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Systemic juvenile idiopathic arthritis: canakinumab (ESNM36)

Summary of the evidence on canakinumab for treating systemic juvenile idiopathic arthritis (JIA) to inform local NHS planning and decision-making

Evidence summary Published March 2014

Type 2 diabetes: insulin degludec/liraglutide (Xultophy) (ESNM60)

Summary of the evidence on insulin degludec/liraglutide (Xultophy) for treating type 2 diabetes to inform local NHS planning and decision-making

Evidence summary Published July 2015

Pre-exposure prophylaxis of HIV in adults at high risk: Truvada (emtricitabine/tenofovir disoproxil) (ESNM78)

Summary of the evidence on Truvada (emtricitabine/tenofovir disoproxil) for pre-exposure prophylaxis (PrEP) of HIV in adults at high risk

Evidence summary Published October 2016

Hyperhidrosis: oral glycopyrronium bromide (ESUOM16)

Summary of the evidence on oral glycopyrronium bromide for treating hyperhidrosis (excessive sweating) to inform local NHS planning and decision-making

Evidence summary Published July 2013

Bile acid malabsorption: colesevelam (ESUOM22)

Summary of the evidence on colesevelam for treating bile acid malabsorption (BAM) to inform local NHS planning and decision-making

Evidence summary Published October 2013

Difficult-to-treat scabies: oral ivermectin (ESUOM29)

Summary of the evidence on oral ivermectin for treating difficult-to-treat scabies to inform local NHS planning and decision-making

Evidence summary Published March 2014

Interstitial cystitis: dimethyl sulfoxide bladder instillation (ESUOM26)

Summary of the evidence on dimethyl sulfoxide bladder instillation for treating interstitial cystitis to inform local NHS planning and decision-making

Evidence summary Published February 2014

Migraine prophylaxis: flunarizine (ESUOM33)

Summary of the evidence on flunarizine for treating migraine prophylaxis to inform local NHS planning and decision-making

Evidence summary Published September 2014

The AutoPulse non-invasive cardiac support pump for cardiopulmonary resuscitation (MIB18)

Advice on the use of AutoPulse non-invasive cardiac support pump for cardiopulmonary resuscitation (CPR) to aid local decision-making

Medtech innovation briefing Published February 2015

Shiley Endotracheal Tube with TaperGuard Cuff for intensive care patients at risk of ventilator‑associated pneumonia (MIB22)

Advice on the use of Shiley Endotracheal Tube with TaperGuard Cuff for patients at risk of ventilator-associated pneumonia to aid local decision-making

Medtech innovation briefing Published March 2015

The PediGuard for placing pedicle screws in spinal surgery (MIB26)

Advice on the use of the PediGuard for placing pedicle screws in spinal surgery to aid local decision-making

Medtech innovation briefing Published March 2015

Xpert GBS test for the intrapartum detection of group B streptococcus (MIB28)

Advice on the use of the Xpert GBS test for the intrapartum detection of group B streptococcus (GBS) colonisation in pregnant women...

Medtech innovation briefing Published April 2015

Attention deficit hyperactivity disorder in children and young people: clonidine (ESUOM8)

Summary of the evidences on clonidine for attention deficit hyperactivity disorder (ADHD) in children and young people..

Evidence summary Published April 2013

Renin-angiotensin system drugs: dual therapy (KTT2)

KTT2 Renin-angiotensin system drugs: dual therapy Options for local implementation Dual

Key therapeutic topic Published January 2015 Last updated February 2016

The Versajet II hydrosurgery system for surgical debridement of acute and chronic wounds and burns (MIB1)

Advice on the use of the Versajet II hydrosurgery system for surgical debridement of acute and chronic wounds and burns to aid local decision-making

Medtech innovation briefing Published February 2014

Irritable bowel syndrome with constipation in adults: linaclotide (ESNM16)

Summary of the evidence on linaclotide for irritable bowel syndrome (IBS) with constipation in adults to inform local NHS planning and decision-making

Evidence summary Published April 2013

Pulmonary sarcoidosis: infliximab (ES2)

Summary of the evidence on infliximab for treating pulmonary sarcoidosis to inform local NHS planning and decision-making

