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Stopping preventive medicines:- What is the clinical and cost effectiveness of stopping preventive medicines in people with multimorbidity who may not benefit from continuing them?

Recommendation ID NG56/3 Question Stopping preventive medicines:- What is the clinical and cost effectiveness of stopping preventive medicines

Research recommendation Published October 2016

Standard principles of infection prevention and control:- What are the barriers to compliance with the standard principles of infection prevention and control that patients and carers experience in their own homes?

Recommendation ID CG139/1 Question Standard principles of infection prevention and control:- What are the barriers to compliance with the

Research recommendation Published June 2015

Studies exploring the effectiveness of bevacizumab in people previously treated with a taxane and its effects on health-related quality of life.

Recommendation ID TA263/1 Question Studies exploring the effectiveness of bevacizumab in people previously treated with a taxane and its

Research recommendation Published June 2015

Subsequent health assessment:- When should subsequent health assessments be carried out in prison for people serving long-term sentences?

Recommendation ID NG57/1 Question Subsequent health assessment:- When should subsequent health assessments be carried out in prison for

Research recommendation Published February 2017

Supporting people in care homes to stay active:- What is the most effective and cost-effective way of supporting older people with social care needs and multiple long-term conditions in care homes to live as independently as possible?

Recommendation ID NG22/3 Question Supporting people in care homes to stay active:- What is the most effective and cost-effective way of

Research recommendation Published December 2015

Shoulder pain:- Which people with a weak arm after stroke are at risk of developing shoulder pain? What management strategies are effective in the prevention or management of shoulder pain of different aetiologies?

Recommendation ID CG162/4 Question Shoulder pain:- Which people with a weak arm after stroke are at risk of developing shoulder pain? What

Research recommendation Published June 2015

Spinal fusion:- Should people with low back pain be offered spinal fusion as a surgical option?

Recommendation ID NG59/5 Question Spinal fusion:- Should people with low back pain be offered spinal fusion as a surgical option? Any

Research recommendation Published February 2017

Surveillance programmes for people at increased risk of colorectal cancer:- How effective are colonoscopic surveillance programmes in improving overall survival and cancer-related survival in people at increased risk of colorectal cancer?

Recommendation ID CG118/1 Question Surveillance programmes for people at increased risk of colorectal cancer:- How effective are colonoscopic

Research recommendation Published June 2015

Specific versus generic CBT for children and young people with social anxiety disorder:- What is the clinical and cost effectiveness of specific CBT for children and young people with social anxiety disorder compared with generic anxiety-focused CBT?

Recommendation ID CG159/2 Question Specific versus generic CBT for children and young people with social anxiety disorder:- What is the

Research recommendation Published June 2015

The experiences of people with learning disabilities and mental health problems in services:- What experience do people with learning disabilities have of services designed to prevent and treat mental health problems and how does this relate to clinical outcomes?

Recommendation ID NG54/6 Question The experiences of people with learning disabilities and mental health problems in services:- What experience

Research recommendation Published October 2016

The value of primary surgery for women with advanced ovarian cancer:- Research should be undertaken to determine the effectiveness of primary surgery for women with advanced ovarian cancer whose tumour cannot be fully excised.

Recommendation ID CG122/5 Question The value of primary surgery for women with advanced ovarian cancer:- Research should be undertaken to

Research recommendation Published June 2015

Stroke risk assessment:- Can routine data from UK primary care databases clarify stroke risk in people with atrial fibrillation according to baseline risk factors and treatment?

Recommendation ID CG180/5 Question Stroke risk assessment:- Can routine data from UK primary care databases clarify stroke risk in people

Research recommendation Published June 2015

Supporting young people to manage their conditions:- What is the relationship between transition and subsequent self-management?

Recommendation ID NG43/6 Question Supporting young people to manage their conditions:- What is the relationship between transition and subsequent

Research recommendation Published March 2016

There is a need for additional research on the management of bleeds that occur while people are receiving apixaban, rivaroxaban or dabigatran etexilate, as there are no antidotes or established treatments to stop active bleeding for these agents.

Recommendation ID TA275/1 Question There is a need for additional research on the management of bleeds that occur while people are receiving

Research recommendation Published June 2015

Telecare:- What types of telecare are most effective and cost effective, when provided to older people as part of a package of home care?

Recommendation ID NG21/2 Question Telecare:- What types of telecare are most effective and cost effective, when provided to older people

Research recommendation Published October 2015

Training:- What are the effects of different approaches to home care training on outcomes for people who use home care services?

Recommendation ID NG21/3 Question Training:- What are the effects of different approaches to home care training on outcomes for people who

Research recommendation Published October 2015

The role of parents in the treatment of children and young people with social anxiety disorder:- What is the best way of involving parents in the treatment of children and young people (at different stages of development) with social anxiety disorder?

Recommendation ID CG159/3 Question The role of parents in the treatment of children and young people with social anxiety disorder:- What

Research recommendation Published June 2015

Thrombolytic therapy for DVT:- What is the clinical and cost effectiveness of clot removal using catheter-directed thrombolytic therapy or pharmacomechanical thrombolysis compared with standard anticoagulation therapy for the treatment of acute proximal DVT?

