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PlGF-based testing to help diagnose suspected pre-eclampsia (Triage PlGF test, Elecsys immunoassay sFlt-1/PlGF ratio, DELFIA Xpress PlGF 1-2-3 test, and BRAHMS sFlt-1 Kryptor/BRAHMS PlGF plus Kryptor PE ratio) (DG23)

Evidence-based recommendations on PlGF-based testing to help diagnose suspected pre-eclampsia

Diagnostics guidance Published May 2016

SeHCAT (tauroselcholic [75 selenium] acid) for the investigation of diarrhoea due to bile acid malabsorption in people with diarrhoea-predominant irritable bowel syndrome (IBS-D) or Crohn's disease without ileal resection (DG7)

Evidence-based recommendations on SeHCAT (tauroselcholic [75 selenium] acid) for investigating diarrhoea due to bile acid malabsorption (BAM)

Diagnostics guidance Published November 2012

Depth of anaesthesia monitors – Bispectral Index (BIS), E-Entropy and Narcotrend-Compact M (DG6)

Evidence-based recommendations on the Bispectral Index (BIS), E-Entropy and Narcotrend-Compact M depth of anaesthesia monitors

Diagnostics guidance Published November 2012

SonoVue (sulphur hexafluoride microbubbles) – contrast agent for contrast-enhanced ultrasound imaging of the liver (DG5)

Evidence-based recommendations on theSonoVue (sulphur hexafluoride microbubbles) contrast agent for contrast-enhanced ultrasound imaging of the liver

Diagnostics guidance Published August 2012

Therapeutic monitoring of TNF-alpha inhibitors in rheumatoid arthritis (DG36)

Evidence-based recommendations on enzyme-linked immunosorbent assay (ELISA) tests for therapeutic monitoring of TNF-alpha inhibitors in rheumatoid arthritis

Diagnostics guidance Published July 2019

Detecting, managing and monitoring haemostasis: viscoelastometric point‑of‑care testing (ROTEM, TEG and Sonoclot systems) (DG13)

Evidence-based recommendations on viscoelastometric point-of-care testing (ROTEM, TEG and Sonoclot systems) to detect, manage and monitor haemostasis

Diagnostics guidance Published August 2014

Fluorouracil chemotherapy: The My5‑FU assay for guiding dose adjustment (DG16)

Evidence-based recommendations on the My5-FU assay for guiding dose adjustment for fluorouracil chemotherapy

Diagnostics guidance Published December 2014

Point-of-care creatinine devices to assess kidney function before CT imaging with intravenous contrast (DG37)

Evidence-based recommendations on point-of-care creatinine devices to assess kidney function before CT imaging with intravenous contrast

Diagnostics guidance Published November 2019

Intraoperative tests (RD‑100i OSNA system and Metasin test) for detecting sentinel lymph node metastases in breast cancer (DG8)

Evidence-based recommendations on the RD-100i OSNA system and Metasin test for detecting sentinel lymph node metastases in breast cancer

Diagnostics guidance Published August 2013

EGFR‑TK mutation testing in adults with locally advanced or metastatic non-small-cell lung cancer (DG9)

Evidence-based recommendations on EGFR-TK mutation testing in adults with locally advanced or metastatic non-small-cell lung cancer (NSCLC)

Diagnostics guidance Published August 2013

Testing strategies for Lynch syndrome in people with endometrial cancer

In development [GID-DG10033] Expected publication date: 29 July 2020

Diagnostics guidance In development

High-sensitivity troponin for the early rule out of acute myocardial infarction

In development [GID-DG10035] Expected publication date: 26 August 2020

Diagnostics guidance In development

QAngio XA 3D/ QFR and CAAS vFFR imaging software for assessing the functional significance of coronary obstructions during invasive coronary angiography

In development [GID-DG10034] Expected publication date: 30 September 2020

Diagnostics guidance In development

Implantable cardiac monitors to detect atrial fibrillation after cryptogenic stroke

In development [GID-DG10023] Expected publication date: 27 May 2020

Diagnostics guidance In development

Implantable cardiac monitors to detect atrial fibrillation after cryptogenic stroke: diagnostics consultation

We are listening to your views on this diagnostics guidance. Comments close 04 February 2020.

Diagnostics guidance In consultation

PredictSURE-IBD and IBDX to guide personalised treatment of Crohn's disease

In development [GID-DG10029] Expected publication date: 26 August 2020

Diagnostics guidance In development

Eteplirsen for treating Duchenne muscular dystrophy [ID1003]

In development [GID-HST10007] Expected publication date: TBC

Highly specialised technologies guidance In development

Drisapersen for the first-line treatment of Duchenne's muscular dystrophy [ID911]

In development [GID-HST10004] Expected publication date: TBC

Highly specialised technologies guidance In development

Xpert MTB/RIF assay for the detection of active pulmonary tuberculosis and multi-drug resistant tuberculosis

In development [GID-DT9] Expected publication date: TBC

Diagnostics guidance In development

KRAS mutation testing of tumours in adults with metastatic colorectal cancer (discontinued)

In development [GID-DT14] Expected publication date: TBC

Diagnostics guidance In development

Elucigene FH20 and LIPOchip for the diagnosis of familial hypercholesterolaemia (DG2)

Both index tests included in this guidance are no longer commercially available. Therefore the guidance has been withdrawn.

Diagnostics guidance Published December 2011

Diagnosing prostate cancer: PROGENSA PCA3 assay and Prostate Health Index (DG17)

This guideline has been updated and replaced by NICE guideline NG131.

