Updating results

Radical treatment of squamous cell carcinoma of the oesophagus:- Does the addition of surgery to chemoradiotherapy improve disease-free and overall survival inpeople with squamous cell carcinoma of the oesophagus?

Recommendation ID NG83/1 Question Radical treatment of squamous cell carcinoma of the oesophagus:- Does the addition of surgery to chemoradiotherapy

Research recommendation Published November 2018

Nutritional support after radical surgery:- What is the optimal method of delivering nutritional support to adults after surgery with curative intent for oesophago-gastric cancer?

Recommendation ID NG83/3 Question Nutritional support after radical surgery:- What is the optimal method of delivering nutritional support

Research recommendation Published November 2018

Pain management:- A randomised trial should be undertaken comparing early endoscopic ultrasound-guided neurolytic coeliac plexus (EUS-guided NCP) interventions with on-demand EUS-guided NCP interventions in people with unresectable pancreatic cancer.

Recommendation ID NG85/4 Question Pain management:- A randomised trial should be undertaken comparing early endoscopic ultrasound-guided

Research recommendation Published November 2018

Jejunostomy support after radical surgery:- What is the effectiveness of long-term jejunostomy support compared to intensive dietary counselling and support along with symptom management for people having radical surgery for oesophago-gastric cancer?

Recommendation ID NG83/4 Question Jejunostomy support after radical surgery:- What is the effectiveness of long-term jejunostomy support

Research recommendation Published November 2018

Frequency of monitoring:- What is the long-term cost effectiveness, in terms of patient-relevant outcomes including bestcorrected visual acuity and quality of life, of different review frequencies/strategies for people at risk of progression to late AMD (wet active)?

Recommendation ID NG82/4 Question Frequency of monitoring:- What is the long-term cost effectiveness, in terms of patient-relevant outcomes

Research recommendation Published November 2018

Follow-up after treatment with curative intent:- Is the routine use of CT and tumour markers effective in detecting recurrent disease suitable for radical treatment in asymptomatic people who have had treatment for oesophago-gastric cancer with curative intent?

Recommendation ID NG83/5 Question Follow-up after treatment with curative intent:- Is the routine use of CT and tumour markers effective

Research recommendation Published November 2018

Monitoring pulmonary disease:- Is lung clearance index a useful and cost-effective tool for the routine assessment and monitoring of changes in pulmonary status in people with cystic fibrosis?

Recommendation ID NG78/3 Question Monitoring pulmonary disease:- Is lung clearance index a useful and cost-effective tool for the routine

Research recommendation Published November 2018

Indicators and thresholds for referral for cataract surgery:- What is the association between preoperative vision- and health-related quality of life, and postoperative vision-related quality of life, health-related quality of life, and self-reported postoperative improvement?

Recommendation ID NG77/3 Question Indicators and thresholds for referral for cataract surgery:- What is the association between preoperative

Research recommendation Published November 2018

Further research on high-intensity focused ultrasound for symptomatic breast fibroadenoma should include publication of patient-reported outcome measures and studies with long-term follow-up.

Recommendation ID IPG592 Question Further research on high-intensity focused ultrasound for symptomatic breast fibroadenoma should include

Research recommendation Published November 2018

Airway clearance techniques:- How effective are daily airway clearance techniques in maintaining lung function in infants and children with cystic fibrosis?

Recommendation ID NG78/2 Question Airway clearance techniques:- How effective are daily airway clearance techniques in maintaining lung

Research recommendation Published November 2018

NICE encourages further research into total artificial heart implantation as a bridge to transplantation for end-stage refractory biventricular heart failure, including well matched comparative studies. NICE may update the guidance on publication of further evidence.

Recommendation ID IPG602/1 Question NICE encourages further research into total artificial heart implantation as a bridge to transplantation

Research recommendation Published October 2018

Further research on the safety of transvaginal mesh repair of anterior or posterior vaginal wall prolapse should include details of patient selection, long-term outcomes including complications, type of mesh used and method of fixation, and quality of life.

Recommendation ID IPG599/1 Question Further research on the safety of transvaginal mesh repair of anterior or posterior vaginal wall prolapse should

Research recommendation Published October 2018

Effectiveness of home visiting following child abuse or neglect:- Are home visiting interventions effective and cost effective in improving parenting and preventingrecurrence of child abuse and neglect in families in which abuse or neglect is occurring or has occurred?

Recommendation ID NG76/12 Question Effectiveness of home visiting following child abuse or neglect:- Are home visiting interventions effective

Research recommendation Published October 2018

Early help home visiting:- What are the components of effective home visiting programmes for preventing child abuse and neglect in families of children and young people at risk of child abuse and neglect in the UK?

Recommendation ID NG76/4 Question Early help home visiting:- What are the components of effective home visiting programmes for preventing

Research recommendation Published October 2018

Diagnosing asthma in adults (aged 17 and over):- What is the clinical and cost effectiveness of using an indirect bronchial challenge test with mannitol to diagnose asthma in adults (aged 17 and over)?

Recommendation ID NG80/2 Question Diagnosing asthma in adults (aged 17 and over):- What is the clinical and cost effectiveness of using

Research recommendation Published October 2018

An instrument to measure quality of life in people with glaucoma:- What instrument should be used to measure health related quality of life in people with glaucoma?