Evidence summary Published December 2016

Inflammatory lesions of papulopustular rosacea: ivermectin 10 mg/g cream (ESNM68)

Summary of the evidence on ivermectin 10 mg/g cream for treating papulopustular rosacea to inform local NHS planning and decision-making

Evidence summary Published January 2016

Type 1 diabetes mellitus in adults: high-strength insulin glargine 300 units/ml (Toujeo) (ESNM62)

Summary of the evidence on high-strength insulin glargine 300 units/ml (Toujeo) for type 1 diabetes mellitus to inform local NHS planning and decision-making

Evidence summary Published October 2015

The PressureWire fractional flow reserve measurement system for coronary artery disease (MIB2)

Advice on the use of the PressureWire fractional flow reserve measurement system for coronary artery disease to aid local decision-making

Medtech innovation briefing Published February 2014

The Space GlucoseControl system for managing blood‑glucose in critically ill patients in intensive care (MIB17)

Advice on the use of the Space GlucoseControl system for managing blood-glucose in critically ill patients in intensive care to aid local decision-making

Medtech innovation briefing Published December 2014

Autoimmune haemolytic anaemia: rituximab (ESUOM39)

Summary of the evidence on rituximab for treating autoimmune haemolytic anaemia (AIHA) to inform local NHS planning and decision-making

Evidence summary Published February 2015

Hypersexuality: fluoxetine (ESUOM46)

Summary of the evidence on fluoxetine for treating hypersexuality to inform local NHS planning and decision-making

Evidence summary Published July 2015

Polycystic ovary syndrome: metformin in women not planning pregnancy (ESUOM6)

Summary of the evidence on metformin for polycystic ovary syndrome (PCOS) in women not planning pregnancy to inform local NHS planning and decision-making

Evidence summary Published February 2013

NaviCam for diagnosing gastrointestinal tract conditions (MIB104)

Advice on the use of NaviCam for diagnosing gastrointestinal (GI) tract and small bowel conditions to aid local decision-making

Medtech innovation briefing Published May 2017

The SENSIMED Triggerfish contact lens sensor for continuous 24-hour recording of ocular dimensional changes in people with or at risk of developing glaucoma (MIB14)

Advice on the use of the SENSIMED Triggerfish contact lens sensor for use in people with or at risk of developing glaucoma

Medtech innovation briefing Published November 2014

The OSCAR 3 ultrasonic arthroplasty revision instrument for removing bone cement during prosthetic joint revision (MIB13)

Advice on the use of the OSCAR 3 ultrasonic arthroplasty revision instrument for removing bone cement during prosthetic joint revision..

Medtech innovation briefing Published November 2014

Reversal of the anticoagulant effect of dabigatran: idarucizumab (ESNM73)

Summary of the evidence on idarucizumab for reversing the anticoagulant effect of dabigtatran to inform local NHS planning and decision-making

Evidence summary Published May 2016

Partial-onset seizures in epilepsy: perampanel as adjunctive treatment (ESNM7)

Summary of the evidence on perampanel for partial-onset seizures in epilepsy (in people aged 12 and over) to inform local NHS planning and decision-making

Evidence summary Published December 2012

Gastroparesis in adults: oral erythromycin (ESUOM13)

Summary of the evidence on oral erythromycin for gastroparesis (delayed stomach emptying) in adults to inform local NHS planning and decision-making

Evidence summary Published June 2013

Chronic obstructive pulmonary disease: beclometasone, formoterol and glycopyrronium (Trimbow) (ES17)

Summary of the evidence on beclometasone, formoterol and glycopyrronium (Trimbow) for chronic obstructive pulmonary disease (COPD) to inform local NHS planning

Evidence summary Published May 2018

Plasma EGFR mutation tests for adults with locally advanced or metastatic non-small-cell lung cancer (MIB137)

Advice on the use of plasma EGFR mutation tests for adults with locally advanced or metastatic non-small-cell lung cancer (NSCLC) to aid local decision-making

Medtech innovation briefing Published January 2018

Health app: GDm-Health for people with gestational diabetes (MIB131)

Advice on the GDm-Health app to remotely monitor blood glucose in people with gestational diabetes (diabetes in pregnancy) to aid local decision-making

