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Preventing behaviour that challenges from developing in children aged under 5 years with a learning disability:- Can positive behaviour support provided for children aged under 5 years with a learning disability reduce the risk of developing behaviour that challenges?

Recommendation ID NG11/1 Question Preventing behaviour that challenges from developing in children aged under 5 years with a learning disability:-

Research recommendation Published October 2015

Predicting life expectancy:- Is it possible to analyse primary care data to identify characteristics that affect life expectancy and to develop algorithms and prediction tools for patients and healthcare providers to predict reduced life expectancy?

Recommendation ID NG56/4 Question Predicting life expectancy:- Is it possible to analyse primary care data to identify characteristics that

Research recommendation Published October 2016

Research should be carried out to compare the clinical effectiveness of bendamustine with chlorambucil at the higher dose used in the Chronic Lymphocytic Leukaemia Trial 4 (CLL4).

Recommendation ID TA216/1 Question Research should be carried out to compare the clinical effectiveness of bendamustine with chlorambucil

Research recommendation Published June 2015

Research is needed to establish the efficacy and tolerability of bile acid sequestrants among people with irritable bowel syndrome (IBS-D) or Crohn's disease without ileal resection.

Recommendation ID DG7/3 Question Research is needed to establish the efficacy and tolerability of bile acid sequestrants among people with

Research recommendation Published June 2015

Research is needed on the impact of treating Alzheimer's disease on mortality and institutionalisation, and to assess the relationship between disease progression and carer utility (quality of life).

Recommendation ID TA217/2 Question Research is needed on the impact of treating Alzheimer's disease on mortality and institutionalisation

Research recommendation Published June 2015

Risk assessment in neonates, infants, children and young people:- Which pressure ulcer tools are most effective for predicting pressure ulcer risk in children?

Recommendation ID CG179/3 Question Risk assessment in neonates, infants, children and young people:- Which pressure ulcer tools are most

Research recommendation Published June 2015

Research is recommended to address uncertainties about the claimed patient and system benefits of using Parafricta Bootees and Undergarments. This should take the form of comparative research against standard care, preferably carried out in a hospital.

Recommendation ID MTG20/1 Question Research is recommended to address uncertainties about the claimed patient and system benefits of using

Research recommendation Published June 2015

Routine outcome measurement:- In people with a common mental health disorder, what is the clinical utility of routine outcome measurement and is it cost effective compared with standard care?

Recommendation ID CG123/4 Question Routine outcome measurement:- In people with a common mental health disorder, what is the clinical utility

Research recommendation Published June 2015

Self-management:- What is the impact of different early intervention-focused approaches to self-management on outcomes for older people with social care needs and multiple long-term conditions?

Recommendation ID NG22/5 Question Self-management:- What is the impact of different early intervention-focused approaches to self-management

Research recommendation Published December 2015

Safety and efficacy of botulinum toxin:- What is the safety and efficacy of botulinum toxin compared with (a) usual care, (b) antimuscarinics and (c) augmentation cystoplasty in people with neurogenic lower urinary tract dysfunction?

Recommendation ID CG148/2 Question Safety and efficacy of botulinum toxin:- What is the safety and efficacy of botulinum toxin compared

Research recommendation Published June 2015

Screening assessment tools:- Develop reliable and valid screening assessment tools for attachment and sensitivity that can be made available and used in routine health, social care and education settings.

Recommendation ID NG26/1 Question Screening assessment tools:- Develop reliable and valid screening assessment tools for attachment and

Research recommendation Published December 2015

Social media:- How effective are online social media and networks at improving health and wellbeing and reducing health inequalities when they are used:- as a method of community engagement?- to support an existing community engagement approach?

Recommendation ID NG44/4 Question Social media:- How effective are online social media and networks at improving health and wellbeing and

Research recommendation Published April 2016

Self-monitoring of blood glucose levels:- What is the optimal frequency for self-monitoring of blood glucose in adults with type 2 diabetes?

Recommendation ID NG28/5 Question Self-monitoring of blood glucose levels:- What is the optimal frequency for self-monitoring of blood glucose

Research recommendation Published January 2016

Service delivery models:- Which models of service delivery are effective and cost-effective for older people with social care needs and multiple long-term conditions?

