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Secondary prevention in acute coronary syndrome: rivaroxaban (ESNM27)

This evidence summary has been replaced by NICE technology appraisal guidance 335

Evidence summary Published October 2013

Curos disinfecting cap for needleless connectors (MIB143)

This advice has been updated and replaced by NICE medical technologies guidance 44.

Medtech innovation briefing Published April 2018

Promonitor for monitoring response to biologics in rheumatoid arthritis (MIB126)

This advice has been replaced by NICE diagnostics guidance 36.

Medtech innovation briefing Published October 2017

Mepilex Border dressings for preventing pressure ulcers (MIB124)

This advice has been updated and replaced by NICE medical technologies guidance 40.

Medtech innovation briefing Published October 2017

The BCM – Body Composition Monitor for managing fluid in people having dialysis (MIB41)

This guidance has been updated and replaced by NICE diagnostics guidance 29.

Medtech innovation briefing Published October 2015

The Prosigna gene expression profiling assay for assessing long‑term risk of breast cancer recurrence (MIB27)

This guidance has been updated and replaced by NICE diagnostics guidance 34.

Medtech innovation briefing Published March 2015

EndoPredict gene expression profiling assay for assessing risk of breast cancer recurrence (MIB44)

This guidance has been updated and replaced by NICE diagnostics guidance 34.

Medtech innovation briefing Published November 2015

Critical limb ischaemia in peripheral vascular disease: intravenous iloprost (ESUOM24)

April 2019: This evidence summary has been withdrawn because a product containing intravenous iloprost with a marketing authorisation for treating critical limb ischaemia in peripheral vascular disease is now available in the UK.

Evidence summary Published December 2013

Multidrug resistant urinary tract infections: fosfomycin trometamol (ESUOM17)

This evidence summary has been withdrawn because a product containing fosfomycin trometamol with a marketing authorisation for treating multidrug resistant urinary tract infections is now available in the UK.

Evidence summary Published July 2013

Visual impairment due to myopic choroidal neovascularisation: aflibercept (ESNM76)

This evidence summary has been replaced by NICE technology appraisal guidance 486.  

Evidence summary Published June 2016

Nocturia and nocturnal polyuria in men with lower urinary tract symptoms: oral desmopressin (ESUOM10)

This evidence summary has been withdrawn because a product containing oral desmopressin with a marketing authorisation for treating nocturia and nocturnal polyuria in men with lower urinary tract symptom is now available in the UK.

Evidence summary Published April 2013

Excessive daytime sleepiness in Parkinson's disease: modafinil (ESUOM48)

This evidence summary has been updated and replaced by NICE guideline NG71.

Evidence summary Published September 2015

Moderate to severe acute post-operative pain: fentanyl transdermal system (ESNM77)

This evidence summary was withdrawn in September 2017 as the medicine is no longer available.

Evidence summary Published June 2016

Absorb Bioresorbable Vascular Scaffold system for coronary artery disease (MIB84)

NICE withdrew this medtech innovation briefing in November 2017 after the company stopped manufacturing Absorb because of low uptake. Some UK hospitals continue to use the technology in ongoing clinical studies.

Medtech innovation briefing Published October 2016

Lutonix drug-coated balloon for peripheral arterial disease (MIB72)

NICE withdrew this medtech innovation briefing in October 2019 after the MHRA withdrew support for this type of technology being used in intermittent claudication for arterial disease.

Medtech innovation briefing Published July 2016

Management of aggression, agitation and behavioural disturbances in dementia: valproate preparations (ESUOM41)

This evidence summary has been updated and replaced by NICE guideline NG97.

Evidence summary Published March 2015

The ZedScan as an adjunct to colposcopy in women with suspected cervical intra‑epithelial neoplasia (MIB20)

This advice has been updated and replaced by NICE diagnostics guidance 32.

Medtech innovation briefing Published February 2015

UrgoStart for chronic wounds (MIB82)

This advice has been updated and replaced by NICE medical technologies guidance 42.

Medtech innovation briefing Published October 2016

Psoriatic arthritis in adults: certolizumab pegol (ESNM42)

This evidence summary has been updated and replaced by NICE technology appraisal guidance 445.

