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Appeal panel rules that NICE needs to request evidence for erenumab effectiveness in subgroup of people with chronic migraine

NICE has today (4 February 2020) published the outcome of the appeal against its final draft guidance (FAD) on erenumab (also called Aimovig and made by Novartis) for preventing chronic migraine.

News Published February 2020 Last updated February 2020

Broader types of data to be used in development of NICE guidance

An expanded evidence base could allow NICE to address evidence gaps and enhance reviews of the impact of our guidance

News Published February 2020 Last updated February 2020

Researchers wanted to study the public's views of health-related quality of life

Applications close on Wednesday 4 March 2020

News Published February 2020 Last updated February 2020

Wireless device recommended for treating people with overactive bladder

Axonics SNS has potential to save the NHS around £6,200 per patient if the device lasts more than six years

News Published February 2020 Last updated February 2020

NICE recommends new 'chemotherapy-free' treatment for lymphoma

A new treatment option for patients with previously treated follicular lymphoma (grade 1 to 3A) has been approved by NICE.

News Published February 2020 Last updated February 2020

NICE publishes updated principles

NICE has today, 30 January 2020, published a simple guide to the way we develop our guidance and standards.

News Published January 2020 Last updated January 2020

Nasal spray medicine for treatment-resistant depression not recommended by NICE

More evidence on the clinical and cost effectiveness of esketamine needed

News Published January 2020 Last updated January 2020

Digital and mobile interventions could support regular health services in helping people stop smoking and reduce their risk of obesity, says NICE

Health professionals can consider digital and mobile interventions as a supplement to regular services to support behaviour change in people at risk of developing chronic conditions.

News Published January 2020 Last updated January 2020

Care matters – Working together to get support right for adult carers

Dame Philippa Russell, Vice-President of Carers UK and Topic Adviser for the NICE guideline on Supporting Adult Carers

News Published January 2020 Last updated January 2020

Make use of community pharmacists' skills, says NICE

Community pharmacy teams have the potential to play a greater role in health promotion and prevention says NICE, in a new draft quality standard.

News Published January 2020 Last updated January 2020

NICE encourages further data collection on 'game changing' histology independent cancer drugs

Larotrectinib (also called Vitrakvi and made by Bayer), a new treatment for a range of cancers, can’t be recommended for use in the NHS because at its current price, it doesn’t have the potential to be cost-effective.

News Published January 2020 Last updated January 2020

Breast cancer patients to have further NICE-approved drug combination option on Cancer Drugs Fund

Another potentially life-extending drug combination for some people with advanced breast cancer will now be available on the Cancer Drugs Fund (CDF) following its approval by NICE in final guidance published today (15 January 2020).

News Published January 2020 Last updated January 2020

Implantable cardiac monitors detect atrial fibrillation after stroke of unknown cause recommended for routine NHS adoption

Doctors can check on their patients remotely using Reveal LINQ monitor

News Published January 2020 Last updated January 2020

Shared Learning Awards 2020 now accepting entries

Submit your shared learning entry by 4 March 2020 for a chance to be one of our 20 finalists at this year’s NICE Conference

News Published January 2020 Last updated January 2020

Additional evidence needed to assess histology-independent cancer drugs says paper co-authored by NICE staff

Paper looks at how histology-independent cancer drugs might be appraised

News Published January 2020 Last updated January 2020

ion (with or without type 2 diabetes), what are the appropriate risk and blood pressure thresholds for starting treatment?

Recommendation ID NG136/2 Question ion (with or without type 2 diabetes), what are the appropriate risk and blood pressure thresholds for

Research recommendation Published November 2019

Thrombolytic therapy for DVT:- What is the clinical and cost effectiveness of clot removal using catheter-directed thrombolytic therapy or pharmacomechanical thrombolysis compared with standard anticoagulation therapy for the treatment of acute proximal DVT?

Recommendation ID CG144/4 Question Thrombolytic therapy for DVT:- What is the clinical and cost effectiveness of clot removal using catheter-directed

Research recommendation Published June 2015

What are the costs associated with best supportive care?

Recommendation ID TA575/1 Question What are the costs associated with best supportive care? Any explanatory notes(if applicable)

Research recommendation Published August 2019

What are the clinically and cost-effective surgical approaches to managing complicated acute diverticulitis, including timing of surgery (elective or emergency)?

Recommendation ID NG147/5 Question What are the clinically and cost-effective surgical approaches to managing complicated acute diverticulitis

Research recommendation Published February 2020

Topiramate to prevent recurrent cluster headache:- Is topiramate a clinically and cost effective prophylactic treatment for recurrent cluster headache?

Recommendation ID CG150/3 Question Topiramate to prevent recurrent cluster headache:- Is topiramate a clinically and cost effective prophylactic

Research recommendation Published June 2015

What training, support or interventions help to reduce caring-related accidents or incidents?

Recommendation ID NG150/3 Question What training, support or interventions help to reduce caring-related accidents or incidents?

Research recommendation Published February 2020

Training:- What are the effects of different approaches to home care training on outcomes for people who use home care services?

Recommendation ID NG21/3 Question Training:- What are the effects of different approaches to home care training on outcomes for people

Research recommendation Published October 2015

Transition in special groups: looked-after young people:- What is the most effective way of supporting care leavers in transition from children's to adults' health services?

