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Safety and efficacy of antimuscarinics:- What is the safety and efficacy of more recently developed antimuscarinics compared with (a) placebo/usual care and (b) other antimuscarinics in the treatment of neurogenic lower urinary tract dysfunction?

Recommendation ID CG148/1 Question Safety and efficacy of antimuscarinics:- What is the safety and efficacy of more recently developed antimuscarinics

Research recommendation Published June 2015

Signs and symptoms that predict neutropenic sepsis in the community:- A prospective study should be carried out to determine which signs and symptoms experienced by patients in the community predict neutropenic sepsis and the outcomes of these episodes.

Recommendation ID CG151/3 Question Signs and symptoms that predict neutropenic sepsis in the community:- A prospective study should be carried

Research recommendation Published June 2015

Support to carers and practitioners to help young people's independence:- What is the most effective way to help carers and practitioners support young people's independence?

Recommendation ID NG43/5 Question Support to carers and practitioners to help young people's independence:- What is the most effective way

Research recommendation Published March 2016

Sequence of invasive OAB procedures:- What is the effectiveness and optimum sequence of treatment with botulinum toxin A and percutaneous sacral nerve stimulation for the treatment of OAB after failed conservative (including drug) management?

Recommendation ID CG171/4 Question Sequence of invasive OAB procedures:- What is the effectiveness and optimum sequence of treatment with

Research recommendation Published June 2015

Serological testing in people who have IgA deficiency:- What is the sensitivity and specificity of IgG tissue transglutaminase (tTG), IgG endomysial antibodies (EMA) and IgG deamidated gliadin peptide (DGP) tests in detecting coeliac disease in people with IgA deficiency?

Recommendation ID NG20/1 Question Serological testing in people who have IgA deficiency:- What is the sensitivity and specificity of IgG

Research recommendation Published October 2015

Self-management:- Do structured psoriasis-focused self-management programmes improve patient confidence, wellbeing and disease control compared with standard care?

Recommendation ID CG153/4 Question Self-management:- Do structured psoriasis-focused self-management programmes improve patient confidence

Research recommendation Published June 2015

Serological testing in people who test negative for anti-transglutaminase:- What is the sensitivity and specificity of IgA EMA and IgA DGP tests in detecting coeliac disease inpeople who test negative for IgA tTG?

Recommendation ID NG20/2 Question Serological testing in people who test negative for anti-transglutaminase:- What is the sensitivity and

Research recommendation Published October 2015

Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study should be carried out to assess the incidence of suspected and proven neutropenic sepsis in patients having anticancer treatment.

Recommendation ID CG151/1 Question Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study

Research recommendation Published June 2015

Saliva:- How is excessive drooling of saliva (sialorrhoea) managed in people with motor neurone disease (MND)?

Recommendation ID NG42/4 Question Saliva:- How is excessive drooling of saliva (sialorrhoea) managed in people with motor neurone disease

Research recommendation Published March 2016

Specialist investigation:- What specialist investigations should be conducted to exclude a diagnosis of functional dyspepsia in people with uninvestigated dyspepsia that does not respond to PPIs or H2 receptor antagonists (H2RAs) despite optimum primary care?

Recommendation ID CG184/5 Question Specialist investigation:- What specialist investigations should be conducted to exclude a diagnosis

Research recommendation Published June 2015

Specialist dementia support:- What is the most effective and cost effective way to support people with dementia living at home?

Recommendation ID NG21/4 Question Specialist dementia support:- What is the most effective and cost effective way to support people with

Research recommendation Published October 2015

Research into the long-term treatment effects of rivaroxaban is needed.

Recommendation ID TA287/2 Question Research into the long-term treatment effects of rivaroxaban is needed. Any explanatory notes(if

Research recommendation Published June 2015

Research is recommended on patient preferences, and their impact on quality of life, for contrast-enhanced ultrasound and other imaging modalities. Ideally such research should compare all appropriate imaging modalities in the same patient group.

Recommendation ID DG5/2 Question Research is recommended on patient preferences, and their impact on quality of life, for contrast-enhanced

Research recommendation Published June 2015

Reducing use of emergency dental care:- What interventions are effective and cost effective at encouraging people who usually only go to emergency dental services to use general dental services regularly, in a bid to improve their oral health?

Recommendation ID NG30/2 Question Reducing use of emergency dental care:- What interventions are effective and cost effective at encouraging

Research recommendation Published January 2016

Risk stratification tool for HbA1c targets for adults with type 1 diabetes:- Can a risk stratification tool be used to aid the setting of individualised HbA1c targets for adultswith type 1 diabetes?

Recommendation ID NG17/4 Question Risk stratification tool for HbA1c targets for adults with type 1 diabetes:- Can a risk stratification

Research recommendation Published October 2015

Recommendation 4 Weight management programmes. Who should take action? Research councils, commissioners and funders. Researchers and investigators.

Recommendation ID PH47/4 Question Recommendation 4 Weight management programmes. Who should take action? Research councils, commissioners

Research recommendation Published June 2015

Reducing demands on health and social care services:- Do preventive oral health interventions in residential and nursing care homes reduce demands on other health and social care services?

Recommendation ID NG48/5 Question Reducing demands on health and social care services:- Do preventive oral health interventions in residential

Research recommendation Published August 2016

Sequencing and combining of phosphate binders in adults:- For adults with stage 4 or 5 chronic kidney disease (CKD), including those on dialysis, what is the most effective sequence or combination of phosphate binders to control serum phosphate?

