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  1. Sickle cell disease: acute painful episode

    Everything NICE has said on managing acute painful sickle cell disease episodes in patients presenting to hospital until discharge in an interactive flowchart

  2. Intrapartum care

    Everything NICE has said on the care of healthy women and their babies during childbirth in an interactive flowchart

  3. Induction of labour

    Everything NICE has said on inducing labour in an interactive flowchart

  4. Postnatal care

    Everything NICE has said on postnatal care in an interactive flowchart

  5. Immunisations for under 19s

    Everything NICE has said on immunisation in under 19s in an interactive flowchart

  6. Abortion care

    Everything NICE has said on abortion care in an interactive flowchart.

  7. Antenatal care

    Everything NICE has said on routine antenatal care for healthy women in an interactive flowchart

  8. Non-Hodgkin's lymphoma

    Everything NICE has said on diagnosing and managing non-Hodgkin's lymphoma in adults and young people 16 years and older in an interactive flowchart

  9. Prostate cancer

    Everything NICE has said on diagnosing and treating prostate cancer in an interactive flowchart

  10. Evidence on the safety of repetitive short-pulse transscleral cyclophotocoagulation for glaucoma shows no major safety concerns. Evidence on efficacy is inadequate in quality. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE website.

    Recommendation ID IPG692/1 Question Evidence on the safety of repetitive short-pulse transscleral cyclophotocoagulation for glaucoma shows

  11. Rheumatoid arthritis

    Everything NICE has said on managing rheumatoid arthritis in adults in an interactive flowchart

  12. Technologies for preventing and treating impaired hypoglycaemia awareness in adults with type 1 diabetes: For adults with type 1 diabetes, what are the optimum technologies (such as insulin pump therapy and/or continuous glucose monitoring, partially or fully automated insulin delivery, and behavioural, psychological and educational interventions) and how are they best used, in terms of clinical and cost effectiveness, for preventing and treating impaired hypoglycaemia awareness?

    Recommendation ID NG17/5 Question Technologies for preventing and treating impaired hypoglycaemia awareness in adults with type 1 diabetes:

  13. Evidence on the safety and efficacy of inducing and maintaining normothermia using temperature modulation devices to improve outcomes after stroke or subarachnoid haemorrhage is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    Recommendation ID IPG701/1 Question Evidence on the safety and efficacy of inducing and maintaining normothermia using temperature modulation

  14. Newly diagnosed seizures (focal and generalised) – monotherapy: How do the newer AEDs compare in efficacy to the standard AEDs in the treatment of newly diagnosed epilepsy? Focal seizures: carbamazepine, eslicarbazepine acetate, lacosamide, lamotrigine, levetiracetam, pregabalin  and zonisamide. Generalised seizures: lamotrigine, levetiracetam, sodium valproate and zonisamide.

    Recommendation ID CG137/1 Question Newly diagnosed seizures (focal and generalised) – monotherapy: How do the newer AEDs compare in efficacy

  15. Oral teicoplanin compared with oral vancomycin or oral fidaxomicin for treating Clostridioides difficile infection: What is the clinical effectiveness, cost effectiveness and safety of oral teicoplanin 100 mg to 200 mg twice a day for 7 to 14 days compared with oral vancomycin or oral fidaxomicin for treating C. difficile infection in adults?

    Recommendation ID NG199/1 Question Oral teicoplanin compared with oral vancomycin or oral fidaxomicin for treating Clostridioides difficile

  16. NICE draft guidance recommends abemaciclib for advanced breast cancer

    NICE has today published draft guidance which recommends twice-daily pill abemaciclib (also called Verzenios and made by Eli Lilly) as an option for adults with a type of breast cancer called hormone receptor-positive, HER2-negative breast cancer which has spread to other parts of the body.

  17. Further evidence to address uncertainties about the relative clinical and cost effectiveness of UroLift compared with Rezum, especially in the NHS, would be welcome. This should include: • exploring long-term clinical outcomes and reintervention rates after UroLift • assessing the suitability of UroLift for prostates larger than 80 ml and for those with an obstructive median lobe.

    Recommendation ID MTG58/1 Question Further evidence to address uncertainties about the relative clinical and cost effectiveness of UroLift

  18. The evidence on transvaginal laser therapy for stress urinary incontinence does not show any short-term safety concerns. Evidence on long-term safety andefficacy is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means onthe NICE interventional procedures guidance page.

    Recommendation ID IPG696/1 Question The evidence on transvaginal laser therapy for stress urinary incontinence does not show any short-term

  19. The evidence on transvaginal laser therapy for urogenital atrophy does not show any short-term safety concerns. Evidence on long-term safety and efficacy is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    Recommendation ID IPG697/1 Question The evidence on transvaginal laser therapy for urogenital atrophy does not show any short-term safety

  20. Evidence on the safety and efficacy of permanent His-bundle pacemaker implantation for treating heart failure is inadequate in quality and quantity.Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    Recommendation ID IPG694/1 Question Evidence on the safety and efficacy of permanent His-bundle pacemaker implantation for treating heart

  21. Are comprehensive early interventions that combine multiple elements and are delivered by parents and teachers (for example, the Learning Experiences – an Alternative Program for Preschoolers and their Parents [LEAP] model) effective in managing the core features of autism and coexisting difficulties (such as adaptive behaviour and developmental skills) in pre‑school children?

    Recommendation ID CG170/4 Question Are comprehensive early interventions that combine multiple elements and are delivered by parents and