Does early intervention to treat neuropathic pain reduce the likelihood of chronic pain?
Recommendation ID CG173/8 Question Does early intervention to treat neuropathic pain reduce the likelihood of chronic pain? Any explanatory
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1804 results
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How should the symptomatic treatment of neuropathic pain relate to its cause?
Recommendation ID CG173/7 Question How should the symptomatic treatment of neuropathic pain relate to its cause? Any explanatory
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Aside from mast cell tryptase, which other chemical inflammatory mediators offer potential as indicators of anaphylaxis?
Recommendation ID CG134/1 Question Aside from mast cell tryptase, which other chemical inflammatory mediators offer potential as indicators
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What are the frequency, timing, severity and predictors of biphasic reactions in people who have received emergency treatment for anaphylaxis?
Recommendation ID CG134/2 Question What are the frequency, timing, severity and predictors of biphasic reactions in people who have received
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For how long should a person who has received emergency treatment for anaphylaxis be observed?
Recommendation ID CG134/3 Question For how long should a person who has received emergency treatment for anaphylaxis be observed?
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What is the annual incidence of anaphylaxis and its related outcomes within the UK?
Recommendation ID CG134/4 Question What is the annual incidence of anaphylaxis and its related outcomes within the UK? Any explanatory
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What is the clinical effectiveness, cost effectiveness and tolerability of pharmacological monotherapy compared with combination therapy for treating neuropathic pain?
Recommendation ID CG173/1 Question What is the clinical effectiveness, cost effectiveness and tolerability of pharmacological monotherapy
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Is response to pharmacological treatment predicted more reliably by underlying aetiology or by symptom characteristics?
Recommendation ID CG173/2 Question Is response to pharmacological treatment predicted more reliably by underlying aetiology or by symptom
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What is the impact of drug-related adverse effects on health economics and quality of life in neuropathic pain?
Recommendation ID CG173/5 Question What is the impact of drug-related adverse effects on health economics and quality of life in neuropathic
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What are the most effective and cost-effective mid-life services and interventions in the long term for reducing behavioural risk, leading to healthier ageing and preventing or delaying the development of dementia, disability and frailty in later life? How can these be delivered in a consistent and sustainable manner? How can multiple interventions be effectively packaged to maximise efficiency? What are the barriers and facilitators to the uptake of services and interventions, and to the development and maintenance of healthy behaviours of people in mid-life? What are the effects on health inequalities?
Recommendation ID NG16/3 Question What are the most effective and cost-effective mid-life services and interventions in the long term for
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What are the most effective and cost-effective population-level measures to help people in mid-life maintain or adopt healthy behaviours and build up resilience to dementia, disability and frailty? What are the best methods for evaluating their effect? How do these measures affect health inequalities?
Recommendation ID NG16/2 Question What are the most effective and cost-effective population-level measures to help people in mid-life maintain
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What are the most effective and cost effective ways of delivering needle and syringe programmes to: young people aged under 18; users of image- and performance- enhancing drugs?
Recommendation ID PH52/2 Question What are the most effective and cost effective ways of delivering needle and syringe programmes to: young
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What are the most effective and cost effective ways of developing, implementing and assessing tailored and culturally appropriate community-level interventions to prevent type 2 diabetes among people at high risk? This includes people from a range of black and minority ethnic groups and those from lower socioeconomic communities.
Recommendation ID PH35/2 Question What are the most effective and cost effective ways of developing, implementing and assessing tailored
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Underserved groups:- What are the most effective and cost-effective ways of reaching underserved groups and removing barriers to access in order to increase their uptake of flu vaccination?
Recommendation ID NG103/2 Question Underserved groups:- What are the most effective and cost-effective ways of reaching underserved groups
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What are the most effective and cost effective ways to provide contraceptive services for socially disadvantaged young people to prevent unwanted pregnancies? In particular, what are the most effective and cost effective ways to provide contraceptive services for looked after children, those with learning difficulties, those who are not in education, employment or training or women who have had an abortion?
Recommendation ID PH51/1 Question What are the most effective and cost effective ways to provide contraceptive services for socially disadvantaged
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Care and support planning:- What are the most effective methods of care planning for people who do not have regular contact with an informal carer?
Recommendation ID NG97/5 Question Care and support planning:- What are the most effective methods of care planning for people who do not
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What are the most effective methods of identifying and targeting individuals and groups at risk of either over- or underexposure to sunlight?
Recommendation ID NG34/3 Question What are the most effective methods of identifying and targeting individuals and groups at risk of either
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What are the most effective methods of monitoring smoking status at the population level? This includes the development of biomarkers that can distinguish between nicotine use and smoking in order to validate these measures.
Recommendation ID PH45/7 Question What are the most effective methods of monitoring smoking status at the population level? This includes
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What are the most effective ways of conveying complex risk messages and influencing behaviours in relation to over- and underexposure to sunlight? In particular, what are the most effective ways of using social and digital media? Consideration should be given to the following: how does effectiveness vary according to communicator, message, audience and medium? How does this vary at individual, group and population level in the UK? How does this vary for black and minority ethnic groups in the UK?
