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Support to carers and practitioners to help young people's independence:- What is the most effective way to help carers and practitioners support young people's independence?

Recommendation ID NG43/5 Question Support to carers and practitioners to help young people's independence:- What is the most effective way

Research recommendation Published March 2016

Sequence of invasive OAB procedures:- What is the effectiveness and optimum sequence of treatment with botulinum toxin A and percutaneous sacral nerve stimulation for the treatment of OAB after failed conservative (including drug) management?

Recommendation ID CG171/4 Question Sequence of invasive OAB procedures:- What is the effectiveness and optimum sequence of treatment with

Research recommendation Published June 2015

Serological testing in people who have IgA deficiency:- What is the sensitivity and specificity of IgG tissue transglutaminase (tTG), IgG endomysial antibodies (EMA) and IgG deamidated gliadin peptide (DGP) tests in detecting coeliac disease in people with IgA deficiency?

Recommendation ID NG20/1 Question Serological testing in people who have IgA deficiency:- What is the sensitivity and specificity of IgG

Research recommendation Published October 2015

Self-management:- Do structured psoriasis-focused self-management programmes improve patient confidence, wellbeing and disease control compared with standard care?

Recommendation ID CG153/4 Question Self-management:- Do structured psoriasis-focused self-management programmes improve patient confidence

Research recommendation Published June 2015

Serological testing in people who test negative for anti-transglutaminase:- What is the sensitivity and specificity of IgA EMA and IgA DGP tests in detecting coeliac disease inpeople who test negative for IgA tTG?

Recommendation ID NG20/2 Question Serological testing in people who test negative for anti-transglutaminase:- What is the sensitivity and

Research recommendation Published October 2015

Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study should be carried out to assess the incidence of suspected and proven neutropenic sepsis in patients having anticancer treatment.

Recommendation ID CG151/1 Question Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study

Research recommendation Published June 2015

Saliva:- How is excessive drooling of saliva (sialorrhoea) managed in people with motor neurone disease (MND)?

Recommendation ID NG42/4 Question Saliva:- How is excessive drooling of saliva (sialorrhoea) managed in people with motor neurone disease

Research recommendation Published March 2016

Specialist investigation:- What specialist investigations should be conducted to exclude a diagnosis of functional dyspepsia in people with uninvestigated dyspepsia that does not respond to PPIs or H2 receptor antagonists (H2RAs) despite optimum primary care?

Recommendation ID CG184/5 Question Specialist investigation:- What specialist investigations should be conducted to exclude a diagnosis

Research recommendation Published June 2015

NICE recommends that future trials should include longer-term follow-up, beyond the initial hospital episode, with a view to informing the cost-effectiveness modelling and reducing uncertainty.

Recommendation ID DG13/4 Question NICE recommends that future trials should include longer-term follow-up, beyond the initial hospital episode

Research recommendation Published June 2015

Non-vitamin K antagonist oral anticoagulants:- Do people with atrial fibrillation whose anticoagulant control is poor, or is predicted to be poor, with warfarin benefit from changing to one of the non-vitamin K antagonist (non-VKA) oral anticoagulants?

Recommendation ID CG180/4 Question Non-vitamin K antagonist oral anticoagulants:- Do people with atrial fibrillation whose anticoagulant

Research recommendation Published June 2015

NICE recommends that robust evidence be generated to show the clinical effectiveness of pharmacokinetic dose adjustment of continuous infusion 5-FU in people with colorectal cancer.

Recommendation ID DG16/2 Question NICE recommends that robust evidence be generated to show the clinical effectiveness of pharmacokinetic

Research recommendation Published June 2015

Peer support interventions:- What is the clinical and cost effectiveness of peer support interventions in people with psychosis and schizophrenia?

Recommendation ID CG178/1 Question Peer support interventions:- What is the clinical and cost effectiveness of peer support interventions

Research recommendation Published June 2015

Oxygen saturation measurement in primary care:- What is the clinical and cost effectiveness of oxygen saturation (SpO2) measurement in primary care in children with bronchiolitis?

Recommendation ID NG9/1 Question Oxygen saturation measurement in primary care:- What is the clinical and cost effectiveness of oxygen saturation

Research recommendation Published October 2015

Older people's experiences:- What is the lived experience of older people with social care needs and multiple long-term conditions?

Recommendation ID NG22/1 Question Older people's experiences:- What is the lived experience of older people with social care needs and multiple

Research recommendation Published December 2015

Oral health promotion advice:- For groups at high risk of poor oral health, how effective and cost effective is it to extend an existing appointment by a few minutes, or to offer separate sessions on oral health advice?

Recommendation ID NG30/1 Question Oral health promotion advice:- For groups at high risk of poor oral health, how effective and cost effective

Research recommendation Published January 2016

People who choose not to take antipsychotic medication:- What is the clinical and cost effectiveness of psychological intervention alone, compared with treatment as usual, in people with psychosis or schizophrenia who choose not to take antipsychotic medication?

Recommendation ID CG178/2 Question People who choose not to take antipsychotic medication:- What is the clinical and cost effectiveness

Research recommendation Published June 2015

Pharmacological therapies:- What is the clinical and cost effectiveness of benzodiazepines for the acute management of low back pain?

