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Advocacy and support for decision-making:- What is the effectiveness, cost effectiveness and acceptability of advocacy as a means of supporting people to make decisions?

Recommendation ID NG108/3 Question Advocacy and support for decision-making:- What is the effectiveness, cost effectiveness and acceptability

Research recommendation Published December 2018

Suicide prevention in custodial and detention settings:- What interventions are effective and cost effective in reducing suicide rates in custodial and residential settings?

Recommendation ID NG105/3 Question Suicide prevention in custodial and detention settings:- What interventions are effective and cost effective

Research recommendation Published December 2018

Using mental capacity assessment tools to assess capacity:- What is the accuracy and/or effectiveness, cost effectiveness and acceptability of mental capacity assessment tools that are compliant with the Mental Capacity Act 2005?

Recommendation ID NG108/4 Question Using mental capacity assessment tools to assess capacity:- What is the accuracy and/or effectiveness

Research recommendation Published December 2018

The impact of advanced kidney disease on the natriuretic peptide threshold for diagnosing heart failure:- What are the optimal NT-proBNP thresholds for diagnosing heart failure in people with stage IIIb, IV or V chronic kidney disease?

Recommendation ID NG106/4 Question The impact of advanced kidney disease on the natriuretic peptide threshold for diagnosing heart failure:- What

Research recommendation Published December 2018

Cardiac assessment:- What is the clinical and cost effectiveness of cardiac assessment before transplantation?

Recommendation ID NG107/1 Question Cardiac assessment:- What is the clinical and cost effectiveness of cardiac assessment before transplantation

Research recommendation Published December 2018

Coordinating care:- What is the clinical and cost effectiveness of having keyworkers present in the context of renal replacement therapy (RRT)?

Recommendation ID NG107/5 Question Coordinating care:- What is the clinical and cost effectiveness of having keyworkers present in the context

Research recommendation Published December 2018

Acute haemodialysis versus acute peritoneal dialysis:- What is the clinical and cost effectiveness of initial haemodialysis versus initial peritoneal dialysis for people who start dialysis in an unplanned way?

Recommendation ID NG107/3 Question Acute haemodialysis versus acute peritoneal dialysis:- What is the clinical and cost effectiveness of

Research recommendation Published December 2018

Further research for percutaneous endoscopic catheter laser balloon pulmonary vein isolation for atrial fibrillation (AF) should define patient-selection criteria and should clearly describe adverse events and long-term control of AF.

Recommendation ID IPG399/1 Question Further research for percutaneous endoscopic catheter laser balloon pulmonary vein isolation for atrial

Research recommendation Published June 2015

Treatment of erythropoietic stimulating agents (ESAs) resistance:- In people with chronic ESA-resistant anaemia of CKD, what is the clinical and cost effectiveness oftreating with high-dose ESA compared with blood transfusion?

Recommendation ID NG8/2 Question Treatment of erythropoietic stimulating agents (ESAs) resistance:- In people with chronic ESA-resistant

Research recommendation Published October 2015

Transjugular intrahepatic portosystemic shunt:- What is the quality of life in people who have had a transjugular intrahepatic portosystemic shunt (TIPS)?

Recommendation ID NG50/4 Question Transjugular intrahepatic portosystemic shunt:- What is the quality of life in people who have had a transjugular

Research recommendation Published August 2016

Violence related to drug or alcohol misuse:- What is the best environment in which to contain violence in people who have misused drugs or alcohol?

Recommendation ID NG10/2 Question Violence related to drug or alcohol misuse:- What is the best environment in which to contain violence

Research recommendation Published October 2015

Treatment of erythropoietic stimulating agents (ESAs) resistance in haemodialysis patients:- What is the most effective type of intervention to treat haemodialysis patients with ESA-resistant anaemia?

Recommendation ID NG8/3 Question Treatment of erythropoietic stimulating agents (ESAs) resistance in haemodialysis patients:- What is the

Research recommendation Published October 2015

Transition support for young adults:- What approaches to providing transition support for those who move from child to adult services are effective and/or cost-effective?

Recommendation ID NG43/1 Question Transition support for young adults:- What approaches to providing transition support for those who move

Research recommendation Published March 2016

Unknown primary of presumed upper aerodigestive tract origin:- In people with CUADT of unknown primary, can radiotherapy target volumes be selected based on clinical and pathological factors?

Recommendation ID NG36/3 Question Unknown primary of presumed upper aerodigestive tract origin:- In people with CUADT of unknown primary

Research recommendation Published April 2016

Treatments that modify joint structure in people with osteoarthritis:- In people with osteoarthritis, are there treatments that can modify joint structure, resulting in delayed structural progression and improved outcomes?

