Updating results

Carbon monoxide monitoring:- What is the validity of different thresholds of carbon monoxide in exhaled breath as markers of quitting, based on diagnostic review and modelling?

Recommendation ID NG92/2 Question Carbon monoxide monitoring:- What is the validity of different thresholds of carbon monoxide in exhaled

Research recommendation Published November 2018

Models of supported living:- What is the effectiveness and cost effectiveness of models of shared, supported living, such as Shared Lives?What are the views and experiences of people sharing their home and people who live with themunder programmes such as Shared Lives?

Recommendation ID NG93/3 Question Models of supported living:- What is the effectiveness and cost effectiveness of models of shared, supported

Research recommendation Published November 2018

Interaction between behavioural and environmental interventions:- What is the effectiveness and cost effectiveness of interventions to change the environment alone, compared with interventions to change the environment that are supported by interventions to change people's behaviour?

Recommendation ID NG90/6 Question Interaction between behavioural and environmental interventions:- What is the effectiveness and cost effectiveness

Research recommendation Published November 2018

Duration of prophylaxis for elective total hip replacement surgery:- What is the clinical and cost effectiveness of standard versus extended duration pharmacological prophylaxis for preventing VTE in people undergoing elective total hip replacement surgery?

Recommendation ID NG89/5 Question Duration of prophylaxis for elective total hip replacement surgery:- What is the clinical and cost effectiveness

Research recommendation Published November 2018

Direct oral anticoagulants for people with lower limb immobilisation:- What is the clinical and cost effectiveness of direct oral anticoagulants for preventing VTE in people with lower limb immobilisation?

Recommendation ID NG89/3 Question Direct oral anticoagulants for people with lower limb immobilisation:- What is the clinical and cost effectiveness

Research recommendation Published November 2018

Risk assessment:- What is the accuracy of individual risk assessment tools in predicting the risk of venousthromboembolism (VTE) and risk of bleeding in people admitted to hospital?

Recommendation ID NG89/1 Question Risk assessment:- What is the accuracy of individual risk assessment tools in predicting the risk of

Research recommendation Published November 2018

Standardised criteria for hospital discharge:- Are standardised criteria for hospital discharge clinically and cost effective in specific medical emergencies? [See the evidence review on standardised discharge criteria.]

Recommendation ID NG94/14 Question Standardised criteria for hospital discharge:- Are standardised criteria for hospital discharge clinically

Research recommendation Published November 2018

Specialised units for older people:- What is the most clinically and cost effective way to configure services to assess frail older people who present to hospital with a medical emergency?

Recommendation ID NG94/4 Question Specialised units for older people:- What is the most clinically and cost effective way to configure services

Research recommendation Published November 2018

Extended access to social care services:- What is the clinical and cost effectiveness of providing extended access to social care services, for example during early mornings and evenings, and 7 days a week?

Recommendation ID NG94/2 Question Extended access to social care services:- What is the clinical and cost effectiveness of providing extended

Research recommendation Published November 2018

Primary care-led assessment models:- Which primary care-led models of assessment of people with a suspected medical emergency in the community, such as GP home visits, are most clinically and cost effective? [See the evidence review on GP-led home visits.]

Recommendation ID NG94/8 Question Primary care-led assessment models:- Which primary care-led models of assessment of people with a suspected

Research recommendation Published November 2018

Hospital escalation policies:- Which components of a hospital escalation policy to deal with surges in demand are the most clinically and cost effective? [See the evidence review on escalation measures.]

Recommendation ID NG94/17 Question Hospital escalation policies:- Which components of a hospital escalation policy to deal with surges in

Research recommendation Published November 2018

'Physician extenders':- What is the clinical and cost effectiveness of providing 'physician extenders' such as advanced nurse practitioners, 'physician associates' and advanced clinical practitioners in secondary care?[See the evidence review on physician extenders.]

Recommendation ID NG94/15 Question 'Physician extenders':- What is the clinical and cost effectiveness of providing 'physician extenders'

Research recommendation Published November 2018

Same-day plain X-ray radiology or ultrasound:- What is the clinical and cost effectiveness of providing GPs with access to plain X-ray radiology or ultrasound with same-day results? [See the evidence review on GP access to radiology.]

Recommendation ID NG94/9 Question Same-day plain X-ray radiology or ultrasound:- What is the clinical and cost effectiveness of providing

Research recommendation Published November 2018

Extended access to community nursing:- What is the clinical and cost effectiveness of providing extended access to community nursing, for example during evenings and weekends? [See the evidence review on community nursing.]

Recommendation ID NG94/10 Question Extended access to community nursing:- What is the clinical and cost effectiveness of providing extended

Research recommendation Published November 2018

GPs located in or near emergency departments:- What is the clinical and cost effectiveness of having GPs within or adjoining emergency departments?

Recommendation ID NG94/3 Question GPs located in or near emergency departments:- What is the clinical and cost effectiveness of having GPs

Research recommendation Published November 2018

Integrated patient information systems:- What is the clinical and cost effectiveness of different methods for integrating patient information throughout the emergency medical care pathway?

Recommendation ID NG94/5 Question Integrated patient information systems:- What is the clinical and cost effectiveness of different methods

Research recommendation Published November 2018

Extended access to GP services:- Is extended access to GP services, for example during early mornings, evenings and weekends, more clinically and cost effective than standard access?

Recommendation ID NG94/1 Question Extended access to GP services:- Is extended access to GP services, for example during early mornings

Research recommendation Published November 2018

Co-producing research into the views and experiences of people who use services:- What approaches have been shown to work in supporting the co-production of research for the purposes of service improvement with people who use services?

