Individual research recommendation details

Recommendation ID

CG143/1

Question

Pain management for patients with an acute painful sickle cell episode:- For patients with an acute painful sickle cell episode, what are the effects of different opioid formulations, adjunct pain therapies and routes of administration on pain relief and acute sickle cell complications?

Any explanatory notes
(if applicable)

Why this is important:- Limited evidence is available on the effectiveness of different opioid formulations, routes of administration and adjunct therapies in the treatment of an acute painful sickle cell episode. A series of RCTs should be conducted that compare the effects of different opioid formulations,adjunct pain therapies and routes of administration. These RCTs should be conducted separately in adults and children, and cover the duration of the acute painful episode. Outcomes should include pain and adverse events such as acute chest syndrome.

Source guidance details

Comes from guidance

Sickle cell disease: managing acute painful episodes in hospital

Number

CG143

Date issued

June 2012

Other details