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What is the prognostic value of different risk stratification methods for people with locally advanced prostate cancer?

Recommendation ID NG131/7 Question What is the prognostic value of different risk stratification methods for people with locally advanced

Research recommendation Published October 2019

What is the most clinically and cost-effective pathway for diagnosing clinically significant prostate cancer?

Recommendation ID NG131/3 Question What is the most clinically and cost-effective pathway for diagnosing clinically significant prostate

Research recommendation Published October 2019

How effective are education-based alcohol prevention interventions (universal or targeted) for children and young people aged 11 to 25 with SEND in full-time education?

Recommendation ID NG135/5 Question How effective are education-based alcohol prevention interventions (universal or targeted) for children

Research recommendation Published October 2019

What is the most clinically and cost-effective pathway for excluding the clinically significant progression of cancer in people with low- to intermediate-risk prostate cancer?

Recommendation ID NG131/4 Question What is the most clinically and cost-effective pathway for excluding the clinically significant progression

Research recommendation Published October 2019

At what gestation should treatment with prophylactic vaginal progesterone for the prevention of preterm birth be started and stopped?

Recommendation ID NG25/7 Question At what gestation should treatment with prophylactic vaginal progesterone for the prevention of preterm

Research recommendation Published October 2019

Does progesterone reduce the risk of preterm birth in women who have a short cervix (cervical length of 25 mm or less), but do not have other risk factors for preterm birth?

Recommendation ID NG25/6 Question Does progesterone reduce the risk of preterm birth in women who have a short cervix (cervical length of

Research recommendation Published October 2019

Does progesterone reduce the risk of preterm birth in women who have risk factors for preterm birth, but do not have a short cervix (cervical length of more than 25 mm)?

Recommendation ID NG25/5 Question Does progesterone reduce the risk of preterm birth in women who have risk factors for preterm birth, but

Research recommendation Published October 2019

What is the best and most cost-effective management strategy for people whose first surgery for primary hyperparathyroidism is not successful?

Recommendation ID NG132/2 Question What is the best and most cost-effective management strategy for people whose first surgery for primary

Research recommendation Published October 2019

What are the optimal management strategies for primary hyperparathyroidism during pregnancy?

Recommendation ID NG132/4 Question What are the optimal management strategies for primary hyperparathyroidism during pregnancy? Any

Research recommendation Published October 2019

What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of psychological therapies in children aged 5 to 11 years with mild or moderate to severe depression?

Recommendation ID NG134/1 Question What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of psychological

Research recommendation Published October 2019

What methods and techniques help secondary schools and providers to effectively engage with parents and carers as part of a whole-school approach to promote and support alcohol education?

Recommendation ID NG135/6 Question What methods and techniques help secondary schools and providers to effectively engage with parents and

Research recommendation Published October 2019

The Committee considered that rigorous data collection is needed on the life-extending benefits of lenalidomide when used in people with multiple myeloma who have received two or more prior therapies.

Recommendation ID TA171/1 Question The Committee considered that rigorous data collection is needed on the life-extending benefits of lenalidomide

Research recommendation Published October 2019

What are the long-term outcomes of different management strategies for primary hyperparathyroidism? Which strategies are most cost effective?

Recommendation ID NG132/3 Question What are the long-term outcomes of different management strategies for primary hyperparathyroidism? Which

Research recommendation Published October 2019

What is the natural history of people with a Likert score on MRI of less than 3 without biopsy at long-term follow‑up?

Recommendation ID NG131/5 Question What is the natural history of people with a Likert score on MRI of less than 3 without biopsy at long-term

Research recommendation Published October 2019

What is the optimal regimen for general anaesthesia for women having surgical abortion?

Recommendation ID NG140/7 Question What is the optimal regimen for general anaesthesia for women having surgical abortion? Any explanatory

Research recommendation Published November 2019

What local anaesthetic techniques are most effective for women having surgical abortion?

Recommendation ID NG140/5 Question What local anaesthetic techniques are most effective for women having surgical abortion? Any explanatory

Research recommendation Published November 2019

What is the optimal antibiotic prophylaxis regimen for women who are having a surgical abortion?

Recommendation ID NG140/1 Question What is the optimal antibiotic prophylaxis regimen for women who are having a surgical abortion?

Research recommendation Published November 2019

Should women having a surgical abortion up to and including 10+0 weeks' gestation have anti-D prophylaxis if they are RhD (or D) negative?

Recommendation ID NG140/3 Question Should women having a surgical abortion up to and including 10+0 weeks' gestation have anti-D prophylaxis

Research recommendation Published November 2019

Which automated blood pressure monitors are suitable for people with hypertension and atrial fibrillation?

Recommendation ID NG136/1 Question Which automated blood pressure monitors are suitable for people with hypertension and atrial fibrillation

Research recommendation Published November 2019

What is the optimum blood pressure target for people aged over 80 with treated primary hypertension?

Recommendation ID NG136/3 Question What is the optimum blood pressure target for people aged over 80 with treated primary hypertension?

Research recommendation Published November 2019

What are the most effective and acceptable methods of cervical priming before dilatation and evacuation after 16+0 weeks' gestation?

