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NICE encourages further research into total artificial heart implantation as a bridge to transplantation for end-stage refractory biventricular heart failure, including well matched comparative studies. NICE may update the guidance on publication of further evidence.

Recommendation ID IPG602/1 Question NICE encourages further research into total artificial heart implantation as a bridge to transplantation

Research recommendation Published October 2018

Further research on the safety of transvaginal mesh repair of anterior or posterior vaginal wall prolapse should include details of patient selection, long-term outcomes including complications, type of mesh used and method of fixation, and quality of life.

Recommendation ID IPG599/1 Question Further research on the safety of transvaginal mesh repair of anterior or posterior vaginal wall prolapse should

Research recommendation Published October 2018

Treatment for people with an IOP of 22 or 23 mmHg:- What is the clinical and cost effectiveness of treating an intraocular pressure (IOP) of 22 or 23 mmHg in people with normal optic discs and visual fields?

Recommendation ID NG81/2 Question Treatment for people with an IOP of 22 or 23 mmHg:- What is the clinical and cost effectiveness of treating

Research recommendation Published October 2018

Further research on unilateral MRI-guided focused ultrasound thalamotomy for moderate to severe tremor in Parkinson's disease, which could include randomised controlled trials, should address patient selection and report on long-term follow-up.

Recommendation ID IPG606/1 Question Further research on unilateral MRI-guided focused ultrasound thalamotomy for moderate to severe tremor

Research recommendation Published November 2018

Further research on aortic valve reconstruction with processed bovine pericardium should address patient selection and report long-term outcomes, particularly the durability of the valve.

Recommendation ID IPG604/1 Question Further research on aortic valve reconstruction with processed bovine pericardium should address patient

Research recommendation Published November 2018

Co-producing research into the views and experiences of people who use services:- What approaches have been shown to work in supporting the co-production of research for the purposes of service improvement with people who use services?

Recommendation ID NG86/2 Question Co-producing research into the views and experiences of people who use services:- What approaches have

Research recommendation Published November 2018

Cachexia interventions: - A cohort study followed by phase II and III studies should be undertaken in people with pancreatic cancer and cachexia or pre-cachexia, to compare cachexia assessment methods and anti-cachexia interventions with standard care.

Recommendation ID NG85/2 Question Cachexia interventions: - A cohort study followed by phase II and III studies should be undertaken in

Research recommendation Published November 2018

Strategies to slow the progression of age-related macular degeneration (AMD):- What is the effectiveness of antioxidant and zinc supplements on AMD disease progression for people with early AMD at high risk of progression in the context of a randomised controlled trial?

Recommendation ID NG82/1 Question Strategies to slow the progression of age-related macular degeneration (AMD):- What is the effectiveness

Research recommendation Published November 2018

Stopping rules for antiangiogenic treatment for late AMD (wet):- When should anti-vascular endothelial growth factor (VEGF) treatment be suspended or stoppedin people with late AMD (wet)?

Recommendation ID NG82/3 Question Stopping rules for antiangiogenic treatment for late AMD (wet):- When should anti-vascular endothelial

Research recommendation Published November 2018

Self-monitoring strategies:- Does earlier detection of the incidence of late AMD (wet active) by self-monitoring in people diagnosed with early AMD, indeterminate AMD or late AMD (dry) lead to earlier treatment and better long-term outcomes?

Recommendation ID NG82/5 Question Self-monitoring strategies:- Does earlier detection of the incidence of late AMD (wet active) by self-monitoring

Research recommendation Published November 2018

Radical treatment of T1bN0 adenocarcinoma of the oesophagus:- What is the optimal treatment for T1bN0 adenocarcinoma of the oesophagus?

Recommendation ID NG83/2 Question Radical treatment of T1bN0 adenocarcinoma of the oesophagus:- What is the optimal treatment for T1bN0

Research recommendation Published November 2018

Radical treatment of squamous cell carcinoma of the oesophagus:- Does the addition of surgery to chemoradiotherapy improve disease-free and overall survival inpeople with squamous cell carcinoma of the oesophagus?

