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Further research in superior rectal artery embolisation for haemorrhoids should report details of patient selection, and follow-up efficacy (including symptom relief), need for subsequent treatments, quality of life and safety outcomes for at least 1 year.

Recommendation ID IPG627/1 Question Further research in superior rectal artery embolisation for haemorrhoids should report details of patient

Research recommendation Published December 2018

Opt-out strategies for front-line health and social care staff:- Are opt-out strategies effective and cost effective at increasing uptake of flu vaccination among front-line health and social care staff?

Recommendation ID NG103/4 Question Opt-out strategies for front-line health and social care staff:- Are opt-out strategies effective and

Research recommendation Published December 2018

Adjuvant bisphosphonate therapy:- Which groups of people with early and locally advanced breast cancer would benefit from the use of adjuvant bisphosphonates?

Recommendation ID NG101/2 Question Adjuvant bisphosphonate therapy:- Which groups of people with early and locally advanced breast cancer

Research recommendation Published December 2018

Surgery to the breast:- What is the optimum tumour-free margin width after breast-conserving surgery for women with ductal carcinoma in situ (DCIS) and invasive breast cancer?

Recommendation ID NG101/1 Question Surgery to the breast:- What is the optimum tumour-free margin width after breast-conserving surgery

Research recommendation Published December 2018

Ultrasound in monitoring:- What is the clinical and cost effectiveness of using ultrasound to monitor disease in adults with RA when clinical examination is inconclusive or inconsistent with other signs of disease activity?

Recommendation ID NG100/3 Question Ultrasound in monitoring:- What is the clinical and cost effectiveness of using ultrasound to monitor

Research recommendation Published December 2018

Ultrasound in diagnosis:- What is the clinical and cost effectiveness of using ultrasound in addition to clinical assessment when there is uncertainty about the diagnosis in adults with suspected RA?

Recommendation ID NG100/4 Question Ultrasound in diagnosis:- What is the clinical and cost effectiveness of using ultrasound in addition

Research recommendation Published December 2018

Subcutaneous methotrexate:- What is the clinical and cost effectiveness of subcutaneous methotrexate compared with oral methotrexate for adults with early onset RA starting a new DMARD?

Recommendation ID NG100/6 Question Subcutaneous methotrexate:- What is the clinical and cost effectiveness of subcutaneous methotrexate

Research recommendation Published December 2018

Specialised units for older people:- What is the most clinically and cost effective way to configure services to assess frail older people who present to hospital with a medical emergency?

Recommendation ID NG94/4 Question Specialised units for older people:- What is the most clinically and cost effective way to configure services

Research recommendation Published November 2018

Extended access to social care services:- What is the clinical and cost effectiveness of providing extended access to social care services, for example during early mornings and evenings, and 7 days a week?

Recommendation ID NG94/2 Question Extended access to social care services:- What is the clinical and cost effectiveness of providing extended

Research recommendation Published November 2018

Primary care-led assessment models:- Which primary care-led models of assessment of people with a suspected medical emergency in the community, such as GP home visits, are most clinically and cost effective? [See the evidence review on GP-led home visits.]

Recommendation ID NG94/8 Question Primary care-led assessment models:- Which primary care-led models of assessment of people with a suspected

Research recommendation Published November 2018

Hospital escalation policies:- Which components of a hospital escalation policy to deal with surges in demand are the most clinically and cost effective? [See the evidence review on escalation measures.]

Recommendation ID NG94/17 Question Hospital escalation policies:- Which components of a hospital escalation policy to deal with surges in

Research recommendation Published November 2018

'Physician extenders':- What is the clinical and cost effectiveness of providing 'physician extenders' such as advanced nurse practitioners, 'physician associates' and advanced clinical practitioners in secondary care?[See the evidence review on physician extenders.]

Recommendation ID NG94/15 Question 'Physician extenders':- What is the clinical and cost effectiveness of providing 'physician extenders'

Research recommendation Published November 2018

Same-day plain X-ray radiology or ultrasound:- What is the clinical and cost effectiveness of providing GPs with access to plain X-ray radiology or ultrasound with same-day results? [See the evidence review on GP access to radiology.]

Recommendation ID NG94/9 Question Same-day plain X-ray radiology or ultrasound:- What is the clinical and cost effectiveness of providing

Research recommendation Published November 2018

Selective dorsal rhizotomy treatment to reduce spasticity:- What is the clinical and cost effectiveness of selective dorsal rhizotomy compared with intrathecal baclofen to reduce spasticity in adults with cerebral palsy?

Recommendation ID NG119/2 Question Selective dorsal rhizotomy treatment to reduce spasticity:- What is the clinical and cost effectiveness

Research recommendation Published March 2019

Metabolic assessment:- What is the clinical and cost effectiveness of full metabolic assessment compared with standard advice alone, in people with recurrent calcium oxalate stones?

Recommendation ID NG118/1 Question Metabolic assessment:- What is the clinical and cost effectiveness of full metabolic assessment compared

Research recommendation Published March 2019

Frequency of follow-up imaging:- What is the clinical and cost effectiveness of 6-monthly imaging for 3 years for people with recurrent calcium renal or ureteric stones?

Recommendation ID NG118/4 Question Frequency of follow-up imaging:- What is the clinical and cost effectiveness of 6-monthly imaging for

Research recommendation Published March 2019

The health-related quality-of-life evidence of patients with perianal fistulas is also lacking, therefore further research is recommended. Any research should measure the effect of treatment using preference-based measures (such as use of the EQ-5D questionnaire).

