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Probiotic and prebiotic supplements:- What is the clinical and cost effectiveness of probiotics or prebiotics to treat NAFLD in adults, young people and children?

Recommendation ID NG49/4 Question Probiotic and prebiotic supplements:- What is the clinical and cost effectiveness of probiotics or prebiotics

Research recommendation Published August 2016

Prognostic tools:- Is the amyotrophic lateral sclerosis (ALS) Prognostic Index an accurate predictor of survival in people with MND under NHS care in England and/or Wales?

Recommendation ID NG42/3 Question Prognostic tools:- Is the amyotrophic lateral sclerosis (ALS) Prognostic Index an accurate predictor of

Research recommendation Published March 2016

Priority of treatment for people with anxiety and depression:- For people with both anxiety and depression, which disorder should be treated first to improve their outcomes?

Recommendation ID CG123/6 Question Priority of treatment for people with anxiety and depression:- For people with both anxiety and depression

Research recommendation Published June 2015

Relationship between volume of procedures and clinical outcomes:- What is the relationship between hospital volume of primary PCI procedures and optimal outcomes in people with acute STEMI?

Recommendation ID CG167/5 Question Relationship between volume of procedures and clinical outcomes:- What is the relationship between hospital

Research recommendation Published June 2015

Recognising dying:- What can multiprofessional teams do to reduce the impact of uncertainty of recognising when a person is entering the last days of life on clinical care, shared decision-making and communication with the dying person and those important to them?

Recommendation ID NG31/1 Question Recognising dying:- What can multiprofessional teams do to reduce the impact of uncertainty of recognising

Research recommendation Published January 2016

Refractory [Irritable bowel syndrome] (IBS):- What factors contribute to refractory IBS?

Recommendation ID CG61/3 Question Refractory [Irritable bowel syndrome] (IBS):- What factors contribute to refractory IBS? Any explanatory

Research recommendation Published June 2015

NICE encourages further research into normothermic extracorporeal preservation of hearts for transplantation following donation after brainstem death. Outcomes should include primary graft function, graft function in the long term and device-related complications.

Recommendation ID IPG549/1 Question NICE encourages further research into normothermic extracorporeal preservation of hearts for transplantation

Research recommendation Published March 2016

Metformin preparations for children and young people with type 2 diabetes:- What is the long-term comparative clinical and cost effectiveness of different metformin preparations for treating type 2 diabetes in children and young people?

Recommendation ID NG18/3 Question Metformin preparations for children and young people with type 2 diabetes:- What is the long-term comparative

Research recommendation Published October 2015

Neurostimulation:- What is the comparative effectiveness and cost-effectiveness of transcutaneous stimulation of the sacral nerve roots, and transcutaneous and percutaneous posterior tibial nerve stimulation for the treatment of OAB?

Recommendation ID CG171/2 Question Neurostimulation:- What is the comparative effectiveness and cost-effectiveness of transcutaneous stimulation

Research recommendation Published June 2015

Measuring improvements in care home residents' oral health:- How can interventions to improve and maintain oral health and wellbeing, or to prevent dental disease, be measured using a patient-centred approach that can also be used to judge cost effectiveness?

Recommendation ID NG48/3 Question Measuring improvements in care home residents' oral health:- How can interventions to improve and maintain

Research recommendation Published August 2016

Nasal suction:- What is the clinical and cost effectiveness of suction to remove secretions from the upper respiratory tract compared with minimal handling?

Recommendation ID NG9/5 Question Nasal suction:- What is the clinical and cost effectiveness of suction to remove secretions from the upper

Research recommendation Published October 2015

NICE concluded that further research directly comparing the clinical and cost effectiveness of ranibizumab and bevacizumab in people with macular oedema secondary to retinal vein occlusion should be conducted.

Recommendation ID TA283/1 Question NICE concluded that further research directly comparing the clinical and cost effectiveness of ranibizumab

Research recommendation Published June 2015

Natural history of varicose veins:- In people with varicose veins at CEAP (Clinical, etiological, anatomical and pathophysiological) stage C2 or C3, what are the factors that influence progression of the disease to CEAP stages C5 or C6?

Recommendation ID CG168/1 Question Natural history of varicose veins:- In people with varicose veins at CEAP (Clinical, etiological, anatomical

Research recommendation Published June 2015

NICE considered that if enzalutamide is used in routine clinical practice for treating hormone relapsed metastatic prostate cancer that has been previously treated with abiraterone, data should be collected on resource use and overall survival.

Recommendation ID TA316/2 Question NICE considered that if enzalutamide is used in routine clinical practice for treating hormone relapsed

Research recommendation Published June 2015

Needs assessment:- In the UK, how prevalent is coexisting severe mental illness with substance misuse and what are the physical health, social care, housing or other support needs of people with this diagnosis?

Recommendation ID NG58/1 Question Needs assessment:- In the UK, how prevalent is coexisting severe mental illness with substance misuse

Research recommendation Published February 2017

Neuropathic pain relief:- Does early treatment with a centrally acting analgesic (for example pregabalin) reduce the frequency or severity of neuropathic pain in people with spinal cord injury?