Recommendation ID NG22/2 Question Service delivery models:- Which models of service delivery are effective and cost-effective for older

Research recommendation Published December 2015

Safety and safeguarding:- What safeguarding practices are most effective in improving outcomes for people using services?

Recommendation ID NG21/5 Question Safety and safeguarding:- What safeguarding practices are most effective in improving outcomes for people

Research recommendation Published October 2015

Safety and efficacy of antimuscarinics:- What is the safety and efficacy of more recently developed antimuscarinics compared with (a) placebo/usual care and (b) other antimuscarinics in the treatment of neurogenic lower urinary tract dysfunction?

Recommendation ID CG148/1 Question Safety and efficacy of antimuscarinics:- What is the safety and efficacy of more recently developed antimuscarinics

Research recommendation Published June 2015

Signs and symptoms that predict neutropenic sepsis in the community:- A prospective study should be carried out to determine which signs and symptoms experienced by patients in the community predict neutropenic sepsis and the outcomes of these episodes.

Recommendation ID CG151/3 Question Signs and symptoms that predict neutropenic sepsis in the community:- A prospective study should be carried

Research recommendation Published June 2015

Support to carers and practitioners to help young people's independence:- What is the most effective way to help carers and practitioners support young people's independence?

Recommendation ID NG43/5 Question Support to carers and practitioners to help young people's independence:- What is the most effective way

Research recommendation Published March 2016

Sequence of invasive OAB procedures:- What is the effectiveness and optimum sequence of treatment with botulinum toxin A and percutaneous sacral nerve stimulation for the treatment of OAB after failed conservative (including drug) management?

Recommendation ID CG171/4 Question Sequence of invasive OAB procedures:- What is the effectiveness and optimum sequence of treatment with

Research recommendation Published June 2015

Serological testing in people who have IgA deficiency:- What is the sensitivity and specificity of IgG tissue transglutaminase (tTG), IgG endomysial antibodies (EMA) and IgG deamidated gliadin peptide (DGP) tests in detecting coeliac disease in people with IgA deficiency?

Recommendation ID NG20/1 Question Serological testing in people who have IgA deficiency:- What is the sensitivity and specificity of IgG

Research recommendation Published October 2015

Self-management:- Do structured psoriasis-focused self-management programmes improve patient confidence, wellbeing and disease control compared with standard care?

Recommendation ID CG153/4 Question Self-management:- Do structured psoriasis-focused self-management programmes improve patient confidence

Research recommendation Published June 2015

Serological testing in people who test negative for anti-transglutaminase:- What is the sensitivity and specificity of IgA EMA and IgA DGP tests in detecting coeliac disease inpeople who test negative for IgA tTG?

Recommendation ID NG20/2 Question Serological testing in people who test negative for anti-transglutaminase:- What is the sensitivity and

Research recommendation Published October 2015

Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study should be carried out to assess the incidence of suspected and proven neutropenic sepsis in patients having anticancer treatment.

Recommendation ID CG151/1 Question Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study

Research recommendation Published June 2015

Saliva:- How is excessive drooling of saliva (sialorrhoea) managed in people with motor neurone disease (MND)?

Recommendation ID NG42/4 Question Saliva:- How is excessive drooling of saliva (sialorrhoea) managed in people with motor neurone disease

Research recommendation Published March 2016

Specialist investigation:- What specialist investigations should be conducted to exclude a diagnosis of functional dyspepsia in people with uninvestigated dyspepsia that does not respond to PPIs or H2 receptor antagonists (H2RAs) despite optimum primary care?

Recommendation ID CG184/5 Question Specialist investigation:- What specialist investigations should be conducted to exclude a diagnosis

Research recommendation Published June 2015

Specialist dementia support:- What is the most effective and cost effective way to support people with dementia living at home?

Recommendation ID NG21/4 Question Specialist dementia support:- What is the most effective and cost effective way to support people with

Research recommendation Published October 2015

Safety of selective internal radiation therapy (SIRT) is a potentially beneficial treatment for patients with on-resectable colorectal metastases in the liver, but that more research and data collection are required to demonstrate its efficacy.

Recommendation ID IPG401/1 Question Safety of selective internal radiation therapy (SIRT) is a potentially beneficial treatment for patients

Research recommendation Published June 2015

Screening and intrapartum antibiotic prophylaxis for group B streptococcal colonisation:- What is the clinical and cost effectiveness of intrapartum antibiotic prophylaxis targeting group B streptococcus and guided by routine antenatal screening?

