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Interaction between behavioural and environmental interventions:- What is the effectiveness and cost effectiveness of interventions to change the environment alone, compared with interventions to change the environment that are supported by interventions to change people's behaviour?

Recommendation ID NG90/6 Question Interaction between behavioural and environmental interventions:- What is the effectiveness and cost effectiveness

Research recommendation Published November 2018

Models of supported living:- What is the effectiveness and cost effectiveness of models of shared, supported living, such as Shared Lives?What are the views and experiences of people sharing their home and people who live with themunder programmes such as Shared Lives?

Recommendation ID NG93/3 Question Models of supported living:- What is the effectiveness and cost effectiveness of models of shared, supported

Research recommendation Published November 2018

Risk assessment:- What is the accuracy of individual risk assessment tools in predicting the risk of venousthromboembolism (VTE) and risk of bleeding in people admitted to hospital?

Recommendation ID NG89/1 Question Risk assessment:- What is the accuracy of individual risk assessment tools in predicting the risk of

Research recommendation Published November 2018

Direct oral anticoagulants for people with lower limb immobilisation:- What is the clinical and cost effectiveness of direct oral anticoagulants for preventing VTE in people with lower limb immobilisation?

Recommendation ID NG89/3 Question Direct oral anticoagulants for people with lower limb immobilisation:- What is the clinical and cost effectiveness

Research recommendation Published November 2018

Reducing car ownership:- Does reducing car use or ownership change physical activity levels? Are effects maintained over time?

Recommendation ID NG90/5 Question Reducing car ownership:- Does reducing car use or ownership change physical activity levels? Are effects

Research recommendation Published November 2018

Supporting family members, carers and staff:- What types of services or approaches are effective in supporting family members, carers and staffto be resilient and able to provide care and support to people with a learning disability and behaviour that challenges?

Recommendation ID NG93/2 Question Supporting family members, carers and staff:- What types of services or approaches are effective in supporting

Research recommendation Published November 2018

Carbon monoxide monitoring:- What is the validity of different thresholds of carbon monoxide in exhaled breath as markers of quitting, based on diagnostic review and modelling?

Recommendation ID NG92/2 Question Carbon monoxide monitoring:- What is the validity of different thresholds of carbon monoxide in exhaled

Research recommendation Published November 2018

The structure and organisation of specialist teams:- What structure and organisation of specialist autism teams are associated with improvements in care for people with autism?

Recommendation ID CG142/4 Question The structure and organisation of specialist teams:- What structure and organisation of specialist autism

Research recommendation Published June 2015

Systemic imaging – who and why?:- What factors determine the risk of a person presenting with CUADT having metastasis or a second primary cancer?

Recommendation ID NG36/1 Question Systemic imaging – who and why?:- What factors determine the risk of a person presenting with CUADT having

Research recommendation Published April 2016

The role of families in supporting young adults discharged from children's services:- What is the most effective way of helping families to support young people who have been discharged from children's services (whether or not they meet criteria for adult services)?

Recommendation ID NG43/2 Question The role of families in supporting young adults discharged from children's services:- What is the most

Research recommendation Published March 2016

The physical health benefits of discontinuing antipsychotic medication:- What are the short- and long-term benefits to physical health of guided medication discontinuation and/or reduction in first episode psychosis and can this be achieved without major risks?

Recommendation ID CG178/3 Question The physical health benefits of discontinuing antipsychotic medication:- What are the short- and long-term

Research recommendation Published June 2015

Training:- What are the effects of different approaches to home care training on outcomes for people who use home care services?

Recommendation ID NG21/3 Question Training:- What are the effects of different approaches to home care training on outcomes for people who

Research recommendation Published October 2015

Thrombolytic therapy for DVT:- What is the clinical and cost effectiveness of clot removal using catheter-directed thrombolytic therapy or pharmacomechanical thrombolysis compared with standard anticoagulation therapy for the treatment of acute proximal DVT?

Recommendation ID CG144/4 Question Thrombolytic therapy for DVT:- What is the clinical and cost effectiveness of clot removal using catheter-directed

Research recommendation Published June 2015

The risk of neonatal morbidity and mortality is higher with 'small for gestational age' babies. However, the effect of planned Caesarean Section (CS) in improving these outcomes remains uncertain and therefore CS should not routinely be offered outside a research context. [2004]

Recommendation ID CG132/8 Question The risk of neonatal morbidity and mortality is higher with 'small for gestational age' babies. However

Research recommendation Published June 2015

The effectiveness and safety of single layer closure of the uterine incision is uncertain. Except within a research context, the uterine incision should be sutured with two layers. [2004]

Recommendation ID CG132/11 Question The effectiveness and safety of single layer closure of the uterine incision is uncertain. Except within

Research recommendation Published June 2015

Treating small oesophageal varices:- Do non-selective beta-blockers improve survival and prevent first variceal bleeds in people with cirrhosis that is associated with small oesophageal varices?

Recommendation ID NG50/2 Question Treating small oesophageal varices:- Do non-selective beta-blockers improve survival and prevent first

Research recommendation Published August 2016

Upper limb electrical stimulation:- What is the clinical and cost effectiveness of electrical stimulation (ES) as an adjunct to rehabilitation to improve hand and arm function in people after stroke, from early rehabilitation through to use in the community?

