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NICE recommends that robust evidence be generated to show the clinical effectiveness of pharmacokinetic dose adjustment of continuous infusion 5-FU in people with colorectal cancer.

Recommendation ID DG16/2 Question NICE recommends that robust evidence be generated to show the clinical effectiveness of pharmacokinetic

Research recommendation Published June 2015

Recommendation 3 Barriers and facilitators. Who should take action? Research councils, commissioners and funders. Researchers and investigators.

Recommendation ID PH47/3 Question Recommendation 3 Barriers and facilitators. Who should take action? Research councils, commissioners and

Research recommendation Published June 2015

Reasons for refusal for consent:- Why do families refuse to give permission for organ donation?

Recommendation ID CG135/2 Question Reasons for refusal for consent:- Why do families refuse to give permission for organ donation?

Research recommendation Published June 2015

Reducing antimicrobial resistance:- What interventions, systems and processes are effective and cost effective in reducing antimicrobial resistance without causing harm to patients?

Recommendation ID NG15/1 Question Reducing antimicrobial resistance:- What interventions, systems and processes are effective and cost effective

Research recommendation Published October 2015

Recommendation 1 Research studies and trials. Who should take action? Research councils, commissioners and funders.

Recommendation ID PH47/1 Question Recommendation 1 Research studies and trials. Who should take action? Research councils, commissioners

Research recommendation Published June 2015

Referral criteria for the foot protection service and the multidisciplinary foot care service:- When and with what criteria should people with diabetes be referred to the foot protection service or the multidisciplinary foot care service?

Recommendation ID NG19/2 Question Referral criteria for the foot protection service and the multidisciplinary foot care service:- When and

Research recommendation Published October 2015

Risk factors for early-onset neonatal infection and symptoms and signs:- Which risk factors for early-onset neonatal infection, clinical symptoms and signs of infection, and laboratory investigations should be used to identify babies who should receive antibiotics?

Recommendation ID CG149/2 Question Risk factors for early-onset neonatal infection and symptoms and signs:- Which risk factors for early-onset

Research recommendation Published June 2015

Research is needed to establish the nature of bile acid malabsorption and whether bile acid malabsorption is a primary or secondary condition in people diagnosed with irritable bowel syndrome (IBS-D) or Crohn's disease without ileal resection.

Recommendation ID DG7/2 Question Research is needed to establish the nature of bile acid malabsorption and whether bile acid malabsorption

Research recommendation Published June 2015

Robust evidence is needed on the comparative performance of different faecal calprotectin tests, including the performance of POCTs compared with laboratory-based tests.

Recommendation ID DG11/3 Question Robust evidence is needed on the comparative performance of different faecal calprotectin tests, including

Research recommendation Published June 2015

Relaxation and biofeedback:- What is the effect of relaxation and biofeedback therapies on [Irritable bowel syndrome] (IBS) symptoms and patient-related outcomes?

Recommendation ID CG61/4 Question Relaxation and biofeedback:- What is the effect of relaxation and biofeedback therapies on [Irritable

Research recommendation Published June 2015

Repositioning:- When repositioning a person who is at risk of developing a pressure ulcer, what is the most effective position – and optimum frequency of repositioning – to prevent a pressure ulcer developing?

Recommendation ID CG179/5 Question Repositioning:- When repositioning a person who is at risk of developing a pressure ulcer, what is the

Research recommendation Published June 2015

Research is needed to generate robust and relevant data on the effects of treating people with Alzheimer's disease on both short-term and long-term outcomes, disease progression through relevant health states, and quality of life.

Recommendation ID TA217/1 Question Research is needed to generate robust and relevant data on the effects of treating people with Alzheimer's

Research recommendation Published June 2015

Research is recommended in the UK clinical setting to compare the BRAHMS copeptin assay in combination with cardiac troponin testing against sequential cardiac troponin testing for ruling out myocardial infarction.

Recommendation ID MTG4/1 Question Research is recommended in the UK clinical setting to compare the BRAHMS copeptin assay in combination

Research recommendation Published June 2015

Research investigating the health-related quality of life of people with epilepsy would be of value.

Recommendation ID TA232/1 Question Research investigating the health-related quality of life of people with epilepsy would be of value.

Research recommendation Published June 2015

Research into the long-term treatment effects of rivaroxaban is needed.

Recommendation ID TA287/2 Question Research into the long-term treatment effects of rivaroxaban is needed. Any explanatory notes(if

Research recommendation Published June 2015

Research is recommended on patient preferences, and their impact on quality of life, for contrast-enhanced ultrasound and other imaging modalities. Ideally such research should compare all appropriate imaging modalities in the same patient group.

Recommendation ID DG5/2 Question Research is recommended on patient preferences, and their impact on quality of life, for contrast-enhanced

Research recommendation Published June 2015

Reducing use of emergency dental care:- What interventions are effective and cost effective at encouraging people who usually only go to emergency dental services to use general dental services regularly, in a bid to improve their oral health?

Recommendation ID NG30/2 Question Reducing use of emergency dental care:- What interventions are effective and cost effective at encouraging

Research recommendation Published January 2016

Risk stratification tool for HbA1c targets for adults with type 1 diabetes:- Can a risk stratification tool be used to aid the setting of individualised HbA1c targets for adultswith type 1 diabetes?

Recommendation ID NG17/4 Question Risk stratification tool for HbA1c targets for adults with type 1 diabetes:- Can a risk stratification

Research recommendation Published October 2015

Recommendation 4 Weight management programmes. Who should take action? Research councils, commissioners and funders. Researchers and investigators.

Recommendation ID PH47/4 Question Recommendation 4 Weight management programmes. Who should take action? Research councils, commissioners

Research recommendation Published June 2015

Reducing demands on health and social care services:- Do preventive oral health interventions in residential and nursing care homes reduce demands on other health and social care services?

