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What local anaesthetic techniques are most effective for women having surgical abortion?

Recommendation ID NG140/5 Question What local anaesthetic techniques are most effective for women having surgical abortion? Any

Research recommendation Published November 2019

What is the optimal antibiotic prophylaxis regimen for women who are having a surgical abortion?

Recommendation ID NG140/1 Question What is the optimal antibiotic prophylaxis regimen for women who are having a surgical abortion?

Research recommendation Published November 2019

Should women having a surgical abortion up to and including 10 +0  weeks' gestation have anti-D prophylaxis if they are RhD (or D) negative?

Recommendation ID NG140/3 Question Should women having a surgical abortion up to and including 10 +0 weeks' gestation have anti-D prophylaxis

Research recommendation Published November 2019

What is the effectiveness and safety of regimens using mifepristone and misoprostol for women who are having medical abortion after 23 +6  weeks' gestation, particularly for those who have had a previous caesarean section or uterine surgery?

Recommendation ID NG140/6 Question What is the effectiveness and safety of regimens using mifepristone and misoprostol for women who are

Research recommendation Published November 2019

Postnatal care

Everything NICE has said on the essential care that every woman and her baby should receive in the first 6–8 weeks after birth in an interactive flowchart

NICE Pathway Published May 2011 Last updated November 2019

Bacterial meningitis and meningococcal septicaemia in under 16s

Everything NICE has said on managing bacterial meningitis and meningococcal septicaemia in children and young people in an interactive flowchart

NICE Pathway Published July 2012 Last updated November 2019

Maternal and child nutrition

Everything NICE has said on maternal and child nutrition in an interactive flowchart

NICE Pathway Published November 2012 Last updated November 2019

Social and emotional wellbeing for children and young people

Everything NICE has said on supporting the social and emotional wellbeing of children and young people in an interactive flowchart

NICE Pathway Published December 2011 Last updated November 2019

Fever in under 5s

Everything NICE has said on assessing and initiating management of fever with no obvious cause in children under 5 in an interactive flowchart

NICE Pathway Published May 2013 Last updated November 2019

Urinary tract infections

Everything NICE has said on diagnosing, treating and managing urinary tract infections including lower (cystitis), upper (acute pyelonephritis) and recurrent UTIs in people with or without a catheter in an interactive flowchart

NICE Pathway Published August 2012 Last updated November 2019

What is the clinical and cost effectiveness of relaxation therapies for managing primary hypertension in adults in terms of reducing cardiovascular events and improving quality of life?

Recommendation ID NG136/5 Question What is the clinical and cost effectiveness of relaxation therapies for managing primary hypertension

Research recommendation Published November 2019

Bronchiolitis in children

Everything NICE has said on diagnosing and managing bronchiolitis in children in an interactive flowchart

NICE Pathway Published June 2015 Last updated November 2019

What is the optimum blood pressure target for people aged over 80 with treated primary hypertension?

Recommendation ID NG136/3 Question What is the optimum blood pressure target for people aged over 80 with treated primary hypertension

Research recommendation Published November 2019

ion (with or without type 2 diabetes), what are the appropriate risk and blood pressure thresholds for starting treatment?

Recommendation ID NG136/2 Question ion (with or without type 2 diabetes), what are the appropriate risk and blood pressure thresholds for

Research recommendation Published November 2019

Are there subgroups of people with hypertension who should start on dual therapy?

Recommendation ID NG136/4 Question Are there subgroups of people with hypertension who should start on dual therapy? Any explanatory

Research recommendation Published November 2019

Which automated blood pressure monitors are suitable for people with hypertension and atrial fibrillation?

Recommendation ID NG136/1 Question Which automated blood pressure monitors are suitable for people with hypertension and atrial fibrillation

Research recommendation Published November 2019

Respiratory conditions

Everything NICE has said on respiratory conditions in an interactive flowchart

NICE Pathway Published June 2015 Last updated October 2019

Generalised anxiety disorder

Everything NICE has said on managing generalised anxiety disorder in adults in primary, secondary and community care in an interactive flowchart

NICE Pathway Published March 2012 Last updated October 2019

Non-Hodgkin's lymphoma

Everything NICE has said on diagnosing and managing non-Hodgkin's lymphoma in adults and young people 16 years and older in an interactive flowchart

NICE Pathway Published July 2016 Last updated October 2019

What is the clinical and cost effectiveness, post treatment and at longer-term follow‑up, of behavioural activation compared with other psychological therapies in children aged 5 to 11 years and young people aged 12 to 18 years with mild or moderate to severe depression?

Recommendation ID NG134/5 Question What is the clinical and cost effectiveness, post treatment and at longer-term follow‑up, of behavioural

Research recommendation Published October 2019

What is the clinical utility of bone turnover markers in the diagnosis and management of primary hyperparathyroidism?

Recommendation ID NG132/1 Question What is the clinical utility of bone turnover markers in the diagnosis and management of primary...

Research recommendation Published October 2019

What components of alcohol education delivery contribute to its effectiveness for children and young people aged 11 to 18 in full-time education, and those with special educational needs and disabilities (SEND) up to the age of 25?

Recommendation ID NG135/1 Question What components of alcohol education delivery contribute to its effectiveness for children and young

Research recommendation Published October 2019

What is the prognostic value of different risk stratification methods for people with locally advanced prostate cancer?

Recommendation ID NG131/7 Question What is the prognostic value of different risk stratification methods for people with locally advanced

Research recommendation Published October 2019

What is the most clinically and cost-effective pathway for diagnosing clinically significant prostate cancer?