Diagnostics guidance Published June 2015

Endopyelotomy for pelviureteric junction obstruction (IPG325)

Evidence-based recommendations on endopyelotomy for treating pelviureteric junction (PUJ) obstruction

Interventional procedures guidance Published December 2009

Electrocautery cutting balloon treatment for pelviureteric junction obstruction (IPG324)

Evidence-based recommendations on electrocautery cutting balloon treatment for pelviureteric junction (PUJ) obstruction

Interventional procedures guidance Published December 2009

Balloon catheter insertion for Bartholin's cyst or abscess (IPG323)

Evidence-based recommendations on balloon catheter insertion for treating Bartholin's cyst or abscess

Interventional procedures guidance Published December 2009

Endoscopic transsphenoidal pituitary adenoma resection (IPG32)

Evidence-based recommendations on endoscopic transsphenoidal pituitary adenoma resection for treating pituitary adenomas (benign tumours)

Interventional procedures guidance Published December 2003

Individually magnetic resonance imaging-designed unicompartmental interpositional implant insertion for osteoarthritis of the knee (IPG317)

Evidence-based recommendations on inserting individually MRI-designed unicompartmental, interpositional (customised) implant for knee osteoarthritis

Interventional procedures guidance Published September 2009

Extracorporeal albumin dialysis for acute liver failure (IPG316)

Evidence-based recommendations on extracorporeal albumin dialysis for acute liver failure

Interventional procedures guidance Published September 2009

Extracorporeal shockwave therapy for refractory tennis elbow (IPG313)

Evidence-based recommendations on extracorporeal shockwave (inaudible sound waves) therapy for refractory tennis elbow

Interventional procedures guidance Published August 2009

Extracorporeal shockwave therapy for refractory plantar fasciitis (IPG311)

Evidence-based recommendations on extracorporeal shockwave therapy for refractory plantar fasciitis (ligament deterioration between the heel and foot)

Interventional procedures guidance Published August 2009

Placement of pectus bar for pectus excavatum (also known as MIRPE or the Nuss procedure) (IPG310)

Evidence-based recommendations on placing a pectus bar (MIRPE/the Nuss procedure) to treat pectus excavatum (‘funnel chest’)

Interventional procedures guidance Published August 2009

Endoscopic laser foraminoplasty (IPG31)

Evidence-based recommendations on endoscopic laser foraminoplasty for treating back pain caused by a prolapsed intervertebral disc

Interventional procedures guidance Published December 2003

Interstitial laser therapy for breast cancer (IPG89)

Evidence-based recommendations on interstitial laser therapy for treating breast cancer

Interventional procedures guidance Published September 2004

Photodynamic therapy for advanced bronchial carcinoma (IPG87)

Evidence-based recommendations on photodynamic therapy to treat bronchial carcinoma (non-small cell lung cancer/NSCLC)

Interventional procedures guidance Published August 2004

Endovascular atrial septostomy (IPG86)

Evidence-based recommendations on endovascular atrial septostomy for cyanotic congenital heart disease in babies

Interventional procedures guidance Published August 2004

Stereotactic radiosurgery for trigeminal neuralgia using the gamma knife (IPG85)

Evidence-based recommendations on stereotactic radiosurgery using the gamma knife to treat trigeminal neuralgia (nerve pain in the face)

Interventional procedures guidance Published August 2004

Supraorbital minicraniotomy for intracranial aneurysm (IPG84)

Evidence-based recommendations on supraorbital minicraniotomy for intracranial aneurysm (cerebral aneurysm)

Interventional procedures guidance Published August 2004

Selective peripheral denervation for cervical dystonia (IPG80)

Evidence-based recommendations on selective peripheral denervation for treating cervical dystonia

Interventional procedures guidance Published August 2004

Radiofrequency ablation of varicose veins (IPG8)

Evidence-based recommendations on radiofrequency ablation of varicose veins

Interventional procedures guidance Published September 2003

Stent placement for vena caval obstruction (IPG79)

Evidence-based recommendations on stent placement for vena caval obstruction

Interventional procedures guidance Published July 2004

Balloon valvuloplasty for aortic valve stenosis in adults and children (IPG78)

Evidence-based recommendations on balloon valvuloplasty for treating aortic valve stenosis (narrowing)

Interventional procedures guidance Published July 2004

Balloon dilatation of systemic to pulmonary arterial shunts in children (IPG77)

Evidence-based recommendations on balloon dilatation of systemic to pulmonary arterial shunts for cyanotic congenital heart disease in children

Interventional procedures guidance Published July 2004

Balloon dilatation with or without stenting for pulmonary artery or non-valvar right ventricular outflow tract obstruction in children (IPG76)

Evidence-based recommendations on balloon dilatation for pulmonary artery or non-valvar right ventricular outflow tract obstruction in children

Interventional procedures guidance Published July 2004

Balloon angioplasty of pulmonary vein stenosis in infants (IPG75)

Evidence-based recommendations on balloon angioplasty of pulmonary vein stenosis (narrowing) in infants

Interventional procedures guidance Published July 2004

Balloon angioplasty with or without stenting for coarctation or recoarctation of the aorta in adults and children (IPG74)

Evidence-based recommendations on balloon angioplasty with or without stenting for coarctation (narrowing) or recoarctation of the aorta

Interventional procedures guidance Published July 2004

Fallopian tube recanalisation by guidewire (IPG71)

Evidence-based recommendations on fallopian tube recanalisation by guidewire to treat infertility

Interventional procedures guidance Published July 2004