Recommendation ID NG48/5 Question Reducing demands on health and social care services:- Do preventive oral health interventions in residential

Research recommendation Published August 2016

Sequencing and combining of phosphate binders in adults:- For adults with stage 4 or 5 chronic kidney disease (CKD), including those on dialysis, what is the most effective sequence or combination of phosphate binders to control serum phosphate?

Recommendation ID CG157/5 Question Sequencing and combining of phosphate binders in adults:- For adults with stage 4 or 5 chronic kidney

Research recommendation Published June 2015

Research is recommended on the percentage of unenhanced ultrasound scans that are inconclusive, particularly in people with cirrhosis. Such studies should explicitly define and describe why scans are 'inconclusive'.

Recommendation ID DG5/1 Question Research is recommended on the percentage of unenhanced ultrasound scans that are inconclusive, particularly

Research recommendation Published June 2015

Research should be carried out to compare the clinical effectiveness of bendamustine with chlorambucil at the higher dose used in the Chronic Lymphocytic Leukaemia Trial 4 (CLL4).

Recommendation ID TA216/1 Question Research should be carried out to compare the clinical effectiveness of bendamustine with chlorambucil

Research recommendation Published June 2015

Research is needed to establish the efficacy and tolerability of bile acid sequestrants among people with irritable bowel syndrome (IBS-D) or Crohn's disease without ileal resection.

Recommendation ID DG7/3 Question Research is needed to establish the efficacy and tolerability of bile acid sequestrants among people with

Research recommendation Published June 2015

Research is needed on the impact of treating Alzheimer's disease on mortality and institutionalisation, and to assess the relationship between disease progression and carer utility (quality of life).

Recommendation ID TA217/2 Question Research is needed on the impact of treating Alzheimer's disease on mortality and institutionalisation

Research recommendation Published June 2015

Risk assessment in neonates, infants, children and young people:- Which pressure ulcer tools are most effective for predicting pressure ulcer risk in children?

Recommendation ID CG179/3 Question Risk assessment in neonates, infants, children and young people:- Which pressure ulcer tools are most

Research recommendation Published June 2015

Research is recommended to address uncertainties about the claimed patient and system benefits of using Parafricta Bootees and Undergarments. This should take the form of comparative research against standard care, preferably carried out in a hospital.

Recommendation ID MTG20/1 Question Research is recommended to address uncertainties about the claimed patient and system benefits of using

Research recommendation Published June 2015

Routine outcome measurement:- In people with a common mental health disorder, what is the clinical utility of routine outcome measurement and is it cost effective compared with standard care?

Recommendation ID CG123/4 Question Routine outcome measurement:- In people with a common mental health disorder, what is the clinical utility

Research recommendation Published June 2015

Self-management:- What is the impact of different early intervention-focused approaches to self-management on outcomes for older people with social care needs and multiple long-term conditions?

Recommendation ID NG22/5 Question Self-management:- What is the impact of different early intervention-focused approaches to self-management

Research recommendation Published December 2015

Safety and efficacy of botulinum toxin:- What is the safety and efficacy of botulinum toxin compared with (a) usual care, (b) antimuscarinics and (c) augmentation cystoplasty in people with neurogenic lower urinary tract dysfunction?

Recommendation ID CG148/2 Question Safety and efficacy of botulinum toxin:- What is the safety and efficacy of botulinum toxin compared

Research recommendation Published June 2015

Screening assessment tools:- Develop reliable and valid screening assessment tools for attachment and sensitivity that can be made available and used in routine health, social care and education settings.

Recommendation ID NG26/1 Question Screening assessment tools:- Develop reliable and valid screening assessment tools for attachment and

Research recommendation Published December 2015

Social media:- How effective are online social media and networks at improving health and wellbeing and reducing health inequalities when they are used:- as a method of community engagement?- to support an existing community engagement approach?

Recommendation ID NG44/4 Question Social media:- How effective are online social media and networks at improving health and wellbeing and

Research recommendation Published April 2016

Self-monitoring of blood glucose levels:- What is the optimal frequency for self-monitoring of blood glucose in adults with type 2 diabetes?

Recommendation ID NG28/5 Question Self-monitoring of blood glucose levels:- What is the optimal frequency for self-monitoring of blood glucose

Research recommendation Published January 2016

Service delivery models:- Which models of service delivery are effective and cost-effective for older people with social care needs and multiple long-term conditions?

Recommendation ID NG22/2 Question Service delivery models:- Which models of service delivery are effective and cost-effective for older

Research recommendation Published December 2015

Safety and efficacy of antimuscarinics:- What is the safety and efficacy of more recently developed antimuscarinics compared with (a) placebo/usual care and (b) other antimuscarinics in the treatment of neurogenic lower urinary tract dysfunction?

Recommendation ID CG148/1 Question Safety and efficacy of antimuscarinics:- What is the safety and efficacy of more recently developed antimuscarinics

Research recommendation Published June 2015

Signs and symptoms that predict neutropenic sepsis in the community:- A prospective study should be carried out to determine which signs and symptoms experienced by patients in the community predict neutropenic sepsis and the outcomes of these episodes.

Recommendation ID CG151/3 Question Signs and symptoms that predict neutropenic sepsis in the community:- A prospective study should be carried

Research recommendation Published June 2015

Treating comorbid anxiety in children and young people with autism:- What is the comparative clinical and cost effectiveness of pharmacological and psychosocial interventions for anxiety disorders in children and young people with autism?

Recommendation ID CG170/4 Question Treating comorbid anxiety in children and young people with autism:- What is the comparative clinical

Research recommendation Published June 2015