Evidence summary Published June 2014

Rapid tranquillisation in mental health settings: promethazine hydrochloride (ESUOM28)

This evidence summary has been updated and replaced by NICE guideline NG10.

Evidence summary Published March 2014

Prophylactic antibiotics for preventing exacerbations:- Which subgroups of people with stable COPD who are at high risk of exacerbations are most likely to benefit from prophylactic antibiotics?

Recommendation ID NG115/5 Question Prophylactic antibiotics for preventing exacerbations:- Which subgroups of people with stable COPD who

Research recommendation Published February 2019

Mucolytic therapy:- In people with COPD, does mucolytic drug therapy prevent exacerbations in comparison with placebo and other therapies?

Recommendation ID NG115/11 Question Mucolytic therapy:- In people with COPD, does mucolytic drug therapy prevent exacerbations in comparison

Research recommendation Published February 2019

Inhaled therapies for people with COPD and asthma- What is the clinical and cost effectiveness of inhaled therapies (bronchodilators and/or inhaled corticosteroids) in people with both stable COPD and asthma?

Recommendation ID NG115/3 Question Inhaled therapies for people with COPD and asthma- What is the clinical and cost effectiveness of inhaled

Research recommendation Published February 2019

Inhaled corticosteroid responsiveness:- What features predict inhaled corticosteroid responsiveness most accurately in people with COPD?

Recommendation ID NG115/4 Question Inhaled corticosteroid responsiveness:- What features predict inhaled corticosteroid responsiveness most

Research recommendation Published February 2019

Further research on transcutaneous neuromuscular electrical stimulation for oropharyngeal dysphagia in adults should address patient selection, variations in technique, the need for retreatments and long-term outcomes.

Recommendation ID IPG634/1 Question Further research on transcutaneous neuromuscular electrical stimulation for oropharyngeal dysphagia

Research recommendation Published January 2019

Personalisation and risk markers:- What prognostic and prescriptive factors are important in determining the choice of PTSD treatment?

Recommendation ID NG116/4 Question Personalisation and risk markers:- What prognostic and prescriptive factors are important in determining

Research recommendation Published February 2019

Prophylactic antibiotics for preventing exacerbations: - What is the long-term clinical and cost effectiveness of prophylactic antibiotics for people with stable COPD who are at high risk of exacerbations?

Recommendation ID NG115/7 Question Prophylactic antibiotics for preventing exacerbations: - What is the long-term clinical and cost effectiveness

Research recommendation Published February 2019

Prophylactic antibiotics for preventing exacerbations:- What is the comparative effectiveness of seasonal versus continuous prophylactic antibiotics for people with stable COPD who are at high risk of exacerbations?

Recommendation ID NG115/9 Question Prophylactic antibiotics for preventing exacerbations:- What is the comparative effectiveness of seasonal

Research recommendation Published February 2019

Prophylactic antibiotics for preventing exacerbations:- What is the comparative effectiveness of different antibiotics, doses and regimens of prophylactic antibiotics for people with stable COPD who are at high risk of exacerbations?

Recommendation ID NG115/8 Question Prophylactic antibiotics for preventing exacerbations:- What is the comparative effectiveness of different

Research recommendation Published February 2019

Trauma-informed approaches:- What is the clinical and cost effectiveness of trauma-informed care or trauma-informed approaches?

Recommendation ID NG116/3 Question Trauma-informed approaches:- What is the clinical and cost effectiveness of trauma-informed care or

Research recommendation Published February 2019

Stepped care for post-traumatic stress disorder:- What is the clinical and cost effectiveness of stepped care for post-traumatic stress disorder (PTSD)?

Recommendation ID NG116/1 Question Stepped care for post-traumatic stress disorder:- What is the clinical and cost effectiveness of stepped

Research recommendation Published February 2019

Sequencing and further line treatment:- What is the clinical and cost effectiveness of sequencing and further line treatment in PTSD?

Recommendation ID NG116/2 Question Sequencing and further line treatment:- What is the clinical and cost effectiveness of sequencing and

Research recommendation Published February 2019

Complex PTSD:- What is the clinical and cost effectiveness of interventions to deliver stabilisation and reintegration for people with complex PTSD?