Recommendation ID NG43/8 Question Transition in special groups: looked-after young people:- What is the most effective way of supporting

Research recommendation Published March 2016

Transition in special groups: young offenders institutions:- What is the most effective way of supporting young offenders in transition from children's to adults' health and social care services?

Recommendation ID NG43/7 Question Transition in special groups: young offenders institutions:- What is the most effective way of supporting

Research recommendation Published March 2016

Transition support for young adults:- What approaches to providing transition support for those who move from child to adult services are effective and/or cost-effective?

Recommendation ID NG43/1 Question Transition support for young adults:- What approaches to providing transition support for those who move

Research recommendation Published March 2016

Transjugular intrahepatic portosystemic shunt:- What is the quality of life in people who have had a transjugular intrahepatic portosystemic shunt (TIPS)?

Recommendation ID NG50/4 Question Transjugular intrahepatic portosystemic shunt:- What is the quality of life in people who have had a

Research recommendation Published August 2016

Treating an eating disorder in people with a comorbidity:- What is the impact of comorbidities on treatment outcomes for eating disorders, and whatapproaches are effective in managing these comorbidities?

Recommendation ID NG69/4 Question Treating an eating disorder in people with a comorbidity:- What is the impact of comorbidities on treatment

Research recommendation Published October 2018

Treating common presentations of osteoarthritis for which there is little evidence:- What are effective treatments for people with osteoarthritis who have common but poorly researched problems, such as pain in more than one joint or foot osteoarthritis?

Recommendation ID CG177/3 Question Treating common presentations of osteoarthritis for which there is little evidence:- What are effective

Research recommendation Published June 2015

Treating comorbid anxiety in children and young people with autism:- What is the comparative clinical and cost effectiveness of pharmacological and psychosocial interventions for anxiety disorders in children and young people with autism?

Recommendation ID CG170/4 Question Treating comorbid anxiety in children and young people with autism:- What is the comparative clinical

Research recommendation Published June 2015

For isoniazid-resistant TB, what is the most effective regimen for reducing mortality andmorbidity?

Recommendation ID NG33/3 Question For isoniazid-resistant TB, what is the most effective regimen for reducing mortality andmorbidity?

Research recommendation Published November 2019

Treating small oesophageal varices:- Do non-selective beta-blockers improve survival and prevent first variceal bleeds in people with cirrhosis that is associated with small oesophageal varices?

Recommendation ID NG50/2 Question Treating small oesophageal varices:- Do non-selective beta-blockers improve survival and prevent first

Research recommendation Published August 2016

Serological testing in people who have IgA deficiency:- What is the sensitivity and specificity of IgG tissue transglutaminase (tTG), IgG endomysial antibodies (EMA) and IgG deamidated gliadin peptide (DGP) tests in detecting coeliac disease in people with IgA deficiency?

Recommendation ID NG20/1 Question Serological testing in people who have IgA deficiency:- What is the sensitivity and specificity of IgG

Research recommendation Published October 2015

Serological testing in people who test negative for anti-transglutaminase:- What is the sensitivity and specificity of IgA EMA and IgA DGP tests in detecting coeliac disease inpeople who test negative for IgA tTG?

Recommendation ID NG20/2 Question Serological testing in people who test negative for anti-transglutaminase:- What is the sensitivity and

Research recommendation Published October 2015

Service delivery models:- Which models of service delivery are effective and cost-effective for older people with social care needs and multiple long-term conditions?

Recommendation ID NG22/2 Question Service delivery models:- Which models of service delivery are effective and cost-effective for older

Research recommendation Published December 2015

Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study should be carried out to assess the incidence of suspected and proven neutropenic sepsis in patients having anticancer treatment.

Recommendation ID CG151/1 Question Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study

Research recommendation Published June 2015

Shoulder pain:- Which people with a weak arm after stroke are at risk of developing shoulder pain? What management strategies are effective in the prevention or management of shoulder pain of different aetiologies?

Recommendation ID CG162/4 Question Shoulder pain:- Which people with a weak arm after stroke are at risk of developing shoulder pain? What

Research recommendation Published June 2015

Which signs and symptoms (or combinations of signs and symptoms) predict a diagnosis of Kawasaki disease in children under 5 presenting with fever lasting 5 days or more?

Recommendation ID NG143/8 Question Which signs and symptoms (or combinations of signs and symptoms) predict a diagnosis of Kawasaki disease

Research recommendation Published February 2020

Signs and symptoms that predict neutropenic sepsis in the community:- A prospective study should be carried out to determine which signs and symptoms experienced by patients in the community predict neutropenic sepsis and the outcomes of these episodes.

Recommendation ID CG151/3 Question Signs and symptoms that predict neutropenic sepsis in the community:- A prospective study should be

Research recommendation Published June 2015

Social media:- How effective are online social media and networks at improving health and wellbeing and reducing health inequalities when they are used:- as a method of community engagement?- to support an existing community engagement approach?

Recommendation ID NG44/4 Question Social media:- How effective are online social media and networks at improving health and wellbeing and

Research recommendation Published April 2016

What is the clinical and cost effectiveness of cannabis-based medicinal products other than THC: CBD spray for children, young people and adults with spasticity? In particular, what is the impact of spasticity on improvements in quality of life?

Recommendation ID NG144/5 Question What is the clinical and cost effectiveness of cannabis-based medicinal products other than THC: CBD

Research recommendation Published February 2020