Recommendation ID NG83/1 Question Radical treatment of squamous cell carcinoma of the oesophagus:- Does the addition of surgery to chemoradiotherapy

Research recommendation Published November 2018

Nutritional support after radical surgery:- What is the optimal method of delivering nutritional support to adults after surgery with curative intent for oesophago-gastric cancer?

Recommendation ID NG83/3 Question Nutritional support after radical surgery:- What is the optimal method of delivering nutritional support

Research recommendation Published November 2018

Jejunostomy support after radical surgery:- What is the effectiveness of long-term jejunostomy support compared to intensive dietary counselling and support along with symptom management for people having radical surgery for oesophago-gastric cancer?

Recommendation ID NG83/4 Question Jejunostomy support after radical surgery:- What is the effectiveness of long-term jejunostomy support

Research recommendation Published November 2018

Frequency of monitoring:- What is the long-term cost effectiveness, in terms of patient-relevant outcomes including bestcorrected visual acuity and quality of life, of different review frequencies/strategies for people at risk of progression to late AMD (wet active)?

Recommendation ID NG82/4 Question Frequency of monitoring:- What is the long-term cost effectiveness, in terms of patient-relevant outcomes

Research recommendation Published November 2018

Follow-up after treatment with curative intent:- Is the routine use of CT and tumour markers effective in detecting recurrent disease suitable for radical treatment in asymptomatic people who have had treatment for oesophago-gastric cancer with curative intent?

Recommendation ID NG83/5 Question Follow-up after treatment with curative intent:- Is the routine use of CT and tumour markers effective

Research recommendation Published November 2018

Supporting family members, carers and staff:- What types of services or approaches are effective in supporting family members, carers and staffto be resilient and able to provide care and support to people with a learning disability and behaviour that challenges?

Recommendation ID NG93/2 Question Supporting family members, carers and staff:- What types of services or approaches are effective in supporting

Research recommendation Published November 2018

Carbon monoxide monitoring:- What is the validity of different thresholds of carbon monoxide in exhaled breath as markers of quitting, based on diagnostic review and modelling?

Recommendation ID NG92/2 Question Carbon monoxide monitoring:- What is the validity of different thresholds of carbon monoxide in exhaled

Research recommendation Published November 2018

Models of supported living:- What is the effectiveness and cost effectiveness of models of shared, supported living, such as Shared Lives?What are the views and experiences of people sharing their home and people who live with themunder programmes such as Shared Lives?

Recommendation ID NG93/3 Question Models of supported living:- What is the effectiveness and cost effectiveness of models of shared, supported

Research recommendation Published November 2018

Interaction between behavioural and environmental interventions:- What is the effectiveness and cost effectiveness of interventions to change the environment alone, compared with interventions to change the environment that are supported by interventions to change people's behaviour?

Recommendation ID NG90/6 Question Interaction between behavioural and environmental interventions:- What is the effectiveness and cost effectiveness

Research recommendation Published November 2018

Duration of prophylaxis for elective total hip replacement surgery:- What is the clinical and cost effectiveness of standard versus extended duration pharmacological prophylaxis for preventing VTE in people undergoing elective total hip replacement surgery?

Recommendation ID NG89/5 Question Duration of prophylaxis for elective total hip replacement surgery:- What is the clinical and cost effectiveness

Research recommendation Published November 2018

Direct oral anticoagulants for people with lower limb immobilisation:- What is the clinical and cost effectiveness of direct oral anticoagulants for preventing VTE in people with lower limb immobilisation?

Recommendation ID NG89/3 Question Direct oral anticoagulants for people with lower limb immobilisation:- What is the clinical and cost effectiveness

Research recommendation Published November 2018

Risk assessment:- What is the accuracy of individual risk assessment tools in predicting the risk of venousthromboembolism (VTE) and risk of bleeding in people admitted to hospital?

Recommendation ID NG89/1 Question Risk assessment:- What is the accuracy of individual risk assessment tools in predicting the risk of

Research recommendation Published November 2018

Case management:- What is the effectiveness and cost effectiveness of high-intensity case management compared with usual care on quality of life (for the person living with dementia and for their carers) and the timing of entry to long-term care?

