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Which behaviour change interventions and programmes are effective and cost effective at changing multiple behaviours and maintaining behaviour change? How does this vary among people from different sociodemographic groups?

Recommendation ID PH49/4 Question Which behaviour change interventions and programmes are effective and cost effective at changing multiple

Research recommendation Published June 2015

Women with breast cancer:- What is the safety and effectiveness of alternatives to systemic HRT as treatments for menopausal symptoms in women who have had treatment for breast cancer?

Recommendation ID NG23/1 Question Women with breast cancer:- What is the safety and effectiveness of alternatives to systemic HRT as treatments

Research recommendation Published December 2015

What methods are most effective for assessing and diagnosing the presence and severity of alcohol misuse in children and young people?

Recommendation ID CG115/2 Question What methods are most effective for assessing and diagnosing the presence and severity of alcohol misuse

Research recommendation Published June 2015

What key factors influence the effectiveness of population-level or whole-area approaches to encouraging walking or cycling? How do these factors interact?

Recommendation ID PH41/2 Question What key factors influence the effectiveness of population-level or whole-area approaches to encouraging

Research recommendation Published June 2015

What proxy outcome measures are suitable for studies of the primary prevention of skin cancer?

Recommendation ID PH32/4 Question What proxy outcome measures are suitable for studies of the primary prevention of skin cancer? Any

Research recommendation Published June 2015

What proportion of people with melanoma who are referred into secondary care under the 2 week wait rule, have equivocal moles that are excised and have equivocal moles that are monitored?

Recommendation ID DG19/2 Question What proportion of people with melanoma who are referred into secondary care under the 2 week wait rule

Research recommendation Published January 2016

What types of home-based intervention are effective in promoting the social and emotional wellbeing of vulnerable children aged under 5 years without involving the parents? (This could include childcare provided by other family members or childminders.)

Recommendation ID PH40/4 Question What types of home-based intervention are effective in promoting the social and emotional wellbeing of

Research recommendation Published June 2015

What service delivery models allow people with psychosis and coexisting substance misuse to remain living outside hospital?

Recommendation ID CG120/4 Question What service delivery models allow people with psychosis and coexisting substance misuse to remain living

Research recommendation Published June 2015

Neuropathic pain relief:- Does early treatment with a centrally acting analgesic (for example pregabalin) reduce the frequency or severity of neuropathic pain in people with spinal cord injury?

Recommendation ID NG41/1 Question Neuropathic pain relief:- Does early treatment with a centrally acting analgesic (for example pregabalin)

Research recommendation Published April 2016

Social media:- How effective are online social media and networks at improving health and wellbeing and reducing health inequalities when they are used:- as a method of community engagement?- to support an existing community engagement approach?

Recommendation ID NG44/4 Question Social media:- How effective are online social media and networks at improving health and wellbeing and

Research recommendation Published April 2016

Self-monitoring of blood glucose levels:- What is the optimal frequency for self-monitoring of blood glucose in adults with type 2 diabetes?

Recommendation ID NG28/5 Question Self-monitoring of blood glucose levels:- What is the optimal frequency for self-monitoring of blood glucose

Research recommendation Published January 2016

Service delivery models:- Which models of service delivery are effective and cost-effective for older people with social care needs and multiple long-term conditions?

Recommendation ID NG22/2 Question Service delivery models:- Which models of service delivery are effective and cost-effective for older

Research recommendation Published December 2015

Safety and safeguarding:- What safeguarding practices are most effective in improving outcomes for people using services?

Recommendation ID NG21/5 Question Safety and safeguarding:- What safeguarding practices are most effective in improving outcomes for people

Research recommendation Published October 2015

Safety and efficacy of antimuscarinics:- What is the safety and efficacy of more recently developed antimuscarinics compared with (a) placebo/usual care and (b) other antimuscarinics in the treatment of neurogenic lower urinary tract dysfunction?

Recommendation ID CG148/1 Question Safety and efficacy of antimuscarinics:- What is the safety and efficacy of more recently developed antimuscarinics

Research recommendation Published June 2015

Signs and symptoms that predict neutropenic sepsis in the community:- A prospective study should be carried out to determine which signs and symptoms experienced by patients in the community predict neutropenic sepsis and the outcomes of these episodes.

Recommendation ID CG151/3 Question Signs and symptoms that predict neutropenic sepsis in the community:- A prospective study should be carried

Research recommendation Published June 2015

Support to carers and practitioners to help young people's independence:- What is the most effective way to help carers and practitioners support young people's independence?

Recommendation ID NG43/5 Question Support to carers and practitioners to help young people's independence:- What is the most effective way

Research recommendation Published March 2016

Sequence of invasive OAB procedures:- What is the effectiveness and optimum sequence of treatment with botulinum toxin A and percutaneous sacral nerve stimulation for the treatment of OAB after failed conservative (including drug) management?

Recommendation ID CG171/4 Question Sequence of invasive OAB procedures:- What is the effectiveness and optimum sequence of treatment with

Research recommendation Published June 2015

Serological testing in people who have IgA deficiency:- What is the sensitivity and specificity of IgG tissue transglutaminase (tTG), IgG endomysial antibodies (EMA) and IgG deamidated gliadin peptide (DGP) tests in detecting coeliac disease in people with IgA deficiency?

