Updating results

What is the most clinically and cost-effective pathway for diagnosing clinically significant prostate cancer?

Recommendation ID NG131/3 Question What is the most clinically and cost-effective pathway for diagnosing clinically significant prostate

Research recommendation Published October 2019

What methods and techniques help secondary schools and providers to effectively engage with parents and carers as part of a whole-school approach to promote and support alcohol education?

Recommendation ID NG135/6 Question What methods and techniques help secondary schools and providers to effectively engage with parents

Research recommendation Published October 2019

The committee recommended further research to determine if using the lead‑I electrocardiogram (ECG) devices in primary care for people with signs or symptoms of atrial fibrillation, and an irregular pulse, increases the number of people with atrial fibrillation (including paroxysmal) detected,  ompared with current practice (that is, a 12‑lead ECG done later). The committee considered the feasibility of collecting data to see if using the lead‑I ECG devices increased the detection of atrial fibrillation that would be missed if only 12‑lead ECGs done later were available. It noted that even if a lead‑I ECG is used and atrial fibrillation is detected, a subsequent 12‑lead ECG would still be done to check for structural cardiac abnormalities and inform further management decisions. The committee concluded that practices using lead‑I ECG devices could determine the number of additional cases of atrial fibrillation detected by the devices. This can be done by identifying people with a confirmed positive lead‑I ECG for atrial fibrillation who subsequently had a 12‑lead ECG that was negative because the atrial fibrillation had stopped. The committee also considered that data collected on the time between the initial lead‑I ECG and the subsequent 12‑lead ECG would be useful.

Recommendation ID DG35/1 Question The committee recommended further research to determine if using the lead‑I electrocardiogram (ECG) devices

Research recommendation Published October 2019

Further primary research is recommended on the clinical effectiveness of using ELISA tests for therapeutic monitoring of TNF‑alpha inhibitors in people with rheumatoid arthritis.

Recommendation ID DG36/1 Question Further primary research is recommended on the clinical effectiveness of using ELISA tests for therapeutic

Research recommendation Published October 2019

How effective are education-based alcohol prevention interventions (universal or targeted) for children and young people aged 11 to 25 with SEND in full-time education?

Recommendation ID NG135/5 Question How effective are education-based alcohol prevention interventions (universal or targeted) for children

Research recommendation Published October 2019

What is the most clinically and cost-effective pathway for excluding the clinically significant progression of cancer in people with low- to intermediate-risk prostate cancer?

Recommendation ID NG131/4 Question What is the most clinically and cost-effective pathway for excluding the clinically significant progression

Research recommendation Published October 2019

At what gestation should treatment with prophylactic vaginal progesterone for the prevention of preterm birth be started and stopped?

Recommendation ID NG25/7 Question At what gestation should treatment with prophylactic vaginal progesterone for the prevention of preterm

Research recommendation Published October 2019

Does progesterone reduce the risk of preterm birth in women who have a short cervix (cervical length of 25 mm or less), but do not have other risk factors for preterm birth?

Recommendation ID NG25/6 Question Does progesterone reduce the risk of preterm birth in women who have a short cervix (cervical length

Research recommendation Published October 2019

Does progesterone reduce the risk of preterm birth in women who have risk factors for preterm birth, but do not have a short cervix (cervical length of more than 25 mm)?

Recommendation ID NG25/5 Question Does progesterone reduce the risk of preterm birth in women who have risk factors for preterm birth,

Research recommendation Published October 2019

What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of psychological therapies in children aged 5 to 11 years with mild or moderate to severe depression?

Recommendation ID NG134/1 Question What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of psychological

Research recommendation Published October 2019

The Committee considered that rigorous data collection is needed on the life-extending benefits of lenalidomide when used in people with multiple myeloma who have received two or more prior therapies.

Recommendation ID TA171/1 Question The Committee considered that rigorous data collection is needed on the life-extending benefits of lenalidomide

Research recommendation Published October 2019

What are the long-term outcomes of different management strategies for primary hyperparathyroidism? Which strategies are most cost effective?

