Search results

1533 results

Sorted by Relevance . Sort by Date

  1. Supervised exercise programmes for treating people with intermittent claudication:- What is the clinical and cost effectiveness of supervised exercise programmes compared with unsupervised exercise for treating people with intermittent claudication, taking into account the effects on long-term outcomes and continuing levels of exercise?

    Recommendation ID CG147/2 Question Supervised exercise programmes for treating people with intermittent claudication:- What is the clinical

  2. Surgical excision for people with lentigo maligna:- For people with lentigo maligna (stage 0 in sun-damaged skin, usually on the face) how effective is Mohs micrographic surgery, compared with excision with a 0.5 cm clinical margin, in preventing biopsy-proven local recurrence at 5 years?This should be investigated in a randomised controlled trial. Secondary outcomes should include cosmetic and functional outcomes.

    Recommendation ID NG14/2 Question Surgical excision for people with lentigo maligna:- For people with lentigo maligna (stage 0 in sun-damaged

  3. Switching from inpatient intravenous to outpatient oral antibiotic therapy in patients with neutropenic sepsis:- A randomised controlled trial should be undertaken to evaluate the clinical and cost effectiveness of stopping intravenous antibiotic therapy and switching to oral therapy within the first 24 hours of treatment in patients with neutropenic sepsis who are having treatment with intravenous antibiotics. The outcomes to be measured are overtreatment, death, need for critical care, length of hospital stay, duration of fever and quality of life.

    Recommendation ID CG151/5 Question Switching from inpatient intravenous to outpatient oral antibiotic therapy in patients with neutropenic

  4. Teacher-, parent- and peer-mediated psychosocial interventions in pre-school children with autism:- Are comprehensive early interventions that combine multiple elements and are delivered by parents and teachers (for example, the Learning Experiences – an Alternative Program for Preschoolers and their Parents [LEAP] model) effective in managing the core symptoms of autism and coexisting difficulties (such as adaptive behaviour and developmental skills) in pre-school children?

    Recommendation ID CG170/5 Question Teacher-, parent- and peer-mediated psychosocial interventions in pre-school children with autism:-

  5. Techniques for confirming a diagnosis in people with suspected atypical spitzoid melanocytic lesions:- In people with reported atypical spitzoid lesions, how effective are fluorescence in-situ hybridization (FISH), comparative genomic hybridization (CGH) and tests to detect driver mutations compared with histopathological examination alone in predicting disease-specific survival?This should be investigated in a prospective diagnostic study. Secondary outcomes should include sensitivity, specificity, accuracy, positive predictive value, disease-specific survival and progression-free survival.

    Recommendation ID NG14/1 Question Techniques for confirming a diagnosis in people with suspected atypical spitzoid melanocytic lesions:-

  6. Technologies for preventing and treating impaired awareness of hypoglycaemia in adults with type 1 diabetes:- For adults with type 1 diabetes, what are the optimum technologies (such as insulin pump therapy and/or continuous glucose monitoring, partially or fully automated insulin delivery, and behavioural, psychological and educational interventions) and how are they best used, in terms of clinical and cost effectiveness, for preventing and treating impaired awareness of hypoglycaemia?

    Recommendation ID NG17/5 Question Technologies for preventing and treating impaired awareness of hypoglycaemia in adults with type 1 diabetes:-

  7. Further research is recommended to assess the effect of test-guided preventive care (see section 5.1) on clinical outcomes (such as length of stay in hospital, mortality and need for renal replacement therapy and progression to chronic kidney disease). Research should be done in children, young people and adults, but specific considerations may be needed for children and young people when care differs from that for an adult population. Studies should investigate the effects of both positive and negative test results on clinical decisions and subsequent care.

    Recommendation ID DG39/2 Question Further research is recommended to assess the effect of test-guided preventive care (see section 5.1)

  8. Companies should specify patient populations in the NHS who could benefit from test-guided preventive care for acute kidney injury. Further research is then recommended in these populations to assess the clinical effectiveness of defined care bundles designed to prevent or reduce the effect of acute kidney injury in the NHS. Research should be done in children, young people and adults, but specific considerations may be needed for children and young people when care differs from that for an adult population (see  section 4.11 ).

    Recommendation ID DG39/1 Question Companies should specify patient populations in the NHS who could benefit from test-guided preventive

  9. The committee recommended that further studies should be done in a HPV primary screening setting. These studies should incorporate clinical outcome data and be designed to minimise verification bias. Future studies should consider measuring variability and should also take into account HPV genotyping status when possible, so that the difference in accuracy in a population vaccinated against HPV types 16 and 18 can be better understood.

    Recommendation ID DG32/1 Question The committee recommended that further studies should be done in a HPV primary screening setting. These studies

  10. The effect of drug therapy for concurrent conditions on melanoma survival:- In people diagnosed with melanoma what is the effect of drug therapy to treat concurrentconditions on disease-specific survival?This should be investigated in a national prospective cohort study. Secondary outcomes should include overall survival and quality of life.

    Recommendation ID NG14/5 Question The effect of drug therapy for concurrent conditions on melanoma survival:- In people diagnosed with