Recommendation ID CG157/5 Question Sequencing and combining of phosphate binders in adults:- For adults with stage 4 or 5 chronic kidney

Research recommendation Published June 2015

Research should be carried out to compare the clinical effectiveness of bendamustine with chlorambucil at the higher dose used in the Chronic Lymphocytic Leukaemia Trial 4 (CLL4).

Recommendation ID TA216/1 Question Research should be carried out to compare the clinical effectiveness of bendamustine with chlorambucil

Research recommendation Published June 2015

Research is needed to establish the efficacy and tolerability of bile acid sequestrants among people with irritable bowel syndrome (IBS-D) or Crohn's disease without ileal resection.

Recommendation ID DG7/3 Question Research is needed to establish the efficacy and tolerability of bile acid sequestrants among people with

Research recommendation Published June 2015

Research is needed on the impact of treating Alzheimer's disease on mortality and institutionalisation, and to assess the relationship between disease progression and carer utility (quality of life).

Recommendation ID TA217/2 Question Research is needed on the impact of treating Alzheimer's disease on mortality and institutionalisation

Research recommendation Published June 2015

Risk assessment in neonates, infants, children and young people:- Which pressure ulcer tools are most effective for predicting pressure ulcer risk in children?

Recommendation ID CG179/3 Question Risk assessment in neonates, infants, children and young people:- Which pressure ulcer tools are most

Research recommendation Published June 2015

Research is recommended to address uncertainties about the claimed patient and system benefits of using Parafricta Bootees and Undergarments. This should take the form of comparative research against standard care, preferably carried out in a hospital.

Recommendation ID MTG20/1 Question Research is recommended to address uncertainties about the claimed patient and system benefits of using

Research recommendation Published June 2015

Routine outcome measurement:- In people with a common mental health disorder, what is the clinical utility of routine outcome measurement and is it cost effective compared with standard care?

Recommendation ID CG123/4 Question Routine outcome measurement:- In people with a common mental health disorder, what is the clinical utility

Research recommendation Published June 2015

Self-management:- What is the impact of different early intervention-focused approaches to self-management on outcomes for older people with social care needs and multiple long-term conditions?

Recommendation ID NG22/5 Question Self-management:- What is the impact of different early intervention-focused approaches to self-management

Research recommendation Published December 2015

Safety and efficacy of botulinum toxin:- What is the safety and efficacy of botulinum toxin compared with (a) usual care, (b) antimuscarinics and (c) augmentation cystoplasty in people with neurogenic lower urinary tract dysfunction?

Recommendation ID CG148/2 Question Safety and efficacy of botulinum toxin:- What is the safety and efficacy of botulinum toxin compared

Research recommendation Published June 2015

Screening assessment tools:- Develop reliable and valid screening assessment tools for attachment and sensitivity that can be made available and used in routine health, social care and education settings.

Recommendation ID NG26/1 Question Screening assessment tools:- Develop reliable and valid screening assessment tools for attachment and

Research recommendation Published December 2015

Reducing antimicrobial resistance:- What interventions, systems and processes are effective and cost effective in reducing antimicrobial resistance without causing harm to patients?

Recommendation ID NG15/1 Question Reducing antimicrobial resistance:- What interventions, systems and processes are effective and cost effective

Research recommendation Published October 2015

Recommendation 1 Research studies and trials. Who should take action? Research councils, commissioners and funders.

Recommendation ID PH47/1 Question Recommendation 1 Research studies and trials. Who should take action? Research councils, commissioners

Research recommendation Published June 2015

Referral criteria for the foot protection service and the multidisciplinary foot care service:- When and with what criteria should people with diabetes be referred to the foot protection service or the multidisciplinary foot care service?

Recommendation ID NG19/2 Question Referral criteria for the foot protection service and the multidisciplinary foot care service:- When and

Research recommendation Published October 2015

Risk factors for early-onset neonatal infection and symptoms and signs:- Which risk factors for early-onset neonatal infection, clinical symptoms and signs of infection, and laboratory investigations should be used to identify babies who should receive antibiotics?

Recommendation ID CG149/2 Question Risk factors for early-onset neonatal infection and symptoms and signs:- Which risk factors for early-onset

Research recommendation Published June 2015

Research is needed to establish the nature of bile acid malabsorption and whether bile acid malabsorption is a primary or secondary condition in people diagnosed with irritable bowel syndrome (IBS-D) or Crohn's disease without ileal resection.

Recommendation ID DG7/2 Question Research is needed to establish the nature of bile acid malabsorption and whether bile acid malabsorption

Research recommendation Published June 2015

Robust evidence is needed on the comparative performance of different faecal calprotectin tests, including the performance of POCTs compared with laboratory-based tests.

Recommendation ID DG11/3 Question Robust evidence is needed on the comparative performance of different faecal calprotectin tests, including

Research recommendation Published June 2015

Relaxation and biofeedback:- What is the effect of relaxation and biofeedback therapies on [Irritable bowel syndrome] (IBS) symptoms and patient-related outcomes?

Recommendation ID CG61/4 Question Relaxation and biofeedback:- What is the effect of relaxation and biofeedback therapies on [Irritable

Research recommendation Published June 2015

Repositioning:- When repositioning a person who is at risk of developing a pressure ulcer, what is the most effective position – and optimum frequency of repositioning – to prevent a pressure ulcer developing?

Recommendation ID CG179/5 Question Repositioning:- When repositioning a person who is at risk of developing a pressure ulcer, what is the

Research recommendation Published June 2015

Research is needed to generate robust and relevant data on the effects of treating people with Alzheimer's disease on both short-term and long-term outcomes, disease progression through relevant health states, and quality of life.

Recommendation ID TA217/1 Question Research is needed to generate robust and relevant data on the effects of treating people with Alzheimer's

Research recommendation Published June 2015