Updating results

2285 results

Sort: Relevance | Date

What is the clinical effectiveness of continuous positive pressure ventilation compared with usual care in patients with community-acquired pneumonia and type I respiratory failure without a history of chronic obstructive pulmonary disease?

Recommendation ID CG191/3 Question What is the clinical effectiveness of continuous positive pressure ventilation compared with usual care

Research recommendation Published June 2015

Structured clinical management interventions in probation service providers:- What is the effectiveness of structured clinical (case) management in improving mental health outcomes using interventions within probation service providers?

Recommendation ID NG66/2 Question Structured clinical management interventions in probation service providers:- What is the effectiveness

Research recommendation Published May 2017

What is the optimum wound-healing environment and what is the optimum dressing to treat diabetic foot ulcers?

Recommendation ID CG119/2 Question What is the optimum wound-healing environment and what is the optimum dressing to treat diabetic foot

Research recommendation Published June 2015

What is the differential impact of interventions that aim to reduce unintended conception and abortion rates among young people aged under 25 years on subgroups of socially disadvantaged young people?

Recommendation ID PH51/4 Question What is the differential impact of interventions that aim to reduce unintended conception and abortion

Research recommendation Published June 2015

What is the effectiveness of age alone and other routinely available risk factors compared with the formal structured multifactorial risk assessment to identify people at high risk of developing CVD?

Recommendation ID CG181/1 Question What is the effectiveness of age alone and other routinely available risk factors compared with the formal

Research recommendation Published June 2015

What is the effectiveness of statin therapy in older people?

Recommendation ID CG181/3 Question What is the effectiveness of statin therapy in older people? Any explanatory notes(if applicable)

Research recommendation Published June 2015

What is the long-term effect of laparoscopic cholecystectomy on outcomes that are important to patients?

Recommendation ID CG188/5 Question What is the long-term effect of laparoscopic cholecystectomy on outcomes that are important to patients

Research recommendation Published June 2015

What is the effectiveness and cost effectiveness of a trial of hydrolysed formula in formula-fed infants with frequent regurgitation associated with marked distress?

Recommendation ID NG1/2 Question What is the effectiveness and cost effectiveness of a trial of hydrolysed formula in formula-fed infants

Research recommendation Published June 2015

What is the comparative effectiveness and cost effectiveness of exercise referral schemes compared with other interventions that aim to help people to become more physically active? Relative effectiveness and cost effectiveness should be compared in controlled trials.

Recommendation ID PH54/4 Question What is the comparative effectiveness and cost effectiveness of exercise referral schemes compared with

Research recommendation Published June 2015

What is the effectiveness of Birthrate Plus compared with other decision support methods or professional judgement for identifying safe midwifery staffing requirements and midwifery skill mix for maternity services in England?

Recommendation ID NG4/2 Question What is the effectiveness of Birthrate Plus compared with other decision support methods or professional

Research recommendation Published June 2015

Cost utility:- What is the cost utility of increasing the offer or uptake of HIV testing in different settings, for different types of tests, using different strategies (for example opt-in or opt-out approaches) and in areas and groups with different background prevalence?

Recommendation ID NG60/5 Question Cost utility:- What is the cost utility of increasing the offer or uptake of HIV testing in different

Research recommendation Published February 2017

What is the clinical effectiveness of clozapine for children and young people with schizophrenia with symptoms unresponsive to antipsychotic medication and psychological treatment combined?

Recommendation ID CG155/5 Question What is the clinical effectiveness of clozapine for children and young people with schizophrenia with

Research recommendation Published June 2015

What is the effectiveness of using defined approaches or decision support toolkits to determine nursing staff requirements and skill mix on acute adult inpatient wards in the UK?

Recommendation ID SG1/3 Question What is the effectiveness of using defined approaches or decision support toolkits to determine nursing

Research recommendation Published June 2015

What is the clinical and cost effectiveness of omega-3 fatty acids in the treatment of children and young people considered to be at high risk of developing psychosis?

Recommendation ID CG155/2 Question What is the clinical and cost effectiveness of omega-3 fatty acids in the treatment of children and young

Research recommendation Published June 2015

What is the clinical effectiveness of using the VivaScope 1500 and 3000 imaging systems to define margins of lentigo maligna and basal cell carcinoma compared with histological margins determined by Mohs surgery?

Recommendation ID DG19/4 Question What is the clinical effectiveness of using the VivaScope 1500 and 3000 imaging systems to define margins

Research recommendation Published January 2016

What is the clinical effectiveness and rate of adverse events of statin therapy using atorvastatin 20 mg per day compared with atorvastatin 40 mg per day and atorvastatin 80 mg per day in people without established CVD?

Recommendation ID CG181/5 Question What is the clinical effectiveness and rate of adverse events of statin therapy using atorvastatin 20

Research recommendation Published June 2015

What models of service delivery enable intraoperative endoscopic retrograde cholangiopancreatography (ERCP) for bile duct clearance to be delivered within the NHS? What are the costs and benefits of different models of service delivery?

Recommendation ID CG188/3 Question What models of service delivery enable intraoperative endoscopic retrograde cholangiopancreatography

Research recommendation Published June 2015

Prevalence of mental health problems:- What is the prevalence of mental health problems and associated social problems for those in contact with the criminal justice system?

Recommendation ID NG66/5 Question Prevalence of mental health problems:- What is the prevalence of mental health problems and associated

Research recommendation Published May 2017

What methods can improve the identification of women at high risk of postpartum psychosis and reduce this risk?

