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What is the optimum blood pressure target for people aged over 80 with treated primary hypertension?

Recommendation ID NG136/3 Question What is the optimum blood pressure target for people aged over 80 with treated primary hypertension?

Research recommendation Published November 2019

What are the most effective and acceptable methods of cervical priming before dilatation and evacuation after 16+0 weeks' gestation?

Recommendation ID NG140/2 Question What are the most effective and acceptable methods of cervical priming before dilatation and evacuation

Research recommendation Published November 2019

Apart from culture, what other diagnostic tests or combinations of tests are effective inestablishing an accurate diagnosis of active respiratory TB in children and young people withsuspected active TB?

Recommendation ID NG33/2 Question Apart from culture, what other diagnostic tests or combinations of tests are effective inestablishing

Research recommendation Published November 2019

The evidence on cardiac contractility modulation device implantation for heart failure raises no major safety concerns. However, the evidence on efficacy is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research.

Recommendation ID IPG655 Question The evidence on cardiac contractility modulation device implantation for heart failure raises no major

Research recommendation Published November 2019

Current evidence on the safety and efficacy of low-energy contact X‑ray brachytherapy (the Papillon technique) for locally advanced rectal cancer is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research.

Recommendation ID IPG659/1 Question Current evidence on the safety and efficacy of low-energy contact X‑ray brachytherapy (the Papillon

Research recommendation Published November 2019

Current evidence on the safety and efficacy of implant insertion for prominent ears is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research.

Recommendation ID IPG660/1 Question Current evidence on the safety and efficacy of implant insertion for prominent ears is inadequate in

Research recommendation Published November 2019

Evidence on the safety and efficacy of high-intensity focused ultrasound for glaucoma is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research.

Recommendation ID IPG661/1 Question Evidence on the safety and efficacy of high-intensity focused ultrasound for glaucoma is inadequate

Research recommendation Published November 2019

Current evidence on the safety and efficacy of bronchoscopic thermal vapour ablation for upper-lobe emphysema is inadequate in quantity and quality. Therefore the procedure should only be used in the context of research.

Recommendation ID IPG652/1 Question Current evidence on the safety and efficacy of bronchoscopic thermal vapour ablation for upper-lobe

Research recommendation Published November 2019

Early interventions to prevent problems escalating:- What interventions are effective in diverting children and young people away from further harmful sexual behaviour before a legal response is needed?

Recommendation ID NG55/4 Question Early interventions to prevent problems escalating:- What interventions are effective in diverting children

Research recommendation Published October 2016

Duration of antibiotic treatment:- What is the optimal duration of treatment (course length) in babies who receive antibiotics for confirmed early-onset neonatal infection?

Recommendation ID CG149/5 Question Duration of antibiotic treatment:- What is the optimal duration of treatment (course length) in babies

Research recommendation Published June 2015

For which service users who are moderately and severely dependent on alcohol is an assertive community treatment model a clinically and cost-effective intervention compared with standard care?

Recommendation ID CG115/4 Question For which service users who are moderately and severely dependent on alcohol is an assertive community

Research recommendation Published June 2015

Does the provision of educational and supportive interventions to people with chronic kidney disease (CKD) by healthcare professionals increase patients' skills and confidence in managing their conditions and improve clinical outcomes?

Recommendation ID CG182/1 Question Does the provision of educational and supportive interventions to people with chronic kidney disease

Research recommendation Published June 2015

Recognition and early management of pain in children and young people with cerebral palsy:- Does use of pain assessment tools by parents or carers improve the recognition and early management of pain in children and young people with cerebral palsy in a community setting?

Recommendation ID NG62/3 Question Recognition and early management of pain in children and young people with cerebral palsy:- Does use of

Research recommendation Published February 2017

Effectiveness and costs of oral health interventions for care home residents:- How effective and cost effective are oral health interventions in care homes including suitableperson-centred outcome measures?

Recommendation ID NG48/2 Question Effectiveness and costs of oral health interventions for care home residents:- How effective and cost

Research recommendation Published August 2016

Effectiveness of 'rescue' cerclage:- What is the clinical effectiveness of 'rescue' cerclage in improving outcomes for women at risk of preterm birth?

Recommendation ID NG25/3 Question Effectiveness of 'rescue' cerclage:- What is the clinical effectiveness of 'rescue' cerclage in improving

Research recommendation Published December 2015

Effectiveness and cost effectiveness:- Are particular components of community engagement approaches more effective and cost effective at improving health and wellbeing and reducing health inequalities than other components?

Recommendation ID NG44/1 Question Effectiveness and cost effectiveness:- Are particular components of community engagement approaches more

Research recommendation Published April 2016

Education and psycho-behavioural interventions for prevention:- What is the role of educational models and psycho-behavioural interventions in prevention of diabetic foot complications?

Recommendation ID NG19/3 Question Education and psycho-behavioural interventions for prevention:- What is the role of educational models

Research recommendation Published October 2015

Electronic Decision Support:- What is the clinical and cost effectiveness of an electronic decision support system compared with current practice in reducing inappropriate blood transfusions, overall rates of blood transfusion and mortality?

Recommendation ID NG24/2 Question Electronic Decision Support:- What is the clinical and cost effectiveness of an electronic decision support

Research recommendation Published December 2015

Early supported discharge in care home patients:- What is the clinical and cost effectiveness of early supported discharge on mortality, quality of life and functional status in patients with hip fracture who are admitted from a care home?