Recommendation ID NG34/2 Question What are the most effective ways of conveying complex risk messages and influencing behaviours in relation
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What are the most effective ways of involving people from groups at increased risk in awareness-raising about, and promoting testing and treatment for, hepatitis B and C infection? Specifically, how cost effective are peer mentor programmes at increasing the number of people at increased risk who are tested and treated for hepatitis B and C?
Recommendation ID PH43/6 Question What are the most effective ways of involving people from groups at increased risk in awareness-raising
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What are the most effective ways to get socially disadvantaged young women and men involved in designing contraceptive services that meet their needs and reduce the barriers to access?
Recommendation ID PH51/2 Question What are the most effective ways to get socially disadvantaged young women and men involved in designing
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What are the natural frequencies of the avoidable harms that cardiotocography is intended to prevent for women who are assessed as being at low risk of complications at the start of labour? Does using cardiotocography in labours where complications develop confer a net benefit compared with intermittent auscultation?
Recommendation ID CG190/5 Question What are the natural frequencies of the avoidable harms that cardiotocography is intended to prevent
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What are the optimal frequency and tools for self-monitoring body weight and associated behaviours in populations with a healthy weight?
Recommendation ID NG7/3 Question What are the optimal frequency and tools for self-monitoring body weight and associated behaviours in
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Use of a simple algorithm compared with a standard clinical assessment:- For people with a common mental health disorder, is the use of a simple algorithm (based on factors associated with treatment response), when compared with a standard clinical assessment, more clinically and cost effective?
Recommendation ID CG123/5 Question Use of a simple algorithm compared with a standard clinical assessment:- For people with a common mental
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Use of biomarkers to diagnose and initiate treatment:- What is the clinical and cost effectiveness of procalcitonin (PCT) point-of-care tests at initial triage for diagnosis of serious infection and the initiation of appropriate antibiotic therapy?
Recommendation ID NG51/3 Question Use of biomarkers to diagnose and initiate treatment:- What is the clinical and cost effectiveness of
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Use of low-molecular-weight heparin to treat patients with an acute painful sickle cell episode:- Are therapeutic doses of low-molecular-weight heparin (LMWH) effective, compared with prophylactic doses of LMWH, in reducing the length of stay in hospital of patients with an acute painful sickle cell episode?
Recommendation ID CG143/2 Question Use of low-molecular-weight heparin to treat patients with an acute painful sickle cell episode:- Are
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Use of technology in providing care- What are the views and experiences of people who use adult social care services on assistive technologies?
Recommendation ID NG86/4 Question Use of technology in providing care- What are the views and experiences of people who use adult social
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Using biomarkers to diagnose brain injury:- In adults with medium risk indications for brain injury under the 2014 NICE CT head injury guidance, what is the clinical and cost effectiveness of using the diagnostic circulating biomarker S100B to rule out significant intracranial injury?
Recommendation ID CG176/4 Question Using biomarkers to diagnose brain injury:- In adults with medium risk indications for brain injury
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What is the clinical and cost effectiveness of using different thresholds of LDL‑C concentration in primary care case finding?
Recommendation ID CG71/1 Question What is the clinical and cost effectiveness of using different thresholds of LDL‑C concentration in primary
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Using GP practice lists to identify people at high risk:- What is the clinical and cost effectiveness of using GP practice lists to identify people at high risk of fracture, leading to formal risk assessment and possible treatment?
Recommendation ID CG146/1 Question Using GP practice lists to identify people at high risk:- What is the clinical and cost effectiveness
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Using selective cyclooxygenase 2 inhibitors in people with previous severe allergic reactions to non-selective non-steroidal anti-inflammatory drugs:- Should all patients who have experienced a severe allergic reaction to a non-selective non-steroidal anti-inflammatory drug (NSAID) be assessed by specialist drug allergy services or should they be advised to take a selective cyclooxygenase 2 (COX 2) inhibitor without further investigations if clinically appropriate?
Recommendation ID CG183/3 Question Using selective cyclooxygenase 2 inhibitors in people with previous severe allergic reactions to non-selective
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Validation of clinical early warning scores in pre-hospital and emergency care settings:- Can early warning scores, for example NEWS (national early warning scores for adults) and PEWS (paediatric early warning score), be used to improve the detection of sepsis and facilitate prompt and appropriate clinical response in pre-hospital settings and in emergency departments?
Recommendation ID NG51/4 Question Validation of clinical early warning scores in pre-hospital and emergency care settings:- Can early warning
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Values of skin prick testing and specific IgE antibody testing and their predictive value:- Can skin prick testing and specific IgE antibody testing cut-off points be established to diagnose IgE-mediated food allergy in children and young people, and to predict the severity of reaction?
Recommendation ID CG116/4 Question Values of skin prick testing and specific IgE antibody testing and their predictive value:- Can skin
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Current evidence on the safety and efficacy of valve-in-valve transcatheter aortic valve implantation (ViV‑TAVI) for aortic bioprosthetic dysfunction is adequate to support the use of this procedure provided that standard arrangements are in place for clinical governance, consent and audit.
