Updating results

Neoadjuvant treatment:- What are the indications for postmastectomy radiotherapy after neoadjuvant chemotherapy?

Recommendation ID NG101/6 Question Neoadjuvant treatment:- What are the indications for postmastectomy radiotherapy after neoadjuvant chemotherapy

Research recommendation Published December 2018

NICE encourages further research into low-intensity pulsed ultrasound to promote healing of delayed-union and non-union fractures. Further research should include details of patient selection, fracture site, and risk factors and comorbidities that delay fracture healing.

Recommendation ID IPG623/1 Question NICE encourages further research into low-intensity pulsed ultrasound to promote healing of delayed-union

Research recommendation Published December 2018

Neoadjuvant endocrine therapy in postmenopausal women:- Is there a benefit for neoadjuvant endocrine therapy in postmenopausal women with early breast cancer?

Recommendation ID NG101/5 Question Neoadjuvant endocrine therapy in postmenopausal women:- Is there a benefit for neoadjuvant endocrine

Research recommendation Published December 2018

Neoadjuvant endocrine therapy in premenopausal women:- Is neoadjuvant endocrine therapy safe in premenopausal women with early breast cancer?

Recommendation ID NG101/4 Question Neoadjuvant endocrine therapy in premenopausal women:- Is neoadjuvant endocrine therapy safe in premenopausal

Research recommendation Published December 2018

Managing meningioma: immediate versus deferred radiotherapy for incompletely excised grade I meningioma:- Is immediate or deferred radiotherapy better for incompletely excised grade I meningioma?

Recommendation ID NG99/5 Question Managing meningioma: immediate versus deferred radiotherapy for incompletely excised grade I meningioma:-

Research recommendation Published December 2018

Further research in low-intensity pulsed ultrasound to promote healing of fresh fractures at high risk of non-healing should include details of patient selection, fracture site, and risk factors and comorbidities that delay fracture healing.

Recommendation ID IPG622/1 Question Further research in low-intensity pulsed ultrasound to promote healing of fresh fractures at high risk

Research recommendation Published December 2018

Managing glioma: management of IDH wildtype grade II glioma:- Does the addition of concurrent and adjuvant temozolomide to radiotherapy improve overall survival in patients with IDH wildtype grade II glioma?

Recommendation ID NG99/1 Question Managing glioma: management of IDH wildtype grade II glioma:- Does the addition of concurrent and adjuvant

Research recommendation Published December 2018

Managing glioma: early referral to palliative care for glioblastoma:- Does early referral to palliative care improve outcomes for people with glioblastomas in comparison with standard oncology care?

Recommendation ID NG99/3 Question Managing glioma: early referral to palliative care for glioblastoma:- Does early referral to palliative

Research recommendation Published December 2018

Managing glioma: early detection of recurrence after treatment:- Does early detection of recurrence after treatment improve overall survival/outcomes inmolecularly stratified glioma?

Recommendation ID NG99/4 Question Managing glioma: early detection of recurrence after treatment:- Does early detection of recurrence after

Research recommendation Published December 2018

Managing glioma: supportive care clinics for low-grade glioma:- Does a dedicated supportive care clinic in addition to standard care improve outcomes for people with low-grade gliomas?

Recommendation ID NG99/2 Question Managing glioma: supportive care clinics for low-grade glioma:- Does a dedicated supportive care clinic

Research recommendation Published December 2018

Hearing loss prevalence in people who under-present for hearing loss:- What is the prevalence of hearing loss among populations who under-present for possible hearingloss?

Recommendation ID NG98/4 Question Hearing loss prevalence in people who under-present for hearing loss:- What is the prevalence of hearing

Research recommendation Published December 2018

Idiopathic sudden sensorineural hearing loss:- What is the most effective route of administration of steroids as a first-line treatment for idiopathic sudden sensorineural hearing loss?

Recommendation ID NG98/1 Question Idiopathic sudden sensorineural hearing loss:- What is the most effective route of administration of steroids

Research recommendation Published December 2018

Case management:- What is the effectiveness and cost effectiveness of high-intensity case management compared with usual care on quality of life (for the person living with dementia and for their carers) and the timing of entry to long-term care?

Recommendation ID NG97/1 Question Case management:- What is the effectiveness and cost effectiveness of high-intensity case management compared

Research recommendation Published December 2018

Staff training:- What is the cost effectiveness of using a dementia-specific addition to the Care Certificate for community staff, including dementia-specific elements on managing anxiety, communication, nutritional status and personal care?

Recommendation ID NG97/2 Question Staff training:- What is the cost effectiveness of using a dementia-specific addition to the Care Certificate

Research recommendation Published December 2018

Monitoring and follow-up for adults with hearing loss:- What is the clinical and cost effectiveness of monitoring and follow-up for adults with hearing loss post-intervention compared with usual care?

Recommendation ID NG98/5 Question Monitoring and follow-up for adults with hearing loss:- What is the clinical and cost effectiveness of

Research recommendation Published December 2018

Earwax:- What is the clinical and cost effectiveness of microsuction compared with irrigation to remove earwax?

Recommendation ID NG98/2 Question Earwax:- What is the clinical and cost effectiveness of microsuction compared with irrigation to remove earwax

Research recommendation Published December 2018

Care and support planning:- What are the most effective methods of care planning for people who do not have regular contact with an informal carer?

Recommendation ID NG97/5 Question Care and support planning:- What are the most effective methods of care planning for people who do not

Research recommendation Published December 2018

Managing delirium superimposed on dementia:- What are the most clinically and cost-effective non-pharmacological interventions for helping the long-term recovery of people with delirium superimposed on dementia?