Recommendation ID CG124/5 Question Early supported discharge in care home patients:- What is the clinical and cost effectiveness of early

Research recommendation Published June 2015

Effects of HRT on dementia risk:- What are the effects of early HRT use on the risk of dementia?

Recommendation ID NG23/4 Question Effects of HRT on dementia risk:- What are the effects of early HRT use on the risk of dementia?

Research recommendation Published December 2015

Effects of HRT on venous thromboembolism risk:- How does the preparation of HRT affect the risk of venous thromboembolism (VTE)?

Recommendation ID NG23/3 Question Effects of HRT on venous thromboembolism risk:- How does the preparation of HRT affect the risk of venous

Research recommendation Published December 2015

Electronic media:- How does the use of electronic media affect harmful sexual behaviour?

Recommendation ID NG55/6 Question Electronic media:- How does the use of electronic media affect harmful sexual behaviour? Any explanatory

Research recommendation Published October 2016

Effective interventions for the families and carers of children and young people displaying harmful sexual behaviour:- What type of therapeutic interventions are effective when working with the family and carers of children and young people who display harmful sexual behaviour?

Recommendation ID NG55/3 Question Effective interventions for the families and carers of children and young people displaying harmful sexual

Research recommendation Published October 2016

In infants, children and young people with overt or occult reflux, is fundoplication effective in reducing acid reflux as determined by oesophageal pH monitoring?

Recommendation ID NG1/3 Question In infants, children and young people with overt or occult reflux, is fundoplication effective in reducing

Research recommendation Published June 2015

In patients with muscle-invasive bladder cancer suitable for radical treatment, does the use of biomarkers enable patients to select more effective treatment, and improve their outcomes, compared with treatment selected without biomarkers?

Recommendation ID NG2/4 Question In patients with muscle-invasive bladder cancer suitable for radical treatment, does the use of biomarkers

Research recommendation Published June 2015

Long-term safety of ovarian stimulation and ovulation induction for women:- Is there an association between ovulation induction or ovarian stimulation and adverse long-term (over 20 years) effects in women in the UK?

Recommendation ID CG156/4 Question Long-term safety of ovarian stimulation and ovulation induction for women:- Is there an association between

Research recommendation Published June 2015

Long-term versus 3-month oral anticoagulation treatment in subgroups of patients at increased risk of VTE recurrence:- What is the clinical and cost effectiveness of long-term oral anticoagulation treatment in specific subgroups of patients with a first unprovoked VTE?

Recommendation ID CG144/2 Question Long-term versus 3-month oral anticoagulation treatment in subgroups of patients at increased risk of

Research recommendation Published June 2015

Inhibitors of functional ability:- What are the greatest inhibitors of functional ability in children and young people with upper motor neurone lesions?

Recommendation ID CG145/1 Question Inhibitors of functional ability:- What are the greatest inhibitors of functional ability in children

Research recommendation Published June 2015

In people with CKD who are at high risk of progression, what is the clinical and cost effectiveness of uric acid-lowering agents on the progression of CKD and on mortality?

Recommendation ID CG182/4 Question In people with CKD who are at high risk of progression, what is the clinical and cost effectiveness of

Research recommendation Published June 2015

In people with acute heart failure and hypoperfusion syndrome, is the use of intra-aortic balloon counter-pulsation pump (IABP) better than the use of intravenous inotropes?

Recommendation ID CG187/3 Question In people with acute heart failure and hypoperfusion syndrome, is the use of intra-aortic balloon counter-pulsation

Research recommendation Published June 2015

Intensity of home care packages:- What is the effectiveness and cost effectiveness of different intensities of home care packages for older people with a range of care and support needs?

Recommendation ID NG21/1 Question Intensity of home care packages:- What is the effectiveness and cost effectiveness of different intensities

Research recommendation Published October 2015

In people with decompensated heart failure, fluid congestion and diuretic resistance, does ultrafiltration lead to more rapid and effective decongestion compared with continuing diuretictreatment?

Recommendation ID CG187/4 Question In people with decompensated heart failure, fluid congestion and diuretic resistance, does ultrafiltration

Research recommendation Published June 2015

Is chamomile/ginkgo biloba more effective than placebo in increasing response and remission rates and decreasing anxiety ratings for people with generalised anxiety disorder (GAD)?

Recommendation ID CG113/4 Question Is chamomile/ginkgo biloba more effective than placebo in increasing response and remission rates and

Research recommendation Published June 2015

Intrapartum antibiotic prophylaxis in preterm labour:- What is the clinical and cost effectiveness of intrapartum antibiotic prophylaxis using benzylpenicillin in women with preterm labour?

Recommendation ID CG149/3 Question Intrapartum antibiotic prophylaxis in preterm labour:- What is the clinical and cost effectiveness of

Research recommendation Published June 2015

In well-defined generalised anxiety disorder (GAD), what is the clinical and cost effectiveness of two cognitive behavioural therapy (CBT) based low-intensity interventions (CCBT and guided bibliotherapy) compared with a waiting-list control?

Recommendation ID CG113/2 Question In well-defined generalised anxiety disorder (GAD), what is the clinical and cost effectiveness of two

Research recommendation Published June 2015