Recommendation ID CG162/1 Question Upper limb electrical stimulation:- What is the clinical and cost effectiveness of electrical stimulation

Research recommendation Published June 2015

Timing of birth:- What is the incidence of perinatal and neonatal morbidity and mortality in babies born by elective birth in twin and triplet pregnancies?

Recommendation ID CG129/6 Question Timing of birth:- What is the incidence of perinatal and neonatal morbidity and mortality in babies born

Research recommendation Published June 2015

Treating common presentations of osteoarthritis for which there is little evidence:- What are effective treatments for people with osteoarthritis who have common but poorly researched problems, such as pain in more than one joint or foot osteoarthritis?

Recommendation ID CG177/3 Question Treating common presentations of osteoarthritis for which there is little evidence:- What are effective

Research recommendation Published June 2015

Using GP practice lists to identify people at high risk:- What is the clinical and cost effectiveness of using GP practice lists to identify people at high risk of fracture, leading to formal risk assessment and possible treatment?

Recommendation ID CG146/1 Question Using GP practice lists to identify people at high risk:- What is the clinical and cost effectiveness

Research recommendation Published June 2015

Support to carers and practitioners to help young people's independence:- What is the most effective way to help carers and practitioners support young people's independence?

Recommendation ID NG43/5 Question Support to carers and practitioners to help young people's independence:- What is the most effective way

Research recommendation Published March 2016

Sequence of invasive OAB procedures:- What is the effectiveness and optimum sequence of treatment with botulinum toxin A and percutaneous sacral nerve stimulation for the treatment of OAB after failed conservative (including drug) management?

Recommendation ID CG171/4 Question Sequence of invasive OAB procedures:- What is the effectiveness and optimum sequence of treatment with

Research recommendation Published June 2015

Selective dorsal rhizotomy:- Does selective dorsal rhizotomy followed by intensive rehabilitation performed between the ages of 3 and 9 years in children who are at Gross Motor Function Classification System (GMFCS) level II or III result in good community mobility as a young adult?

Recommendation ID CG145/5 Question Selective dorsal rhizotomy:- Does selective dorsal rhizotomy followed by intensive rehabilitation performed

Research recommendation Published June 2015

Serological testing in people who have IgA deficiency:- What is the sensitivity and specificity of IgG tissue transglutaminase (tTG), IgG endomysial antibodies (EMA) and IgG deamidated gliadin peptide (DGP) tests in detecting coeliac disease in people with IgA deficiency?

Recommendation ID NG20/1 Question Serological testing in people who have IgA deficiency:- What is the sensitivity and specificity of IgG

Research recommendation Published October 2015

Self-management:- Do structured psoriasis-focused self-management programmes improve patient confidence, wellbeing and disease control compared with standard care?

Recommendation ID CG153/4 Question Self-management:- Do structured psoriasis-focused self-management programmes improve patient confidence

Research recommendation Published June 2015

Serological testing in people who test negative for anti-transglutaminase:- What is the sensitivity and specificity of IgA EMA and IgA DGP tests in detecting coeliac disease inpeople who test negative for IgA tTG?

Recommendation ID NG20/2 Question Serological testing in people who test negative for anti-transglutaminase:- What is the sensitivity and

Research recommendation Published October 2015

Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study should be carried out to assess the incidence of suspected and proven neutropenic sepsis in patients having anticancer treatment.

Recommendation ID CG151/1 Question Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study

Research recommendation Published June 2015

Saliva:- How is excessive drooling of saliva (sialorrhoea) managed in people with motor neurone disease (MND)?

Recommendation ID NG42/4 Question Saliva:- How is excessive drooling of saliva (sialorrhoea) managed in people with motor neurone disease

Research recommendation Published March 2016

Specialist investigation:- What specialist investigations should be conducted to exclude a diagnosis of functional dyspepsia in people with uninvestigated dyspepsia that does not respond to PPIs or H2 receptor antagonists (H2RAs) despite optimum primary care?

Recommendation ID CG184/5 Question Specialist investigation:- What specialist investigations should be conducted to exclude a diagnosis

Research recommendation Published June 2015

Self-management support for people with mental health difficulties:- Which interventions are effective in supporting self-management for people with mental health difficulties who also have a physical condition and are moving into and out of general inpatient hospital settings?

Recommendation ID NG27/2 Question Self-management support for people with mental health difficulties:- Which interventions are effective

Research recommendation Published January 2016

Specialist dementia support:- What is the most effective and cost effective way to support people with dementia living at home?

Recommendation ID NG21/4 Question Specialist dementia support:- What is the most effective and cost effective way to support people with

Research recommendation Published October 2015

Safety of selective internal radiation therapy (SIRT) is a potentially beneficial treatment for patients with on-resectable colorectal metastases in the liver, but that more research and data collection are required to demonstrate its efficacy.

Recommendation ID IPG401/1 Question Safety of selective internal radiation therapy (SIRT) is a potentially beneficial treatment for patients

Research recommendation Published June 2015

Step 4 antihypertensive treatment:- In adults with hypertension, which drug treatment (diuretic therapy versus other step 4 treatments) is the most clinically and cost effective for step 4 antihypertensive treatment?

Recommendation ID CG127/5 Question Step 4 antihypertensive treatment:- In adults with hypertension, which drug treatment (diuretic therapy

Research recommendation Published June 2015