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Stopping preventive medicines:- What is the clinical and cost effectiveness of stopping preventive medicines in people with multimorbidity who may not benefit from continuing them?

Recommendation ID NG56/3 Question Stopping preventive medicines:- What is the clinical and cost effectiveness of stopping preventive medicines

Research recommendation Published October 2016

Standard principles of infection prevention and control:- What are the barriers to compliance with the standard principles of infection prevention and control that patients and carers experience in their own homes?

Recommendation ID CG139/1 Question Standard principles of infection prevention and control:- What are the barriers to compliance with the

Research recommendation Published June 2015

Studies exploring the effectiveness of bevacizumab in people previously treated with a taxane and its effects on health-related quality of life.

Recommendation ID TA263/1 Question Studies exploring the effectiveness of bevacizumab in people previously treated with a taxane and its

Research recommendation Published June 2015

Subsequent health assessment:- When should subsequent health assessments be carried out in prison for people serving long-term sentences?

Recommendation ID NG57/1 Question Subsequent health assessment:- When should subsequent health assessments be carried out in prison for

Research recommendation Published February 2017

Supporting people in care homes to stay active:- What is the most effective and cost-effective way of supporting older people with social care needs and multiple long-term conditions in care homes to live as independently as possible?

Recommendation ID NG22/3 Question Supporting people in care homes to stay active:- What is the most effective and cost-effective way of

Research recommendation Published December 2015

Does the provision of educational and supportive interventions to people with chronic kidney disease (CKD) by healthcare professionals increase patients' skills and confidence in managing their conditions and improve clinical outcomes?

Recommendation ID CG182/1 Question Does the provision of educational and supportive interventions to people with chronic kidney disease

Research recommendation Published June 2015

Recognition and early management of pain in children and young people with cerebral palsy:- Does use of pain assessment tools by parents or carers improve the recognition and early management of pain in children and young people with cerebral palsy in a community setting?

Recommendation ID NG62/3 Question Recognition and early management of pain in children and young people with cerebral palsy:- Does use of

Research recommendation Published February 2017

Effectiveness and costs of oral health interventions for care home residents:- How effective and cost effective are oral health interventions in care homes including suitableperson-centred outcome measures?

Recommendation ID NG48/2 Question Effectiveness and costs of oral health interventions for care home residents:- How effective and cost

Research recommendation Published August 2016

Effectiveness of 'rescue' cerclage:- What is the clinical effectiveness of 'rescue' cerclage in improving outcomes for women at risk of preterm birth?

Recommendation ID NG25/3 Question Effectiveness of 'rescue' cerclage:- What is the clinical effectiveness of 'rescue' cerclage in improving

Research recommendation Published December 2015

Effectiveness and cost effectiveness:- Are particular components of community engagement approaches more effective and cost effective at improving health and wellbeing and reducing health inequalities than other components?

Recommendation ID NG44/1 Question Effectiveness and cost effectiveness:- Are particular components of community engagement approaches more

Research recommendation Published April 2016

Education and psycho-behavioural interventions for prevention:- What is the role of educational models and psycho-behavioural interventions in prevention of diabetic foot complications?

Recommendation ID NG19/3 Question Education and psycho-behavioural interventions for prevention:- What is the role of educational models

Research recommendation Published October 2015

Electronic Decision Support:- What is the clinical and cost effectiveness of an electronic decision support system compared with current practice in reducing inappropriate blood transfusions, overall rates of blood transfusion and mortality?

Recommendation ID NG24/2 Question Electronic Decision Support:- What is the clinical and cost effectiveness of an electronic decision support

Research recommendation Published December 2015

Early supported discharge in care home patients:- What is the clinical and cost effectiveness of early supported discharge on mortality, quality of life and functional status in patients with hip fracture who are admitted from a care home?

Recommendation ID CG124/5 Question Early supported discharge in care home patients:- What is the clinical and cost effectiveness of early

Research recommendation Published June 2015

Effects of HRT on dementia risk:- What are the effects of early HRT use on the risk of dementia?

Recommendation ID NG23/4 Question Effects of HRT on dementia risk:- What are the effects of early HRT use on the risk of dementia?

Research recommendation Published December 2015

Effects of HRT on venous thromboembolism risk:- How does the preparation of HRT affect the risk of venous thromboembolism (VTE)?

Recommendation ID NG23/3 Question Effects of HRT on venous thromboembolism risk:- How does the preparation of HRT affect the risk of venous

Research recommendation Published December 2015

Electronic media:- How does the use of electronic media affect harmful sexual behaviour?

Recommendation ID NG55/6 Question Electronic media:- How does the use of electronic media affect harmful sexual behaviour? Any explanatory

Research recommendation Published October 2016

Effective interventions for the families and carers of children and young people displaying harmful sexual behaviour:- What type of therapeutic interventions are effective when working with the family and carers of children and young people who display harmful sexual behaviour?

Recommendation ID NG55/3 Question Effective interventions for the families and carers of children and young people displaying harmful sexual

Research recommendation Published October 2016

Enteral nutrition support:- What specific clinical and non-clinical factors allow risk stratification when selecting which people with CUADT would benefit from short- or long-term enteral nutrition?