Recommendation ID NG140/2 Question What are the most effective and acceptable methods of cervical priming before dilatation and evacuation

Research recommendation Published November 2019

Apart from culture, what other diagnostic tests or combinations of tests are effective inestablishing an accurate diagnosis of active respiratory TB in children and young people withsuspected active TB?

Recommendation ID NG33/2 Question Apart from culture, what other diagnostic tests or combinations of tests are effective inestablishing

Research recommendation Published November 2019

The evidence on cardiac contractility modulation device implantation for heart failure raises no major safety concerns. However, the evidence on efficacy is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research.

Recommendation ID IPG655 Question The evidence on cardiac contractility modulation device implantation for heart failure raises no major

Research recommendation Published November 2019

Current evidence on the safety and efficacy of low-energy contact X‑ray brachytherapy (the Papillon technique) for locally advanced rectal cancer is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research.

Recommendation ID IPG659/1 Question Current evidence on the safety and efficacy of low-energy contact X‑ray brachytherapy (the Papillon

Research recommendation Published November 2019

Current evidence on the safety and efficacy of implant insertion for prominent ears is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research.

Recommendation ID IPG660/1 Question Current evidence on the safety and efficacy of implant insertion for prominent ears is inadequate in

Research recommendation Published November 2019

Evidence on the safety and efficacy of high-intensity focused ultrasound for glaucoma is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research.

Recommendation ID IPG661/1 Question Evidence on the safety and efficacy of high-intensity focused ultrasound for glaucoma is inadequate

Research recommendation Published November 2019

Current evidence on the safety and efficacy of bronchoscopic thermal vapour ablation for upper-lobe emphysema is inadequate in quantity and quality. Therefore the procedure should only be used in the context of research.

Recommendation ID IPG652/1 Question Current evidence on the safety and efficacy of bronchoscopic thermal vapour ablation for upper-lobe

Research recommendation Published November 2019

Early interventions to prevent problems escalating:- What interventions are effective in diverting children and young people away from further harmful sexual behaviour before a legal response is needed?

Recommendation ID NG55/4 Question Early interventions to prevent problems escalating:- What interventions are effective in diverting children

Research recommendation Published October 2016

Duration of antibiotic treatment:- What is the optimal duration of treatment (course length) in babies who receive antibiotics for confirmed early-onset neonatal infection?

Recommendation ID CG149/5 Question Duration of antibiotic treatment:- What is the optimal duration of treatment (course length) in babies

Research recommendation Published June 2015

For which service users who are moderately and severely dependent on alcohol is an assertive community treatment model a clinically and cost-effective intervention compared with standard care?

Recommendation ID CG115/4 Question For which service users who are moderately and severely dependent on alcohol is an assertive community

Research recommendation Published June 2015

Does the provision of educational and supportive interventions to people with chronic kidney disease (CKD) by healthcare professionals increase patients' skills and confidence in managing their conditions and improve clinical outcomes?

Recommendation ID CG182/1 Question Does the provision of educational and supportive interventions to people with chronic kidney disease

Research recommendation Published June 2015

Recognition and early management of pain in children and young people with cerebral palsy:- Does use of pain assessment tools by parents or carers improve the recognition and early management of pain in children and young people with cerebral palsy in a community setting?

Recommendation ID NG62/3 Question Recognition and early management of pain in children and young people with cerebral palsy:- Does use of

Research recommendation Published February 2017

Effectiveness and costs of oral health interventions for care home residents:- How effective and cost effective are oral health interventions in care homes including suitableperson-centred outcome measures?

Recommendation ID NG48/2 Question Effectiveness and costs of oral health interventions for care home residents:- How effective and cost

Research recommendation Published August 2016

Effectiveness of 'rescue' cerclage:- What is the clinical effectiveness of 'rescue' cerclage in improving outcomes for women at risk of preterm birth?

Recommendation ID NG25/3 Question Effectiveness of 'rescue' cerclage:- What is the clinical effectiveness of 'rescue' cerclage in improving

Research recommendation Published December 2015

Effectiveness and cost effectiveness:- Are particular components of community engagement approaches more effective and cost effective at improving health and wellbeing and reducing health inequalities than other components?

Recommendation ID NG44/1 Question Effectiveness and cost effectiveness:- Are particular components of community engagement approaches more

Research recommendation Published April 2016

Education and psycho-behavioural interventions for prevention:- What is the role of educational models and psycho-behavioural interventions in prevention of diabetic foot complications?

Recommendation ID NG19/3 Question Education and psycho-behavioural interventions for prevention:- What is the role of educational models

Research recommendation Published October 2015

Electronic Decision Support:- What is the clinical and cost effectiveness of an electronic decision support system compared with current practice in reducing inappropriate blood transfusions, overall rates of blood transfusion and mortality?

Recommendation ID NG24/2 Question Electronic Decision Support:- What is the clinical and cost effectiveness of an electronic decision support

Research recommendation Published December 2015

Early supported discharge in care home patients:- What is the clinical and cost effectiveness of early supported discharge on mortality, quality of life and functional status in patients with hip fracture who are admitted from a care home?

Recommendation ID CG124/5 Question Early supported discharge in care home patients:- What is the clinical and cost effectiveness of early

Research recommendation Published June 2015