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  1. Identification and monitoring:- What are the demographic characteristics and rates of progression to type 2 diabetes among people with a high risk score but normal blood glucose levels (fasting plasma glucose of less than 5.5 mmol/l or HbA1c of less than 42 mmol/mol)? How does this compare with people who have both a high risk score and blood glucose levels that indicate impaired glucose regulation (fasting plasma glucose 5.5–6.9 mmol/l or HbA1c 42–47 mmol/mol (6.0–6.4%)?

    Recommendation ID PH38/2 Question Identification and monitoring:- What are the demographic characteristics and rates of progression to

  2. Identification and monitoring:- What are the most effective and cost-effective methods of increasing uptake of type 2 diabetes risk assessments and monitoring among those at greatest risk? Those at greatest risk include people from lower socioeconomic and black and minority ethnic groups, and those aged 75 or over.

    Recommendation ID PH38/3 Question Identification and monitoring:- What are the most effective and cost-effective methods of increasing

  3. Identification and monitoring:- Which combination of risk-assessment tools and blood tests (HbA1c or fasting plasma glucose [FPG]) are most cost effective and effective at identifying and assessing the risk of type 2 diabetes among populations at high risk? In addition, how frequently should testing take place to be efficient? How does effectiveness and cost effectiveness vary for different black and minority ethnic groups, for example, African-Caribbean and black African; people aged 18–40, people aged 75 and over, and for high-risk vulnerable adults?

    Recommendation ID PH38/1 Question Identification and monitoring:- Which combination of risk-assessment tools and blood tests (HbA1c or

  4. Further research studies into deep brain stimulation (DBS) for intractable trigeminal autonomic cephalalgias (TACs) should clearly define patient selection and report the intensity and duration of stimulation, medication use and quality of life, in addition to documenting the effects on headache symptoms as clearly as possible.

    Recommendation ID IPG381/1 Question Further research studies into deep brain stimulation (DBS) for intractable trigeminal autonomic cephalalgias

  5. Generalized Anxiety Disorder scale (GAD-2) for people with suspected anxiety disorders:- In people with suspected anxiety disorders, what is the clinical utility of using the GAD-2 compared with routine case identification to accurately identify different anxiety disorders? Should an avoidance question be added to improve case identification?

    Recommendation ID CG123/3 Question Generalized Anxiety Disorder scale (GAD-2) for people with suspected anxiety disorders:- In people with

  6. Acceptability of drug misuse prevention interventions:- How acceptable are drug misuse prevention interventions among groups vulnerable to drug misuse in the UK? How acceptable are drug misuse prevention interventions among practitioners in the UK? How can acceptability be improved for groups that are vulnerable to drug misuse and practitioners?

    Recommendation ID NG64/4 Question Acceptability of drug misuse prevention interventions:- How acceptable are drug misuse prevention interventions

  7. How can factors that contribute to the balance of health risks and benefits of sunlight exposure for different populations be quantified? What factors should be included in tailored messages for people with different characteristics and levels of exposure to the sun, including skin colour, age, occupation and lifestyle?

    Recommendation ID NG34/1 Question How can factors that contribute to the balance of health risks and benefits of sunlight exposure for