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Effectiveness of 'rescue' cerclage:- What is the clinical effectiveness of 'rescue' cerclage in improving outcomes for women at risk of preterm birth?

Recommendation ID NG25/3 Question Effectiveness of 'rescue' cerclage:- What is the clinical effectiveness of 'rescue' cerclage in improving

Research recommendation Published December 2015

Effectiveness and cost effectiveness:- Are particular components of community engagement approaches more effective and cost effective at improving health and wellbeing and reducing health inequalities than other components?

Recommendation ID NG44/1 Question Effectiveness and cost effectiveness:- Are particular components of community engagement approaches more

Research recommendation Published April 2016

Electronic Decision Support:- What is the clinical and cost effectiveness of an electronic decision support system compared with current practice in reducing inappropriate blood transfusions, overall rates of blood transfusion and mortality?

Recommendation ID NG24/2 Question Electronic Decision Support:- What is the clinical and cost effectiveness of an electronic decision support

Research recommendation Published December 2015

Expectant management before IVF:- What is the optimum period of expectant management for women of different age groups before invasive treatment such as IVF is considered?

Recommendation ID CG156/1 Question Expectant management before IVF:- What is the optimum period of expectant management for women of different

Research recommendation Published June 2015

Fluid balance charts:- For children and young people receiving IV fluids, does the use of a standardised national fluid balance chart reduce the rate of complications arising as a result of prescription and/or administration errors?

Recommendation ID NG29/3 Question Fluid balance charts:- For children and young people receiving IV fluids, does the use of a standardised

Research recommendation Published January 2016

Epilepsy syndromes:- What are the initial and add-on anti-epileptic drugs (AEDs) of choice in the treatment of the epilepsy syndromes with onset in childhood, for example, myoclonic-astatic epilepsy and Dravet syndrome?

Recommendation ID CG137/2 Question Epilepsy syndromes:- What are the initial and add-on anti-epileptic drugs (AEDs) of choice in the treatment

Research recommendation Published June 2015

Factors predicting outcomes for people with high-grade transformation of follicular lymphoma:- In people with high-grade transformation of follicular lymphoma, which biological and clinical factors predict good outcomes with immunochemotherapy alone?

Recommendation ID NG52/2 Question Factors predicting outcomes for people with high-grade transformation of follicular lymphoma:- In people

Research recommendation Published August 2016

Further research into hand allotransplantation should include data on long-term functional outcomes, and any occurrence of malignancy associated with long-term immunosuppression should be published. NICE may review this procedure on publication of further evidence.

Recommendation ID IPG383/1 Question Further research into hand allotransplantation should include data on long-term functional outcomes

Research recommendation Published June 2015

For people with CKD at the highest risk of cardiovascular disease, what is the clinical effectiveness of low-dose aspirin compared with placebo for primary prevention of cardiovascular disease?

Recommendation ID CG182/2 Question For people with CKD at the highest risk of cardiovascular disease, what is the clinical effectiveness

Research recommendation Published June 2015

Facilitators and barriers to carrying out daily mouth care and oral health assessments for adults in care homes:- What are the facilitators and barriers to delivering daily oral care and conducting oral health assessments in residential and nursing care homes?

Recommendation ID NG48/6 Question Facilitators and barriers to carrying out daily mouth care and oral health assessments for adults in care

Research recommendation Published August 2016

FRAX and QFracture in adults living in residential care:- What is the utility of FRAX and QFracture in detecting risk of fragility fracture in adults living in residential care?

Recommendation ID CG146/5 Question FRAX and QFracture in adults living in residential care:- What is the utility of FRAX and QFracture in

Research recommendation Published June 2015

Evaluation of extensively used interventions:- Evaluate currently unevaluated but extensively used interventions for attachment difficulties.

Recommendation ID NG26/3 Question Evaluation of extensively used interventions:- Evaluate currently unevaluated but extensively used interventions

Research recommendation Published December 2015

FRAX and QFracture in adults with secondary causes of osteoporosis:- What is the utility of FRAX and QFracture in detecting risk of fragility fracture in adults with secondary causes of osteoporosis?

Recommendation ID CG146/3 Question FRAX and QFracture in adults with secondary causes of osteoporosis:- What is the utility of FRAX and

Research recommendation Published June 2015

Facilitated self-help for anxiety and depression in adults with autism:- What is the clinical and cost effectiveness of facilitated self-help for the treatment of mild anxiety and depressive disorders in adults with autism?

Recommendation ID CG142/1 Question Facilitated self-help for anxiety and depression in adults with autism:- What is the clinical and cost

Research recommendation Published June 2015

Factors affecting participation and quality of life:- What are the key factors, including additional care and support, that influence participation and quality of life in people with neuropathic pain?

Recommendation ID CG173/4 Question Factors affecting participation and quality of life:- What are the key factors, including additional

Research recommendation Published June 2015

Follow-up after completion of oncological treatment:- Strategies to integrate oncological surveillance with optimising quality of life, reducing late effects, and detecting second cancers in survivors of colorectal cancer should be developed and explored.

Recommendation ID CG131/4 Question Follow-up after completion of oncological treatment:- Strategies to integrate oncological surveillance

Research recommendation Published June 2015

Evaluation frameworks and logic models:- Which evaluation frameworks and logic models can be used to evaluate the impact of community engagement on health and wellbeing?

Recommendation ID NG44/2 Question Evaluation frameworks and logic models:- Which evaluation frameworks and logic models can be used to evaluate

Research recommendation Published April 2016

The frequency and effects of biphasic reactions:- What are the frequency, timing, severity and predictors of biphasic reactions in people who have received emergency treatment for anaphylaxis?

