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Debridement:- What is the effect of enzymatic debridement of non-viable tissue compared with sharp debridement on the rate of healing of pressure ulcers in adults?

Recommendation ID CG179/1 Question Debridement:- What is the effect of enzymatic debridement of non-viable tissue compared with sharp debridement

Research recommendation Published June 2015

Does continuing beta-blocker treatment beyond 1 year after an MI improve outcomes for people with normal left ventricular systolic function?

Recommendation ID CG172/2 Question Does continuing beta-blocker treatment beyond 1 year after an MI improve outcomes for people with normal

Research recommendation Published June 2015

Derivation of clinical decision rules in suspected sepsis:- Is it possible to derive and validate a set of clinical decision rules or a predictive tool to rule outsepsis which can be applied to patients presenting to hospital; with suspected sepsis?

Recommendation ID NG51/5 Question Derivation of clinical decision rules in suspected sepsis:- Is it possible to derive and validate a set

Research recommendation Published August 2016

Augmentative and alternative communication:- What is the current pattern of provision and use of augmentative and alternative communication (AAC) by people with motor neurone disease (MND) in England?

Recommendation ID NG42/6 Question Augmentative and alternative communication:- What is the current pattern of provision and use of augmentative

Research recommendation Published March 2016

Current evidence on the efficacy and safety of biodegradable subacromial spacer insertion for rotator cuff tears is limited in quantity and quality. Therefore, this procedure should only be used in the context of research.

Recommendation ID IPG558/1 Question Current evidence on the efficacy and safety of biodegradable subacromial spacer insertion for rotator

Research recommendation Published June 2016

Dietary supplements:- Should people with coeliac disease be offered calcium and vitamin D supplements for a specific time period soon after their initial diagnosis?

Recommendation ID NG20/3 Question Dietary supplements:- Should people with coeliac disease be offered calcium and vitamin D supplements

Research recommendation Published October 2015

Chemical sympathectomy for managing critical limb ischaemic pain:- What is the clinical and cost effectiveness of chemical sympathectomy in comparison with other methods of pain control for managing critical limb ischaemic pain?

Recommendation ID CG147/5 Question Chemical sympathectomy for managing critical limb ischaemic pain:- What is the clinical and cost effectiveness

Research recommendation Published June 2015

A trial comparing the long-term effectiveness (beyond 24 weeks) of cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate and placebo would be beneficial. It should collect utility data as well as walking distance outcomes.

Recommendation ID TA223/1 Question A trial comparing the long-term effectiveness (beyond 24 weeks) of cilostazol, naftidrofuryl oxalate

Research recommendation Published June 2015

Automated blood pressure monitoring in people with atrial fibrillation: - Which automated blood pressure monitors are suitable for people with hypertension and atrial fibrillation?

Recommendation ID CG127/6 Question Automated blood pressure monitoring in people with atrial fibrillation: - Which automated blood pressure

Research recommendation Published June 2015

Cardiac rehabilitation:- Is an 8-week, comprehensive, multidisciplinary, cardiac rehabilitation service more clinically and cost effective for managing stable angina than current clinical practice?

Recommendation ID CG126/4 Question Cardiac rehabilitation:- Is an 8-week, comprehensive, multidisciplinary, cardiac rehabilitation service

Research recommendation Published June 2015

Bone mineral density (BMD) with FRAX:- What is the added prognostic value of BMD in the assessment of fracture risk with FRAX?

Recommendation ID CG146/4 Question Bone mineral density (BMD) with FRAX:- What is the added prognostic value of BMD in the assessment of

Research recommendation Published June 2015

Bladder management strategies:- What are the long-term risks and effects on quality of life of different bladder management strategies for lower urinary tract dysfunction in people with neurological disease?

Recommendation ID CG148/4 Question Bladder management strategies:- What are the long-term risks and effects on quality of life of different

Research recommendation Published June 2015

Case volume as an indicator of quality for people offered left atrial catheter ablation:- What is the effect of case volume on complications and outcomes after left atrial catheter ablation?

