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Evidence on the progression of X-linked hypophosphataemia (XLH) over time and the long-term benefits of burosumab would also be valuable.

Recommendation ID HST8/3 Question Evidence on the progression of X-linked hypophosphataemia (XLH) over time and the long-term benefits of

Research recommendation Published March 2019

Safety and safeguarding:- What safeguarding practices are most effective in improving outcomes for people using services?

Recommendation ID NG21/5 Question Safety and safeguarding:- What safeguarding practices are most effective in improving outcomes for people

Research recommendation Published October 2015

Further research on incisionless otoplasty should describe the precise surgical techniques used and should report both short- and long-term outcomes, including the need for further procedures.

Recommendation ID IPG422/1 Question Further research on incisionless otoplasty should describe the precise surgical techniques used and

Research recommendation Published June 2015

Advance statements and decisions:- What forms of management of violence and aggression do service users prefer and do advance statements and decisions have an important role in management and prevention?

Recommendation ID NG10/3 Question Advance statements and decisions:- What forms of management of violence and aggression do service users

Research recommendation Published October 2015

Amitriptyline to prevent recurrent migraine:- Is amitriptyline a clinically and cost effective prophylactic treatment for recurrent migraine?

Recommendation ID CG150/1 Question Amitriptyline to prevent recurrent migraine:- Is amitriptyline a clinically and cost effective prophylactic

Research recommendation Published June 2015

Are there effective long-term pharmacological interventions to prevent the onset of type 2 diabetes that can be recommended postnatally for women who have been diagnosed with gestational diabetes?

Recommendation ID NG3/5 Question Are there effective long-term pharmacological interventions to prevent the onset of type 2 diabetes that

Research recommendation Published June 2015

Bisphosphonates for the prevention of bone disease:- What is the effectiveness of monthly zoledronic acid given indefinitely compared with zoledronic acid given for a fixed duration in patients with myeloma?

Recommendation ID NG35/5 Question Bisphosphonates for the prevention of bone disease:- What is the effectiveness of monthly zoledronic acid

Research recommendation Published April 2016

Decision-making:- What interventions, systems and processes are effective and cost effective in changing health and social care practitioners' decision-making and ensuring appropriate antimicrobial stewardship?

Recommendation ID Ng15/2 Question Decision-making:- What interventions, systems and processes are effective and cost effective in changing

Research recommendation Published October 2015

Pain management: chronic pancreatitis:- Is the long-term use of opioids more clinically effective and cost effective than non-opioid analgesia (including non-pharmacological analgesia) in people with chronic pain due to chronic pancreatitis?

Recommendation ID NG104/3 Question Pain management: chronic pancreatitis:- Is the long-term use of opioids more clinically effective and

Research recommendation Published December 2018

Training:- How effective and cost effective is gatekeeper training in preventing suicides?

Recommendation ID NG105/4 Question Training:- How effective and cost effective is gatekeeper training in preventing suicides? Any explanatory

Research recommendation Published December 2018

Frequency of review:- What is the most clinical and cost-effective frequency of review for people on peritoneal dialysis, haemodiafiltration, haemodialysis or conservative management?

Recommendation ID NG107/4 Question Frequency of review:- What is the most clinical and cost-effective frequency of review for people on

Research recommendation Published December 2018

Timing of pre-emptive transplant:- What is the most clinical and cost-effective strategy for timing of pre-emptive transplantation?

Recommendation ID NG107/2 Question Timing of pre-emptive transplant:- What is the most clinical and cost-effective strategy for timing of

Research recommendation Published December 2018

Management of type 3c diabetes:- What is the most clinically effective and cost-effective insulin regimen to minimise hypo- and hyperglycaemia for type 3c diabetes secondary to pancreatitis?

Recommendation ID NG104/5 Question Management of type 3c diabetes:- What is the most clinically effective and cost-effective insulin regimen

Research recommendation Published December 2018

Pain management: small duct disease:- What is the most clinically effective and cost-effective intervention for managing small duct disease (in the absence of pancreatic duct obstruction, inflammatory mass or pseudocyst) in people with chronic pancreatitis presenting with pain?