Recommendation ID NG36/4 Question Enteral nutrition support:- What specific clinical and non-clinical factors allow risk stratification

Research recommendation Published April 2016

Effectiveness and safety of magnesium carbonate in adults:- In adults with stage 4 or 5 chronic kidney disease (CKD), including those on dialysis, what is the long-term effectiveness and safety of magnesium carbonate in controlling serum phosphate?

Recommendation ID CG157/3 Question Effectiveness and safety of magnesium carbonate in adults:- In adults with stage 4 or 5 chronic kidney

Research recommendation Published June 2015

Epidemiological study on presentation and management of sepsis in England:- What is the incidence, presentation and management of sepsis in the United Kingdom?

Recommendation ID NG51/1 Question Epidemiological study on presentation and management of sepsis in England:- What is the incidence, presentation

Research recommendation Published August 2016

NICE recommends that research should be carried out to directly compare eltrombopag with non-thrombopoietin receptor agonist treatments routinely used in UK clinical practice.

Recommendation ID TA293/1 Question NICE recommends that research should be carried out to directly compare eltrombopag with non-thrombopoietin

Research recommendation Published June 2015

NICE recommended that clinical data, including genotype and sustained virological response at 12 weeks, is collected for all people treated with sofosbuvir in the NHS.

Recommendation ID TA330/1 Question NICE recommended that clinical data, including genotype and sustained virological response at 12 weeks

Research recommendation Published June 2015

NICE recommended further research to explore the impact of having experiences of patients having continuous infusion 5-FU and take into account the impact on quality of life. The potential consequences of introducing pharmacokinetic dose adjustment should also be explored.

Recommendation ID DG16/4 Question NICE recommended further research to explore the impact of having experiences of patients having continuous

Research recommendation Published June 2015

NICE recommends further research to understand the characteristics of patients at high risk of haemostatic instability in whom viscoelastometric testing may be most cost effective.

Recommendation ID DG13/5 Question NICE recommends further research to understand the characteristics of patients at high risk of haemostatic

Research recommendation Published June 2015

NICE recognised the importance of further clinical trials comparing the effectiveness of the tyrosine kinase inhibitors (afatinib, erlotinib and gefitinib) in EGFR mutation-positive locally advanced or metastatic NSCLC.

Recommendation ID TA310/1 Question NICE recognised the importance of further clinical trials comparing the effectiveness of the tyrosine

Research recommendation Published June 2015

Optimal dosage of intravenous insulin for managing diabetic ketoacidosis in children and young people:- What is the optimal dosage of intravenous insulin for managing diabetic ketoacidosis (DKA) in children and young people?

Recommendation ID NG18/5 Question Optimal dosage of intravenous insulin for managing diabetic ketoacidosis in children and young people:-

Research recommendation Published October 2015

Out-of-office monitoring: In adults with primary hypertension, does the use of out-of-office monitoring (home blood pressure monitoring-HBPM or ambulatory blood pressure monitoring-ABPM) improve response to treatment?

Recommendation ID CG127/1 Question Out-of-office monitoring: In adults with primary hypertension, does the use of out-of-office monitoring

Research recommendation Published June 2015

Parent training programmes for children aged 12 years and over with a conduct disorder:- What is the effectiveness of parent training programmes for conduct disorders in children and young people aged 12 years and over?

Recommendation ID CG158/1 Question Parent training programmes for children aged 12 years and over with a conduct disorder:- What is the

Research recommendation Published June 2015

NICE recommends that further research directly comparing the clinical and cost effectiveness of ranibizumab and bevacizumab in people with diabetic macular oedema should be conducted.

Recommendation ID TA274/1 Question NICE recommends that further research directly comparing the clinical and cost effectiveness of ranibizumab

Research recommendation Published June 2015

Nutrition:- Does a high calorific diet prolong survival of people with motor neurone disease (MND) if initiated following diagnosis or following initiation of feeding using a gastrostomy?

Recommendation ID NG42/5 Question Nutrition:- Does a high calorific diet prolong survival of people with motor neurone disease (MND) if

Research recommendation Published March 2016

NICE recommends that a study is conducted to generate robust evidence about the benefits of roflumilast as an add-on to LAMA plus LABA/ICS or LAMA plus LABA for those people who are intolerant to ICS.

Recommendation ID TA244/1 Question NICE recommends that a study is conducted to generate robust evidence about the benefits of roflumilast

Research recommendation Published June 2015

NICE recommends that future trials should include longer-term follow-up, beyond the initial hospital episode, with a view to informing the cost-effectiveness modelling and reducing uncertainty.

Recommendation ID DG13/4 Question NICE recommends that future trials should include longer-term follow-up, beyond the initial hospital episode

Research recommendation Published June 2015

Non-vitamin K antagonist oral anticoagulants:- Do people with atrial fibrillation whose anticoagulant control is poor, or is predicted to be poor, with warfarin benefit from changing to one of the non-vitamin K antagonist (non-VKA) oral anticoagulants?

Recommendation ID CG180/4 Question Non-vitamin K antagonist oral anticoagulants:- Do people with atrial fibrillation whose anticoagulant

Research recommendation Published June 2015