Recommendation ID CG180/3 Question Case volume as an indicator of quality for people offered left atrial catheter ablation:- What is the

Research recommendation Published June 2015

Botulinum toxin A:- What is the long-term effectiveness, optimal dose and optimal frequency of repeat therapy of botulinum toxin A in women with OAB based on detrusor overactivity including risk of adverse events such as urinary infection and intermittent catheterisation?

Recommendation ID CG171/3 Question Botulinum toxin A:- What is the long-term effectiveness, optimal dose and optimal frequency of repeat

Research recommendation Published June 2015

Can vitamin D slow down the progression of disability in Multiple Sclerosis (MS)?

Recommendation ID CG186/5 Question Can vitamin D slow down the progression of disability in Multiple Sclerosis (MS)? Any explanatory

Research recommendation Published June 2015

Chemosaturation via percutaneous hepatic artery perfusion and hepatic vein isolation for primary or metastatic liver cancer ('hepatic chemosaturation') should only be performed within the context of research, which may take the form of observational studies.

Recommendation ID IPG488/1 Question Chemosaturation via percutaneous hepatic artery perfusion and hepatic vein isolation for primary or

Research recommendation Published June 2015

Activities and occupations on inpatient wards:- For people receiving adult mental health hospital care, what activities and occupations do service users want when staying on inpatient wards?

Recommendation ID CG136/4 Question Activities and occupations on inpatient wards:- For people receiving adult mental health hospital care

Research recommendation Published June 2015

Further research on endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused by cancer should address: patient selection, relief of biliary obstruction, quality of life and survival.

Recommendation ID IPG614/1 Question Further research on endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused

Research recommendation Published December 2018

Core outcome set for studies of management of Lyme disease:- Can a core outcome set be developed for clinical trials of management of Lyme disease?

Recommendation ID NG95/1 Question Core outcome set for studies of management of Lyme disease:- Can a core outcome set be developed for clinical

Research recommendation Published November 2018

NICE encourages further research into microinvasive subconjunctival insertion of a trans-scleral gelatin stent for primary open-angle glaucoma, including randomised studies. Further research should include details of patient selection and long-term outcomes.

Recommendation ID IPG612/1 Question NICE encourages further research into microinvasive subconjunctival insertion of a trans-scleral gelatin

Research recommendation Published November 2018

Further research is needed to understand the effect of having the additional information provided by the adjunctive colposcopy technologies on anxiety for people having a colposcopy, when this information is shown to a person during the examination.

Recommendation ID DG32/3 Question Further research is needed to understand the effect of having the additional information provided by the

Research recommendation Published November 2018

Dedicated transfer service:- Is it clinically and cost effective to provide a dedicated service to transfer patients with major trauma from the emergency department for ongoing care?

Recommendation ID NG40/3 Question Dedicated transfer service:- Is it clinically and cost effective to provide a dedicated service to transfer

Research recommendation Published April 2016

Definition of acute kidney injury – system for staging and detection:- Can a simplified definition and staging system, based on Système International (SI) units, be used to predict short- to medium-term outcomes in acute kidney injury?

Recommendation ID CG169/3 Question Definition of acute kidney injury – system for staging and detection:- Can a simplified definition and

Research recommendation Published June 2015

What is the benefit of bilateral cochlear implantation compared with unilateral cochlear implantation in adults with severe to profound deafness?

Recommendation ID TA566/1 Question What is the benefit of bilateral cochlear implantation compared with unilateral cochlear implantation

Research recommendation Published May 2019

Frequency of monitoring:- What is the long-term cost effectiveness, in terms of patient-relevant outcomes including bestcorrected visual acuity and quality of life, of different review frequencies/strategies for people at risk of progression to late AMD (wet active)?

Recommendation ID NG82/4 Question Frequency of monitoring:- What is the long-term cost effectiveness, in terms of patient-relevant outcomes

Research recommendation Published November 2018

Does a staff education programme (compared with an educational leaflet or usual care) reduce the incidence of delirium and improve the recognition and recording of delirium in people in hospital?

