbations:- What is the comparative effectiveness of different antibiotics, doses and regimens of prophylactic antibiotics for people with stable COPD who are at high risk of exacerbations?

Recommendation ID NG115/8 Question Prophylactic antibiotics for preventing exacerbations:- What is the comparative effectiveness of different

Research recommendation Published February 2019

Trauma-informed approaches:- What is the clinical and cost effectiveness of trauma-informed care or trauma-informed approaches?

Recommendation ID NG116/3 Question Trauma-informed approaches:- What is the clinical and cost effectiveness of trauma-informed care or

Research recommendation Published February 2019

Stepped care for post-traumatic stress disorder:- What is the clinical and cost effectiveness of stepped care for post-traumatic stress disorder (PTSD)?

Recommendation ID NG116/1 Question Stepped care for post-traumatic stress disorder:- What is the clinical and cost effectiveness of stepped

Research recommendation Published February 2019

Sequencing and further line treatment:- What is the clinical and cost effectiveness of sequencing and further line treatment in PTSD?

Recommendation ID NG116/2 Question Sequencing and further line treatment:- What is the clinical and cost effectiveness of sequencing and

Research recommendation Published February 2019

Complex PTSD:- What is the clinical and cost effectiveness of interventions to deliver stabilisation and reintegration for people with complex PTSD?

Recommendation ID NG116/5 Question Complex PTSD:- What is the clinical and cost effectiveness of interventions to deliver stabilisation

Research recommendation Published February 2019

Emotional freedom techniques:- What is the clinical and cost effectiveness of emotional freedom techniques (EFT) for the treatment of PTSD in adults?

Recommendation ID NG116/6 Question Emotional freedom techniques:- What is the clinical and cost effectiveness of emotional freedom techniques

Research recommendation Published February 2019

Pulmonary hypertension:- What are the most clinical and cost-effective treatments for pulmonary hypertension in people with COPD?

Recommendation ID NG115/10 Question Pulmonary hypertension:- What are the most clinical and cost-effective treatments for pulmonary hypertension

Research recommendation Published February 2019

Diagnosing COPD: -  What are the characteristics of people diagnosed with COPD as a result of an incidental finding ofemphysema on a CT scan, compared with those diagnosed with symptoms?

Recommendation ID NG115/6 Question Diagnosing COPD: - What are the characteristics of people diagnosed with COPD as a result of an incidental

Research recommendation Published February 2019

Prophylactic antibiotics for preventing exacerbations:- Which subgroups of people with stable COPD who are at high risk of exacerbations are most likely to benefit from prophylactic antibiotics?

Recommendation ID NG115/5 Question Prophylactic antibiotics for preventing exacerbations:- Which subgroups of people with stable COPD who

Research recommendation Published February 2019

Mucolytic therapy:- In people with COPD, does mucolytic drug therapy prevent exacerbations in comparison with placebo and other therapies?

Recommendation ID NG115/11 Question Mucolytic therapy:- In people with COPD, does mucolytic drug therapy prevent exacerbations in comparison

Research recommendation Published February 2019

Inhaled therapies for people with COPD and asthma- What is the clinical and cost effectiveness of inhaled therapies (bronchodilators and/or inhaled corticosteroids) in people with both stable COPD and asthma?

Recommendation ID NG115/3 Question Inhaled therapies for people with COPD and asthma- What is the clinical and cost effectiveness of inhaled

Research recommendation Published February 2019

Inhaled corticosteroid responsiveness:- What features predict inhaled corticosteroid responsiveness most accurately in people with COPD?

Recommendation ID NG115/4 Question Inhaled corticosteroid responsiveness:- What features predict inhaled corticosteroid responsiveness most

Research recommendation Published February 2019

Further research on transcutaneous neuromuscular electrical stimulation for oropharyngeal dysphagia in adults should address patient selection, variations in technique, the need for retreatments and long-term outcomes.

Recommendation ID IPG634/1 Question Further research on transcutaneous neuromuscular electrical stimulation for oropharyngeal dysphagia

Research recommendation Published January 2019

Further research on percutaneous insertion of a temporary heart pump for left ventricular haemodynamic support in high-risk percutaneous coronary interventions should report details of patient selection and subsequent management.

Recommendation ID IPG633/1 Question Further research on percutaneous insertion of a temporary heart pump for left ventricular haemodynamic

Research recommendation Published December 2018

Anticholinergic burden:- Does actively reducing anticholinergic burden in people living with dementia improve cognitive outcomes compared with usual care?

Recommendation ID NG97/3 Question Anticholinergic burden:- Does actively reducing anticholinergic burden in people living with dementia

Research recommendation Published December 2018

Clinicians should enter details about all patients having selective internal radiation therapy (SIRT) for unresectable primary intrahepatic cholangiocarcinoma onto a suitable registry.

Recommendation ID IPG630/2 Question Clinicians should enter details about all patients having selective internal radiation therapy (SIRT)

Research recommendation Published December 2018

Community-based models of flu vaccination:- What models of community-based flu vaccination provision (for example, community pharmacies, community nursing and midwifery teams and outreach services) are effective and cost-effective for increasing uptake in eligible groups?

Recommendation ID NG103/5 Question Community-based models of flu vaccination:- What models of community-based flu vaccination provision

Research recommendation Published December 2018

Underserved groups:- What are the most effective and cost-effective ways of reaching underserved groups and removing barriers to access in order to increase their uptake of flu vaccination?

Recommendation ID NG103/2 Question Underserved groups:- What are the most effective and cost-effective ways of reaching underserved groups

Research recommendation Published December 2018

Further research is needed on the benefits and consequences of detecting preclinical diabetic peripheral neuropathy.

Recommendation ID MTG38/1 Question Further research is needed on the benefits and consequences of detecting preclinical diabetic peripheral

Research recommendation Published January 2019

The impact of atrial fibrillation on the natriuretic peptide threshold for diagnosing heart failure:- What is the optimal NT-proBNP threshold for the diagnosis of heart failure in people with atrial fibrillation?

Recommendation ID NG106/3 Question The impact of atrial fibrillation on the natriuretic peptide threshold for diagnosing heart failure:- What

Research recommendation Published December 2018