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  1. Pulmonary rehabilitation during hospital admission:- In people with COPD, does pulmonary rehabilitation during hospital admission for exacerbation and/or in the early recovery period (within 1 month of an exacerbation) improve quality of life and reduce hospitalisations and exacerbations compared with a later (defined as after 1 month)pulmonary rehabilitation programme, and in which groups is it most clinically and cost effective?

    Recommendation ID NG115/1 Question Pulmonary rehabilitation during hospital admission:- In people with COPD, does pulmonary rehabilitation

  2. Multidimensional assessment of outcomes- How can the individual factors associated with COPD prognosis (collected from a range of sources including primary care, imaging and pulmonary rehabilitation results) be combined into a multidimensional analysis that provides accurate and useful information on prognosis?

    Recommendation ID NG115/2 Question Multidimensional assessment of outcomes- How can the individual factors associated with COPD prognosis

  3. Risk tools for predicting non-sudden death in heart failure:- What is the most accurate prognostic risk tool in predicting 1-year mortality from heart failure at specific clinically relevant thresholds (for example, sensitivity, specificity, negative predictive value and positive predictive value at a threshold of 50% risk of mortality at 1 year)?

    Recommendation ID NG106/5 Question Risk tools for predicting non-sudden death in heart failure:- What is the most accurate prognostic risk

  4. Training and support for practitioners:- What is the effectiveness and cost effectiveness of different training programmes on the Mental Capacity Act 2005 at improving practice for practitioners involved in supporting decision-making, conducting capacity assessments and making best interests decisions?

    Recommendation ID NG108/1 Question Training and support for practitioners:- What is the effectiveness and cost effectiveness of different

  5. Targeted interventions to support and improve decision-making capacity for treatment:- What is the effectiveness and cost effectiveness of different targeted interventions (speech and language therapy and psychological and psychosocial interventions) to support and improve decision-making capacity for treatment in specific groups?

    Recommendation ID NG108/2 Question Targeted interventions to support and improve decision-making capacity for treatment:- What is the effectiveness

  6. Further research on selective internal radiation therapy (SIRT) for unresectable primary intrahepatic cholangiocarcinoma in the form of prospective studies, including randomised controlled trials, should address patient selection, quality-of-life outcomes and overall survival. Patient selection for the research studies should be done by amultidisciplinary team. The procedure should only be done in specialist centres by clinicians trained and experienced in managing cholangiocarcinoma.

    Recommendation ID IPG630/1 Question Further research on selective internal radiation therapy (SIRT) for unresectable primary intrahepatic

  7. Diagnosis of chronic pancreatitis:- In people with suspected (or under investigation for) chronic pancreatitis, whose diagnosis has not been confirmed by the use of 'first-line' tests (for example, CT scan, ultrasound scan, upper gastrointestinal [GI] endoscopy or combinations of these), what is the accuracy of magnetic resonance cholangiopancreatography (MRCP) with or without secretin and endoscopic ultrasound to identify whether chronic pancreatitis is present?

    Recommendation ID NG104/1 Question Diagnosis of chronic pancreatitis:- In people with suspected (or under investigation for) chronic pancreatitis

  8. Further research in people who could have conventional cardiac pacemaker implantation should report the patient selection criteria and compare leadless pacemakers with conventional pacemakers. Follow-up should be for at least 5 years and outcomes should include adverse events, symptom relief, quality of life and device durability in the long-term.

    Recommendation ID IPG626/1 Question Further research in people who could have conventional cardiac pacemaker implantation should report

  9. NICE encourages further research into intravesical microwave hyperthermia and chemotherapy for non-muscle-invasive bladder cancer. Research should include randomised controlled trials, which stratify patients by risk and give adequate follow-up. They should report frequency of adverse events, patientreported outcome measures, overall and disease-free survival and quality of life.

    Recommendation ID IPG628/1 Question NICE encourages further research into intravesical microwave hyperthermia and chemotherapy for non-muscle-invasive

  10. Patient activation:- How effective and cost effective is advice, education or behavioural support offered by community pharmacy teams to improve patient activation and measures of behaviour and health changes, particularly in areas where activation levels are lower? This includes evaluating factors such as frequency, intensity and duration of the intervention.

    Recommendation ID NG102/5 Question Patient activation:- How effective and cost effective is advice, education or behavioural support offered

  11. Characteristics of a person delivering an intervention:- How do the professional characteristics of pharmacy staff affect the effectiveness and cost effectiveness of delivering information, advice, education or behavioural support to underserved groups and the general population? (Characteristics include, for example, job roles such as health champion, as well as competencies and level of training.)

    Recommendation ID NG102/4 Question Characteristics of a person delivering an intervention:- How do the professional characteristics of