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NICE encourages research into endovascular stentgrafting of popliteal aneurysms and may review this procedure on publication of further evidence.

Recommendation ID IPG390/1 Question NICE encourages research into endovascular stentgrafting of popliteal aneurysms and may review this

Research recommendation Published June 2015

NICE encourages further research on sphenopalatine ganglion stimulation for chronic cluster headache. Reported outcomes should include long-term efficacy and device durability.

Recommendation ID IPG527/1 Question NICE encourages further research on sphenopalatine ganglion stimulation for chronic cluster headache

Research recommendation Published October 2015

NICE encourages further research into single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) for treating morbid obesity, particularly research examining long-term outcomes. NICE may update the guidance on publication of further evidence.

Recommendation ID IPG569/1 Question NICE encourages further research into single-anastomosis duodeno-ileal bypass with sleeve gastrectomy

Research recommendation Published February 2017

NICE encourages further research on insertion of an annular disc implant at lumbar discectomy, particularly comparative trials. All studies should report details of patient selection and recurrence rates.

Recommendation ID IPG506/1 Question NICE encourages further research on insertion of an annular disc implant at lumbar discectomy, particularly

Research recommendation Published June 2015

NICE discussed the potential for future research. NICE accepted that there is a need to further establish the accuracy of current practice in diagnosing asthma and the incremental accuracy associated with the addition of FeNO testing.

Recommendation ID DG12/1 Question NICE discussed the potential for future research. NICE accepted that there is a need to further establish

Research recommendation Published June 2015

NICE considered that there is an important need for head-to-head comparisons between biological treatments for psoriatic arthritis, particularly in people for whom treatment with tumour necrosis factor (TNF) alpha inhibitors has been unsuccessful.

Recommendation ID TA340/1 Question NICE considered that there is an important need for head-to-head comparisons between biological treatments

Research recommendation Published October 2015

NICE concluded that the cost consequences of using HumiGard in abdominal surgery are very uncertain, and that further research is needed on resource use.

Recommendation ID MTG31/2 Question NICE concluded that the cost consequences of using HumiGard in abdominal surgery are very uncertain,

Research recommendation Published April 2017

NICE encourages further research into the effects of uterine artery embolisation compared with other procedures to treat adenomyosis, particularly for patients wishing to maintain or improve their fertility.

Recommendation ID IPG473/1 Question NICE encourages further research into the effects of uterine artery embolisation compared with other

Research recommendation Published June 2015

NICE considered that more research is needed to establish the treatment sequence for vemurafenib and ipilimumab in patients who have BRAF V600 mutation-positive melanoma.

Recommendation ID TA319/1 Question NICE considered that more research is needed to establish the treatment sequence for vemurafenib and

Research recommendation Published June 2015

NICE considered that further research would be helpful to compare the CardioQ-ODM with other techniques for monitoring cardiac output, particularly in patients in the critical care environment.

Recommendation ID MTG3/1 Question NICE considered that further research would be helpful to compare the CardioQ-ODM with other techniques

Research recommendation Published June 2015

NICE encourages further research into epiduroscopic lumbar discectomy through the sacral hiatus for sciatica and may update the guidance on publication of further evidence. Research studies should include details of patient selection, complications and long-term results.

Recommendation ID IPG570/1 Question NICE encourages further research into epiduroscopic lumbar discectomy through the sacral hiatus for

Research recommendation Published February 2017

NICE considered that further research on the geko device in clinical settings could focus on reducing the current uncertainties about the reduction in relative risk in the defined patient population, and allow investigation into its use in broader patient populations.

Recommendation ID MTG19/1 Question NICE considered that further research on the geko device in clinical settings could focus on reducing

Research recommendation Published June 2015

NICE encourages further research into percutaneous electrical nerve stimulation (PENS) for refractory neuropathic pain, particularly to provide more information about selection criteria and long-term outcomes, with clear documentation of the indications for treatment.

Recommendation ID IPG450/1 Question NICE encourages further research into percutaneous electrical nerve stimulation (PENS) for refractory

Research recommendation Published June 2015

NICE encourages further research into faecal microbiota transplant for C. difficile infection, specifically to investigate optimal dosage, mode of administration and choice of donor.

Recommendation ID IPG485/1 Question NICE encourages further research into faecal microbiota transplant for C. difficile infection, specifically

Research recommendation Published June 2015

NICE encourages further research on subretinal prosthesis system for retinitis pigmentosa. Outcomes should include the impact on quality of life and activities of day-to-day living, and durability of implants. NICE may update the guidance on publication of further evidence.

Recommendation ID IPG537/1 Question NICE encourages further research on subretinal prosthesis system for retinitis pigmentosa. Outcomes

Research recommendation Published January 2016

NICE proposes that a clinical trial is needed to establish the relative effectiveness of mannitol compared with hypertonic saline.

Recommendation ID TA266/1 Question NICE proposes that a clinical trial is needed to establish the relative effectiveness of mannitol compared

Research recommendation Published June 2015

NICE recommends further research to establish optimal target dose ranges for 5-FU plasma levels in people with head and neck cancer, stomach cancer and pancreatic cancer.

Recommendation ID DG16/3 Question NICE recommends further research to establish optimal target dose ranges for 5-FU plasma levels in people

Research recommendation Published June 2015

NICE recommends research generating and analysing observational data including, but not limited to, the existing UK ITP Registry, which collects data on the long-term outcomes of patients treated with eltrombopag and romiplostim.

Recommendation ID TA293/2 Question NICE recommends research generating and analysing observational data including, but not limited to, the

Research recommendation Published June 2015

NICE encourages further research into the use of innovative technologies for the management of severe acute respiratory failure, and may review this guidance on publication of further evidence.

Recommendation ID IPG391/1 Question NICE encourages further research into the use of innovative technologies for the management of severe

Research recommendation Published June 2015

NICE highlighted the importance of collecting further data within registries of patients receiving biological treatments for psoriatic arthritis to obtain information on long-term outcomes, including adverse events.

Recommendation ID TA220/1 Question NICE highlighted the importance of collecting further data within registries of patients receiving biological

Research recommendation Published June 2015

NICE recommends further research to understand the underlying biological causes and the clinical implications of chronically elevated troponin levels in older people, and people with conditions known to cause troponin elevation in the absence of ischaemia.

Recommendation ID DG15/4 Question NICE recommends further research to understand the underlying biological causes and the clinical implications

Research recommendation Published June 2015

NICE recommended that clinical data, including genotype and sustained virological response at 12 weeks, are collected for all people having treatment with simeprevir in the NHS.

Recommendation ID TA333/1 Question NICE recommended that clinical data, including genotype and sustained virological response at 12 weeks

Research recommendation Published June 2015

NICE recommended that research should be carried out to determine the relationship between activity and prosthesis failure.

Recommendation ID TA304/1 Question NICE recommended that research should be carried out to determine the relationship between activity and

Research recommendation Published June 2015

NICE recommends further research to demonstrate the utility of the Sonoclot system in detecting, managing and monitoring haemostasis in cardiac surgery.

Recommendation ID DG13/1 Question NICE recommends further research to demonstrate the utility of the Sonoclot system in detecting, managing

Research recommendation Published June 2015