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  1. Assessment of disease severity and impact:- In children, young people and adults with psoriasis, can tools be developed and/or existing ones further refined and validated to: - assess disease severity and impact in both non-specialist and specialist healthcare settings, to facilitate assessment, appropriate referral, treatment planning and measurement of outcomes - measure burden and cumulative effect of disease activity, severity and impact for people with both psoriasis and psoriatic arthritis?

    Recommendation ID CG153/1 Question Assessment of disease severity and impact:- In children, young people and adults with psoriasis, can

  2. Relationship between attachment difficulties and complex trauma:- This research recommendation is composed of 2 parts:Assess the prevalence of attachment difficulties (including attachment disorders), complex trauma and the combination of both in children and young people in the care system and on the edge of care.Investigate the effect of various factors, such as multiple placements, on the likelihood of having attachment difficulties, complex trauma or both.

    Recommendation ID NG26/5 Question Relationship between attachment difficulties and complex trauma:- This research recommendation is composed

  3. The committee also noted that the additional evidence exploring the relationship between radiological measures of bone defects (that is, the Rickets Severity Score and the Radiographic Global Impression of Change) and health-related quality of life would help to address several key uncertainties in the economic analysis.

    Recommendation ID HST8/2 Question The committee also noted that the additional evidence exploring the relationship between radiological

  4. Additional maintenance therapy for asthma uncontrolled on a moderate dose of ICS plus LABA with or without LTRA:- What is the clinical and cost effectiveness of offering additional maintenance therapy to adults, young people and children with asthma that is uncontrolled on a moderate dose of ICS plus LABA with or without LTRA?

    Recommendation ID NG80/8 Question Additional maintenance therapy for asthma uncontrolled on a moderate dose of ICS plus LABA with or without

  5. Additional methodological research is needed to determine the most appropriate model structures to assess the benefit arising from radiation dose reduction. Additional work is needed to assess when the radiation-induced cancers actually occur and the impact of the timing of the emergence of cancer on health status.

    Recommendation ID DG1/2 Question Additional methodological research is needed to determine the most appropriate model structures to assess

  6. Age thresholds in cancer:- Longitudinal studies should be carried out to identify and quantify factors in adults that are associated with development of specific cancers at a younger age than the norm. They should be designed to inform age thresholds in clinical guidance. The primary outcome should be likelihood ratios and positive predictive values for cancer occurring in younger age groups.

    Recommendation ID NG12/1 Question Age thresholds in cancer:- Longitudinal studies should be carried out to identify and quantify factors

  7. A key worker approach for children and young people with autism and their families:- What is the value of a key worker approach (defined by protocol and delivered in addition to usual care) for children and young people with autism in terms of parental satisfaction, functioning and stress and child psychopathology?

    Recommendation ID CG170/1 Question A key worker approach for children and young people with autism and their families:- What is the value