Recommendation ID NG41/1 Question Neuropathic pain relief:- Does early treatment with a centrally acting analgesic (for example pregabalin)

Research recommendation Published April 2016

Social media:- How effective are online social media and networks at improving health and wellbeing and reducing health inequalities when they are used:- as a method of community engagement?- to support an existing community engagement approach?

Recommendation ID NG44/4 Question Social media:- How effective are online social media and networks at improving health and wellbeing and

Research recommendation Published April 2016

Self-monitoring of blood glucose levels:- What is the optimal frequency for self-monitoring of blood glucose in adults with type 2 diabetes?

Recommendation ID NG28/5 Question Self-monitoring of blood glucose levels:- What is the optimal frequency for self-monitoring of blood glucose

Research recommendation Published January 2016

Service delivery models:- Which models of service delivery are effective and cost-effective for older people with social care needs and multiple long-term conditions?

Recommendation ID NG22/2 Question Service delivery models:- Which models of service delivery are effective and cost-effective for older

Research recommendation Published December 2015

Safety and safeguarding:- What safeguarding practices are most effective in improving outcomes for people using services?

Recommendation ID NG21/5 Question Safety and safeguarding:- What safeguarding practices are most effective in improving outcomes for people

Research recommendation Published October 2015

Safety and efficacy of antimuscarinics:- What is the safety and efficacy of more recently developed antimuscarinics compared with (a) placebo/usual care and (b) other antimuscarinics in the treatment of neurogenic lower urinary tract dysfunction?

Recommendation ID CG148/1 Question Safety and efficacy of antimuscarinics:- What is the safety and efficacy of more recently developed antimuscarinics

Research recommendation Published June 2015

Signs and symptoms that predict neutropenic sepsis in the community:- A prospective study should be carried out to determine which signs and symptoms experienced by patients in the community predict neutropenic sepsis and the outcomes of these episodes.

Recommendation ID CG151/3 Question Signs and symptoms that predict neutropenic sepsis in the community:- A prospective study should be carried

Research recommendation Published June 2015

Support to carers and practitioners to help young people's independence:- What is the most effective way to help carers and practitioners support young people's independence?

Recommendation ID NG43/5 Question Support to carers and practitioners to help young people's independence:- What is the most effective way

Research recommendation Published March 2016

Sequence of invasive OAB procedures:- What is the effectiveness and optimum sequence of treatment with botulinum toxin A and percutaneous sacral nerve stimulation for the treatment of OAB after failed conservative (including drug) management?

Recommendation ID CG171/4 Question Sequence of invasive OAB procedures:- What is the effectiveness and optimum sequence of treatment with

Research recommendation Published June 2015

Serological testing in people who have IgA deficiency:- What is the sensitivity and specificity of IgG tissue transglutaminase (tTG), IgG endomysial antibodies (EMA) and IgG deamidated gliadin peptide (DGP) tests in detecting coeliac disease in people with IgA deficiency?

Recommendation ID NG20/1 Question Serological testing in people who have IgA deficiency:- What is the sensitivity and specificity of IgG

Research recommendation Published October 2015

Self-management:- Do structured psoriasis-focused self-management programmes improve patient confidence, wellbeing and disease control compared with standard care?

Recommendation ID CG153/4 Question Self-management:- Do structured psoriasis-focused self-management programmes improve patient confidence

Research recommendation Published June 2015

Serological testing in people who test negative for anti-transglutaminase:- What is the sensitivity and specificity of IgA EMA and IgA DGP tests in detecting coeliac disease inpeople who test negative for IgA tTG?

Recommendation ID NG20/2 Question Serological testing in people who test negative for anti-transglutaminase:- What is the sensitivity and

Research recommendation Published October 2015

Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study should be carried out to assess the incidence of suspected and proven neutropenic sepsis in patients having anticancer treatment.

Recommendation ID CG151/1 Question Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study

Research recommendation Published June 2015

Saliva:- How is excessive drooling of saliva (sialorrhoea) managed in people with motor neurone disease (MND)?

Recommendation ID NG42/4 Question Saliva:- How is excessive drooling of saliva (sialorrhoea) managed in people with motor neurone disease

Research recommendation Published March 2016

Specialist investigation:- What specialist investigations should be conducted to exclude a diagnosis of functional dyspepsia in people with uninvestigated dyspepsia that does not respond to PPIs or H2 receptor antagonists (H2RAs) despite optimum primary care?

Recommendation ID CG184/5 Question Specialist investigation:- What specialist investigations should be conducted to exclude a diagnosis

Research recommendation Published June 2015

Specialist dementia support:- What is the most effective and cost effective way to support people with dementia living at home?

Recommendation ID NG21/4 Question Specialist dementia support:- What is the most effective and cost effective way to support people with

Research recommendation Published October 2015

Research into the long-term treatment effects of rivaroxaban is needed.

Recommendation ID TA287/2 Question Research into the long-term treatment effects of rivaroxaban is needed. Any explanatory notes(if

Research recommendation Published June 2015