Recommendation ID CG149/1 Question Screening and intrapartum antibiotic prophylaxis for group B streptococcal colonisation:- What is the

Research recommendation Published June 2015

Stopping preventive medicines:- What is the clinical and cost effectiveness of stopping preventive medicines in people with multimorbidity who may not benefit from continuing them?

Recommendation ID NG56/3 Question Stopping preventive medicines:- What is the clinical and cost effectiveness of stopping preventive medicines

Research recommendation Published October 2016

Standard principles of infection prevention and control:- What are the barriers to compliance with the standard principles of infection prevention and control that patients and carers experience in their own homes?

Recommendation ID CG139/1 Question Standard principles of infection prevention and control:- What are the barriers to compliance with the

Research recommendation Published June 2015

Studies exploring the effectiveness of bevacizumab in people previously treated with a taxane and its effects on health-related quality of life.

Recommendation ID TA263/1 Question Studies exploring the effectiveness of bevacizumab in people previously treated with a taxane and its

Research recommendation Published June 2015

Subsequent health assessment:- When should subsequent health assessments be carried out in prison for people serving long-term sentences?

Recommendation ID NG57/1 Question Subsequent health assessment:- When should subsequent health assessments be carried out in prison for

Research recommendation Published February 2017

Supporting people in care homes to stay active:- What is the most effective and cost-effective way of supporting older people with social care needs and multiple long-term conditions in care homes to live as independently as possible?

Recommendation ID NG22/3 Question Supporting people in care homes to stay active:- What is the most effective and cost-effective way of

Research recommendation Published December 2015

Shoulder pain:- Which people with a weak arm after stroke are at risk of developing shoulder pain? What management strategies are effective in the prevention or management of shoulder pain of different aetiologies?

Recommendation ID CG162/4 Question Shoulder pain:- Which people with a weak arm after stroke are at risk of developing shoulder pain? What

Research recommendation Published June 2015

Optimal dosage of intravenous insulin for managing diabetic ketoacidosis in children and young people:- What is the optimal dosage of intravenous insulin for managing diabetic ketoacidosis (DKA) in children and young people?

Recommendation ID NG18/5 Question Optimal dosage of intravenous insulin for managing diabetic ketoacidosis in children and young people:-

Research recommendation Published October 2015

Parent training programmes for children aged 12 years and over with a conduct disorder:- What is the effectiveness of parent training programmes for conduct disorders in children and young people aged 12 years and over?

Recommendation ID CG158/1 Question Parent training programmes for children aged 12 years and over with a conduct disorder:- What is the

Research recommendation Published June 2015

NICE recommends that further research directly comparing the clinical and cost effectiveness of ranibizumab and bevacizumab in people with diabetic macular oedema should be conducted.

Recommendation ID TA274/1 Question NICE recommends that further research directly comparing the clinical and cost effectiveness of ranibizumab

Research recommendation Published June 2015

Nutrition:- Does a high calorific diet prolong survival of people with motor neurone disease (MND) if initiated following diagnosis or following initiation of feeding using a gastrostomy?

Recommendation ID NG42/5 Question Nutrition:- Does a high calorific diet prolong survival of people with motor neurone disease (MND) if

Research recommendation Published March 2016

NICE recommends that a study is conducted to generate robust evidence about the benefits of roflumilast as an add-on to LAMA plus LABA/ICS or LAMA plus LABA for those people who are intolerant to ICS.

Recommendation ID TA244/1 Question NICE recommends that a study is conducted to generate robust evidence about the benefits of roflumilast

Research recommendation Published June 2015

NICE recommends that future trials should include longer-term follow-up, beyond the initial hospital episode, with a view to informing the cost-effectiveness modelling and reducing uncertainty.

Recommendation ID DG13/4 Question NICE recommends that future trials should include longer-term follow-up, beyond the initial hospital episode

Research recommendation Published June 2015

Non-vitamin K antagonist oral anticoagulants:- Do people with atrial fibrillation whose anticoagulant control is poor, or is predicted to be poor, with warfarin benefit from changing to one of the non-vitamin K antagonist (non-VKA) oral anticoagulants?

Recommendation ID CG180/4 Question Non-vitamin K antagonist oral anticoagulants:- Do people with atrial fibrillation whose anticoagulant

Research recommendation Published June 2015