Recommendation ID TA556/2 Question The health-related quality-of-life evidence of patients with perianal fistulas is also lacking, therefore

Research recommendation Published March 2019

Further research on platelet-rich plasma injections for knee osteoarthritis should be in the form of randomised controlled trials with medium- to long-term follow-up, including validated measures of knee function and patient-reported outcomes.

Recommendation ID IPG637/1 Question Further research on platelet-rich plasma injections for knee osteoarthritis should be in the form of

Research recommendation Published February 2019

Further research on ex-situ machine perfusion for extracorporeal preservation of livers for transplantation should report the exact method of perfusion used (such ashypothermic or normothermic), graft survival and the use of marginal grafts.

Recommendation ID IPG636/1 Question Further research on ex-situ machine perfusion for extracorporeal preservation of livers for transplantation

Research recommendation Published February 2019

Further research on electrically stimulated intravesical chemotherapy for nonmuscle-invasive bladder cancer should include randomised controlled trials compared withstandard care, which should report details of patient selection.

Recommendation ID IPG638/1 Question Further research on electrically stimulated intravesical chemotherapy for nonmuscle-invasive bladder

Research recommendation Published February 2019

Detection and management of respiratory disorders in primary and community care:- Can detection and management of respiratory disorders in adults with cerebral palsy be improved in primary and community care?

Recommendation ID NG119/3 Question Detection and management of respiratory disorders in primary and community care:- Can detection and management

Research recommendation Published March 2019

Prophylactic antibiotics for respiratory disorders:- Are prophylactic antibiotics clinically and cost effective in the management of respiratory symptoms in adults with cerebral palsy with significant respiratory comorbidity?

Recommendation ID NG119/4 Question Prophylactic antibiotics for respiratory disorders:- Are prophylactic antibiotics clinically and cost

Research recommendation Published March 2019

Augmentative and alternative communication systems:- Are augmentative and alternative communication systems clinically and cost effective in promoting  communication for adults with cerebral palsy who have communication difficulties?

Recommendation ID NG119/6 Question Augmentative and alternative communication systems:- Are augmentative and alternative communication systems

Research recommendation Published March 2019

Complex PTSD:- What is the clinical and cost effectiveness of interventions to deliver stabilisation and reintegration for people with complex PTSD?

Recommendation ID NG116/5 Question Complex PTSD:- What is the clinical and cost effectiveness of interventions to deliver stabilisation

Research recommendation Published February 2019

Emotional freedom techniques:- What is the clinical and cost effectiveness of emotional freedom techniques (EFT) for the treatment of PTSD in adults?

Recommendation ID NG116/6 Question Emotional freedom techniques:- What is the clinical and cost effectiveness of emotional freedom techniques

Research recommendation Published February 2019

Pulmonary hypertension:- What are the most clinical and cost-effective treatments for pulmonary hypertension in people with COPD?

Recommendation ID NG115/10 Question Pulmonary hypertension:- What are the most clinical and cost-effective treatments for pulmonary hypertension

Research recommendation Published February 2019

Diagnosing COPD: -  What are the characteristics of people diagnosed with COPD as a result of an incidental finding ofemphysema on a CT scan, compared with those diagnosed with symptoms?

Recommendation ID NG115/6 Question Diagnosing COPD: - What are the characteristics of people diagnosed with COPD as a result of an incidental

Research recommendation Published February 2019

Prophylactic antibiotics for preventing exacerbations:- Which subgroups of people with stable COPD who are at high risk of exacerbations are most likely to benefit from prophylactic antibiotics?

Recommendation ID NG115/5 Question Prophylactic antibiotics for preventing exacerbations:- Which subgroups of people with stable COPD who

Research recommendation Published February 2019

Mucolytic therapy:- In people with COPD, does mucolytic drug therapy prevent exacerbations in comparison with placebo and other therapies?

Recommendation ID NG115/11 Question Mucolytic therapy:- In people with COPD, does mucolytic drug therapy prevent exacerbations in comparison

Research recommendation Published February 2019

Inhaled therapies for people with COPD and asthma- What is the clinical and cost effectiveness of inhaled therapies (bronchodilators and/or inhaled corticosteroids) in people with both stable COPD and asthma?

Recommendation ID NG115/3 Question Inhaled therapies for people with COPD and asthma- What is the clinical and cost effectiveness of inhaled

Research recommendation Published February 2019

Inhaled corticosteroid responsiveness:- What features predict inhaled corticosteroid responsiveness most accurately in people with COPD?

Recommendation ID NG115/4 Question Inhaled corticosteroid responsiveness:- What features predict inhaled corticosteroid responsiveness most

Research recommendation Published February 2019

Further research on transcutaneous neuromuscular electrical stimulation for oropharyngeal dysphagia in adults should address patient selection, variations in technique, the need for retreatments and long-term outcomes.

Recommendation ID IPG634/1 Question Further research on transcutaneous neuromuscular electrical stimulation for oropharyngeal dysphagia

Research recommendation Published January 2019

Monitoring pulmonary disease:- Is lung clearance index a useful and cost-effective tool for the routine assessment and monitoring of changes in pulmonary status in people with cystic fibrosis?

Recommendation ID NG78/3 Question Monitoring pulmonary disease:- Is lung clearance index a useful and cost-effective tool for the routine

Research recommendation Published November 2018

Indicators and thresholds for referral for cataract surgery:- What is the association between preoperative vision- and health-related quality of life, and postoperative vision-related quality of life, health-related quality of life, and self-reported postoperative improvement?

Recommendation ID NG77/3 Question Indicators and thresholds for referral for cataract surgery:- What is the association between preoperative

Research recommendation Published November 2018