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Prophylactic antibiotics for preventing exacerbations:- Which subgroups of people with stable COPD who are at high risk of exacerbations are most likely to benefit from prophylactic antibiotics?

Recommendation ID NG115/5 Question Prophylactic antibiotics for preventing exacerbations:- Which subgroups of people with stable COPD who

Research recommendation Published February 2019

Mucolytic therapy:- In people with COPD, does mucolytic drug therapy prevent exacerbations in comparison with placebo and other therapies?

Recommendation ID NG115/11 Question Mucolytic therapy:- In people with COPD, does mucolytic drug therapy prevent exacerbations in comparison

Research recommendation Published February 2019

Inhaled therapies for people with COPD and asthma- What is the clinical and cost effectiveness of inhaled therapies (bronchodilators and/or inhaled corticosteroids) in people with both stable COPD and asthma?

Recommendation ID NG115/3 Question Inhaled therapies for people with COPD and asthma- What is the clinical and cost effectiveness of inhaled

Research recommendation Published February 2019

Inhaled corticosteroid responsiveness:- What features predict inhaled corticosteroid responsiveness most accurately in people with COPD?

Recommendation ID NG115/4 Question Inhaled corticosteroid responsiveness:- What features predict inhaled corticosteroid responsiveness most

Research recommendation Published February 2019

Further research on transcutaneous neuromuscular electrical stimulation for oropharyngeal dysphagia in adults should address patient selection, variations in technique, the need for retreatments and long-term outcomes.

Recommendation ID IPG634/1 Question Further research on transcutaneous neuromuscular electrical stimulation for oropharyngeal dysphagia

Research recommendation Published January 2019

Further research on endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused by cancer should address: patient selection, relief of biliary obstruction, quality of life and survival.

Recommendation ID IPG614/1 Question Further research on endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused

Research recommendation Published December 2018

Further research is needed to understand the effect of having the additional information provided by the adjunctive colposcopy technologies on anxiety for people having a colposcopy, when this information is shown to a person during the examination.

Recommendation ID DG32/3 Question Further research is needed to understand the effect of having the additional information provided by the

Research recommendation Published November 2018

Core outcome set for studies of management of Lyme disease:- Can a core outcome set be developed for clinical trials of management of Lyme disease?

Recommendation ID NG95/1 Question Core outcome set for studies of management of Lyme disease:- Can a core outcome set be developed for clinical

Research recommendation Published November 2018

Anticholinergic burden:- Does actively reducing anticholinergic burden in people living with dementia improve cognitive outcomes compared with usual care?

Recommendation ID NG72/3 Question Anticholinergic burden:- Does actively reducing anticholinergic burden in people living with dementia

Research recommendation Published December 2018

Models of care and support at home:- What is the effectiveness and cost effectiveness of care and support models (for example, assistive technology) for people growing older with learning disabilities to enable them to live in the family home?

Recommendation ID NG96/1 Question Models of care and support at home:- What is the effectiveness and cost effectiveness of care and support

Research recommendation Published November 2018

Seroprevalence of Lyme disease-specific antibodies and other tick-borne infections in the UK population:- What is the current seroprevalence of Lyme disease-specific antibodies and other tick-borne infections in people in the UK?

Recommendation ID NG95/3 Question Seroprevalence of Lyme disease-specific antibodies and other tick-borne infections in the UK population:- What

Research recommendation Published November 2018

Antimicrobial management of Lyme disease:- What are the most clinically and cost-effective treatment options for different clinical presentations of Lyme disease in the UK?

Recommendation ID NG95/4 Question Antimicrobial management of Lyme disease:- What are the most clinically and cost-effective treatment options

Research recommendation Published November 2018

Clinical epidemiology of Lyme disease in the UK:- What are the incidence, presenting features, management and outcome of Lyme disease in the UK?

Recommendation ID NG95/2 Question Clinical epidemiology of Lyme disease in the UK:- What are the incidence, presenting features, management

Research recommendation Published November 2018

The committee recommended that further research is needed to better understand the natural history of low-volume cervical intraepithelial neoplasia (CIN) 2 lesions.

Recommendation ID DG32/4 Question The committee recommended that further research is needed to better understand the natural history of

Research recommendation Published November 2018

The  committee recommended that data should be collected to show how the results of the technologies affect decision-making, including biopsy decisions and decisions todischarge people with a negative colposcopy examination back to routine screening.

Recommendation ID DG32/2 Question The committee recommended that data should be collected to show how the results of the technologies affect

Research recommendation Published November 2018

NICE encourages further research into microinvasive subconjunctival insertion of a trans-scleral gelatin stent for primary open-angle glaucoma, including randomised studies. Further research should include details of patient selection and long-term outcomes.