Recommendation ID NG131/3 Question What is the most clinically and cost-effective pathway for diagnosing clinically significant prostate

Research recommendation Published October 2019

The committee recommended further research to determine if using the lead‑I electrocardiogram (ECG) devices in primary care for people with signs or symptoms of atrial fibrillation, and an irregular pulse, increases the number of people with atrial fibrillation (including paroxysmal) detected,  ompared with current practice (that is, a 12‑lead ECG done later). The committee considered the feasibility of collecting data to see if using the lead‑I ECG devices increased the detection of atrial fibrillation that would be missed if only 12‑lead ECGs done later were available. It noted that even if a lead‑I ECG is used and atrial fibrillation is detected, a subsequent 12‑lead ECG would still be done to check for structural cardiac abnormalities and inform further management decisions. The committee concluded that practices using lead‑I ECG devices could determine the number of additional cases of atrial fibrillation detected by the devices. This can be done by identifying people with a confirmed positive lead‑I ECG for atrial fibrillation who subsequently had a 12‑lead ECG that was negative because the atrial fibrillation had stopped. The committee also considered that data collected on the time between the initial lead‑I ECG and the subsequent 12‑lead ECG would be useful.

Recommendation ID DG35/1 Question The committee recommended further research to determine if using the lead‑I electrocardiogram (ECG) devices

Research recommendation Published October 2019

Further primary research is recommended on the clinical effectiveness of using ELISA tests for therapeutic monitoring of TNF‑alpha inhibitors in people with rheumatoid arthritis.

Recommendation ID DG36/1 Question Further primary research is recommended on the clinical effectiveness of using ELISA tests for therapeutic

Research recommendation Published October 2019

What is the clinical and cost effectiveness of prednisolone, budesonide, and beclometasone in addition to aminosalicylates compared with each other and with aminosalicylate monotherapy for the induction of remission for people with mild-to-moderate ulcerative colitis?

Recommendation ID NG130/3 Question What is the clinical and cost effectiveness of prednisolone, budesonide, and beclometasone in addition

Research recommendation Published October 2019

How effective and cost effective are education-based alcohol interventions targeted at children and young people aged 11 to 25 with SEND who are thought to be vulnerable to alcohol misuse?

Recommendation ID NG135/4 Question How effective and cost effective are education-based alcohol interventions targeted at children and

Research recommendation Published October 2019

How effective and cost effective are individual, compared with group, education-based interventions for children and young people aged 11 to 18 in full-time education who are thought to be vulnerable to alcohol misuse?

Recommendation ID NG135/2 Question How effective and cost effective are individual, compared with group, education-based interventions

Research recommendation Published October 2019

How effective and cost effective are universal, education-based alcohol interventions for children and young people aged 11 to 25 with SEND?

Recommendation ID NG135/3 Question How effective and cost effective are universal, education-based alcohol interventions for children and

Research recommendation Published October 2019

What is the effectiveness of oral tacrolimus and systemic (intramuscular/subcutaneous/oral) methotrexate in the induction of remission in mild-to-moderate ulcerative colitis unresponsive to aminosalicylates?

Recommendation ID NG130/2 Question What is the effectiveness of oral tacrolimus and systemic (intramuscular/subcutaneous/oral) methotrexate

Research recommendation Published October 2019

What methods and techniques help secondary schools and providers to effectively engage with parents and carers as part of a whole-school approach to promote and support alcohol education?

Recommendation ID NG135/6 Question What methods and techniques help secondary schools and providers to effectively engage with parents

Research recommendation Published October 2019

What is the clinical and cost effectiveness of prednisolone compared with aminosalicylates for the induction of remission for people with moderate ulcerative colitis?

Recommendation ID NG130/4 Question What is the clinical and cost effectiveness of prednisolone compared with aminosalicylates for the induction

Research recommendation Published October 2019

What is the clinical and cost effectiveness of prednisolone plus an aminosalicylate compared with beclometasone plus an aminosalicylate for induction of remission for people with moderate ulcerative colitis?

Recommendation ID NG130/5 Question What is the clinical and cost effectiveness of prednisolone plus an aminosalicylate compared with beclometasone

Research recommendation Published October 2019

What are the benefits, risks and cost effectiveness of methotrexate, ciclosporin, tacrolimus, adalimumab and infliximab compared with each other and with placebo for induction of remission for people with subacute ulcerative colitis that is refractory to systemic corticosteroids?

Recommendation ID NG130/6 Question What are the benefits, risks and cost effectiveness of methotrexate, ciclosporin, tacrolimus, adalimumab

Research recommendation Published October 2019

What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of psychological therapies in children aged 5 to 11 years with mild or moderate to severe depression?

Recommendation ID NG134/1 Question What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of psychological

Research recommendation Published October 2019

Secondary research is recommended to understand the comparative performance of different ELISA tests for therapeutic monitoring of tumour necrosis factor (TNF)‑alpha inhibitors in rheumatoid arthritis

Recommendation ID DG36/3 Question Secondary research is recommended to understand the comparative performance of different ELISA tests

Research recommendation Published October 2019

What is the most clinically and cost-effective pathway for excluding the clinically significant progression of cancer in people with low- to intermediate-risk prostate cancer?

Recommendation ID NG131/4 Question What is the most clinically and cost-effective pathway for excluding the clinically significant progression

Research recommendation Published October 2019