Recommendation ID CG177/5 Question Treatments that modify joint structure in people with osteoarthritis:- In people with osteoarthritis

Research recommendation Published June 2015

Use of biomarkers to diagnose and initiate treatment:- What is the clinical and cost effectiveness of procalcitonin (PCT) point-of-care tests at initial triage for diagnosis of serious infection and the initiation of appropriate antibiotic therapy?

Recommendation ID NG51/3 Question Use of biomarkers to diagnose and initiate treatment:- What is the clinical and cost effectiveness of

Research recommendation Published August 2016

Transition in special groups: looked-after young people:- What is the most effective way of supporting care leavers in transition from children's to adults' health services?

Recommendation ID NG43/8 Question Transition in special groups: looked-after young people:- What is the most effective way of supporting

Research recommendation Published March 2016

Treatment of torus fractures:- What is the clinical effectiveness and cost effectiveness of no treatment for torus fractures of the distal radius in children compared with soft splints, removable splints or bandages?

Recommendation ID NG38/5 Question Treatment of torus fractures:- What is the clinical effectiveness and cost effectiveness of no treatment

Research recommendation Published March 2016

Treatments for osteoarthritis in very old people:- What are the short-term and long-term benefits of non-pharmacological and pharmacological treatments for osteoarthritis in very old people (for example, aged 80 years and older)?

Recommendation ID CG177/1 Question Treatments for osteoarthritis in very old people:- What are the short-term and long-term benefits of

Research recommendation Published June 2015

Shoulder pain:- Which people with a weak arm after stroke are at risk of developing shoulder pain? What management strategies are effective in the prevention or management of shoulder pain of different aetiologies?

Recommendation ID CG162/4 Question Shoulder pain:- Which people with a weak arm after stroke are at risk of developing shoulder pain? What

Research recommendation Published June 2015

Specialist care:- Does specialist antenatal care for women with twin and triplet pregnancies improve outcomes for women and their babies?

Recommendation ID CG129/2 Question Specialist care:- Does specialist antenatal care for women with twin and triplet pregnancies improve

Research recommendation Published June 2015

Spinal fusion:- Should people with low back pain be offered spinal fusion as a surgical option?

Recommendation ID NG59/5 Question Spinal fusion:- Should people with low back pain be offered spinal fusion as a surgical option? Any

Research recommendation Published February 2017

Surveillance programmes for people at increased risk of colorectal cancer:- How effective are colonoscopic surveillance programmes in improving overall survival and cancer-related survival in people at increased risk of colorectal cancer?

Recommendation ID CG118/1 Question Surveillance programmes for people at increased risk of colorectal cancer:- How effective are colonoscopic

Research recommendation Published June 2015

The experiences of people with learning disabilities and mental health problems in services:- What experience do people with learning disabilities have of services designed to prevent and treat mental health problems and how does this relate to clinical outcomes?

Recommendation ID NG54/6 Question The experiences of people with learning disabilities and mental health problems in services:- What experience

Research recommendation Published October 2016

The value of primary surgery for women with advanced ovarian cancer:- Research should be undertaken to determine the effectiveness of primary surgery for women with advanced ovarian cancer whose tumour cannot be fully excised.

Recommendation ID CG122/5 Question The value of primary surgery for women with advanced ovarian cancer:- Research should be undertaken to

Research recommendation Published June 2015

Stroke risk assessment:- Can routine data from UK primary care databases clarify stroke risk in people with atrial fibrillation according to baseline risk factors and treatment?

Recommendation ID CG180/5 Question Stroke risk assessment:- Can routine data from UK primary care databases clarify stroke risk in people

Research recommendation Published June 2015

Supporting young people to manage their conditions:- What is the relationship between transition and subsequent self-management?

Recommendation ID NG43/6 Question Supporting young people to manage their conditions:- What is the relationship between transition and subsequent

Research recommendation Published March 2016

There is a need for additional research on the management of bleeds that occur while people are receiving apixaban, rivaroxaban or dabigatran etexilate, as there are no antidotes or established treatments to stop active bleeding for these agents.

Recommendation ID TA275/1 Question There is a need for additional research on the management of bleeds that occur while people are receiving

Research recommendation Published June 2015

Telecare:- What types of telecare are most effective and cost effective, when provided to older people as part of a package of home care?

Recommendation ID NG21/2 Question Telecare:- What types of telecare are most effective and cost effective, when provided to older people

Research recommendation Published October 2015

The experience of consenting for organ donation:- Does a positive experience of approach and process of consent for families increase consent rates?

Recommendation ID CG135/5 Question The experience of consenting for organ donation:- Does a positive experience of approach and process

Research recommendation Published June 2015

Topiramate to prevent recurrent cluster headache:- Is topiramate a clinically and cost effective prophylactic treatment for recurrent cluster headache?

Recommendation ID CG150/3 Question Topiramate to prevent recurrent cluster headache:- Is topiramate a clinically and cost effective prophylactic

Research recommendation Published June 2015