Recommendation ID NG132/3 Question What are the long-term outcomes of different management strategies for primary hyperparathyroidism?

Research recommendation Published October 2019

What are the benefits, risks and cost effectiveness of methotrexate, ciclosporin, tacrolimus, adalimumab and infliximab compared with each other and with placebo for induction of remission for people with subacute ulcerative colitis that is refractory to systemic corticosteroids?

Recommendation ID NG130/6 Question What are the benefits, risks and cost effectiveness of methotrexate, ciclosporin, tacrolimus, adalimumab

Research recommendation Published October 2019

What is the clinical and cost effectiveness of prednisolone compared with aminosalicylates for the induction of remission for people with moderate ulcerative colitis?

Recommendation ID NG130/4 Question What is the clinical and cost effectiveness of prednisolone compared with aminosalicylates for the induction

Research recommendation Published October 2019

What is the clinical and cost effectiveness of prednisolone plus an aminosalicylate compared with beclometasone plus an aminosalicylate for induction of remission for people with moderate ulcerative colitis?

Recommendation ID NG130/5 Question What is the clinical and cost effectiveness of prednisolone plus an aminosalicylate compared with beclometasone

Research recommendation Published October 2019

How effective and cost effective are education-based alcohol interventions targeted at children and young people aged 11 to 25 with SEND who are thought to be vulnerable to alcohol misuse?

Recommendation ID NG135/4 Question How effective and cost effective are education-based alcohol interventions targeted at children and

Research recommendation Published October 2019

How effective and cost effective are individual, compared with group, education-based interventions for children and young people aged 11 to 18 in full-time education who are thought to be vulnerable to alcohol misuse?

Recommendation ID NG135/2 Question How effective and cost effective are individual, compared with group, education-based interventions

Research recommendation Published October 2019

Secondary research is recommended to understand the comparative performance of different ELISA tests for therapeutic monitoring of tumour necrosis factor (TNF)‑alpha inhibitors in rheumatoid arthritis

Recommendation ID DG36/3 Question Secondary research is recommended to understand the comparative performance of different ELISA tests

Research recommendation Published October 2019

What is the effectiveness of oral tacrolimus and systemic (intramuscular/subcutaneous/oral) methotrexate in the induction of remission in mild-to-moderate ulcerative colitis unresponsive to aminosalicylates?

Recommendation ID NG130/2 Question What is the effectiveness of oral tacrolimus and systemic (intramuscular/subcutaneous/oral) methotrexate

Research recommendation Published October 2019

What is the clinical and cost effectiveness of prednisolone, budesonide, and beclometasone in addition to aminosalicylates compared with each other and with aminosalicylate monotherapy for the induction of remission for people with mild-to-moderate ulcerative colitis?

Recommendation ID NG130/3 Question What is the clinical and cost effectiveness of prednisolone, budesonide, and beclometasone in addition

Research recommendation Published October 2019

What are the benefits, risk and cost effectiveness of enteral nutrition in maintaining remission in the post-surgical period of Crohn's disease?

Recommendation ID NG129/1 Question What are the benefits, risk and cost effectiveness of enteral nutrition in maintaining remission in

Research recommendation Published October 2019

What is the clinical utility of bone turnover markers in the diagnosis and management of primary hyperparathyroidism?

Recommendation ID NG132/1 Question What is the clinical utility of bone turnover markers in the diagnosis and management of primary...

Research recommendation Published October 2019

What is the clinical and cost effectiveness, post treatment and at longer-term follow‑up, of behavioural activation compared with other psychological therapies in children aged 5 to 11 years and young people aged 12 to 18 years with mild or moderate to severe depression?

Recommendation ID NG134/5 Question What is the clinical and cost effectiveness, post treatment and at longer-term follow‑up, of behavioural

Research recommendation Published October 2019

What components of alcohol education delivery contribute to its effectiveness for children and young people aged 11 to 18 in full-time education, and those with special educational needs and disabilities (SEND) up to the age of 25?

