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  1. How effective and cost-effective is the NHS Health Check programme? What are the patterns of uptake in relation to the demographics of the population and their degree of behavioural risk? What is the programme's effect on the development of dementia, disability and frailty? How feasible is extending the NHS Health Check programme to a younger age range?

    Recommendation ID NG16/5 Question How effective and cost-effective is the NHS Health Check programme? What are the patterns of uptake in

  2. Further research on implanting a baroreceptor stimulation device for resistant hypertension should document patient selection in detail and should specify the devices and techniques used, and any adjunctive therapies. It should describe the changes in blood pressure that are considered to result from baroreceptor stimulation, and those that might be caused by other factors. Outcomes should include the duration of effect of baroreceptor stimulation; device durability; and the complications of hypertension, such as myocardial infarction and stroke.

    Recommendation ID IPG533/1 Question Further research on implanting a baroreceptor stimulation device for resistant hypertension should

  3. Further research on robot-assisted kidney transplant should include studies comparing robot-assisted kidney transplant with open surgery. This should collect data on patient selection, warm ischaemia times, the need for conversion to open surgery, graft function, and long-term graft and patient survival.

    Recommendation ID IPG609/1 Question Further research on robot-assisted kidney transplant should include studies comparing robot-assisted

  4. Further research on selective internal radiation therapy (SIRT) for unresectable primary intrahepatic cholangiocarcinoma in the form of prospective studies, including randomised controlled trials, should address patient selection, quality-of-life outcomes and overall survival. Patient selection for the research studies should be done by amultidisciplinary team. The procedure should only be done in specialist centres by clinicians trained and experienced in managing cholangiocarcinoma.

    Recommendation ID IPG630/1 Question Further research on selective internal radiation therapy (SIRT) for unresectable primary intrahepatic

  5. Further research on the efficacy and safety of intranasal phototherapy for allergic rhinitis should include: details of patient selection including medication use; underlying medical conditions; the intensity, duration and wavelength of light used; patient-reported outcomes; comparison with existing treatments; and the effects of repeated long-term use. NICE may update the guidance if further evidence is published.

    Recommendation ID IPG616/1 Question Further research on the efficacy and safety of intranasal phototherapy for allergic rhinitis should

  6. Further research on the routine adoption of Actim Partus and PartoSure to help diagnose preterm labour in women with intact membranes when transvaginal ultrasound measurement of cervical length is needed on the accuracy of the tests and their effect on clinical outcomes. Centres using the tests to help diagnose preterm labour in women with intact membranes are encouraged to take part in studies to address the research considerations (see the guidance sections 5.12 to 5.16). Data are needed on:- the impact of gestational age on the accuracy of the tests- how the tests affect clinical decision-making- the effect of the tests on outcomes for mother and baby

    Recommendation ID DG33/1 Question Further research on the routine adoption of Actim Partus and PartoSure to help diagnose preterm labour

  7. Further research on the safety of unilateral MRI-guided focused ultrasound thalamotomy for treatment-resistant essential tremor, which could include randomised controlled trials, should address patient selection, report on functional improvement and quality of life, and provide long-term follow-up data.

    Recommendation ID IPG617/1 Question Further research on the safety of unilateral MRI-guided focused ultrasound thalamotomy for treatment-resistant

  8. How effective are programmes that aim to prevent domestic violence and abuse from ever happening in the first place? This includes media-based public health awareness campaigns. It also includes social movements to establish people's rights, and community-building and primary prevention activities that tackle underlying assumptions in society. (Examples of the latter might include the role and status of women.)

    Recommendation ID PH50/1 Question How effective are programmes that aim to prevent domestic violence and abuse from ever happening in the

  9. How effective are the following interventions in the short, medium and long term, across various levels of risk and including diverse and marginalised groups: - advocacy - domestic abuse recovery programmes - perpetrator programmes - psychological or social interventions modified for domestic violence and abuse, including programmes for those who have suffered multiple forms of abuse and those who are still experiencing it - interventions for primary carers apart from mothers (for example, fathers, grandparents) - interventions for other family members?

    Recommendation ID PH50/3 Question How effective are the following interventions in the short, medium and long term, across various levels

  10. How strong are the associations between hearing and visual loss, and sleep patterns and positive and negative health outcomes, in particular the development of dementia, disability and frailty? What are the most effective and cost-effective interventions to protect hearing and vision and improve sleep and what is their effect on the development of dementia, disability and frailty?

    Recommendation ID NG16/4 Question How strong are the associations between hearing and visual loss, and sleep patterns and positive and

  11. How strong are the cultural motivations (stemming from religion, tradition, media, and advertising) to use smokeless tobacco among people of South Asian origin? How do they compare with the physical addiction to nicotine? How might this information help in designing smokeless tobacco cessation programmes that are culturally appropriate?

    Recommendation ID PH39/6 Question How strong are the cultural motivations (stemming from religion, tradition, media, and advertising) to

  12. How effective are different behavioural strategies in helping people to cut down, either in order to stop smoking or to reduce the amount they smoke? This should include an evaluation of behavioural support used on its own and evaluations of specific components of such support (such as scheduling). It should also include evaluations of different types of behavioural support and follow-up, delivered within a clearly defined harm-reduction intervention.

    Recommendation ID PH45/4 Question How effective are different behavioural strategies in helping people to cut down, either in order to

  13. How effective are interventions to help people reduce the amount they smoke (without the intention of stopping)? How great are the health benefits of smoking reduction (by substituting some cigarettes with licensed nicotine-containing products) compared to stopping smoking? What proportion of people who reduce the amount they smoke go on to stop smoking? How soon after starting to reduce the amount they smoke do they stop completely?

    Recommendation ID PH45/3 Question How effective are interventions to help people reduce the amount they smoke (without the intention of