Recommendation ID NG59/1 Question Pharmacological therapies:- What is the clinical and cost effectiveness of benzodiazepines for the acute

Research recommendation Published February 2017

How can the implementation of the recommendations made in this guideline be evaluated?

Recommendation ID NG13/1 Question How can the implementation of the recommendations made in this guideline be evaluated? Any explanatory

Research recommendation Published October 2015

How effective and cost effective are behaviour change interventions delivered remotely (that is, by telephone, text message, phone and tablet apps or the internet)? How does this vary among behaviours and among people from different sociodemographic groups?

Recommendation ID PH49/6 Question How effective and cost effective are behaviour change interventions delivered remotely (that is, by telephone

Research recommendation Published June 2015

Impact of risk-reducing surgery:- Further research is recommended to compare psychosocial and clinical outcomes in women who choose and women who do not choose to have risk-reducing surgery. [new 2013]

Recommendation ID CG164/5 Question Impact of risk-reducing surgery:- Further research is recommended to compare psychosocial and clinical

Research recommendation Published June 2015

How effective and cost effective are interventions that use varenicline for people who are using acute, maternity and mental health services?

Recommendation ID PH48/7 Question How effective and cost effective are interventions that use varenicline for people who are using acute

Research recommendation Published June 2015

Imaging of ankle fractures:- Is CT scanning in addition to initial plain film X-ray clinically effective and cost effective for planning surgical treatment of unstable/displaced ankle fractures compared with plain film X-ray alone?

Recommendation ID NG38/1 Question Imaging of ankle fractures:- Is CT scanning in addition to initial plain film X-ray clinically effective

Research recommendation Published March 2016

Improving consent rates:- What are the key components of an intervention to improve consent rates?

Recommendation ID CG135/4 Question Improving consent rates:- What are the key components of an intervention to improve consent rates?

Research recommendation Published June 2015

Identifying older people at high risk:- In the UK, what are the most effective ways to identify older people who at risk of a decline in their independence and mental wellbeing?

Recommendation ID NG32/2 Question Identifying older people at high risk:- In the UK, what are the most effective ways to identify older

Research recommendation Published January 2016

In people who have not undergone revascularisation after an MI, does clopidogrel and placebo have a better outcome than clopidogrel and aspirin?

Recommendation ID CG172/1 Question In people who have not undergone revascularisation after an MI, does clopidogrel and placebo have a better

Research recommendation Published June 2015

Intensive rehabilitation after stroke:- In people after stroke what is the clinical and cost effectiveness of intensive rehabilitation (6 hours per day) versus moderate rehabilitation (2 hours per day) on activity, participation and quality of life outcomes?

Recommendation ID CG162/2 Question Intensive rehabilitation after stroke:- In people after stroke what is the clinical and cost effectiveness

Research recommendation Published June 2015

How prevalent is smokeless tobacco use among South Asian women who are pregnant and why? Is there a particular stage during pregnancy when smokeless tobacco is used? What impact does its use during pregnancy have on maternal and child health?

Recommendation ID PH39/2 Question How prevalent is smokeless tobacco use among South Asian women who are pregnant and why? Is there a particular

Research recommendation Published June 2015

How many confirmatory diagnostic biopsies are carried out before definitive treatment, in people who have a clinical diagnosis of basal cell carcinoma and which different modalities used to treat basal cell carcinoma?

Recommendation ID DG19/3 Question How many confirmatory diagnostic biopsies are carried out before definitive treatment, in people who have

Research recommendation Published January 2016

How effective are licensed nicotine-containing products when used for more than one year? What is the impact of different doses and duration of use? What is the effect on health of long-term use? What are smokers' and practitioners' views on long-term use?

Recommendation ID PH45/1 Question How effective are licensed nicotine-containing products when used for more than one year? What is the

Research recommendation Published June 2015

In adults with common bile duct stones, should laparoscopic cholecystectomy be performed early (within 2 weeks of bile duct clearance), or should it be delayed (until 6 weeks after bile duct clearance)?

Recommendation ID CG188/4 Question In adults with common bile duct stones, should laparoscopic cholecystectomy be performed early (within

Research recommendation Published June 2015

In people with acute heart failure, congestion and worsening renal function, does the addition of low-dose dopamine to standard therapy lead to greater diuresis and renal protection compared with adding placebo to standard therapy?

Recommendation ID CG187/1 Question In people with acute heart failure, congestion and worsening renal function, does the addition of low-dose

Research recommendation Published June 2015

How effective and cost effective are interventions which use either a 'total population' or 'high-risk population' approach to preventing type 2 diabetes among people from black and minority ethnic or lower socioeconomic groups?

Recommendation ID PH35/1 Question How effective and cost effective are interventions which use either a 'total population' or 'high-risk

Research recommendation Published June 2015

How safe are drugs used to treat bipolar disorder in pregnancy and the postnatal period?

Recommendation ID CG192/2 Question How safe are drugs used to treat bipolar disorder in pregnancy and the postnatal period? Any explanatory

Research recommendation Published July 2017