Recommendation ID CG192/1 Question What methods can improve the identification of women at high risk of postpartum psychosis and reduce

Research recommendation Published June 2015

Indicator conditions:- What is the UK prevalence of HIV in various indicator conditions, and how effective are interventions using indicator condition-targeted testing compared with other testing strategies?

Recommendation ID NG60/4 Question Indicator conditions:- What is the UK prevalence of HIV in various indicator conditions, and how effective

Research recommendation Published February 2017

What key factors influence differences in walking and cycling behaviour among different groups – and what are the implications for interventions aiming to achieve population-level change and reduce inequalities?

Recommendation ID PH41/5 Question What key factors influence differences in walking and cycling behaviour among different groups – and what

Research recommendation Published June 2015

Recognising that a child or young person may be dying:- What signs and symptoms indicate that a child or young person with a life-limiting condition is likely to die within hours or days?

Recommendation ID NG61/5 Question Recognising that a child or young person may be dying:- What signs and symptoms indicate that a child

Research recommendation Published February 2017

What organisational mechanisms can ensure interventions to improve the social and emotional wellbeing and 'readiness for school' of vulnerable children aged under 5 years are effectively implemented? How do these differ according to the local context?

Recommendation ID PH40/6 Question What organisational mechanisms can ensure interventions to improve the social and emotional wellbeing

Research recommendation Published June 2015

What non-pharmacological interventions are effective in reducing spasticity in people with Multiple Sclerosis (MS)?

Recommendation ID CG186/4 Question What non-pharmacological interventions are effective in reducing spasticity in people with Multiple Sclerosis

Research recommendation Published June 2015

What models of cross-organisational working improve clinical and cost effectiveness in relation to the suboptimal prescribing of medicines – for example, between NHS and social care, or primary and secondary care, or between NHS and commercial organisations?

Recommendation ID NG5/4 Question What models of cross-organisational working improve clinical and cost effectiveness in relation to the

Research recommendation Published August 2015

What risk factors predict the onset of substance misuse in young people with psychosis?

Recommendation ID CG120/10 Question What risk factors predict the onset of substance misuse in young people with psychosis? Any explanatory

Research recommendation Published June 2015

Prevalence of mental health problems in young people (up to the age of 25) with cerebral palsy:- What is the prevalence of mental health problems in young people (up to the age of 25) with cerebral palsy?

Recommendation ID NG62/5 Question Prevalence of mental health problems in young people (up to the age of 25) with cerebral palsy:- What

Research recommendation Published February 2017

What is the relationship between midwifery staffing and outcomes in maternity settings in England, and what factors act as modifiers or confounders of the relationship between midwifery staffing and outcomes?

Recommendation ID NG4/1 Question What is the relationship between midwifery staffing and outcomes in maternity settings in England, and

Research recommendation Published June 2015

Which behaviour change interventions and programmes are effective and cost effective at changing multiple behaviours and maintaining behaviour change? How does this vary among people from different sociodemographic groups?

Recommendation ID PH49/4 Question Which behaviour change interventions and programmes are effective and cost effective at changing multiple

Research recommendation Published June 2015

Women with breast cancer:- What is the safety and effectiveness of alternatives to systemic HRT as treatments for menopausal symptoms in women who have had treatment for breast cancer?

Recommendation ID NG23/1 Question Women with breast cancer:- What is the safety and effectiveness of alternatives to systemic HRT as treatments

Research recommendation Published December 2015

What methods are most effective for assessing and diagnosing the presence and severity of alcohol misuse in children and young people?

Recommendation ID CG115/2 Question What methods are most effective for assessing and diagnosing the presence and severity of alcohol misuse

Research recommendation Published June 2015

What key factors influence the effectiveness of population-level or whole-area approaches to encouraging walking or cycling? How do these factors interact?

Recommendation ID PH41/2 Question What key factors influence the effectiveness of population-level or whole-area approaches to encouraging

Research recommendation Published June 2015

What proxy outcome measures are suitable for studies of the primary prevention of skin cancer?

Recommendation ID PH32/4 Question What proxy outcome measures are suitable for studies of the primary prevention of skin cancer? Any

Research recommendation Published June 2015

What proportion of people with melanoma who are referred into secondary care under the 2 week wait rule, have equivocal moles that are excised and have equivocal moles that are monitored?

Recommendation ID DG19/2 Question What proportion of people with melanoma who are referred into secondary care under the 2 week wait rule

Research recommendation Published January 2016

What types of home-based intervention are effective in promoting the social and emotional wellbeing of vulnerable children aged under 5 years without involving the parents? (This could include childcare provided by other family members or childminders.)

Recommendation ID PH40/4 Question What types of home-based intervention are effective in promoting the social and emotional wellbeing of

Research recommendation Published June 2015

What service delivery models allow people with psychosis and coexisting substance misuse to remain living outside hospital?

Recommendation ID CG120/4 Question What service delivery models allow people with psychosis and coexisting substance misuse to remain living

Research recommendation Published June 2015

Phosphate binders in adults with chronic kidney disease (CKD) stage 4 or 5:- Which binders are most effective in controlling serum phosphate in adults with stage 4 or 5 CKD who are not on dialysis?

Recommendation ID CG157/1 Question Phosphate binders in adults with chronic kidney disease (CKD) stage 4 or 5:- Which binders are most effective

Research recommendation Published June 2015