Updating results

Managing glioma: management of IDH wildtype grade II glioma:- Does the addition of concurrent and adjuvant temozolomide to radiotherapy improve overall survival in patients with IDH wildtype grade II glioma?

Recommendation ID NG99/1 Question Managing glioma: management of IDH wildtype grade II glioma:- Does the addition of concurrent and adjuvant

Research recommendation Published December 2018

Managing glioma: early referral to palliative care for glioblastoma:- Does early referral to palliative care improve outcomes for people with glioblastomas in comparison with standard oncology care?

Recommendation ID NG99/3 Question Managing glioma: early referral to palliative care for glioblastoma:- Does early referral to palliative

Research recommendation Published December 2018

Managing glioma: early detection of recurrence after treatment:- Does early detection of recurrence after treatment improve overall survival/outcomes inmolecularly stratified glioma?

Recommendation ID NG99/4 Question Managing glioma: early detection of recurrence after treatment:- Does early detection of recurrence after

Research recommendation Published December 2018

Managing glioma: supportive care clinics for low-grade glioma:- Does a dedicated supportive care clinic in addition to standard care improve outcomes for people with low-grade gliomas?

Recommendation ID NG99/2 Question Managing glioma: supportive care clinics for low-grade glioma:- Does a dedicated supportive care clinic

Research recommendation Published December 2018

Adjuvant bisphosphonate therapy:- Which groups of people with early and locally advanced breast cancer would benefit from the use of adjuvant bisphosphonates?

Recommendation ID NG101/2 Question Adjuvant bisphosphonate therapy:- Which groups of people with early and locally advanced breast cancer

Research recommendation Published December 2018

Surgery to the breast:- What is the optimum tumour-free margin width after breast-conserving surgery for women with ductal carcinoma in situ (DCIS) and invasive breast cancer?

Recommendation ID NG101/1 Question Surgery to the breast:- What is the optimum tumour-free margin width after breast-conserving surgery

Research recommendation Published December 2018

Ultrasound in monitoring:- What is the clinical and cost effectiveness of using ultrasound to monitor disease in adults with RA when clinical examination is inconclusive or inconsistent with other signs of disease activity?

Recommendation ID NG100/3 Question Ultrasound in monitoring:- What is the clinical and cost effectiveness of using ultrasound to monitor

Research recommendation Published December 2018

Ultrasound in diagnosis:- What is the clinical and cost effectiveness of using ultrasound in addition to clinical assessment when there is uncertainty about the diagnosis in adults with suspected RA?

Recommendation ID NG100/4 Question Ultrasound in diagnosis:- What is the clinical and cost effectiveness of using ultrasound in addition

Research recommendation Published December 2018

Subcutaneous methotrexate:- What is the clinical and cost effectiveness of subcutaneous methotrexate compared with oral methotrexate for adults with early onset RA starting a new DMARD?

Recommendation ID NG100/6 Question Subcutaneous methotrexate:- What is the clinical and cost effectiveness of subcutaneous methotrexate

Research recommendation Published December 2018

Analgesics:- What is the clinical and cost effectiveness of analgesic drugs other than non-steroidal antiinflammatory drugs (NSAIDs) in adults with rheumatoid arthritis (RA) whose pain or stiffness control is not adequate?

Recommendation ID NG100/1 Question Analgesics:- What is the clinical and cost effectiveness of analgesic drugs other than non-steroidal

Research recommendation Published December 2018

Breast reconstruction:- What are the long-term outcomes for breast reconstruction in women having radiotherapy to the chest wall?

Recommendation ID NG101/3 Question Breast reconstruction:- What are the long-term outcomes for breast reconstruction in women having radiotherapy

Research recommendation Published December 2018

Neoadjuvant treatment:- What are the indications for postmastectomy radiotherapy after neoadjuvant chemotherapy?

Recommendation ID NG101/6 Question Neoadjuvant treatment:- What are the indications for postmastectomy radiotherapy after neoadjuvant chemotherapy

Research recommendation Published December 2018

Hearing loss prevalence in people who under-present for hearing loss:- What is the prevalence of hearing loss among populations who under-present for possible hearingloss?

Recommendation ID NG98/4 Question Hearing loss prevalence in people who under-present for hearing loss:- What is the prevalence of hearing

Research recommendation Published December 2018

Idiopathic sudden sensorineural hearing loss:- What is the most effective route of administration of steroids as a first-line treatment for idiopathic sudden sensorineural hearing loss?

Recommendation ID NG98/1 Question Idiopathic sudden sensorineural hearing loss:- What is the most effective route of administration of steroids

Research recommendation Published December 2018

Case management:- What is the effectiveness and cost effectiveness of high-intensity case management compared with usual care on quality of life (for the person living with dementia and for their carers) and the timing of entry to long-term care?

Recommendation ID NG97/1 Question Case management:- What is the effectiveness and cost effectiveness of high-intensity case management compared

Research recommendation Published December 2018

Staff training:- What is the cost effectiveness of using a dementia-specific addition to the Care Certificate for community staff, including dementia-specific elements on managing anxiety, communication, nutritional status and personal care?

Recommendation ID NG97/2 Question Staff training:- What is the cost effectiveness of using a dementia-specific addition to the Care Certificate

Research recommendation Published December 2018

Monitoring and follow-up for adults with hearing loss:- What is the clinical and cost effectiveness of monitoring and follow-up for adults with hearing loss post-intervention compared with usual care?