Medtech innovation briefing Published November 2017

Antimicrobial prescribing: Ceftazidime/avibactam (ES16)

Summary of the evidence on ceftazidime/avibactam for complicated intra-abdominal and UTI infections and hospital-acquired pneumonia

Evidence summary: antimicrobial prescribing Published November 2017

Point-of-care and home faecal calprotectin tests for monitoring treatment response in inflammatory bowel disease (MIB132)

Advice on the use of point-of-care and home faecal calprotectin tests for monitoring treatment response in inflammatory bowel disease

Medtech innovation briefing Published December 2017

Chemotherapy dose standardisation (KTT22)

KTT22 Chemotherapy dose standardisation Key points Chemotherapy dose standardisation

Key therapeutic topic Published February 2018 Last updated September 2019

EpiFix for chronic wounds (MIB139)

Advice on the use of EpiFix (an allograft comprising dehydrated human amnion/chorion membrane tissue/dHACM) for chronic wounds to aid local decision-making

Medtech innovation briefing Published January 2018

RIDASCREEN tests for monitoring infliximab in inflammatory bowel disease (MIB109)

Advice on the use of RIDASCREEN tests for monitoring infliximab in inflammatory bowel disease (IBD) to aid local decision-making

Medtech innovation briefing Published June 2017

FreeStyle Libre for glucose monitoring (MIB110)

Advice on the use of FreeStyle Libre for monitoring glucose levels in diabetes to aid local decision-making

Medtech innovation briefing Published July 2017 Last updated September 2017

Biopatch for venous or arterial catheter sites (MIB117)

Advice on the use of Biopatch hydrophilic foam dressing with chlorhexidine gluconate (CHG) for venous or arterial catheter sites to aid local decision-making

Medtech innovation briefing Published August 2017

myAIRVO2 for the treatment of chronic obstructive pulmonary disease (MIB161)

Advice on the use of myAIRVO2 (warms and humidifies respiratory gases) for treating chronic obstructive pulmonary disease (COPD) to aid local decision-making

Medtech innovation briefing Published October 2018

OxyMask for delivering oxygen therapy (MIB160)

Advice on the use of OxyMask for delivering oxygen therapy to aid local decision-making

Medtech innovation briefing Published September 2018

NephroCheck test to help assess the risk of acute kidney injury in critically ill patients (MIB156)

Advice on the use of NephroCheck test (Ortho Clinical Diagnostics) to help assess acute kidney injury risk in critically ill patients to aid local decision

Medtech innovation briefing Published August 2018

Caris Molecular Intelligence for guiding cancer treatment (MIB120)

Advice on the use of Caris Molecular Intelligence (CMI; solid tumour biomarker analysis service) for guiding cancer treatment to aid local decision-making

Medtech innovation briefing Published September 2017

HTG EdgeSeq ALKPlus Assay EU for ALK status testing in non-small-cell lung cancer (MIB128)

Advice on the use of HTG EdgeSeq ALKPlus Assay EU for ALK status testing in non-small-cell lung cancer (NSCLC) to aid local decision-making

Medtech innovation briefing Published November 2017

Medicines optimisation in chronic pain (KTT21)

KTT21 Medicines optimisation in chronic pain Key points Controlling chronic pain can

Key therapeutic topic Published January 2017 Last updated September 2019

Psychotropic medicines in people with learning disabilities whose behaviour challenges (KTT19)

KTT19 Psychotropic medicines in people with learning disabilities whose behaviour challenges Key points

Key therapeutic topic Published January 2017 Last updated September 2019

Non-steroidal anti-inflammatory drugs (KTT13)

KTT13 Non-steroidal anti-inflammatory drugs Options for local implementation Review

Key therapeutic topic Published January 2015 Last updated February 2018

Safer insulin prescribing (KTT20)

KTT20 Safer insulin prescribing Key points Several new insulin products have been launched

Key therapeutic topic Published January 2017 Last updated September 2019

Complicated urinary tract infections: ceftolozane/tazobactam (ESNM74)

Summary of the evidence on ceftolozane/tazobactam for treating complicated urinary tract infections to inform local NHS planning and decision-making

Evidence summary Published June 2016