Recommendation ID NG104/4 Question Pain management: small duct disease:- What is the most clinically effective and cost-effective intervention

Research recommendation Published December 2018

Speed of intravenous fluid resuscitation for people with acute pancreatitis:- What is the most clinically effective and cost-effective speed of administration of intravenous fluid for resuscitation in people with acute pancreatitis?

Recommendation ID NG104/2 Question Speed of intravenous fluid resuscitation for people with acute pancreatitis:- What is the most clinically

Research recommendation Published December 2018

Cardiac MRI versus other imaging techniques for diagnosing heart failure:- What is the optimal imaging technique for the diagnosis of heart failure?

Recommendation ID NG106/2 Question Cardiac MRI versus other imaging techniques for diagnosing heart failure:- What is the optimal imaging

Research recommendation Published December 2018

The impact of atrial fibrillation on the natriuretic peptide threshold for diagnosing heart failure:- What is the optimal NT-proBNP threshold for the diagnosis of heart failure in people with atrial fibrillation?

Recommendation ID NG106/3 Question The impact of atrial fibrillation on the natriuretic peptide threshold for diagnosing heart failure:- What

Research recommendation Published December 2018

Advocacy and support for decision-making:- What is the effectiveness, cost effectiveness and acceptability of advocacy as a means of supporting people to make decisions?

Recommendation ID NG108/3 Question Advocacy and support for decision-making:- What is the effectiveness, cost effectiveness and acceptability

Research recommendation Published December 2018

Suicide prevention in custodial and detention settings:- What interventions are effective and cost effective in reducing suicide rates in custodial and residential settings?

Recommendation ID NG105/3 Question Suicide prevention in custodial and detention settings:- What interventions are effective and cost effective

Research recommendation Published December 2018

Using mental capacity assessment tools to assess capacity:- What is the accuracy and/or effectiveness, cost effectiveness and acceptability of mental capacity assessment tools that are compliant with the Mental Capacity Act 2005?

Recommendation ID NG108/4 Question Using mental capacity assessment tools to assess capacity:- What is the accuracy and/or effectiveness

Research recommendation Published December 2018

The impact of advanced kidney disease on the natriuretic peptide threshold for diagnosing heart failure:- What are the optimal NT-proBNP thresholds for diagnosing heart failure in people with stage IIIb, IV or V chronic kidney disease?

Recommendation ID NG106/4 Question The impact of advanced kidney disease on the natriuretic peptide threshold for diagnosing heart failure:- What

Research recommendation Published December 2018

Cardiac assessment:- What is the clinical and cost effectiveness of cardiac assessment before transplantation?

Recommendation ID NG107/1 Question Cardiac assessment:- What is the clinical and cost effectiveness of cardiac assessment before transplantation

Research recommendation Published December 2018

Coordinating care:- What is the clinical and cost effectiveness of having keyworkers present in the context of renal replacement therapy (RRT)?

Recommendation ID NG107/5 Question Coordinating care:- What is the clinical and cost effectiveness of having keyworkers present in the context

Research recommendation Published December 2018

Acute haemodialysis versus acute peritoneal dialysis:- What is the clinical and cost effectiveness of initial haemodialysis versus initial peritoneal dialysis for people who start dialysis in an unplanned way?

Recommendation ID NG107/3 Question Acute haemodialysis versus acute peritoneal dialysis:- What is the clinical and cost effectiveness of

Research recommendation Published December 2018

Further research for percutaneous endoscopic catheter laser balloon pulmonary vein isolation for atrial fibrillation (AF) should define patient-selection criteria and should clearly describe adverse events and long-term control of AF.

Recommendation ID IPG399/1 Question Further research for percutaneous endoscopic catheter laser balloon pulmonary vein isolation for atrial

Research recommendation Published June 2015

Use of technology in providing care- What are the views and experiences of people who use adult social care services on assistive technologies?

