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Identifying infection in women with preterm prelabour rupture of membranes (P-PROM):- What is the diagnostic accuracy of serial C-reactive protein testing to identify chorioamnionitis in women with P-PROM?

Recommendation ID NG25/2 Question Identifying infection in women with preterm prelabour rupture of membranes (P-PROM):- What is the diagnostic

Research recommendation Published December 2015

Image guidance in the reduction of displaced distal radius fractures:- For patients with displaced fractures of the distal radius, is manipulation with real-time image guidance more clinically and cost effective than manipulation without real-time image guidance?

Recommendation ID NG38/3 Question Image guidance in the reduction of displaced distal radius fractures:- For patients with displaced fractures

Research recommendation Published March 2016

Ideally roflumilast should be compared with theophylline in those people for whom theophylline would be suitable.

Recommendation ID TA244/2 Question Ideally roflumilast should be compared with theophylline in those people for whom theophylline would

Research recommendation Published June 2015

Impact of drug-related adverse effects on cost effectiveness and quality of life:- What is the impact of drug-related adverse effects on health economics and quality of life in neuropathic pain?

Recommendation ID CG173/5 Question Impact of drug-related adverse effects on cost effectiveness and quality of life:- What is the impact

Research recommendation Published June 2015

Individual versus group CBT for children and young people with social anxiety disorder:- What is the clinical and cost effectiveness of individual and group CBT for children and young people with social anxiety disorder?

Recommendation ID CG159/4 Question Individual versus group CBT for children and young people with social anxiety disorder:- What is the

Research recommendation Published June 2015

Improving rates of identification and referral of potential donors:- What are the key components of an intervention to improve identification and referral rates?

Recommendation ID CG135/3 Question Improving rates of identification and referral of potential donors:- What are the key components of an

Research recommendation Published June 2015

In moderate- to high-severity community-acquired pneumonia does using legionella and pneumococcal urinary antigen testing in addition to other routine tests improve outcomes?

Recommendation ID CG191/1 Question In moderate- to high-severity community-acquired pneumonia does using legionella and pneumococcal urinary

Research recommendation Published June 2015

In people who have had a STEMI who undergo primary PCI with a bare-metal stent, and 4 weeks of aspirin and clopidogrel, is there an additional benefit to continuing clopidogrel for a further 11 months?

Recommendation ID CG172/5 Question In people who have had a STEMI who undergo primary PCI with a bare-metal stent, and 4 weeks of aspirin

Research recommendation Published June 2015

For people with alcohol dependence, which medication is most likely to improve adherence and thereby promote abstinence and prevent relapse?

Recommendation ID CG115/6 Question For people with alcohol dependence, which medication is most likely to improve adherence and thereby

Research recommendation Published June 2015

Facilitated self-help for anxiety and depression in adults with autism:- What is the clinical and cost effectiveness of facilitated self-help for the treatment of mild anxiety and depressive disorders in adults with autism?

Recommendation ID CG142/1 Question Facilitated self-help for anxiety and depression in adults with autism:- What is the clinical and cost

Research recommendation Published June 2015

Factors affecting participation and quality of life:- What are the key factors, including additional care and support, that influence participation and quality of life in people with neuropathic pain?

Recommendation ID CG173/4 Question Factors affecting participation and quality of life:- What are the key factors, including additional

Research recommendation Published June 2015

For people with moderate and severe alcohol dependence who have significant comorbid problems, is an intensive residential rehabilitation programme clinically and cost effective when compared with intensive community-based care?

Recommendation ID CG115/5 Question For people with moderate and severe alcohol dependence who have significant comorbid problems, is an

Research recommendation Published June 2015

Follow-up after completion of oncological treatment:- Strategies to integrate oncological surveillance with optimising quality of life, reducing late effects, and detecting second cancers in survivors of colorectal cancer should be developed and explored.

Recommendation ID CG131/4 Question Follow-up after completion of oncological treatment:- Strategies to integrate oncological surveillance

Research recommendation Published June 2015

Evaluation frameworks and logic models:- Which evaluation frameworks and logic models can be used to evaluate the impact of community engagement on health and wellbeing?

Recommendation ID NG44/2 Question Evaluation frameworks and logic models:- Which evaluation frameworks and logic models can be used to evaluate

Research recommendation Published April 2016

Factors that influence older people's mental wellbeing:- In the UK, which factors or processes in an intervention influence older people's mental wellbeing?How do these factors interact with one another and does the importance differ for different groups?

Recommendation ID NG32/5 Question Factors that influence older people's mental wellbeing:- In the UK, which factors or processes in an intervention

Research recommendation Published January 2016

Epidurals:- What is the clinical and cost effectiveness of image-guided compared with non-image-guided epidural injections for people with acute sciatica?

Recommendation ID NG59/4 Question Epidurals:- What is the clinical and cost effectiveness of image-guided compared with non-image-guided

Research recommendation Published February 2017

Frequency of monitoring:- What is the effectiveness of more frequent monitoring compared with monitoring at 12 months after diagnosis in people with newly diagnosed coeliac disease?

Recommendation ID NG20/5 Question Frequency of monitoring:- What is the effectiveness of more frequent monitoring compared with monitoring

Research recommendation Published October 2015

FRAX and QFracture in adults receiving bone protective therapy:- What is the utility of FRAX and QFracture in adults receiving bone protective therapy?

