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  1. Diagnosing asthma in children and young people aged 5 to 16:- What is the acceptability and diagnostic accuracy of objective tests that could be used to comprisea diagnostic pathway for asthma in children and young people aged 5 to 16 (for example, exercise challenge, direct bronchial challenge with histamine or methacholine, indirect bronchial challenge with mannitol and peripheral blood eosinophil count)?

    Recommendation ID NG80/1 Question Diagnosing asthma in children and young people aged 5 to 16:- What is the acceptability and diagnostic

  2. In patients with negative MRI (Likert score 1 or 2), what is the next best diagnostic investigation to rule out clinically significant prostate cancer? What is the diagnostic accuracy of transperineal mapping biopsy compared with transperineal non-mapping biopsy in the diagnosis of clinically significant prostate cancer?

    Recommendation ID NG131/7 Question In patients with negative MRI (Likert score 1 or 2), what is the next best diagnostic investigation

  3. Diagnostic investigations to predict treatment outcomes:- What is the prognostic value of the Hevylite assay and ratio compared with other prognostic factors and tests, including the serum-free light-chain assay and fluorescence in-situ hybridisation (FISH), in people with newly diagnosed myeloma who are starting treatment?

    Recommendation ID NG35/1 Question Diagnostic investigations to predict treatment outcomes:- What is the prognostic value of the Hevylite

  4. What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of supported digital cognitive–behavioural therapy (CBT) compared with unsupported digital CBT in young people aged 12 to 18 years with mild depression, and what are the key components of the interventions that influence effectiveness?

    Recommendation ID NG134/2 Question What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of supported

  5. Communicating information about drug allergy:- In people with suspected or confirmed drug allergies, are patient-focused information strategies more effective than standard NHS practice in increasing people's likelihood of disclosing their drug allergy (or their suspected drug allergy) and therefore reducing the risk of being re-exposed to the affected drug?

    Recommendation ID CG183/2 Question Communicating information about drug allergy:- In people with suspected or confirmed drug allergies

  6. Comparative research is recommended in the UK to reduce uncertainty about the outcomes of patients with chronic, 'hard-to-heal', complex wounds treated by the MIST Therapy system compared with those treated by standard methods of wound care. This research should define the types and chronicity of wounds being treated and the details of other treatments being used. It should report healing rates, durations of treatment (including debridement) needed to achieve healing, and quality of life measures (including quality of life if wounds heal only partially). It is recommended that centres using the MIST Therapy system take part in research that delivers these outcomes. Current users of the MIST Therapy system who are unable to join research studies should use NICE's audit criteria to collect further information on healing rates, duration of treatment and quality of life and publish their results.

    Recommendation ID MTG5/1 Question Comparative research is recommended in the UK to reduce uncertainty about the outcomes of patients with

  7. Current evidence on the efficacy and safety of distal iliotibial band lengthening for refractory greater trochanteric pain syndrome is inadequate in quantity and quality. Therefore this procedure should only be used in the context of research. Research studies should clearly define patient selection, and outcomes should include measures of function and quality of life.

    Recommendation ID IPG375/1 Question Current evidence on the efficacy and safety of distal iliotibial band lengthening for refractory greater

  8. Current evidence on the safety and efficacy of irreversible electroporation for treating liver metastases is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research. In particular, studies should report the effect of the procedure on local tumour control and patient survival.

    Recommendation ID IPG445/1 Question Current evidence on the safety and efficacy of irreversible electroporation for treating liver metastases

  9. Decision-to-delivery interval (category 2 urgency):- A prospective study to determine whether the decision-to-delivery interval has an impact on maternal and neonatal outcomes when there is a category 2 level of urgency for Caesarean Section (CS). Important primary outcomes would be: • fetal wellbeing (such as cord blood gases, Apgar score at 5 minutes, hypoxic encephalopathy, neonatal respiratory problems, unanticipated admission to neonatal intensive care unit (NICU), duration of stay in the NICU) maternal wellbeing (such as haemoglobin levels on day 2, need for blood transfusion, duration of hospital stay controlled for prolonged neonatal stay and general health/wellbeing). Valuable secondary outcomes could include: • fetal trauma at delivery • iatrogenic maternal bladder or bowel injury • postoperative maternal infectious morbidity • establishment of breastfeeding • psychological outcomes for women, such as the development of postnatal depression/posttraumatic stress disorder.

    Recommendation ID CG132/2 Question Decision-to-delivery interval (category 2 urgency):- A prospective study to determine whether the...

  10. Current evidence on the safety and efficacy of irreversible electroporation for treating primary lung cancer and metastases in the lung is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research. In particular, studies should report the effect of the procedure on local tumour control and patient survival.

    Recommendation ID IPG441/1 Question Current evidence on the safety and efficacy of irreversible electroporation for treating primary lung

  11. Current evidence on the safety and efficacy of irreversible electroporation for treating prostate cancer is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research. Studies should include randomised controlled trials comparing the procedure with current standards of care. They should report details of patient selection and short- and long-term outcomes, including patient-reported outcomes and the effect on any future prostate surgery.

    Recommendation ID IPG572/1 Question Current evidence on the safety and efficacy of irreversible electroporation for treating prostate cancer

  12. Current evidence on the safety and efficacy of irreversible electroporation for treating renal cancer is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research. In particular, studies should report the effect of the procedure on local tumour control and patient survival.

    Recommendation ID IPG443/1 Question Current evidence on the safety and efficacy of irreversible electroporation for treating renal cancer