Recommendation ID NG86/2 Question Co-producing research into the views and experiences of people who use services:- What approaches have

Research recommendation Published November 2018

Cachexia interventions: - A cohort study followed by phase II and III studies should be undertaken in people with pancreatic cancer and cachexia or pre-cachexia, to compare cachexia assessment methods and anti-cachexia interventions with standard care.

Recommendation ID NG85/2 Question Cachexia interventions: - A cohort study followed by phase II and III studies should be undertaken in

Research recommendation Published November 2018

Long-term outcomes of pharmacological and uterine-sparing surgical treatments for HMB associated with adenomyosis:- What are the long-term clinical outcomes of pharmacological and uterine-sparing surgical treatments in women with HMB associated with adenomyosis?

Recommendation ID NG88/3 Question Long-term outcomes of pharmacological and uterine-sparing surgical treatments for HMB associated with

Research recommendation Published November 2018

Prescribing beyond monotherapy:- What is the clinical and cost effectiveness of various ADHD prescribing strategies when monotherapy has failed?

Recommendation ID NG87/4 Question Prescribing beyond monotherapy:- What is the clinical and cost effectiveness of various ADHD prescribing

Research recommendation Published November 2018

Medication choice in people with no previous medication for ADHD:- What is the clinical and cost effectiveness of ADHD medications in people with ADHD with noprevious medication for the condition?

Recommendation ID NG87/3 Question Medication choice in people with no previous medication for ADHD:- What is the clinical and cost effectiveness

Research recommendation Published November 2018

Medication choice in people with coexisting conditions:- What is the clinical and cost effectiveness of ADHD medications in people with ADHD and tic disorders, a history of psychosis or mania, or personality disorder?

Recommendation ID NG87/2 Question Medication choice in people with coexisting conditions:- What is the clinical and cost effectiveness of

Research recommendation Published November 2018

Hysteroscopic removal of submucosal fibroids compared with other uterine-sparing treatments for HMB:- Is hysteroscopic removal of submucosal fibroids more effective and cost-effective than other uterine-sparing treatments for the management of HMB?

Recommendation ID NG88/4 Question Hysteroscopic removal of submucosal fibroids compared with other uterine-sparing treatments for HMB:- Is

Research recommendation Published November 2018

Effectiveness of the progestogen-only pill, injectable progestogens, or progestogen implants in alleviating HMB:- How effective are the progestogen-only pill, injectable progestogens or progestogen implants in alleviating HMB?

Recommendation ID NG88/2 Question Effectiveness of the progestogen-only pill, injectable progestogens, or progestogen implants in alleviating

Research recommendation Published November 2018

Further research on laparoscopic mesh pectopexy for apical prolapse of the uterus or vagina should include details of patient selection and long-term outcomes.

Recommendation ID IPG608/1 Question Further research on laparoscopic mesh pectopexy for apical prolapse of the uterus or vagina should include

Research recommendation Published November 2018

Use of technology in providing care- What are the views and experiences of people who use adult social care services on assistive technologies?

Recommendation ID NG86/4 Question Use of technology in providing care- What are the views and experiences of people who use adult social

Research recommendation Published November 2018

Psychological support needs:- A qualitative study should be undertaken to evaluate information and support interventions to address psychological needs at different points in the care pathway for people with pancreatic cancer.

Recommendation ID NG85/5 Question Psychological support needs:- A qualitative study should be undertaken to evaluate information and support

Research recommendation Published November 2018

Neoadjuvant therapy:- Prospective randomised trials should be undertaken to compare preoperative (neoadjuvant) therapy with standard postoperative therapy in people with resectable pancreatic cancer.

Recommendation ID NG85/1 Question Neoadjuvant therapy:- Prospective randomised trials should be undertaken to compare preoperative (neoadjuvant)...

Research recommendation Published November 2018

Further research on unilateral MRI-guided focused ultrasound thalamotomy for moderate to severe tremor in Parkinson's disease, which could include randomised controlled trials, should address patient selection and report on long-term follow-up.

Recommendation ID IPG606/1 Question Further research on unilateral MRI-guided focused ultrasound thalamotomy for moderate to severe tremor

Research recommendation Published November 2018

Further research on aortic valve reconstruction with processed bovine pericardium should address patient selection and report long-term outcomes, particularly the durability of the valve.

Recommendation ID IPG604/1 Question Further research on aortic valve reconstruction with processed bovine pericardium should address patient

Research recommendation Published November 2018

Strategies to slow the progression of age-related macular degeneration (AMD):- What is the effectiveness of antioxidant and zinc supplements on AMD disease progression for people with early AMD at high risk of progression in the context of a randomised controlled trial?

Recommendation ID NG82/1 Question Strategies to slow the progression of age-related macular degeneration (AMD):- What is the effectiveness

Research recommendation Published November 2018

Stopping rules for antiangiogenic treatment for late AMD (wet):- When should anti-vascular endothelial growth factor (VEGF) treatment be suspended or stoppedin people with late AMD (wet)?

Recommendation ID NG82/3 Question Stopping rules for antiangiogenic treatment for late AMD (wet):- When should anti-vascular endothelial

Research recommendation Published November 2018

Self-monitoring strategies:- Does earlier detection of the incidence of late AMD (wet active) by self-monitoring in people diagnosed with early AMD, indeterminate AMD or late AMD (dry) lead to earlier treatment and better long-term outcomes?

Recommendation ID NG82/5 Question Self-monitoring strategies:- Does earlier detection of the incidence of late AMD (wet active) by self-monitoring

Research recommendation Published November 2018

Radical treatment of T1bN0 adenocarcinoma of the oesophagus:- What is the optimal treatment for T1bN0 adenocarcinoma of the oesophagus?

Recommendation ID NG83/2 Question Radical treatment of T1bN0 adenocarcinoma of the oesophagus:- What is the optimal treatment for T1bN0

Research recommendation Published November 2018