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  1. Management of poor prognosis:- What is the clinical and cost effectiveness of managing RA with a poor prognosis (identified as presence of anti-cyclic citrullinated peptide [CCP] antibodies or evidence of erosions on X-ray at diagnosis) with a different strategy from that used for standard management of RA?

    Recommendation ID NG100/5 Question Management of poor prognosis:- What is the clinical and cost effectiveness of managing RA with a poor

  2. Further research on the routine adoption of Actim Partus and PartoSure to help diagnose preterm labour in women with intact membranes when transvaginal ultrasound measurement of cervical length is needed on the accuracy of the tests and their effect on clinical outcomes. Centres using the tests to help diagnose preterm labour in women with intact membranes are encouraged to take part in studies to address the research considerations (see the guidance sections 5.12 to 5.16). Data are needed on:- the impact of gestational age on the accuracy of the tests- how the tests affect clinical decision-making- the effect of the tests on outcomes for mother and baby

    Recommendation ID DG33/1 Question Further research on the routine adoption of Actim Partus and PartoSure to help diagnose preterm labour

  3. NICE encourages the peer-reviewed publication of all further research for percutaneous balloon valvuloplasty for fetal critical aortic stenosis. Further research could be in the form of controlled trials, analysis of registry data or other observational studies. It should address patient selection, timing of the intervention and the natural history of the disease.

    Recommendation ID IPG613/1 Question NICE encourages the peer-reviewed publication of all further research for percutaneous balloon valvuloplasty

  4. Further research on the efficacy and safety of intranasal phototherapy for allergic rhinitis should include: details of patient selection including medication use; underlying medical conditions; the intensity, duration and wavelength of light used; patient-reported outcomes; comparison with existing treatments; and the effects of repeated long-term use. NICE may update the guidance if further evidence is published.

    Recommendation ID IPG616/1 Question Further research on the efficacy and safety of intranasal phototherapy for allergic rhinitis should

  5. Further research on the safety of unilateral MRI-guided focused ultrasound thalamotomy for treatment-resistant essential tremor, which could include randomised controlled trials, should address patient selection, report on functional improvement and quality of life, and provide long-term follow-up data.

    Recommendation ID IPG617/1 Question Further research on the safety of unilateral MRI-guided focused ultrasound thalamotomy for treatment-resistant

  6. Advance planning about end of life care:- What is the effectiveness and cost effectiveness of advance care planning for end of life care for people growing older with learning disabilities, and their family members and carers?What processes are in place to document and follow the wishes of people growing older with learning disabilities about their decisions on end of life care?

    Recommendation ID NG96/5 Question Advance planning about end of life care:- What is the effectiveness and cost effectiveness of advance

  7. Identifying health conditions:- What is the effectiveness and cost effectiveness of different ways of identifying age-related and other physical and mental health conditions, in people growing older with learning disabilities?What can mainstream and specialist health services do to facilitate:- early identification of health conditions in people with learning disabilities?- equal access to health services in people with learning disabilities?

    Recommendation ID NG96/2 Question Identifying health conditions:- What is the effectiveness and cost effectiveness of different ways of

  8. Education and training programmes: self-management:- What is the effectiveness and cost effectiveness of education programmes to improve information and advice and to support self-management of chronic health conditions (for example, obesity, diabetes and cardiovascular disease) for people growing older with learning disabilities, and their family members and carers?

    Recommendation ID NG96/3 Question Education and training programmes: self-management:- What is the effectiveness and cost effectiveness

  9. Dementia education and training programmes for family members and carers:- What is the effectiveness, cost effectiveness and acceptability of training programmes (forexample, in the use of life story work) for families of people growing older with learning disabilities who have dementia or are at risk of developing it?

    Recommendation ID NG96/4 Question Dementia education and training programmes for family members and carers:- What is the effectiveness

  10. Laboratory tests to diagnose initial and ongoing infection and determine re-infection in the different presentations of Lyme disease in the UK:- What is the most clinically and cost-effective serological antibody-based test, biomarker or other test for diagnosing Lyme disease in the UK at all stages, including re-infection?

    Recommendation ID NG95/5 Question Laboratory tests to diagnose initial and ongoing infection and determine re-infection in the different

  11. The committee recommended that further studies should be done in a HPV primary screening setting. These studies should incorporate clinical outcome data and be designed to minimise verification bias. Future studies should consider measuring variability and should also take into account HPV genotyping status when possible, so that the difference in accuracy in a population vaccinated against HPV types 16 and 18 can be better understood.

    Recommendation ID DG32/1 Question The committee recommended that further studies should be done in a HPV primary screening setting. These studies

  12. Further research on robot-assisted kidney transplant should include studies comparing robot-assisted kidney transplant with open surgery. This should collect data on patient selection, warm ischaemia times, the need for conversion to open surgery, graft function, and long-term graft and patient survival.

    Recommendation ID IPG609/1 Question Further research on robot-assisted kidney transplant should include studies comparing robot-assisted