Recommendation ID CG144/4 Question Thrombolytic therapy for DVT:- What is the clinical and cost effectiveness of clot removal using catheter-directed

Research recommendation Published June 2015

The effectiveness and safety of single layer closure of the uterine incision is uncertain. Except within a research context, the uterine incision should be sutured with two layers. [2004]

Recommendation ID CG132/11 Question The effectiveness and safety of single layer closure of the uterine incision is uncertain. Except within

Research recommendation Published June 2015

Treating small oesophageal varices:- Do non-selective beta-blockers improve survival and prevent first variceal bleeds in people with cirrhosis that is associated with small oesophageal varices?

Recommendation ID NG50/2 Question Treating small oesophageal varices:- Do non-selective beta-blockers improve survival and prevent first

Research recommendation Published August 2016

Upper limb electrical stimulation:- What is the clinical and cost effectiveness of electrical stimulation (ES) as an adjunct to rehabilitation to improve hand and arm function in people after stroke, from early rehabilitation through to use in the community?

Recommendation ID CG162/1 Question Upper limb electrical stimulation:- What is the clinical and cost effectiveness of electrical stimulation

Research recommendation Published June 2015

Transition in special groups: young offenders institutions:- What is the most effective way of supporting young offenders in transition from children's to adults' health and social care services?

Recommendation ID NG43/7 Question Transition in special groups: young offenders institutions:- What is the most effective way of supporting

Research recommendation Published March 2016

Treating common presentations of osteoarthritis for which there is little evidence:- What are effective treatments for people with osteoarthritis who have common but poorly researched problems, such as pain in more than one joint or foot osteoarthritis?

Recommendation ID CG177/3 Question Treating common presentations of osteoarthritis for which there is little evidence:- What are effective

Research recommendation Published June 2015

Using GP practice lists to identify people at high risk:- What is the clinical and cost effectiveness of using GP practice lists to identify people at high risk of fracture, leading to formal risk assessment and possible treatment?

Recommendation ID CG146/1 Question Using GP practice lists to identify people at high risk:- What is the clinical and cost effectiveness

Research recommendation Published June 2015

Treatment of erythropoietic stimulating agents (ESAs) resistance:- In people with chronic ESA-resistant anaemia of CKD, what is the clinical and cost effectiveness oftreating with high-dose ESA compared with blood transfusion?

Recommendation ID NG8/2 Question Treatment of erythropoietic stimulating agents (ESAs) resistance:- In people with chronic ESA-resistant

Research recommendation Published October 2015

Interventions for preventing falls in older inpatients:- How can falls among older inpatients be prevented? Which patients are most likely to benefit from falls prevention interventions, and does the effectiveness of interventions relate to the patient's length of stay?

Recommendation ID CG161/4 Question Interventions for preventing falls in older inpatients:- How can falls among older inpatients be prevented

Research recommendation Published June 2015

Lactate level for monitoring severity of shock:- Is lactate monitoring in patients with major trauma clinically and cost effective?

Recommendation ID NG39/2 Question Lactate level for monitoring severity of shock:- Is lactate monitoring in patients with major trauma clinically

Research recommendation Published March 2016

Interventions for PTSD symptoms in people with psychosis and schizophrenia:- What is the benefit of a CBT-based trauma reprocessing intervention on PTSD symptoms in people with psychosis and schizophrenia?

Recommendation ID CG178/5 Question Interventions for PTSD symptoms in people with psychosis and schizophrenia:- What is the benefit of a

Research recommendation Published June 2015

Intravenous iron in children:- A prospective study of adequate duration of intravenous iron preparations in children with anaemia of chronic kidney disease (CKD), including safety, dosing and efficacy outcomes.

Recommendation ID CG114/1 Question Intravenous iron in children:- A prospective study of adequate duration of intravenous iron preparations

Research recommendation Published June 2015

Maintenance treatment:- In the maintenance treatment of bipolar disorder, what is the relative effect on quality of life of lithium, an antipsychotic (haloperidol, olanzapine, quetiapine or risperidone), or a combination of lithium and an antipsychotic?

Recommendation ID CG185/2 Question Maintenance treatment:- In the maintenance treatment of bipolar disorder, what is the relative effect

Research recommendation Published June 2015

Is intravenous methylprednisolone more clinically and cost effective than oral methylprednisolone in people with relapsing–remitting Multiple Sclerosis (MS) and people with secondary progressive MS with continued relapses?

Recommendation ID CG186/2 Question Is intravenous methylprednisolone more clinically and cost effective than oral methylprednisolone in

Research recommendation Published June 2015

Local coordination:- In the UK, what are the key components of a local coordination role to ensure best value for money in promoting older people's independence and mental wellbeing?

Recommendation ID NG32/3 Question Local coordination:- In the UK, what are the key components of a local coordination role to ensure best

Research recommendation Published January 2016

Is acupuncture effective in reducing alcohol consumption compared with standard care?

Recommendation ID CG115/3 Question Is acupuncture effective in reducing alcohol consumption compared with standard care? Any explanatory

Research recommendation Published June 2015