Recommendation ID NG20/1 Question Serological testing in people who have IgA deficiency:- What is the sensitivity and specificity of IgG

Research recommendation Published October 2015

Self-management:- Do structured psoriasis-focused self-management programmes improve patient confidence, wellbeing and disease control compared with standard care?

Recommendation ID CG153/4 Question Self-management:- Do structured psoriasis-focused self-management programmes improve patient confidence

Research recommendation Published June 2015

Serological testing in people who test negative for anti-transglutaminase:- What is the sensitivity and specificity of IgA EMA and IgA DGP tests in detecting coeliac disease inpeople who test negative for IgA tTG?

Recommendation ID NG20/2 Question Serological testing in people who test negative for anti-transglutaminase:- What is the sensitivity and

Research recommendation Published October 2015

Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study should be carried out to assess the incidence of suspected and proven neutropenic sepsis in patients having anticancer treatment.

Recommendation ID CG151/1 Question Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study

Research recommendation Published June 2015

Saliva:- How is excessive drooling of saliva (sialorrhoea) managed in people with motor neurone disease (MND)?

Recommendation ID NG42/4 Question Saliva:- How is excessive drooling of saliva (sialorrhoea) managed in people with motor neurone disease

Research recommendation Published March 2016

Specialist investigation:- What specialist investigations should be conducted to exclude a diagnosis of functional dyspepsia in people with uninvestigated dyspepsia that does not respond to PPIs or H2 receptor antagonists (H2RAs) despite optimum primary care?

Recommendation ID CG184/5 Question Specialist investigation:- What specialist investigations should be conducted to exclude a diagnosis

Research recommendation Published June 2015

Specialist dementia support:- What is the most effective and cost effective way to support people with dementia living at home?

Recommendation ID NG21/4 Question Specialist dementia support:- What is the most effective and cost effective way to support people with

Research recommendation Published October 2015

Research into the long-term treatment effects of rivaroxaban is needed.

Recommendation ID TA287/2 Question Research into the long-term treatment effects of rivaroxaban is needed. Any explanatory notes(if

Research recommendation Published June 2015

Research is recommended on patient preferences, and their impact on quality of life, for contrast-enhanced ultrasound and other imaging modalities. Ideally such research should compare all appropriate imaging modalities in the same patient group.

Recommendation ID DG5/2 Question Research is recommended on patient preferences, and their impact on quality of life, for contrast-enhanced

Research recommendation Published June 2015

Reducing use of emergency dental care:- What interventions are effective and cost effective at encouraging people who usually only go to emergency dental services to use general dental services regularly, in a bid to improve their oral health?

Recommendation ID NG30/2 Question Reducing use of emergency dental care:- What interventions are effective and cost effective at encouraging

Research recommendation Published January 2016

Risk stratification tool for HbA1c targets for adults with type 1 diabetes:- Can a risk stratification tool be used to aid the setting of individualised HbA1c targets for adultswith type 1 diabetes?

Recommendation ID NG17/4 Question Risk stratification tool for HbA1c targets for adults with type 1 diabetes:- Can a risk stratification

Research recommendation Published October 2015

Recommendation 4 Weight management programmes. Who should take action? Research councils, commissioners and funders. Researchers and investigators.

Recommendation ID PH47/4 Question Recommendation 4 Weight management programmes. Who should take action? Research councils, commissioners

Research recommendation Published June 2015

Reducing demands on health and social care services:- Do preventive oral health interventions in residential and nursing care homes reduce demands on other health and social care services?

Recommendation ID NG48/5 Question Reducing demands on health and social care services:- Do preventive oral health interventions in residential

Research recommendation Published August 2016

Sequencing and combining of phosphate binders in adults:- For adults with stage 4 or 5 chronic kidney disease (CKD), including those on dialysis, what is the most effective sequence or combination of phosphate binders to control serum phosphate?

Recommendation ID CG157/5 Question Sequencing and combining of phosphate binders in adults:- For adults with stage 4 or 5 chronic kidney

Research recommendation Published June 2015

Research should be carried out to compare the clinical effectiveness of bendamustine with chlorambucil at the higher dose used in the Chronic Lymphocytic Leukaemia Trial 4 (CLL4).

Recommendation ID TA216/1 Question Research should be carried out to compare the clinical effectiveness of bendamustine with chlorambucil

Research recommendation Published June 2015

Research is needed to establish the efficacy and tolerability of bile acid sequestrants among people with irritable bowel syndrome (IBS-D) or Crohn's disease without ileal resection.

Recommendation ID DG7/3 Question Research is needed to establish the efficacy and tolerability of bile acid sequestrants among people with

Research recommendation Published June 2015

Research is needed on the impact of treating Alzheimer's disease on mortality and institutionalisation, and to assess the relationship between disease progression and carer utility (quality of life).

Recommendation ID TA217/2 Question Research is needed on the impact of treating Alzheimer's disease on mortality and institutionalisation

Research recommendation Published June 2015

Risk assessment in neonates, infants, children and young people:- Which pressure ulcer tools are most effective for predicting pressure ulcer risk in children?

Recommendation ID CG179/3 Question Risk assessment in neonates, infants, children and young people:- Which pressure ulcer tools are most

Research recommendation Published June 2015

Research is recommended to address uncertainties about the claimed patient and system benefits of using Parafricta Bootees and Undergarments. This should take the form of comparative research against standard care, preferably carried out in a hospital.

Recommendation ID MTG20/1 Question Research is recommended to address uncertainties about the claimed patient and system benefits of using

Research recommendation Published June 2015