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  1. What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of family therapy, psychodynamic psychotherapy and interpersonal psychotherapy for adolescents (IPT‑A) compared with each other and with individual CBT in young people aged 12 to 18 years with moderate to severe depression?

    Recommendation ID NG134/3 Question What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of family

  2. What is the most clinically and cost-effective follow‑up protocol for people with prostate cancer who have had radical treatment, with specific regard to risk stratification, duration of follow‑up, frequency of follow‑up appointments, the type of examination or blood tests, and the roles of primary and secondary care in follow‑up?

    Recommendation ID NG131/2 Question What is the most clinically and cost-effective follow‑up protocol for people with prostate cancer who

  3. What is the most suitable surveillance protocol (including the role of digital rectal examination [DRE] and prostate-specific antigen [PSA] measures) for people for whom active surveillance is appropriate, as assessed by multiparametric MRI and biopsy, when there are no clinical concerns during follow‑up?

    Recommendation ID NG131/1 Question What is the most suitable surveillance protocol (including the role of digital rectal examination [DRE]

  4. Most women will need to use contraception for more than 30 years. Patterns of contraceptive use vary with age, ethnicity, marital status, fertility intention, education and lifestyle. Large prospective cohort studies are needed to identify: patterns of use (initiation, continuation and switching between methods) of LARC methods compared with non‑LARC methods factors that influence the patterns of use of LARC.

    Recommendation ID CG30/2 Question Most women will need to use contraception for more than 30 years. Patterns of contraceptive use vary

  5. Few women use contraception perfectly (that is, exactly in accordance with the product instructions) and consistently. Pregnancy rates during typical use reflect effectiveness of a method among women who use the method incorrectly or inconsistently. Few data are available on typical use of any contraceptive method among women in the UK. Much of the data on contraceptive effectiveness used in the guideline come from clinical trials or surveys undertaken in other countries such as the USA. Large prospective cohort studies are needed to compare the contraceptive effectiveness of LARC methods with non‑LARC methods during typical use in the UK.

    Recommendation ID CG30/1 Question Few women use contraception perfectly (that is, exactly in accordance with the product instructions)

  6. In addition to individual circumstances and needs, a woman's choice and acceptance of LARC may be influenced by potential health disbenefits (side effects and risks) as well as non‑contraceptive benefits of LARC (such as alleviation of menorrhagia). Large population studies of appropriate design are needed to determine the effect of these factors on the uptake of LARC methods and the implications for NHS resources.

    Recommendation ID CG30/3 Question In addition to individual circumstances and needs, a woman's choice and acceptance of LARC may be influenced

  7. Violence and aggression

    Everything NICE has said on managing violence in mental health, health and community settings in an interactive flowchart

  8. Harmful sexual behaviour among children and young people

    Everything NICE has said on harmful sexual behaviour among children and young people (under 18s or under 25s with special educational needs or a disability) in an interactive flowchart.

  9. Medicines optimisation

    Everything NICE has said on shared decision-making and processes to optimise medicines and support adherence in an interactive flowchart

  10. Familial hypercholesterolaemia

    Everything NICE has said on familial hypercholesterolaemia in an interactive flowchart

  11. Ectopic pregnancy and miscarriage

    Everything NICE has said on diagnosing and managing tubal ectopic pregnancy and miscarriage in early pregnancy in an interactive flowchart.

  12. Glaucoma

    Everything NICE has said on assessing, treating and managing glaucoma in adults in an interactive flowchart

  13. Tuberculosis

    Everything NICE has said on preventing, diagnosing and managing latent and active tuberculosis in an interactive flowchart

  14. Suicide prevention

    Everything NICE has said on preventing suicide in community and residential custodial and detention settings in an interactive flowchart

  15. Health of people in the criminal justice system

    Everything NICE has said on managing the physical and mental health of people in prison, and the mental health of people in the criminal justice system

  16. A national evaluation of early pregnancy assessment unit service provision should be carried out to identify factors affecting outcomes. Factors should include whether care is provided in a dedicated unit, staffing configuration and opening hours of dedicated services. Outcomes should include both process (service) outcomes and pregnancy-related outcomes. Data collected should be used to analyse the cost effectiveness of early pregnancy assessment units compared with other models of care.

    Recommendation ID NG126/1 Question A national evaluation of early pregnancy assessment unit service provision should be carried out to