Recommendation ID NG116/5 Question Complex PTSD:- What is the clinical and cost effectiveness of interventions to deliver stabilisation

Research recommendation Published February 2019

Emotional freedom techniques:- What is the clinical and cost effectiveness of emotional freedom techniques (EFT) for the treatment of PTSD in adults?

Recommendation ID NG116/6 Question Emotional freedom techniques:- What is the clinical and cost effectiveness of emotional freedom techniques

Research recommendation Published February 2019

Pulmonary hypertension:- What are the most clinical and cost-effective treatments for pulmonary hypertension in people with COPD?

Recommendation ID NG115/10 Question Pulmonary hypertension:- What are the most clinical and cost-effective treatments for pulmonary hypertension

Research recommendation Published February 2019

Diagnosing COPD: -  What are the characteristics of people diagnosed with COPD as a result of an incidental finding ofemphysema on a CT scan, compared with those diagnosed with symptoms?

Recommendation ID NG115/6 Question Diagnosing COPD: - What are the characteristics of people diagnosed with COPD as a result of an incidental

Research recommendation Published February 2019

How does the timing and frequency of ultrasound examination affect diagnosis and outcomes of early pregnancy complications, including women's experience and cost effectiveness?

Recommendation ID NG126/1 Question How does the timing and frequency of ultrasound examination affect diagnosis and outcomes of early pregnancy

Research recommendation Published August 2019

What are the costs associated with best supportive care?

Recommendation ID TA575/1 Question What are the costs associated with best supportive care? Any explanatory notes(if applicable)

Research recommendation Published August 2019

What is the best technique for delivering surfactant in a minimally invasive manner?

Recommendation ID NG124/2 Question What is the best technique for delivering surfactant in a minimally invasive manner? Any explanatory

Research recommendation Published August 2019

Does caesarean section protect against cerebral haemorrhage in women with a history of subarachnoid haemorrhage or cerebrovascular malformation?

Recommendation ID NG121/1 Question Does caesarean section protect against cerebral haemorrhage in women with a history of subarachnoid haemorrhage

Research recommendation Published August 2019

What clinical features and laboratory investigations can be used to better stratify risk for women in labour with signs of sepsis (including fever and tachycardia)?

Recommendation ID NG121/4 Question What clinical features and laboratory investigations can be used to better stratify risk for women in

Research recommendation Published August 2019

Are progesterone or progestogens effective in treating threatened miscarriage?

Recommendation ID NG136/3 Question Are progesterone or progestogens effective in treating threatened miscarriage? Any explanatory notes(if

Research recommendation Published August 2019

What is the clinical and cost effectiveness of intermittent auscultation compared with continuous cardiotocography for women in labour who have had a previous caesarean section?

Recommendation ID NG121/5 Question What is the clinical and cost effectiveness of intermittent auscultation compared with continuous cardiotocography

Research recommendation Published August 2019

What is the most effective combination of an analgesic with a neuromuscular blocker, or an analgesic with an anaesthetic agent, for premedication in preterm babies requiring elective or semi-elective intubation?

Recommendation ID NG124/5 Question What is the most effective combination of an analgesic with a neuromuscular blocker, or an analgesic

Research recommendation Published August 2019

Does targeting higher oxygen saturations of 92% to 97% in preterm babies lead to improved survival without significant complications?

Recommendation ID NG124/4 Question Does targeting higher oxygen saturations of 92% to 97% in preterm babies lead to improved survival without...

Research recommendation Published August 2019

Is obesity an independent risk factor for perinatal morbidity and mortality?

Recommendation ID NG121/3 Question Is obesity an independent risk factor for perinatal morbidity and mortality? Any explanatory notes(if

Research recommendation Published August 2019

What is the effectiveness of high-pressure non-invasive positive pressure ventilation (NIPPV) compared with continuous positive airways pressure (CPAP) flow driver as the primary mode of ventilation?

Recommendation ID NG124/1 Question What is the effectiveness of high-pressure non-invasive positive pressure ventilation (NIPPV) compared

Research recommendation Published August 2019