Recommendation ID NG97/4 Question Managing delirium superimposed on dementia:- What are the most clinically and cost-effective non-pharmacological

Research recommendation Published December 2018

Use of hearing aids and incidence of dementia:- In adults with hearing loss, does the use of hearing aids reduce the incidence of dementia?

Recommendation ID NG98/3 Question Use of hearing aids and incidence of dementia:- In adults with hearing loss, does the use of hearing aids

Research recommendation Published December 2018

Further research on endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused by cancer should address: patient selection, relief of biliary obstruction, quality of life and survival.

Recommendation ID IPG614/1 Question Further research on endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused

Research recommendation Published December 2018

Anticholinergic burden:- Does actively reducing anticholinergic burden in people living with dementia improve cognitive outcomes compared with usual care?

Recommendation ID NG72/3 Question Anticholinergic burden:- Does actively reducing anticholinergic burden in people living with dementia

Research recommendation Published December 2018

Models of care and support at home:- What is the effectiveness and cost effectiveness of care and support models (for example, assistive technology) for people growing older with learning disabilities to enable them to live in the family home?

Recommendation ID NG96/1 Question Models of care and support at home:- What is the effectiveness and cost effectiveness of care and support

Research recommendation Published November 2018

Seroprevalence of Lyme disease-specific antibodies and other tick-borne infections in the UK population:- What is the current seroprevalence of Lyme disease-specific antibodies and other tick-borne infections in people in the UK?

Recommendation ID NG95/3 Question Seroprevalence of Lyme disease-specific antibodies and other tick-borne infections in the UK population:- What

Research recommendation Published November 2018

Antimicrobial management of Lyme disease:- What are the most clinically and cost-effective treatment options for different clinical presentations of Lyme disease in the UK?

Recommendation ID NG95/4 Question Antimicrobial management of Lyme disease:- What are the most clinically and cost-effective treatment options

Research recommendation Published November 2018

Remote decision-support technologies:- Are paramedic remote decision-support technologies clinically and cost effective? [See the evidence review on paramedic remote support.]

Recommendation ID NG94/7 Question Remote decision-support technologies:- Are paramedic remote decision-support technologies clinically and

Research recommendation Published November 2018

Further research is needed to understand the effect of having the additional information provided by the adjunctive colposcopy technologies on anxiety for people having a colposcopy, when this information is shown to a person during the examination.

Recommendation ID DG32/3 Question Further research is needed to understand the effect of having the additional information provided by the

Research recommendation Published November 2018

Core outcome set for studies of management of Lyme disease:- Can a core outcome set be developed for clinical trials of management of Lyme disease?

Recommendation ID NG95/1 Question Core outcome set for studies of management of Lyme disease:- Can a core outcome set be developed for clinical

Research recommendation Published November 2018

Clinical epidemiology of Lyme disease in the UK:- What are the incidence, presenting features, management and outcome of Lyme disease in the UK?

Recommendation ID NG95/2 Question Clinical epidemiology of Lyme disease in the UK:- What are the incidence, presenting features, management

Research recommendation Published November 2018

The committee recommended that further research is needed to better understand the natural history of low-volume cervical intraepithelial neoplasia (CIN) 2 lesions.

Recommendation ID DG32/4 Question The committee recommended that further research is needed to better understand the natural history of

Research recommendation Published November 2018

The  committee recommended that data should be collected to show how the results of the technologies affect decision-making, including biopsy decisions and decisions todischarge people with a negative colposcopy examination back to routine screening.

Recommendation ID DG32/2 Question The committee recommended that data should be collected to show how the results of the technologies affect

Research recommendation Published November 2018

NICE encourages further research into microinvasive subconjunctival insertion of a trans-scleral gelatin stent for primary open-angle glaucoma, including randomised studies. Further research should include details of patient selection and long-term outcomes.

Recommendation ID IPG612/1 Question NICE encourages further research into microinvasive subconjunctival insertion of a trans-scleral gelatin

Research recommendation Published November 2018

Digital media:- How effective and cost effective are stop smoking interventions delivered using web-basedpackages or apps?

Recommendation ID NG92/1 Question Digital media:- How effective and cost effective are stop smoking interventions delivered using web-basedpackages

Research recommendation Published November 2018

Changes to public open spaces:- How effective and cost effective are environmental changes to public open spaces (including blue, green and grey spaces) in creating and sustaining an increase in physical activity at a population level?

Recommendation ID NG90/2 Question Changes to public open spaces:- How effective and cost effective are environmental changes to public open

Research recommendation Published November 2018

Public transport provision and ticketing:- How effective and cost effective are changes to public transport provision and ticketing in creating and sustaining an increase in physical activity at a population level?

Recommendation ID NG90/1 Question Public transport provision and ticketing:- How effective and cost effective are changes to public transport

Research recommendation Published November 2018

Reducing car ownership:- Does reducing car use or ownership change physical activity levels? Are effects maintained over time?

Recommendation ID NG90/5 Question Reducing car ownership:- Does reducing car use or ownership change physical activity levels? Are effects

Research recommendation Published November 2018

Supporting family members, carers and staff:- What types of services or approaches are effective in supporting family members, carers and staffto be resilient and able to provide care and support to people with a learning disability and behaviour that challenges?

Recommendation ID NG93/2 Question Supporting family members, carers and staff:- What types of services or approaches are effective in supporting

Research recommendation Published November 2018