Recommendation ID CG134/2 Question The frequency and effects of biphasic reactions:- What are the frequency, timing, severity and predictors

Research recommendation Published June 2015

Target haemoglobin levels in conservative management of anaemia of chronickidney disease (CKD):- In people with anaemia of CKD opting for conservative management, what is the clinical and cost effectiveness of treating to differing target haemoglobin (Hb) levels?

Recommendation ID NG8/5 Question Target haemoglobin levels in conservative management of anaemia of chronickidney disease (CKD):- In people

Research recommendation Published October 2015

The consequences and costs of poor transition:- What are the consequences and the costs of young people with ongoing needs not making a transition into adult services, or being poorly supported through the process?

Recommendation ID NG43/4 Question The consequences and costs of poor transition:- What are the consequences and the costs of young people

Research recommendation Published March 2016

The effects of stopping and/or switching drug treatments to control blood glucose levels:- In adults with type 2 diabetes, what are the effects of stopping and/or switching drug treatments to control blood glucose levels, and what criteria should inform the decision?

Recommendation ID NG28/1 Question The effects of stopping and/or switching drug treatments to control blood glucose levels:- In adults with

Research recommendation Published January 2016

The Committee recommends that a study estimating utility values using directly observed health-related quality of life values (such as EQ 5D scores) in patients with myelodysplastic syndromes, chronic myelomonocytic leukaemia or acute myeloid leukaemia is conducted.

Recommendation ID TA218/1 Question The Committee recommends that a study estimating utility values using directly observed health-related

Research recommendation Published June 2015

Symptoms and signs of serious illness: - NICE recommends a UK-based epidemiological study on the symptoms and signs of serious illness. [new 2013]

Recommendation ID CG160/1 Question Symptoms and signs of serious illness: - NICE recommends a UK-based epidemiological study on the symptoms

Research recommendation Published June 2015

The structure and organisation of specialist teams:- What structure and organisation of specialist autism teams are associated with improvements in care for people with autism?

Recommendation ID CG142/4 Question The structure and organisation of specialist teams:- What structure and organisation of specialist autism

Research recommendation Published June 2015

Systemic imaging – who and why?:- What factors determine the risk of a person presenting with CUADT having metastasis or a second primary cancer?

Recommendation ID NG36/1 Question Systemic imaging – who and why?:- What factors determine the risk of a person presenting with CUADT having

Research recommendation Published April 2016

The role of families in supporting young adults discharged from children's services:- What is the most effective way of helping families to support young people who have been discharged from children's services (whether or not they meet criteria for adult services)?

Recommendation ID NG43/2 Question The role of families in supporting young adults discharged from children's services:- What is the most

Research recommendation Published March 2016

The physical health benefits of discontinuing antipsychotic medication:- What are the short- and long-term benefits to physical health of guided medication discontinuation and/or reduction in first episode psychosis and can this be achieved without major risks?

Recommendation ID CG178/3 Question The physical health benefits of discontinuing antipsychotic medication:- What are the short- and long-term

Research recommendation Published June 2015

The effectiveness of pulsatile gonadotrophin-releasing hormone in women with clomifene citrate-resistant polycystic ovary syndrome is uncertain and is therefore not recommended outside a research context. [2004]

Recommendation ID CG156/7 Question The effectiveness of pulsatile gonadotrophin-releasing hormone in women with clomifene citrate-resistant

Research recommendation Published June 2015

Training:- What are the effects of different approaches to home care training on outcomes for people who use home care services?

Recommendation ID NG21/3 Question Training:- What are the effects of different approaches to home care training on outcomes for people who

Research recommendation Published October 2015

The role of parents in the treatment of children and young people with social anxiety disorder:- What is the best way of involving parents in the treatment of children and young people (at different stages of development) with social anxiety disorder?

Recommendation ID CG159/3 Question The role of parents in the treatment of children and young people with social anxiety disorder:- What

Research recommendation Published June 2015

Thrombolytic therapy for DVT:- What is the clinical and cost effectiveness of clot removal using catheter-directed thrombolytic therapy or pharmacomechanical thrombolysis compared with standard anticoagulation therapy for the treatment of acute proximal DVT?

Recommendation ID CG144/4 Question Thrombolytic therapy for DVT:- What is the clinical and cost effectiveness of clot removal using catheter-directed

Research recommendation Published June 2015

The effectiveness and safety of single layer closure of the uterine incision is uncertain. Except within a research context, the uterine incision should be sutured with two layers. [2004]

Recommendation ID CG132/11 Question The effectiveness and safety of single layer closure of the uterine incision is uncertain. Except within

Research recommendation Published June 2015

Individual versus group CBT for children and young people with social anxiety disorder:- What is the clinical and cost effectiveness of individual and group CBT for children and young people with social anxiety disorder?

Recommendation ID CG159/4 Question Individual versus group CBT for children and young people with social anxiety disorder:- What is the

Research recommendation Published June 2015

Improving rates of identification and referral of potential donors:- What are the key components of an intervention to improve identification and referral rates?

Recommendation ID CG135/3 Question Improving rates of identification and referral of potential donors:- What are the key components of an

Research recommendation Published June 2015

In moderate- to high-severity community-acquired pneumonia does using legionella and pneumococcal urinary antigen testing in addition to other routine tests improve outcomes?

Recommendation ID CG191/1 Question In moderate- to high-severity community-acquired pneumonia does using legionella and pneumococcal urinary

Research recommendation Published June 2015

In people who have had a STEMI who undergo primary PCI with a bare-metal stent, and 4 weeks of aspirin and clopidogrel, is there an additional benefit to continuing clopidogrel for a further 11 months?

Recommendation ID CG172/5 Question In people who have had a STEMI who undergo primary PCI with a bare-metal stent, and 4 weeks of aspirin

Research recommendation Published June 2015