Recommendation ID NG97/1 Question Case management:- What is the effectiveness and cost effectiveness of high-intensity case management compared

Research recommendation Published December 2018

Staff training:- What is the cost effectiveness of using a dementia-specific addition to the Care Certificate for community staff, including dementia-specific elements on managing anxiety, communication, nutritional status and personal care?

Recommendation ID NG97/2 Question Staff training:- What is the cost effectiveness of using a dementia-specific addition to the Care Certificate

Research recommendation Published December 2018

Monitoring and follow-up for adults with hearing loss:- What is the clinical and cost effectiveness of monitoring and follow-up for adults with hearing loss post-intervention compared with usual care?

Recommendation ID NG98/5 Question Monitoring and follow-up for adults with hearing loss:- What is the clinical and cost effectiveness of

Research recommendation Published December 2018

Earwax:- What is the clinical and cost effectiveness of microsuction compared with irrigation to remove earwax?

Recommendation ID NG98/2 Question Earwax:- What is the clinical and cost effectiveness of microsuction compared with irrigation to remove earwax

Research recommendation Published December 2018

Care and support planning:- What are the most effective methods of care planning for people who do not have regular contact with an informal carer?

Recommendation ID NG97/5 Question Care and support planning:- What are the most effective methods of care planning for people who do not

Research recommendation Published December 2018

Managing delirium superimposed on dementia:- What are the most clinically and cost-effective non-pharmacological interventions for helping the long-term recovery of people with delirium superimposed on dementia?

Recommendation ID NG97/4 Question Managing delirium superimposed on dementia:- What are the most clinically and cost-effective non-pharmacological

Research recommendation Published December 2018

Use of hearing aids and incidence of dementia:- In adults with hearing loss, does the use of hearing aids reduce the incidence of dementia?

Recommendation ID NG98/3 Question Use of hearing aids and incidence of dementia:- In adults with hearing loss, does the use of hearing aids

Research recommendation Published December 2018

Anticholinergic burden:- Does actively reducing anticholinergic burden in people living with dementia improve cognitive outcomes compared with usual care?

Recommendation ID NG72/3 Question Anticholinergic burden:- Does actively reducing anticholinergic burden in people living with dementia

Research recommendation Published December 2018

Monitoring pulmonary disease:- Is lung clearance index a useful and cost-effective tool for the routine assessment and monitoring of changes in pulmonary status in people with cystic fibrosis?

Recommendation ID NG78/3 Question Monitoring pulmonary disease:- Is lung clearance index a useful and cost-effective tool for the routine

Research recommendation Published November 2018

Indicators and thresholds for referral for cataract surgery:- What is the association between preoperative vision- and health-related quality of life, and postoperative vision-related quality of life, health-related quality of life, and self-reported postoperative improvement?

Recommendation ID NG77/3 Question Indicators and thresholds for referral for cataract surgery:- What is the association between preoperative

Research recommendation Published November 2018

Further research on high-intensity focused ultrasound for symptomatic breast fibroadenoma should include publication of patient-reported outcome measures and studies with long-term follow-up.

Recommendation ID IPG592 Question Further research on high-intensity focused ultrasound for symptomatic breast fibroadenoma should include

Research recommendation Published November 2018

Airway clearance techniques:- How effective are daily airway clearance techniques in maintaining lung function in infants and children with cystic fibrosis?

Recommendation ID NG78/2 Question Airway clearance techniques:- How effective are daily airway clearance techniques in maintaining lung

Research recommendation Published November 2018

Liver disease:- Should all children with meconium ileus receive ursodeoxycholic acid from diagnosis?

Recommendation ID NG78/1 Question Liver disease:- Should all children with meconium ileus receive ursodeoxycholic acid from diagnosis?

Research recommendation Published October 2018

Interventions with male foster carers and adoptive parents:- What interventions are effective and cost effective when working with male foster carers and adoptive parents who are caring for children and young people who have been abused in the past?

Recommendation ID NG76/11 Question Interventions with male foster carers and adoptive parents:- What interventions are effective and cost

Research recommendation Published October 2018