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NICE recommended that research should be carried out to determine the relationship between activity and prosthesis failure.

Recommendation ID TA304/1 Question NICE recommended that research should be carried out to determine the relationship between activity and

Research recommendation Published June 2015

NICE recommends further research to demonstrate the utility of the Sonoclot system in detecting, managing and monitoring haemostasis in cardiac surgery.

Recommendation ID DG13/1 Question NICE recommends further research to demonstrate the utility of the Sonoclot system in detecting, managing

Research recommendation Published June 2015

NICE recommends that a new model for multiple sclerosis is developed, ideally based on UK patient cohorts, which uses the best available evidence (including experience to date from the risk-sharing scheme) and includes all currently available treatments.

Recommendation ID TA254/2 Question NICE recommends that a new model for multiple sclerosis is developed, ideally based on UK patient cohorts

Research recommendation Published June 2015

[NICE] recommends research into the long-term effects of bisphosphonates on bone quality, given the inhibitory effects on bone resorption of these drugs.

Recommendation ID TA161/2 Question [NICE] recommends research into the long-term effects of bisphosphonates on bone quality, given the inhibitory

Research recommendation Published June 2015

Further research on the clinical effectiveness of rivaroxaban compared with low molecular weight heparin (LMWH) in patients with active cancer should be conducted.

Recommendation ID TA261/1 Question Further research on the clinical effectiveness of rivaroxaban compared with low molecular weight heparin

Research recommendation Published June 2015

Glucose concentration:- What is the most appropriate glucose concentration in IV fluids for children and young people of different ages?

Recommendation ID NG29/2 Question Glucose concentration:- What is the most appropriate glucose concentration in IV fluids for children and

Research recommendation Published January 2016

Further research into the comparative efficacy and safety of different surgical and ablative treatments would be useful.

Recommendation ID IPG405/1 Question Further research into the comparative efficacy and safety of different surgical and ablative treatments

Research recommendation Published June 2015

Further research on external aortic root support in Marfan syndrome should report on long-term outcomes, particularly the occurrence of dissection and aortic dilatation, and the need for further procedures.

Recommendation ID IPG394/1 Question Further research on external aortic root support in Marfan syndrome should report on long-term outcomes

Research recommendation Published June 2015

How can fetuses at risk of intrauterine death be identified in women with diabetes?

Recommendation ID NG3/4 Question How can fetuses at risk of intrauterine death be identified in women with diabetes? Any explanatory

Research recommendation Published June 2015

How can case-finding for hepatitis B and C be improved? What modifiable factors influence whether or not specific groups at increased risk of hepatitis B and hepatitis C infection are identified and tested?

Recommendation ID PH43/1 Question How can case-finding for hepatitis B and C be improved? What modifiable factors influence whether or not

Research recommendation Published June 2015

Haemoglobin levels in older people:- An observational study of haemoglobin (Hb) levels and adverse outcomes in older people.

Recommendation ID CG114/3 Question Haemoglobin levels in older people:- An observational study of haemoglobin (Hb) levels and adverse outcomes

Research recommendation Published June 2015

Herbal medicines:- Are Chinese and non-Chinese herbal medicines safe and effective as first-line therapy in the treatment of [Irritable bowel syndrome] (IBS), and which is the most effective and safe option?

Recommendation ID CG61/5 Question Herbal medicines:- Are Chinese and non-Chinese herbal medicines safe and effective as first-line therapy

Research recommendation Published June 2015

Further research is recommended on alternative postpartum testing strategies that do not include cord blood typing of all babies born to rhesus-D (D) negative women.

Recommendation ID DG25/1 Question Further research is recommended on alternative postpartum testing strategies that do not include cord

Research recommendation Published February 2017

How can brief advice be tailored to have the greatest impact on specific groups? For example, can it be tailored to meet the needs of people of a particular gender, socioeconomic status or with a particular disability?

Recommendation ID PH44/5 Question How can brief advice be tailored to have the greatest impact on specific groups? For example, can it be

Research recommendation Published June 2015

How effective and cost effective are interventions that reduce unintended conception and abortion rates among young people aged under 25 years?

Recommendation ID PH51/3 Question How effective and cost effective are interventions that reduce unintended conception and abortion rates

Research recommendation Published June 2015

Further studies on the clinical effectiveness of mifamurtide when combined with the chemotherapy typical of UK clinical practice would be useful to determine the size of the effect of mifamurtide.

Recommendation ID TA235/1 Question Further studies on the clinical effectiveness of mifamurtide when combined with the chemotherapy typical

Research recommendation Published June 2015

How can a multiagency approach to improving awareness, availability and uptake of vitamin D supplements best be established, improved and sustained?

Recommendation ID PH56/3 Question How can a multiagency approach to improving awareness, availability and uptake of vitamin D supplements

Research recommendation Published June 2015

How can the effectiveness of workplace health policies and programmes be measured?

Recommendation ID NG13/3 Question How can the effectiveness of workplace health policies and programmes be measured? Any explanatory

Research recommendation Published October 2015

Geriatric assessment and care:- What is the cost-effectiveness of comprehensive geriatric assessment and care on specialist units compared with alternative models of care on general wards?

Recommendation ID NG27/4 Question Geriatric assessment and care:- What is the cost-effectiveness of comprehensive geriatric assessment and

Research recommendation Published January 2016

Gathering information in schools or nurseries:- Does routine additional information from educational settings (such as nursery or school) improve accuracy in diagnosing autism among children or young people up to the age of 19 compared with signs and symptoms alone?

Recommendation ID CG128/2 Question Gathering information in schools or nurseries:- Does routine additional information from educational

Research recommendation Published June 2015

How can healthy habits that promote oral health be supported and encouraged in families with children at high risk of poor oral health?

Recommendation ID PH55/4 Question How can healthy habits that promote oral health be supported and encouraged in families with children

Research recommendation Published June 2015

Is the risk of ill health the same for first, second and third generation immigrants from black, Asian and other minority ethnic groups at the same BMI and waist circumference thresholds?

Recommendation ID PH46/4 Question Is the risk of ill health the same for first, second and third generation immigrants from black, Asian

Research recommendation Published June 2015

Long duration or very frequent manual restraint:- In what circumstances and how often are long-duration or repeated manual restraint used, and what alternatives are there that are safer and more effective?

Recommendation ID NG10/5 Question Long duration or very frequent manual restraint:- In what circumstances and how often are long-duration

Research recommendation Published October 2015

Locally accessible care: - Does providing care where people live compared with out-of-area placement lead to improvements in both the clinical and cost effectiveness of care for people with a learning disability and behaviour that challenges?

Recommendation ID NG11/3 Question Locally accessible care: - Does providing care where people live compared with out-of-area placement lead

Research recommendation Published October 2015

How does the duration and frequency of brief advice influence its effectiveness and cost effectiveness? For example, do 'micro interventions' of less than 1–2 minutes have an impact on physical activity?

Recommendation ID PH44/1 Question How does the duration and frequency of brief advice influence its effectiveness and cost effectiveness

Research recommendation Published June 2015

How can outcome measures relating to workplace health and wellbeing be measured?

Recommendation ID NG13/2 Question How can outcome measures relating to workplace health and wellbeing be measured? Any explanatory

Research recommendation Published October 2015

High-flow humidified oxygen and oxygen:- What is the clinical and cost effectiveness of high-flow humidified oxygen versus standard supplemental oxygen?

Recommendation ID NG9/4 Question High-flow humidified oxygen and oxygen:- What is the clinical and cost effectiveness of high-flow humidified

Research recommendation Published October 2015