Recommendation ID NG98/5 Question Monitoring and follow-up for adults with hearing loss:- What is the clinical and cost effectiveness of

Research recommendation Published December 2018

Earwax:- What is the clinical and cost effectiveness of microsuction compared with irrigation to remove earwax?

Recommendation ID NG98/2 Question Earwax:- What is the clinical and cost effectiveness of microsuction compared with irrigation to remove earwax

Research recommendation Published December 2018

Care and support planning:- What are the most effective methods of care planning for people who do not have regular contact with an informal carer?

Recommendation ID NG97/5 Question Care and support planning:- What are the most effective methods of care planning for people who do not

Research recommendation Published December 2018

Managing delirium superimposed on dementia:- What are the most clinically and cost-effective non-pharmacological interventions for helping the long-term recovery of people with delirium superimposed on dementia?

Recommendation ID NG97/4 Question Managing delirium superimposed on dementia:- What are the most clinically and cost-effective non-pharmacological

Research recommendation Published December 2018

Use of hearing aids and incidence of dementia:- In adults with hearing loss, does the use of hearing aids reduce the incidence of dementia?

Recommendation ID NG98/3 Question Use of hearing aids and incidence of dementia:- In adults with hearing loss, does the use of hearing aids

Research recommendation Published December 2018

Further research on endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused by cancer should address: patient selection, relief of biliary obstruction, quality of life and survival.

Recommendation ID IPG614/1 Question Further research on endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused

Research recommendation Published December 2018

Anticholinergic burden:- Does actively reducing anticholinergic burden in people living with dementia improve cognitive outcomes compared with usual care?

Recommendation ID NG72/3 Question Anticholinergic burden:- Does actively reducing anticholinergic burden in people living with dementia

Research recommendation Published December 2018

Social anxiety disorder

Everything NICE has said on recognising, assessing and treating social anxiety disorder in children, young people and adults in an interactive flowchart

NICE Pathway Published May 2013 Last updated December 2018

Common mental health disorders in primary care

Everything NICE has said on identifying and managing common mental health disorders in adults in primary care in an interactive flowchart

NICE Pathway Published November 2013 Last updated December 2018

Post-traumatic stress disorder

Everything NICE has said on recognising, assessing and treating post-traumatic stress disorder in children, young people and adults in an interactive flowchart

NICE Pathway Published March 2012 Last updated December 2018

Bacterial meningitis and meningococcal septicaemia in under 16s

Everything NICE has said on managing bacterial meningitis and meningococcal septicaemia in children and young people in an interactive flowchart

NICE Pathway Published July 2012 Last updated November 2018

Models of care and support at home:- What is the effectiveness and cost effectiveness of care and support models (for example, assistive technology) for people growing older with learning disabilities to enable them to live in the family home?

Recommendation ID NG96/1 Question Models of care and support at home:- What is the effectiveness and cost effectiveness of care and support

Research recommendation Published November 2018

Headaches

Everything NICE has said on the most common primary headache disorders in young people aged 12 years and older and adults in an interactive flowchart

NICE Pathway Published September 2012 Last updated November 2018

Myocardial infarction with ST-segment elevation

Everything NICE has said on the acute management of myocardial infarction with ST-segment elevation in an interactive flowchart

NICE Pathway Published July 2013 Last updated November 2018

Seroprevalence of Lyme disease-specific antibodies and other tick-borne infections in the UK population:- What is the current seroprevalence of Lyme disease-specific antibodies and other tick-borne infections in people in the UK?

Recommendation ID NG95/3 Question Seroprevalence of Lyme disease-specific antibodies and other tick-borne infections in the UK population:- What

Research recommendation Published November 2018

Antimicrobial management of Lyme disease:- What are the most clinically and cost-effective treatment options for different clinical presentations of Lyme disease in the UK?

Recommendation ID NG95/4 Question Antimicrobial management of Lyme disease:- What are the most clinically and cost-effective treatment options

Research recommendation Published November 2018

Clinical epidemiology of Lyme disease in the UK:- What are the incidence, presenting features, management and outcome of Lyme disease in the UK?

Recommendation ID NG95/2 Question Clinical epidemiology of Lyme disease in the UK:- What are the incidence, presenting features, management

Research recommendation Published November 2018

The committee recommended that further research is needed to better understand the natural history of low-volume cervical intraepithelial neoplasia (CIN) 2 lesions.

Recommendation ID DG32/4 Question The committee recommended that further research is needed to better understand the natural history of

Research recommendation Published November 2018

The  committee recommended that data should be collected to show how the results of the technologies affect decision-making, including biopsy decisions and decisions todischarge people with a negative colposcopy examination back to routine screening.

Recommendation ID DG32/2 Question The committee recommended that data should be collected to show how the results of the technologies affect

Research recommendation Published November 2018

NICE encourages further research into microinvasive subconjunctival insertion of a trans-scleral gelatin stent for primary open-angle glaucoma, including randomised studies. Further research should include details of patient selection and long-term outcomes.

Recommendation ID IPG612/1 Question NICE encourages further research into microinvasive subconjunctival insertion of a trans-scleral gelatin

Research recommendation Published November 2018

Further research is needed to understand the effect of having the additional information provided by the adjunctive colposcopy technologies on anxiety for people having a colposcopy, when this information is shown to a person during the examination.

Recommendation ID DG32/3 Question Further research is needed to understand the effect of having the additional information provided by the

Research recommendation Published November 2018