Recommendation ID NG86/4 Question Use of technology in providing care- What are the views and experiences of people who use adult social

Research recommendation Published November 2018

Hysteroscopic removal of submucosal fibroids compared with other uterine-sparing treatments for HMB:- Is hysteroscopic removal of submucosal fibroids more effective and cost-effective than other uterine-sparing treatments for the management of HMB?

Recommendation ID NG88/4 Question Hysteroscopic removal of submucosal fibroids compared with other uterine-sparing treatments for HMB:- Is

Research recommendation Published November 2018

Medication choice in people with coexisting conditions:- What is the clinical and cost effectiveness of ADHD medications in people with ADHD and tic disorders, a history of psychosis or mania, or personality disorder?

Recommendation ID NG87/2 Question Medication choice in people with coexisting conditions:- What is the clinical and cost effectiveness of

Research recommendation Published November 2018

Medication choice in people with no previous medication for ADHD:- What is the clinical and cost effectiveness of ADHD medications in people with ADHD with noprevious medication for the condition?

Recommendation ID NG87/3 Question Medication choice in people with no previous medication for ADHD:- What is the clinical and cost effectiveness

Research recommendation Published November 2018

Long-term outcomes of pharmacological and uterine-sparing surgical treatments for HMB associated with adenomyosis:- What are the long-term clinical outcomes of pharmacological and uterine-sparing surgical treatments in women with HMB associated with adenomyosis?

Recommendation ID NG88/3 Question Long-term outcomes of pharmacological and uterine-sparing surgical treatments for HMB associated with

Research recommendation Published November 2018

Effectiveness of the progestogen-only pill, injectable progestogens, or progestogen implants in alleviating HMB:- How effective are the progestogen-only pill, injectable progestogens or progestogen implants in alleviating HMB?

Recommendation ID NG88/2 Question Effectiveness of the progestogen-only pill, injectable progestogens, or progestogen implants in alleviating

Research recommendation Published November 2018

Prescribing beyond monotherapy:- What is the clinical and cost effectiveness of various ADHD prescribing strategies when monotherapy has failed?

Recommendation ID NG87/4 Question Prescribing beyond monotherapy:- What is the clinical and cost effectiveness of various ADHD prescribing

Research recommendation Published November 2018

Further research on laparoscopic mesh pectopexy for apical prolapse of the uterus or vagina should include details of patient selection and long-term outcomes.

Recommendation ID IPG608/1 Question Further research on laparoscopic mesh pectopexy for apical prolapse of the uterus or vagina should include

Research recommendation Published November 2018

Psychological support needs:- A qualitative study should be undertaken to evaluate information and support interventions to address psychological needs at different points in the care pathway for people with pancreatic cancer.

Recommendation ID NG85/5 Question Psychological support needs:- A qualitative study should be undertaken to evaluate information and support

Research recommendation Published November 2018

Public transport provision and ticketing:- How effective and cost effective are changes to public transport provision and ticketing in creating and sustaining an increase in physical activity at a population level?

Recommendation ID NG90/1 Question Public transport provision and ticketing:- How effective and cost effective are changes to public transport

Research recommendation Published November 2018

Changes to public open spaces:- How effective and cost effective are environmental changes to public open spaces (including blue, green and grey spaces) in creating and sustaining an increase in physical activity at a population level?

Recommendation ID NG90/2 Question Changes to public open spaces:- How effective and cost effective are environmental changes to public open

Research recommendation Published November 2018

Digital media:- How effective and cost effective are stop smoking interventions delivered using web-basedpackages or apps?

Recommendation ID NG92/1 Question Digital media:- How effective and cost effective are stop smoking interventions delivered using web-basedpackages

Research recommendation Published November 2018

Duration of prophylaxis for elective total hip replacement surgery:- What is the clinical and cost effectiveness of standard versus extended duration pharmacological prophylaxis for preventing VTE in people undergoing elective total hip replacement surgery?

Recommendation ID NG89/5 Question Duration of prophylaxis for elective total hip replacement surgery:- What is the clinical and cost effectiveness

Research recommendation Published November 2018