Recommendation ID NG135/1 Question What components of alcohol education delivery contribute to its effectiveness for children and young

Research recommendation Published October 2019

What is the effectiveness and cost effectiveness of different scheduling of zoledronic acid in the prevention and reduction of skeletal events in people with hormone-refractory prostate cancer?

Recommendation ID NG131/8 Question What is the effectiveness and cost effectiveness of different scheduling of zoledronic acid in the prevention

Research recommendation Published October 2019

How effective and cost effective are universal, education-based alcohol interventions for children and young people aged 11 to 25 with SEND?

Recommendation ID NG135/3 Question How effective and cost effective are universal, education-based alcohol interventions for children and

Research recommendation Published October 2019

What is the best and most cost-effective management strategy for people whose first surgery for primary hyperparathyroidism is not successful?

Recommendation ID NG132/2 Question What is the best and most cost-effective management strategy for people whose first surgery for primary

Research recommendation Published October 2019

What are the optimal management strategies for primary hyperparathyroidism during pregnancy?

Recommendation ID NG132/4 Question What are the optimal management strategies for primary hyperparathyroidism during pregnancy?

Research recommendation Published October 2019

What is the natural history of people with a Likert score on MRI of less than 3 without biopsy at long-term follow‑up?

Recommendation ID NG131/5 Question What is the natural history of people with a Likert score on MRI of less than 3 without biopsy at long-term

Research recommendation Published October 2019

NICE to support new valuation study for England for EQ-5D-5L questionnaire

Study will measure public’s preference for different health states

News Published October 2019 Last updated October 2019

Another treatment option for ovarian cancer approved for the Cancer Drugs Fund

An ovarian cancer treatment, designed to help maintain the effects of chemotherapy, has been approved by NICE for use in the Cancer Drugs Fund (CDF).

News Published October 2019 Last updated October 2019

NICE looks to company to ensure a new treatment for advanced breast cancer with significant unmet need is cost-effective

Draft guidance published today (3 October 2019) by NICE does not recommend atezolizumab (also called Tecentriq and made by Roche) for treating people with a type of breast cancer called triple A breast cancer that has spread to other parts of the body and who can’t have surgery to remove it.

News Published October 2019 Last updated October 2019

More than one thousand neonatal admissions could be avoided per year by following NICE guidance

Regularly monitoring women who are pregnant with twins or triplets, to spot any possible complications, can lead to better outcomes for mothers and their babies, as highlighted in NICE’s impact report.

News Published September 2019 Last updated September 2019

Migraine drug not cost effective NICE says in final draft guidance

NICE has said that a new drug for preventing migraine is not a cost effective use of NHS resources, in final draft guidance published today (26 September 2019).

News Published September 2019 Last updated September 2019

Procedure carried out on unborn babies with spina bifida could improve their neurodevelopment

Operations are set to start taking place in the NHS

News Published September 2019 Last updated September 2019

Food on a restricted renal diet can still be hugely fun and enjoyable

Deborah Duval, the editor of Kidney Matters magazine, tells us how we can enjoy food even on a restricted renal diet

News Published September 2019 Last updated September 2019

NICE seeks feedback from users of the evidence standards framework for digital health technologies

Consultation on priority areas open to stakeholders until mid October

News Published September 2019 Last updated September 2019

NICE calls for further research on management options for tinnitus

Higher quality evidence would allow NICE to make recommendations on a range of therapies that could help people with tinnitus.

News Published September 2019 Last updated September 2019

Three areas where NICE's collaboration with CMAC can make a difference

Heidi Livingstone, senior public involvement adviser within NICE's Public Involvement Programme, reflects on the partnership with CMAC

News Published September 2019 Last updated September 2019

Applications now open for NICE's prestigious fellows and scholars programmes

Recruitment for the 2020 intake is open until 28 October 2019

News Published September 2019 Last updated September 2019

Children with rare inherited condition to benefit from drug through managed access agreement

It is estimated that in the UK there are around 30 to 50 children living with the condition

News Published September 2019 Last updated September 2019