Recommendation ID IPG612/1 Question NICE encourages further research into microinvasive subconjunctival insertion of a trans-scleral gelatin

Research recommendation Published November 2018

What behaviour change techniques are most effective as part of a condom distribution scheme?:- What combinations of behaviour change techniques can be used to help condom schemes increase condom use among different high risk groups?

Recommendation ID NG68/1 Question What behaviour change techniques are most effective as part of a condom distribution scheme?:- What combinations

Research recommendation Published October 2018

Effectiveness of home visiting following child abuse or neglect:- Are home visiting interventions effective and cost effective in improving parenting and preventingrecurrence of child abuse and neglect in families in which abuse or neglect is occurring or has occurred?

Recommendation ID NG76/12 Question Effectiveness of home visiting following child abuse or neglect:- Are home visiting interventions effective

Research recommendation Published October 2018

Early help home visiting:- What are the components of effective home visiting programmes for preventing child abuse and neglect in families of children and young people at risk of child abuse and neglect in the UK?

Recommendation ID NG76/4 Question Early help home visiting:- What are the components of effective home visiting programmes for preventing

Research recommendation Published October 2018

Team composition for home-based intermediate care:- How effective and cost effective are different approaches, in terms of team structure and composition, to providing home-based intermediate care for adults?

Recommendation ID NG74/2 Question Team composition for home-based intermediate care:- How effective and cost effective are different approaches

Research recommendation Published October 2018

Support needs of parents:- What are the experiences and concerns of parents of children with faltering growth?

Recommendation ID NG75/5 Question Support needs of parents:- What are the experiences and concerns of parents of children with faltering

Research recommendation Published October 2018

Support for black and minority ethnic groups:- How effective and cost effective are different approaches to supporting people from black and minority ethnic groups using intermediate care?

Recommendation ID NG74/8 Question Support for black and minority ethnic groups:- How effective and cost effective are different approaches

Research recommendation Published October 2018

Reablement:- How effective and cost effective are repeated periods of reablement, and reablement that lasts longer than 6 weeks?

Recommendation ID NG74/5 Question Reablement:- How effective and cost effective are repeated periods of reablement, and reablement that

Research recommendation Published October 2018

Pain management programmes:- Are pain management programmes a clinically and cost-effective intervention for women with endometriosis?

Recommendation ID NG73/1 Question Pain management programmes:- Are pain management programmes a clinically and cost-effective intervention

Research recommendation Published October 2018

Optimal time between referral and starting intermediate care:- What is the optimal time between referral to and starting intermediate care in terms of effectiveness and cost effectiveness and in terms of people's experiences?

Recommendation ID NG74/1 Question Optimal time between referral and starting intermediate care:- What is the optimal time between referral

Research recommendation Published October 2018

Lifestyle interventions (diet and exercise):- Are specialist lifestyle interventions (diet and exercise) effective, compared with no specialist lifestyle interventions, for women with endometriosis?

Recommendation ID NG73/3 Question Lifestyle interventions (diet and exercise):- Are specialist lifestyle interventions (diet and exercise)

Research recommendation Published October 2018

Laparoscopic treatment of peritoneal endometriosis (excision or ablation):- Is laparoscopic treatment (excision or ablation) of peritoneal disease in isolation effective formanaging endometriosis-related pain?

Recommendation ID NG73/2 Question Laparoscopic treatment of peritoneal endometriosis (excision or ablation):- Is laparoscopic treatment

Research recommendation Published October 2018

Information and support:- What information and support interventions are effective to help women with endometriosis deal with their symptoms and improve their quality of lives?

Recommendation ID NG73/4 Question Information and support:- What information and support interventions are effective to help women with

Research recommendation Published October 2018

High energy liquid feed supplements:- Do high energy liquid feed supplements improve growth in children with faltering growth?

Recommendation ID NG75/1 Question High energy liquid feed supplements:- Do high energy liquid feed supplements improve growth in children

Research recommendation Published October 2018

Further research should give details of patient selection, patient-reported outcomes and long-term effects including survival and quality of life. NICE may update the guidance on publication of further evidence.

Recommendation ID IPG594/1 Question Further research should give details of patient selection, patient-reported outcomes and long-term effects

Research recommendation Published October 2018

Frequency of monitoring:- How frequently should children be measured to identify faltering growth?

Recommendation ID NG75/4 Question Frequency of monitoring:- How frequently should children be measured to identify faltering growth?

Research recommendation Published October 2018

Feeding interventions for the management of neonatal weight loss:- What is the effectiveness of feeding interventions compared with usual care/advice for breastfedneonates (up to 28 days old) with weight loss of greater than 10%?

Recommendation ID NG75/2 Question Feeding interventions for the management of neonatal weight loss:- What is the effectiveness of feeding

Research recommendation Published October 2018