Recommendation ID IPG653/1 Question Current evidence on the safety and efficacy of valve-in-valve transcatheter aortic valve implantation
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Vascular access devices: skin decontamination:- What is the clinical and cost effectiveness of 2% chlorhexidine in alcohol versus 0.5% chlorhexidine in alcohol versus 2% chlorhexidine aqueous solution versus 0.5% chlorhexidine aqueous solution for cleansing skin (before insertion of peripheral vascular access devices [VADs] and during dressing changes of all VADs) in reducing VAD-related bacteraemia and VAD site infections?
Recommendation ID CG139/6 Question Vascular access devices: skin decontamination:- What is the clinical and cost effectiveness of 2% chlorhexidine
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Vegetation and street trees:- What factors influence how vegetation and street trees affect urban air quality?
Recommendation ID NG70/1 Question Vegetation and street trees:- What factors influence how vegetation and street trees affect urban air
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Violence related to drug or alcohol misuse:- What is the best environment in which to contain violence in people who have misused drugs or alcohol?
Recommendation ID NG10/2 Question Violence related to drug or alcohol misuse:- What is the best environment in which to contain violence
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Virtual compared with face-to-face clinics:- What is the clinical and cost effectiveness of virtual new patient fracture clinics compared with next-day consultant-led face-to-face clinics in people presenting with non-complex fractures in the emergency department and thought to need an orthopaedic opinion?
Recommendation ID NG38/2 Question Virtual compared with face-to-face clinics:- What is the clinical and cost effectiveness of virtual new
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Vulnerable groups:- What are the most effective and cost-effective methods for identifying, assessing and managing the risk of type 2 diabetes among high-risk, vulnerable adults? This group includes: frail older adults, homeless people, those with severe mental illness, learning or physical disabilities, prisoners, refugees, recent migrants and travellers.
Recommendation ID PH38/7 Question Vulnerable groups:- What are the most effective and cost-effective methods for identifying, assessing
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'Walking across' from one assessment instrument to another:- What methodology should be used to allow 'walking across' from one assessment instrument for common mental health disorders to another?
Recommendation ID CG123/2 Question 'Walking across' from one assessment instrument to another:- What methodology should be used to allow
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What are the risks and benefits of developing single-figure cut-off points on BMI and waist circumference for black, Asian and other minority ethnic groups to help prevent diabetes and other conditions?
Recommendation ID PH46/5 Question What are the risks and benefits of developing single-figure cut-off points on BMI and waist circumference
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What are the roles of insulin pump therapy (continuous subcutaneous insulin infusion) and continuous glucose monitoring in helping women with diabetes to achieve blood glucose targets before pregnancy?
Recommendation ID NG3/1 Question What are the roles of insulin pump therapy (continuous subcutaneous insulin infusion) and continuous glucose
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What are the short, medium and long-term economic benefits of interventions aimed at developing the emotional and social skills of vulnerable, preschool children – for the individual, family and wider society? How should these be assessed?
Recommendation ID PH40/7 Question What are the short, medium and long-term economic benefits of interventions aimed at developing the emotional
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What are the similarities and differences between smokeless tobacco and smoked tobacco in terms of chemical content and the harm that it can cause? Should interventions to help people quit smokeless tobacco differ from those used for smoked tobacco?
Recommendation ID PH39/3 Question What are the similarities and differences between smokeless tobacco and smoked tobacco in terms of chemical
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What are the symptoms of gastro-oesophageal reflux gastro-oesophageal reflux disease (GORD) in infants, children and young people with a neurodisability?
Recommendation ID NG1/1 Question What are the symptoms of gastro-oesophageal reflux gastro-oesophageal reflux disease (GORD) in infants
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What behaviour change techniques are most effective as part of a condom distribution scheme?:- What combinations of behaviour change techniques can be used to help condom schemes increase condom use among different high risk groups?
Recommendation ID NG68/1 Question What behaviour change techniques are most effective as part of a condom distribution scheme?:- What combinations
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What characteristics of behaviour change training influence the effectiveness of behaviour change practitioners?
Recommendation ID PH49/5 Question What characteristics of behaviour change training influence the effectiveness of behaviour change practitioners
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What combinations of interventions are most effective at helping people to reduce their risks of, and benefit from, sunlight exposure? How much does this vary according to the type of intervention for example, the communicator, message, audience and medium?
Recommendation ID NG34/4 Question What combinations of interventions are most effective at helping people to reduce their risks of, and
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What community-based interventions are effective and cost effective at improving the uptake of, and reducing inequalities in the use of, dental services by groups of adults and children at high risk of poor oral health?
Recommendation ID PH55/3 Question What community-based interventions are effective and cost effective at improving the uptake of, and reducing
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What community-based interventions are effective and cost effective in improving dietary habits affecting the oral health of children and adults, and in particular those at high risk of poor oral health?
Recommendation ID PH55/5 Question What community-based interventions are effective and cost effective in improving dietary habits affecting