Recommendation ID CG146/2 Question FRAX and QFracture in adults receiving bone protective therapy:- What is the utility of FRAX and QFracture

Research recommendation Published June 2015

For people with generalised anxiety disorder (GAD) who are ready to start a low-intensity intervention, what is the clinical effectiveness of physical activity compared with waiting-list control?

Recommendation ID CG113/3 Question For people with generalised anxiety disorder (GAD) who are ready to start a low-intensity intervention

Research recommendation Published June 2015

Further collection of quality of life data from people who are cured and who have experience of amputation and chemotherapy are also needed. Additional data on the health effects on parents, siblings and others with life-threatening illness would also be of value.

Recommendation ID TA235/2 Question Further collection of quality of life data from people who are cured and who have experience of amputation

Research recommendation Published June 2015

Further research designed to investigate differences in health-related quality of life and the clinical effectiveness of bevacizumab in subgroups, such as those with prior taxane exposure, would be particularly useful.

Recommendation ID TA214/1 Question Further research designed to investigate differences in health-related quality of life and the clinical

Research recommendation Published June 2015

Further research into arthroscopic radiofrequency chondroplasty of the knee should clearly document patient selection and the types of chondral defects being treated. More evidence on long-term outcomes would be useful.

Recommendation ID IPG493/1 Question Further research into arthroscopic radiofrequency chondroplasty of the knee should clearly document

Research recommendation Published June 2015

Fresh frozen plasma for patients with abnormal haemostasis who are having invasive procedures or surgery:- What dose of fresh frozen plasma is most clinically effective at preventing bleeding in patients with abnormal haemostasis who are having invasive procedures or surgery?

Recommendation ID NG24/4 Question Fresh frozen plasma for patients with abnormal haemostasis who are having invasive procedures or surgery:-

Research recommendation Published December 2015

Current evidence on the safety and efficacy of implantation of a duodenal–jejunal bypass liner for managing type 2 diabetes is limited in quality and quantity. Therefore the procedure should only be used in the context of research.

Recommendation ID IPG518/1 Question Current evidence on the safety and efficacy of implantation of a duodenal–jejunal bypass liner for managing

Research recommendation Published June 2015

Continuous glucose monitoring for adults with type 1 diabetes:- In adults with type 1 diabetes who have chronically poor control of blood glucose levels, what is the clinical and cost effectiveness of continuous glucose monitoring technologies?

Recommendation ID NG17/2 Question Continuous glucose monitoring for adults with type 1 diabetes:- In adults with type 1 diabetes who have

Research recommendation Published October 2015

Costing tool:- Which elements of health, social care or other support services work best at a local level and provide the best 'value for money' to address the needs of young people and adults with coexisting severe mental illness and substance misuse?

Recommendation ID NG58/3 Question Costing tool:- Which elements of health, social care or other support services work best at a local level

Research recommendation Published February 2017

Decision-making:- What interventions, systems and processes are effective and cost effective in changing health and social care practitioners' decision-making and ensuring appropriate antimicrobial stewardship?

Recommendation ID Ng15/2 Question Decision-making:- What interventions, systems and processes are effective and cost effective in changing

Research recommendation Published October 2015

Effectiveness and safety of aluminium hydroxide in adults:- In adults with stage 4 or 5 chronic kidney disease (CKD), including those on dialysis, what is the long-term effectiveness and safety of aluminium hydroxide in controlling serum phosphate?

Recommendation ID CG157/2 Question Effectiveness and safety of aluminium hydroxide in adults:- In adults with stage 4 or 5 chronic kidney

Research recommendation Published June 2015

Diabetic ulcer dressings:- What is the clinical effectiveness of different dressing types in treating diabetic foot problems?

Recommendation ID NG19/5 Question Diabetic ulcer dressings:- What is the clinical effectiveness of different dressing types in treating

Research recommendation Published October 2015

Daily mouth care for residents:- Does the delivery of a daily mouth care regimen in care homes maintain or improve adult residents' oral health-related quality of life?

Recommendation ID NG48/4 Question Daily mouth care for residents:- Does the delivery of a daily mouth care regimen in care homes maintain

Research recommendation Published August 2016

Dietary advice based on glycaemic index for children and young people with type 1 diabetes from diagnosis:- What is the impact of educating children and young people with type 1 diabetes and their family members or carers (as appropriate) about their glycaemic index from diagnosis?

Recommendation ID NG18/4 Question Dietary advice based on glycaemic index for children and young people with type 1 diabetes from diagnosis:-

Research recommendation Published October 2015

Does early revascularisation improve outcome in patients with diabetes and a foot ulcer?

Recommendation ID CG119/3 Question Does early revascularisation improve outcome in patients with diabetes and a foot ulcer? Any explanatory

Research recommendation Published June 2015

Displaced intracapsular hip fractures:- What is the clinical and cost effectiveness of large-head total hip replacement versus hemiarthroplasty on functional status, reoperations and quality of life in patients with displaced intracapsular hip fracture?

Recommendation ID CG124/3 Question Displaced intracapsular hip fractures:- What is the clinical and cost effectiveness of large-head total

Research recommendation Published June 2015

Developing a 'risk positive' approach in care homes:- What is the effectiveness and acceptability of different strategies to enable positive risk-taking in care homes?

Recommendation ID NG22/4 Question Developing a 'risk positive' approach in care homes:- What is the effectiveness and acceptability of different

Research recommendation Published December 2015

Do primary care practitioners use NICE guidance when encouraging people to be physically active?

Recommendation ID PH44/6 Question Do primary care practitioners use NICE guidance when encouraging people to be physically active?

Research recommendation Published June 2015