Recommendation ID CG103/5 Question Does a staff education programme (compared with an educational leaflet or usual care) reduce the incidence

Research recommendation Published May 2019

For people in long-term care, is a multicomponent non-pharmacological intervention more clinically and cost effective than usual care in preventing the development of delirium?

Recommendation ID CG103/3 Question For people in long-term care, is a multicomponent non-pharmacological intervention more clinically and

Research recommendation Published May 2019

In people in hospital who have delirium, which is the most effective medication (atypical antipsychotics, typical antipsychotics or benzodiazepines) compared with placebo or each other for treating delirium?

Recommendation ID CG103/2 Question In people in hospital who have delirium, which is the most effective medication (atypical antipsychotics

Research recommendation Published May 2019

How common is delirium and what are its adverse outcomes in people in long-term care?

Recommendation ID CG103/4 Question How common is delirium and what are its adverse outcomes in people in long-term care? Any explanatory

Research recommendation Published May 2019

Pain management: chronic pancreatitis:- Is the long-term use of opioids more clinically effective and cost effective than non-opioid analgesia (including non-pharmacological analgesia) in people with chronic pain due to chronic pancreatitis?

Recommendation ID NG104/3 Question Pain management: chronic pancreatitis:- Is the long-term use of opioids more clinically effective and

Research recommendation Published December 2018

Training:- How effective and cost effective is gatekeeper training in preventing suicides?

Recommendation ID NG105/4 Question Training:- How effective and cost effective is gatekeeper training in preventing suicides? Any explanatory

Research recommendation Published December 2018

Frequency of review:- What is the most clinical and cost-effective frequency of review for people on peritoneal dialysis, haemodiafiltration, haemodialysis or conservative management?

Recommendation ID NG107/4 Question Frequency of review:- What is the most clinical and cost-effective frequency of review for people on

Research recommendation Published December 2018

Timing of pre-emptive transplant:- What is the most clinical and cost-effective strategy for timing of pre-emptive transplantation?

Recommendation ID NG107/2 Question Timing of pre-emptive transplant:- What is the most clinical and cost-effective strategy for timing of

Research recommendation Published December 2018

Management of type 3c diabetes:- What is the most clinically effective and cost-effective insulin regimen to minimise hypo- and hyperglycaemia for type 3c diabetes secondary to pancreatitis?

Recommendation ID NG104/5 Question Management of type 3c diabetes:- What is the most clinically effective and cost-effective insulin regimen

Research recommendation Published December 2018

Pain management: small duct disease:- What is the most clinically effective and cost-effective intervention for managing small duct disease (in the absence of pancreatic duct obstruction, inflammatory mass or pseudocyst) in people with chronic pancreatitis presenting with pain?

Recommendation ID NG104/4 Question Pain management: small duct disease:- What is the most clinically effective and cost-effective intervention

Research recommendation Published December 2018

Speed of intravenous fluid resuscitation for people with acute pancreatitis:- What is the most clinically effective and cost-effective speed of administration of intravenous fluid for resuscitation in people with acute pancreatitis?

Recommendation ID NG104/2 Question Speed of intravenous fluid resuscitation for people with acute pancreatitis:- What is the most clinically

Research recommendation Published December 2018

Cardiac MRI versus other imaging techniques for diagnosing heart failure:- What is the optimal imaging technique for the diagnosis of heart failure?

Recommendation ID NG106/2 Question Cardiac MRI versus other imaging techniques for diagnosing heart failure:- What is the optimal imaging

Research recommendation Published December 2018

The impact of atrial fibrillation on the natriuretic peptide threshold for diagnosing heart failure:- What is the optimal NT-proBNP threshold for the diagnosis of heart failure in people with atrial fibrillation?

Recommendation ID NG106/3 Question The impact of atrial fibrillation on the natriuretic peptide threshold for diagnosing heart failure:- What

Research recommendation Published December 2018