Recommendation ID NG81/3 Question An instrument to measure quality of life in people with glaucoma:- What instrument should be used to measure

Research recommendation Published October 2018

Relative effectiveness of interventions to support foster carers:- What is the relative effectiveness and cost effectiveness of the KEEP intervention for foster carersof abused or neglected children compared to other interventions?

Recommendation ID NG76/15 Question Relative effectiveness of interventions to support foster carers:- What is the relative effectiveness

Research recommendation Published October 2018

Quality of life in cataract surgery:- What vision-specific, quality-of-life measures best capture visual changes in a population with cataracts?

Recommendation ID NG77/2 Question Quality of life in cataract surgery:- What vision-specific, quality-of-life measures best capture visual

Research recommendation Published October 2018

Psychological assessment:- What is the most effective measure of psychological functioning to use as a test for thresholds of concern in people with cystic fibrosis?

Recommendation ID NG78/4 Question Psychological assessment:- What is the most effective measure of psychological functioning to use as a

Research recommendation Published October 2018

Peer support for children and young people who have been abused or neglected:- What peer support programmes are effective and cost effective in improving the wellbeing of children and young people who have been abused or neglected?

Recommendation ID NG76/16 Question Peer support for children and young people who have been abused or neglected:- What peer support programmes

Research recommendation Published October 2018

Mucoactive agents:- What is the most clinically and cost-effective dose of rhDNase (dornase alfa; recombinant human deoxyribonuclease) for people with cystic fibrosis?

Recommendation ID NG78/6 Question Mucoactive agents:- What is the most clinically and cost-effective dose of rhDNase (dornase alfa; recombinant

Research recommendation Published October 2018

Monitoring for cystic-fibrosis-related diabetes:- What is the most effective strategy to detect diabetes in people with cystic fibrosis?

Recommendation ID NG78/5 Question Monitoring for cystic-fibrosis-related diabetes:- What is the most effective strategy to detect diabetes

Research recommendation Published October 2018

Liver disease:- Should all children with meconium ileus receive ursodeoxycholic acid from diagnosis?

Recommendation ID NG78/1 Question Liver disease:- Should all children with meconium ileus receive ursodeoxycholic acid from diagnosis?

Research recommendation Published October 2018

Interventions with male foster carers and adoptive parents:- What interventions are effective and cost effective when working with male foster carers and adoptive parents who are caring for children and young people who have been abused in the past?

Recommendation ID NG76/11 Question Interventions with male foster carers and adoptive parents:- What interventions are effective and cost

Research recommendation Published October 2018

Interventions with fathers and male carers:- What interventions are effective and cost effective when working with fathers and male carers to improve their parenting in families where children are being, or have been, abused or neglected?

Recommendation ID NG76/10 Question Interventions with fathers and male carers:- What interventions are effective and cost effective when

Research recommendation Published October 2018

Interventions to prevent endophthalmitis:- What is the effectiveness of postoperative antibiotic drops to reduce rates of endophthalmitis after cataract surgery?

Recommendation ID NG77/5 Question Interventions to prevent endophthalmitis:- What is the effectiveness of postoperative antibiotic drops

Research recommendation Published October 2018

Interventions to manage cystoid macular oedema:- What is the most effective postoperative medical management for cystoid macular oedema?

Recommendation ID NG77/4 Question Interventions to manage cystoid macular oedema:- What is the most effective postoperative medical management

Research recommendation Published October 2018

Effective prevention of child abuse and neglect in the UK:- What interventions are effective and cost effective in the UK to prevent abuse and neglect of children and young people in families at risk of, or showing early signs of, abuse and neglect?

Recommendation ID NG76/5 Question Effective prevention of child abuse and neglect in the UK:- What interventions are effective and cost

Research recommendation Published October 2018

Effectiveness of web-based parenting programmes:- Are web-based parenting programmes effective and cost effective for improving parenting and preventing recurrence of child abuse and neglect in families where child abuse or neglect has occurred?

Recommendation ID NG76/14 Question Effectiveness of web-based parenting programmes:- Are web-based parenting programmes effective and cost

Research recommendation Published October 2018

Treatment for people with an IOP of 22 or 23 mmHg:- What is the clinical and cost effectiveness of treating an intraocular pressure (IOP) of 22 or 23 mmHg in people with normal optic discs and visual fields?

Recommendation ID NG81/2 Question Treatment for people with an IOP of 22 or 23 mmHg:- What is the clinical and cost effectiveness of treating

Research recommendation Published October 2018

Optical coherence tomography for glaucoma:- What is the effectiveness and cost effectiveness of optical coherence tomography (OCT) for diagnosing and monitoring glaucoma?

Recommendation ID NG81/4 Question Optical coherence tomography for glaucoma:- What is the effectiveness and cost effectiveness of optical

Research recommendation Published October 2018

Monitoring adherence to treatment:- What is the clinical and cost effectiveness of using electronic alert systems designed to monitor and improve adherence with regular inhaled maintenance therapy in people with asthma?

Recommendation ID NG80/3 Question Monitoring adherence to treatment:- What is the clinical and cost effectiveness of using electronic alert

Research recommendation Published October 2018